Article
Radiology, Nuclear Medicine & Medical Imaging
Charlene A. Mauger, Kathleen Gilbert, Avan Suinesiaputra, David A. Bluemke, Colin O. Wu, Joao A. C. Lima, Alistair A. Young, Bharath Ambale-Venkatesh
Summary: This study aimed to quantify the relationship between left ventricular (LV) three-dimensional shape at MRI and incident cardiovascular events over 10 years. Results showed that adding LV remodeling signatures to traditional cardiovascular risk factors improved the prediction of heart failure, coronary heart disease, and cardiovascular disease events over 10 years.
Article
Cardiac & Cardiovascular Systems
Patrick M. Pilz, Jennifer E. Ward, Wei-Ting Chang, Attila Kiss, Edward Bateh, Alokkumar Jha, Sudeshna Fisch, Bruno K. Podesser, Ronglih Liao
Summary: This article outlines the strengths, limitations, and outcomes of small and large animal models of heart failure with reduced ejection fraction currently used in basic and translational research. Animal models play a critical role in understanding the molecular mechanisms of heart failure, although no model completely recapitulates the full human disease.
CIRCULATION RESEARCH
(2022)
Review
Cell Biology
Ming-Yun Ho, Chao-Yung Wang
Summary: Irisin plays a vital role in regulating cardiovascular functions, with both protective and detrimental effects depending on the stage of myocardial infarction. Its functions include modulation of mitochondrial dysfunction, oxidative stress, metabolic imbalance, and energy expenditure in heart failure.
Review
Endocrinology & Metabolism
Megan Cairns, Danzil Joseph, M. Faadiel Essop
Summary: The heart depends on various fuel substrates for energy production, but excessive oxidative stress can lead to DNA damage and activation of poly-ADP-ribose polymerase. This activation inhibits key enzymes involved in glucose metabolism, diverting glucose into non-oxidative pathways such as the hexosamine biosynthetic pathway (HBP). The HBP has a dual role in cardiac physiology and pathophysiology, providing acute cardioprotection but contributing to chronic cardio-metabolic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ulrich Gergs, Tina Jahn, Nico Schulz, Claudia Grossmann, Uwe Rueckschloss, Uta Demus, Igor B. Buchwalow, Joachim Neumann
Summary: This study investigates the role of protein phosphatase 2A (PP2A) in cardiac signaling pathways and its impact on cardiac gene expression and stress response. The results suggest that overexpression of the catalytic subunit of PP2A may alter the expression of cardiac genes and enhance the acute stress tolerance of cardiac myocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Cody A. Rutledge, Brett A. Kaufman, Cameron Dezfulian, Jonathan Elmer
Summary: This study found that metformin may provide cardiac and renal protection for diabetic patients during sudden cardiac arrest, as it was associated with lower peak serum troponin and peak serum creatinine levels.
Review
Cell Biology
Dijana Stojanovic, Miodrag Stojanovic, Jelena Milenkovic, Aleksandra Velickov, Aleksandra Ignjatovic, Maja Milojkovic
Summary: The cellular mechanisms and signaling network underlying cardiac disease are complex, leading to the current lack of effective therapy. Cardiomyocytes and mitochondrial dysfunction have emerged as key targets for intervention. This review explores the potential of renalase to improve mitochondrial dysfunction in cardiac disease through multiple mechanisms, including preserving mitochondrial integrity and dynamics, increasing ATP content, enhancing mtDNA copy numbers, upregulating mitochondrial genes, inhibiting mitochondrial fission, supplementing NAD(+), upregulating sirtuins, and exerting antioxidant, anti-apoptotic, and anti-inflammatory effects.
Article
Cardiac & Cardiovascular Systems
Einar Sjaastad Norden, Bard Andre Bendiksen, Henriette Andresen, Kaja Knudsen Bergo, Emil Knut Espe, Almira Hasic, Ida Marie Hauge-Iversen, Ioanni Veras, Rizwan I. Hussain, Ivar Sjaastad, Geir Christensen, Alessandro Cataliotti
Summary: This study found that in a HFpEF model, sacubitril/valsartan (sac/val) reduced hypertrophy and improved diastolic dysfunction compared to valsartan alone, independent of blood pressure. The observed anti-hypertrophic effects in preserved ejection fraction suggest the potential benefit of sac/val in hypertrophic remodeling and impaired diastolic function.
