Article
Endocrinology & Metabolism
Matthew T. C. Manion, Erica R. R. Glasper, Kuan Hong Wang
Summary: The study discovered a sex difference in the dopaminergic circuit from VTA to BLA in mice, which provides a structural foundation for investigating neural circuit mechanisms underlying sex differences in motivational and emotional behaviors and related psychiatric dysfunctions.
BIOLOGY OF SEX DIFFERENCES
(2022)
Review
Neurosciences
Changuk Chung, Wangyong Shin, Eunjoon Kim
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and repetitive symptoms. Studies in mouse models have shown early pathophysiological mechanisms that can be corrected to prevent phenotypic defects in adulthood. Additionally, gene restorations have demonstrated the rescue of ASD-related phenotypes even after the brain has fully matured.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Mayara C. Ribeiro, Jessica L. MacDonald
Summary: Rett syndrome (RTT) is a neurological disorder caused by MECP2 mutations. Vitamin D can modulate RTT pathology and its supplementation can improve neuronal morphology and behavioral phenotypes in RTT patients.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Marcus M. Weera, Rosetta S. Shackett, Hannah M. Kramer, Jason W. Middleton, Nicholas W. Gilpin
Summary: The study demonstrates the crucial role of CeA projections to the lateral hypothalamus in avoidance behavior of male rats exposed to stress-related stimuli, suggesting potential implications for substance abuse and traumatic stress disorders. Moreover, the avoidance behavior is found to be associated with intrinsic properties of LH-projecting CeA cells.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Nathan P. Achilly, Wei Wang, Huda Y. Zoghbi
Summary: Research using a mouse model of Rett syndrome shows that intensive training before symptom onset can significantly improve specific motor and memory tasks, delaying the onset of symptoms. The study indicates that task-specific neurons activated during training develop more dendritic arbors and have better neurophysiological responses, enhancing their functionality and delaying symptom onset.
Article
Medicine, Research & Experimental
Linda Scaramuzza, Giuseppina De Rocco, Genni Desiato, Clementina Cobolli Gigli, Martina Chiacchiaretta, Filippo Mirabella, Davide Pozzi, Marco De Simone, Paola Conforti, Massimiliano Pagani, Fabio Benfenati, Fabrizia Cesca, Francesco Bedogni, Nicoletta Landsberger
Summary: MECP2 mutations cause Rett syndrome, affecting females and altering early brain development. Increasing neuronal activity may delay specific RTT phenotypes.
EMBO MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Joni Haikonen, Jonas Englund, Shyrley Paola Amarilla, Zoia Kharybina, Alexandra Shintyapina, Kristel Kegler, Marta Saez Garcia, Tsvetomira Atanasova, Tomi Taira, Henrike Hartung, Sari E. Lauri
Summary: Early life stress leads to long-term dysfunction in the corticolimbic circuitry, affecting emotional and social behavior. The underlying neurobiological mechanisms are still not well understood.
Article
Multidisciplinary Sciences
John R. Sinnamon, Michael E. Jacobson, John F. Yung, Jenna R. Fisk, Sophia Jeng, Shannon K. McWeeney, Lindsay K. Parmelee, Chi Ngai Chan, Siu-Pok Yee, Gail Mandel
Summary: This study provides evidence that a targeted RNA-editing approach can alleviate a hallmark symptom in a mouse model of Rett syndrome. Injection of a Mecp2-targeting virus effectively restores MeCP2 expression and function in the brainstem of mice, alleviating abnormal respiratory patterns and prolonging survival.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Camille Mazo, Antoine Nissant, Soham Saha, Enzo Peroni, Pierre-Marie Lledo, Gabriel Lepousez
Summary: In the olfactory system, a group of GABAergic neurons in the anterior olfactory cortex projects inhibitory feedback signals to the olfactory bulb, which can enhance the separation of odor responses and affect the discrimination of similar odors in the output neurons.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Anna Hoerder-Suabedissen, Gabriel Ocana-Santero, Thomas H. Draper, Sophie A. Scott, Jesse G. Kimani, Andrew M. Shelton, Simon J. B. Butt, Zoltan Molnar, Adam M. Packer
Summary: Our study investigates the development of mouse claustrum neurons, including their birth time, location in the developing brain, and the formation of their connections to the cortex. We found that a specific protein distribution and a dense patch of cells are present in the claustrum from postnatal day 21, while most claustrum neurons are born around embryonic day 12.5. The claustrum's connectivity to different cortical regions matures at different times. This research establishes a timeline of claustrum development and provides insights into its unique connectivity.
