Article
Biochemistry & Molecular Biology
Rong Chen, Chen Cao, Huimin Liu, Wanli Jiang, Rui Pan, He He, Ke Ding, Qingtao Meng
Summary: This study identifies macrophage Spry4 as a key regulator in sepsis-induced acute lung injury (ALI) and suggests that targeting Spry4 could be a potential therapeutic approach for ALI. Mechanistically, macrophage Spry4 deficiency alleviates ALI by activating the CaMKK2/AMPK pathway.
Article
Biochemistry & Molecular Biology
Ngan Nguyen, Simin Xu, Terence Yin Weng Lam, Wupeng Liao, W. S. Fred Wong, Ruowen Ge
Summary: This study reveals that ISM1 plays an anti-inflammatory role in acute lung injury (ALI), and its deficiency leads to intensified acute lung inflammation and increased post-ALI lung fibrosis. Recombinant ISM1 effectively suppresses acute lung inflammation and ALI, and inhibits NF-κB activation in mouse alveolar macrophages.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wanli Jiang, Chengtai Ma, Jiawei Bai, Xianjin Du
Summary: This study investigates the role and mechanism of macrophage SAMSN1 in sepsis-induced acute lung injury (ALI). The results demonstrate that macrophage SAMSN1 overexpression can protect against sepsis-induced inflammation, oxidative stress, and ALI by activating AMPKα2 through the GAB1/SHP2/PKA pathway.
Article
Immunology
Hui Liang, Gaoli Liu, Wenhui Zeng, Qinglu Fan, Zhihao Nie, Haifeng Hu, Renquan Zhang, Songping Xie
Summary: The aim of this study was to determine the function of multiple EGF like domains 6 (MEGF6) in sepsis-induced acute lung injury (ALI). Mice were used to investigate the effects of MEGF6 knockdown or overexpression on ALI, and primary peritoneal macrophages were used to confirm its role in vitro. The results showed that elevated levels of MEGF6 were associated with reduced inflammation and oxidative damage in both mouse models and cell cultures.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xinlei Sun, Fujie Shi, Weiran Wang, Yunfei Wu, Shuang Qu, Jing Li, Hongwei Liang, Ke Zen
Summary: Infiltration of polymorphonuclear neutrophils (PMNs) is critical in acute lung injury (ALI). This study reveals that pyruvate kinase type M2 (PKM2) plays a crucial role in PMN inflammatory responses, and deletion of PKM2 in PMNs impairs their function but protects against LPS-induced ALI.
Article
Immunology
Rong Zhuang, Xiyu Yang, Wenchao Cai, Rongxiao Xu, Liang Lv, Yingying Sun, Yayong Guo, Jingjing Ni, Guangju Zhao, Zhongqiu Lu
Summary: The study revealed that MCTR3 can protect mice from LPS-induced ALI, alleviating lung injury and promoting lung function restoration. These protective effects are mainly achieved through down-regulation of the PINK1 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaotao Xu, Yang Su, Kaixuan Wu, Fan Pan, Aizhong Wang
Summary: DOCK2 is a crucial regulator in macrophage activation and acute lung injury, controlling IKKβ activation and inflammatory cytokine release. Inhibition of DOCK2 may be a promising approach for treating endotoxemia-related ALI.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Jian Shen, Shuting Wang, Yong Huang, Zhengjie Wu, Shengyi Han, He Xia, Hui Chen, Lanjuan Li
Summary: The study found that Lactobacillus reuteri can improve gut microbiota composition and modulate immune response, showing therapeutic effects in acute lung injury (ALI) models. L. reuteri effectively attenuated lung tissue injury, reduced inflammation and infiltration, improved intestinal barrier function, and remodeled disordered gut microbiota.