Review
Medicine, General & Internal
Costantino Mancusi, Maria Lembo, Maria Virginia Manzi, Christian Basile, Ilaria Fucile, Carmine Morisco
Summary: Arterial hypertension is a major risk factor for heart failure, which is a leading cause of mortality and morbidity worldwide. Chronic hemodynamic overload caused by arterial hypertension leads to functional and morphological adaptations in the cardiovascular system, known as hypertensive mediated target organ damage (HMOD), which is of fundamental importance for diagnostic and prognostic purposes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Dijana Stojanovic, Valentina Mitic, Miodrag Stojanovic, Dejan Petrovic, Aleksandra Ignjatovic, Maja Milojkovic, Olivera Dunjic, Jelena Milenkovic, Vladmila Bojanic, Marina Deljanin Ilic
Summary: The study demonstrated that plasma renalase concentration could serve as a predictor of ischemia in chronic heart failure (CHF) patients, with similar discriminatory ability to BNP. In patients with left ventricular ejection fraction (LVEF) less than 45%, renalase showed independent predictive power for ischemia.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Sandhya Singh, Aakash Gaur, Rakesh Kumar Sharma, Renu Kumari, Shakti Prakash, Sunaina Kumari, Ayushi Devendrasingh Chaudhary, Pankaj Prasun, Priyanka Pant, Hannah Hunkler, Thomas Thum, Kumaravelu Jagavelu, Pragya Bharati, Kashif Hanif, Pragya Chitkara, Shailesh Kumar, Kalyan Mitra, Shashi Kumar Gupta
Summary: This study confirmed the presence of Msi2 in the heart and found that it can induce cardiomyocyte hypertrophy and heart failure. It was also discovered that Msi2 causes mitochondrial dysfunction in the heart and identified Cluh and Smyd1 as its downstream targets.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Review
Chemistry, Medicinal
Huiting Xia, Aqeela Zahra, Meng Jia, Qun Wang, Yunfu Wang, Susan L. Campbell, Jianping Wu
Summary: In this review, the potential role of NHE1 in cardiac hypertrophy and heart failure is discussed, along with an investigation into the underlying molecular mechanisms.
Article
Cardiac & Cardiovascular Systems
Xavier Revelo, Preethy Parthiban, Chen Chen, Fanta Barrow, Gavin Fredrickson, Haiguang Wang, Dogacan Yucel, Adam Herman, Jop H. van Berlo
Summary: This study assessed the role of cardiac immune cells in the early hypertrophy response to cardiac pressure overload and found that cardiac resident macrophages play a key role in stimulating angiogenesis and inhibiting fibrosis in response to cardiac pressure overload.
CIRCULATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Aviseka Acharya, Harshal Nemade, Symeon Papadopoulos, Jurgen Hescheler, Felix Neumaier, Toni Schneider, Krishna Rajendra Prasad, Khadija Khan, Ruth Hemmersbach, Eduardo Gade Gusmao, Athanasia Mizi, Argyris Papantonis, Agapios Sachinidis
Summary: This study used human-induced pluripotent stem cells to derive cardiomyocytes and exposed them to simulated microgravity. It found that microgravity affects the contractile velocity and function of cardiomyocytes through the induction of senescence processes, which is linked to changes in reactive oxygen species generation and energy metabolism by mitochondria.
Review
Endocrinology & Metabolism
Qingwen Yu, Guangyuan Zhao, Jingjing Liu, Yajie Peng, Xueli Xu, Fei Zhao, Yangyang Shi, Chengyun Jin, Ji Zhang, Bo Wei
Summary: Heart diseases are a major cause of morbidity and mortality worldwide, with complex underlying mechanisms. Disordered cardiac metabolism, including the role of histone deacetylases (HDACs), plays a key role in various heart diseases. Understanding the regulation of HDACs in cardiac energy metabolism could lead to the development of new therapeutic strategies for heart diseases.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)