Article
Multidisciplinary Sciences
Ipek Akol, Annalisa Izzo, Fabian Gather, Stefanie Strack, Stefanie Heidrich, Darren O. Hailin, Alejandro Villarreal, Christine Hacker, Tudor Rauleac, Chiara Bella, Andre Fischer, Thomas Manke, Tanja Vogel
Summary: Forkhead box G1 (FOXG1) plays important roles in neuronal differentiation and maintaining excitatory/inhibitory balance in the network. In this study, the authors investigated how FOXG1 impacts neuronal maturation at the chromatin level in the mouse hippocampus. They found that FOXG1 regulates transcription, binds to enhancer regions, and alters the epigenetic landscape. FOXG1 and NEUROD1 act cooperatively to control neuronal maturation, and the chromatin alterations affect synaptogenesis and axonogenesis. This study provides insights into the multimodality of FOXG1 functions and suggests epigenetic drugs as potential therapeutic options for neuronal dysfunction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Hermany Munguba, Bidisha Chattopadhyaya, Stephan Nilsson, Josianne N. Carrico, Fatima Memic, Polina Oberst, Renata Batista-Brito, Ana Belen Munoz-Manchado, Michael Wegner, Gordon Fishell, Graziella Di Cristo, Jens Hjerling-Leffler
Summary: Pvalb(+) neurons provide robust inhibition to neighboring pyramidal neurons and undergo extensive synaptic formation and maturation during the first weeks after birth and continue to dynamically maintain their synaptic output throughout adulthood. Sox6 plays a crucial role in the postnatal maturation and synaptic function of cortical Pvalb(+) neurons, with its loss leading to synaptic bouton growth failure and shrinkage of established boutons. These findings suggest a constitutive role for Sox6 in maintaining synaptic output from Pvalb(+) neurons into adulthood.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Quanxin Wang, Yun Wang, Hsien-Chi Kuo, Peng Xie, Xiuli Kuang, Karla E. Hirokawa, Maitham Naeemi, Shenqin Yao, Matt Mallory, Ben Ouellette, Phil Lesnar, Yaoyao Li, Min Ye, Chao Chen, Wei Xiong, Leila Ahmadinia, Laila El-Hifnawi, Ali Cetin, Staci A. Sorensen, Julie A. Harris, Hongkui Zeng, Christof Koch
Summary: Using multimodal reference datasets, the study confirmed the delineation of the mouse claustrum (CLA) as a single group of neurons embedded in the agranular insular cortex. Through quantitative investigation, the study revealed the brain-wide inputs and outputs of CLA and identified the cell-type-specific connections. The study also found that the prefrontal module has more cell types projecting to the CLA and identified nine morphological types of CLA principal neurons.
Review
Neurosciences
Snow Bach, Stephen Shovlin, Michael Moriarty, Barbara Bardoni, Daniela Tropea
Summary: RTT and FXS are two monogenetic neurodevelopmental disorders with overlapping features possibly due to interactions between MeCP2 and FMRP. Both syndromes affect brain development and result in dysregulation of common molecular signaling pathways.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Julia L. Napoli, Corrie R. Camalier, Anna-Leigh Brown, Jessica Jacobs, Mortimer M. Mishkin, Bruno B. Averbeck