Article
Medicine, Research & Experimental
Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv, Wei Han
Summary: Panaxydol (PX) isolated from Panax ginseng roots attenuates ferroptosis against LPS-induced ALI via the Keap1-Nrf2/HO-1 pathway, showing promising therapeutic potential for ALI treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell & Tissue Engineering
Junwen Han, Gu Li, Minmin Hou, Julie Ng, Min-Young Kwon, Kevin Xiong, Xiaoliang Liang, Elizabeth Taglauer, Yuanyuan Shi, S. Alex Mitsialis, Stella Kourembanas, Souheil El-Chemaly, James A. Lederer, Ivan O. Rosas, Mark A. Perrella, Xiaoli Liu
Summary: Intratracheal transplantation of trophoblast stem cells reduced pulmonary inflammation and cell death in mice with acute lung injury induced by bleomycin, suggesting their potential for ALI treatment.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Toxicology
Shunsaku Goto, Robert M. H. Grange, Riccardo Pinciroli, Ivy A. Rosales, Rebecca Li, Sophie L. Boerboom, Katrina F. Ostrom, Eizo Marutani, Hatus Wanderley, Aranya Bagchi, Robert B. Colvin, Lorenzo Berra, Olga Minaeva, Lee E. Goldstein, Rajeev Malhotra, Warren M. Zapol, Fumito Ichinose, Binglan Yu
Summary: Research found that the concentration of formaldehyde and acetaldehyde in aerosols increased with the usage of e-cigarette coils. Aerosols produced from aged coils caused acute lung injury, increased lung wet/dry weight ratio, and induced lung inflammation in mice.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuting Lin, Qingdi Lu, Chaolei Chen, Beibei Wang, Lisha Guo, Jingwen Xie, Chengshui Chen, Lili Huang, Li Dong
Summary: The study showed that compound 39 has anti-inflammatory, antioxidant, and anti-apoptotic activities against LPS-induced acute lung injury, possibly through suppression of the MAPK/NF-κB pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Plant Sciences
Rentsen Badamjav, Lu Zhang, Dolgor Sonom, Yun-Hao Wu, Jun-Ping Kou, Bo-Yang Yu, Fang Li
Summary: Thalictrum minus L., a traditional Mongolian folk medicinal plant, demonstrates effectiveness in attenuating particulate matter-induced acute lung injury by modulating inflammatory cytokines and oxidative damage signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Xiang Li, Lina Yin, Jing Liao, Jun Yang, Binhao Cai, Yiming Yu, Sijia Su, Zhiteng Du, Xiaobo Li, Ying Zhou, Pan Chen, Won-Jea Cho, Nipon Chattipakorn, Aleksandr V. Samorodov, Valentin N. Pavlov, Fengzhi Zhang, Guang Liang, Qidong Tang
Summary: A series of novel O-benzylcinnamic acid derivatives were designed and synthesized, and compound L26 showed the best anti-inflammatory activity, being 7-fold more active than CIN. Further experiments revealed that L26 targeted MD-2 protein and competed with LPS to bind to MD-2, resulting in inflammation inhibition. In vivo experiments demonstrated that high doses of L26 were safe and it exhibited optimal pharmacodynamic and pharmacokinetic characteristics, suggesting its potential as a treatment agent for ALI.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Zhiguo Gong, Shuangyi Zhang, Baichen Gu, Jinshan Cao, Wei Mao, Yuan Yao, Jiamin Zhao, Peipei Ren, Kai Zhang, Bo Liu
Summary: This study demonstrated that Codonopsis pilosula polysaccharides (CPPS) have a protective effect on acute lung injury (ALI) induced by lipopolysaccharide (LPS) and Escherichia coli (E. coli) infection. CPPS can reduce the secretion of inflammatory molecules and the activation of signaling pathways, enhance bacterial phagocytosis, and inhibit bacterial growth. In addition, CPPS can attenuate lung damage in mice, reducing the production of tissue damage biomarkers.