Summary: The study found that in a spatial selective listening task, primary auditory cortex (AC) encoded the cue and target characteristics before the dorsolateral prefrontal cortex (dlPFC) and the basolateral amygdala (BLA), and also encoded the monkey's choice at an earlier stage. The similarity between AC and dlPFC responses was eliminated during passive sensory stimulation, suggesting that the strong sensory encoding in dlPFC is contextually gated. The study suggests that unlike in the visual domain, the BLA does not appear to be robustly involved in selective spatial processing in this auditory task.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Julia Lauer Zillhardt, Karine Poirier, Loic Broix, Nicolas Lebrun, Adrienne Elmorjani, Jelena Martinovic, Yoann Saillour, Giuseppe Muraca, Juliette Nectoux, Bettina Bessieres, Catherine Fallet-Bianco, Stanislas Lyonnet, Olivier Dulac, Sylvie Odent, Imen Rejeb, Lamia Ben Jemaa, Francois Rivier, Lucile Pinson, David Genevieve, Yuri Musizzano, Nicole Bigi, Nicolas Leboucq, Fabienne Giuliano, Nicole Philip, Catheline Vilain, Patrick Van Bogaert, Helsne Maurey, Cherif Beldjord, Franois Artiguenave, Anne Boland, Robert Olaso, Cecile Masson, Patrick Nitschke, Jean-Francois Deleuze, Nadia Bahi-Buisson, Jamel Chelly
EUROPEAN JOURNAL OF HUMAN GENETICS
(2016)
Article
Biochemistry & Molecular Biology
H. Hu, S. A. Haas, J. Chelly, H. Van Esch, M. Raynaud, A. P. M. de Brouwer, S. Weinert, G. Froyen, S. G. M. Frints, F. Laumonnier, T. Zemojtel, M. I. Love, H. Richard, A-K Emde, M. Bienek, C. Jensen, M. Hambrock, U. Fischer, C. Langnick, M. Feldkamp, W. Wissink-Lindhout, N. Lebrun, L. Castelnau, J. Rucci, R. Montjean, O. Dorseuil, P. Billuart, T. Stuhlmann, M. Shaw, M. A. Corbett, A. Gardner, S. Willis-Owen, C. Tan, K. L. Friend, S. Belet, K. E. P. van Roozendaal, M. Jimenez-Pocquet, M-P Moizard, N. Ronce, R. Sun, S. O'Keeffe, R. Chenna, A. Van Boemmel, J. Goeke, A. Hackett, M. Field, L. Christie, J. Boyle, E. Haan, J. Nelson, G. Turner, G. Baynam, G. Gillessen-Kaesbach, U. Mueller, D. Steinberger, B. Budny, M. Badura-Stronka, A. Latos-Bielenska, L. B. Ousager, P. Wieacker, G. Rodriguez Criado, M-L Bondeson, G. Anneren, A. Dufke, M. Cohen, L. Van Maldergem, C. Vincent-Delorme, B. Echenne, B. Simon-Bouy, T. Kleefstra, M. Willemsen, J-P Fryns, K. Devriendt, R. Ullmann, M. Vingron, K. Wrogemann, T. F. Wienker, A. Tzschach, H. van Bokhoven, J. Gecz, T. J. Jentsch, W. Chen, H-H Ropers, V. M. Kalscheuer
MOLECULAR PSYCHIATRY
(2016)
Article
Clinical Neurology
Mathilde Renaud, Christophe Marcel, Gabrielle Rudolf, Mickael Schaeffer, Ouhaid Lagha-Boukbiza, Jean-Baptiste Chanson, Jamel Chelly, Mathieu Anheim, Christine Tranchant
Article
Genetics & Heredity
Annie Laquerriere, Marie Gonzales, Yoann Saillour, Mara Cavallin, Nicole Joye, Chloe Quelin, Laurent Bidat, Marc Dommergues, Ghislaine Plessis, Ferechte Encha-Razavi, Jamel Chelly, Nadia Bahi-Buisson, Karine Poirier
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2016)
Article
Biochemistry & Molecular Biology
Hamid Meziane, Malik Khelfaoui, Noemi Morello, Bassem Hiba, Eleonora Calcagno, Sophie Reibel-Foisset, Mohammed Selloum, Jamel Chelly, Yann Humeau, Fabrice Riet, Ginevra Zanni, Yann Herault, Thierry Bienvenu, Maurizio Giustetto, Pierre Billuart
HUMAN MOLECULAR GENETICS
(2016)
Article
Genetics & Heredity