Article
Psychology, Clinical
Guillaume Fond, Vanessa Pauly, Marc Leone, Veronica Orleans, Alexandra Garosi, Christophe Lancon, Pascal Auquier, Karine Baumstarck, Pierre-Michel Llorca, Laurent Boyer
Summary: This study examined whether bipolar disorder (BD) patients with COVID-19 have an increased risk of mortality. It found that patients with BD had a higher mortality rate, which was more pronounced in younger and socioeconomically disadvantaged patients.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Anesthesiology
G. Duclos, S. Granier, A. Hili, J. Blanc, S. Einav, M. Leone, L. Zieleskiewicz
Summary: This study found that using a digital non-invasive monitoring device to analyze stroke volume variation can predict the occurrence of hypotension after spinal anesthesia in third trimester parturients who undergo cesarean delivery and receive appropriate hypotension prophylaxis.
INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA
(2022)
Article
Anesthesiology
Ines Lakbar, Manon Munoz, Vanessa Pauly, Veronica Orleans, Cyprien Fabre, Guillaume Fond, Jean-Louis Vincent, Laurent Boyer, Marc Leone
Summary: The incidence of septic shock is increasing, but the mortality rates have decreased over the years. Pathogen identification and prompt admission to the ICU are associated with improved outcomes, while the increasing rate of hospital readmission raises questions about discharge criteria.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Article
Anesthesiology
Tobias Gauss, Herve Quintard, Benjamin Bijok, Guillaume Bouhours, Thomas Clavier, Fabrice Cook, Hugues de Courson, Jean-Stephane David, Caroline Duracher-Gout, Delphine Garrigue, Thomas Geeraerts, Sophie Hamada, Olivier Joannes-Boyau, Romain Jouffroy, Antoine Lamblin, Olivier Langeron, Pierre Lanot, Sigismond Lasocki, Marc Leone, Sebastien Mirek, Laurent Muller, Pierre Pasquier, Bertrand Prunet, Sebastien Perbet, Mathieu Raux, Justin Richards, Claire Roger, Antoine Roquilly, Emmanuel Weiss, Pierre Bouzat, Julien Pottecher
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Letter
Anesthesiology
Olivier Joannes-Boyau, Claire Dahyot-Fizelier, Pierre Albaladejo, Herve Bouaziz, Marie-Laure Cittanova, Jean-Michel Constantin, Laurent Delaunay, Marc Leone, Karine Nouette-Gaulain, Bernard Allaouchiche, Roland Amathieu, Enora Atchade, Emmanuel Besnier, Belaid Bouhemad, Benjamin Chousterman, Olivier Collange, Vincent Degos, Olivier Langeron, Yoann Launey, Nicolas Mayeur, Jordi Miatello, Nicolas Mongardon, Jerome Morel, Pierre Trouiller, Fanny Vardon Bounes, Claire Fazilleau
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Alexandre Cereuil, Romain Ronfle, Aurelien Culver, Mohamed Boucekine, Laurent Papazian, Laurent Lefebvre, Marc Leone
Summary: The study identified relevant variables and patient phenotypes to predict sepsis outcomes and proposed an algorithm based on norepinephrine dose, lactate concentration, and venous-to-arterial carbon dioxide difference (P(v-a)CO2) with a 74% area under the curve (AUC).
ADVANCES IN THERAPY
(2022)
Article
Emergency Medicine
Matthieu Vasse, Marc Leone, Laurent Boyer, Pierre Michelet, Yvain Goudard, Michael Cardinale, Raphael Paris, Jean Philippe Avaro, Pascal Alexandre Thomas, Henri de Lesquen
Summary: This study aimed to assess compliance with protocols in penetrating thoracic trauma on admission to a level I trauma centre and determine whether compliance impacts morbidity and mortality. The implementation of a trauma system was associated with better compliance to European recommendations and improved outcomes for severe trauma patients.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Infectious Diseases
Perrine Tritscher, Matthieu Delannoy, Nelly Agrinier, Alexandre Charmillon, Nicolas Degand, Jean Dellamonica, Claire Roger, Marc Leone, Julien Scala-Bertola, Emmanuel Novy
Summary: The current practice of beta-lactam monitoring in French ICUs is not optimal, with the major barriers being the interpretation of beta-lactam monitoring results and the required time for obtaining results.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Emmanuel Futier, Samir Jaber, Matthias Garot, Marie Vignaud, Yves Panis, Karem Slim, Jean-Christophe Lucet, Gilles Lebuffe, Alexandre Ouattara, Younes El Amine, Philippe Couderc, Aurelien Dupre, Audrey De Jong, Sigismond Lasocki, Marc Leone, Julien Pottecher, Bruno Pereira, Catherine Paugam-Burtz
Summary: Oral antimicrobial prophylaxis as an adjunct to intravenous antibiotic prophylaxis can significantly reduce surgical site infections after elective colorectal surgery.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Editorial Material
Anesthesiology
Emmanuel Dudoignon, Francois Camelena, Marc Leone, Francois Depret
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Review
Microbiology
Ines Lakbar, Sharon Einav, Nathalie Lalevee, Ignacio Martin-Loeches, Bruno Pastene, Marc Leone
Summary: Sex and gender dimorphisms are observed in various diseases, including sepsis and septic shock, with a higher prevalence in men. Animal models indicate that females and males have different responses to pathogens, mainly due to sex polarization of intracellular pathways. Sex hormones play a role in this polarization, but further research is needed to investigate other factors.
Review
Microbiology
Alexis Garduno, Rachael Cusack, Marc Leone, Sharon Einav, Ignacio Martin-Loeches
Summary: It is evident that delayed admission of sepsis and septic shock patients to hospitals contributes to poor outcomes and high fatalities worldwide. The current diagnostic procedure is inaccurate and often delayed, while the immune response in sepsis involves cytokine storm and changes in immune cell proportions. This review explores the potential use of multi-omics data integration and immunological profiling at the single-cell level to define endotypes in sepsis and septic shock, as well as the parallels with cancer and immunosuppression, sepsis-induced cardiomyopathy, and endothelial damage. The added value of transcriptomic-driven endotypes for inferring regulatory interactions and measuring clinical response in ICU will also be assessed.
Article
Economics
Jay L. Koyner, Rachel H. Mackey, Ning A. Rosenthal, Leslie A. Carabuena, J. Patrick Kampf, Paul McPherson, Toni Rodriguez, Aarti Sanghani, Julien Textoris
Summary: In hospitalized patients with COVID-19, acute kidney injury (AKI) is associated with higher mortality. This study analyzed the healthcare resource utilization (HRU) and costs related to AKI, community-acquired AKI (CA-AKI), and hospital-acquired AKI (HA-AKI). The findings showed that HA-AKI had higher excess mortality, HRU, and costs than CA-AKI, emphasizing the importance of preventing HA-AKI in COVID-19 patients.
JOURNAL OF HEALTH ECONOMICS AND OUTCOMES RESEARCH
(2023)
Article
Infectious Diseases
Matthieu Rossi, Louis Delamarre, Gary Duclos, Ines Lakbar, Emmanuelle Hammad, Charlotte Arbelot, Laurent Zieleskiewicz, Marc Leone
Summary: Compliance with the PCT protocol for VAP treatment was assessed in this study, with a compliance rate of 58%. Noncompliance was mainly due to lack of PCT measurements. Higher compliance was observed in medical patients and those admitted for SARS-CoV-2 infection, while compliance regarding antibiotic therapy interruption based on PCT was lower on weekends and holidays.
Article
Critical Care Medicine
Niccolo Buetti, Alexis Tabah, Ambre Loiodice, Stephane Ruckly, Abdullah Tarik Aslan, Giorgia Montrucchio, Andrea Cortegiani, Nese Saltoglu, Bircan Kayaaslan, Firdevs Aksoy, Akova Murat, Ozlem Akdogan, Kemal Tolga Saracoglu, Cem Erdogan, Marc Leone, Ricard Ferrer, Jose-Artur Paiva, Yoshiro Hayashi, Mahesh Ramanan, Andrew Conway Morris, Francois Barbier, Jean-Francois Timsit
Summary: This study describes the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) among COVID-19 and non-COVID-19 critically ill patients. The results show differences in the characteristics of HABSI between the two groups, with COVID-19 patients having a higher risk of mortality.