Loic Broix, Helene Jagline, Ekaterina L. Ivanova, Stephane Schmucker, Nathalie Drouot, Jill Clayton-Smith, Alistair T. Pagnamenta, Kay A. Metcalfe, Bertrand Isidor, Ulrike Walther Louvier, Annapurna Poduri, Jenny C. Taylor, Peggy Tilly, Karine Poirier, Yoann Saillour, Nicolas Lebrun, Tristan Stemmelen, Gabrielle Rudolf, Giuseppe Muraca, Benjamin Saintpierre, Adrienne Elmorjani, Martin Moise, Nathalie Bednarek Weirauch, Renzo Guerrini, Anne Boland, Robert Olaso, Cecile Masson, Ratna Tripathy, David Keays, Cherif Beldjord, Laurent Nguyen, Juliette Godin, Usha Kini, Patrick Nischke, Jean-Francois Deleuze, Nadia Bahi-Buisson, Izabela Sumara, Maria-Victoria Hinckelmann, Jamel Chelly
Editorial Material
Genetics & Heredity
Marguerite Miguet, Julien Thevenon, Vincent Laugel, Mathilde Lefebvre, Aurelie Bourchany, Jean-Baptiste Riviere, Yannis Duffourd, Elise Schaefer, Maria Cristina Antal, Rosalie Abida, Anne-Sophie Weingertner, Valerie Kremer, Pierre Vabres, Fanny Morice-Picard, Marie Gonzales, Dan Lipsker, Sylvie Fraitag, Jean-Louis Mandel, Jamel Chelly, Helene Dollfus, Laurence Faivre, Christel Thauvin-Robinet, Nadege Calmels, Salima El Chehadeh
PRENATAL DIAGNOSIS
(2016)
Article
Biochemistry & Molecular Biology
Juliette Nectoux, Rafael de Cid, Sylvain Baulande, France Leturcq, Jon Andoni Urtizberea, Isabelle Penisson-Besnier, Aleksandra Nadaj-Pakleza, Carinne Roudaut, Audrey Criqui, Lucie Orhant, Delphine Peyroulan, Raba Ben Yaou, Isabelle Nelson, Anna Maria Cobo, Marie-Christine Arne-Bes, Emmanuelle Uro-Coste, Patrick Nitschke, Mireille Claustres, Gisele Bonne, Nicolas Levy, Jamel Chelly, Isabelle Richard, Mireille Cossee
EUROPEAN JOURNAL OF HUMAN GENETICS
(2015)
Article
Biochemistry & Molecular Biology
Mariana Ramos-Brossier, Caterina Montani, Nicolas Lebrun, Laura Gritti, Christelle Martin, Christine Seminatore-Nole, Aurelie Toussaint, Sarah Moreno, Karine Poirier, Olivier Dorseuil, Jamel Chelly, Anna Hackett, Jozef Gecz, Eric Bieth, Anne Faudet, Delphine Heron, R. Frank Kooy, Bart Loeys, Yann Humeau, Carlo Sala, Pierre Billuart
HUMAN MOLECULAR GENETICS
(2015)
Article
Multidisciplinary Sciences
Aurore Curie, Amandine Brun, Anne Cheylus, Anne Reboul, Tatjana Nazir, Gerald Bussy, Karine Delange, Yves Paulignan, Sandra Mercier, Albert David, Stephanie Marignier, Lydie Merle, Benedicte de Freminville, Fabienne Prieur, Michel Till, Isabelle Mortemousque, Annick Toutain, Eric Bieth, Renaud Touraine, Damien Sanlaville, Jamel Chelly, Jian Kong, Daniel Ott, Behrouz Kassai, Nouchine Hadjikhani, Randy L. Gollub, Vincent des Portes
Review
Neurosciences
Elisabete Augusto, Frederic Gambino
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2019)
Editorial Material
Neurosciences
Frederic Gambino, Daniel Choquet
Article
Cell Biology
Tiago Campelo, Elisabete Augusto, Nicolas Chenouard, Aron de Miranda, Vladimir Kouskoff, Come Camus, Daniel Choquet, Frederic Gambino
Article
Biology
Mattia Aime, Elisabete Augusto, Vladimir Kouskoff, Tiago Campelo, Christelle Martin, Yann Humeau, Nicolas Chenouard, Frederic Gambino
Meeting Abstract
Clinical Neurology
I De lange, K. Helbig, S. Weckhuysen, R. Moller, M. Velinov, N. Dolzhanskaya, E. Marsh, I Helbig, O. Devinsky, S. Tang, H. Mefford, C. Myers, W. Van Paesschen, P. Striano, K. Van Gassen, M. Van Kempen, C. De Kovel, J. Piard, B. Minassian, M. Nezarati, A. Pessoa, A. Jacquette, R. Van't Slot, L. Van Maldergem, E. Brilstra, B. Koeleman