Article
Immunology
Yaxing Zhao, Peng Liu, Yuanqiang Zhang, Hua Jiang, Haofan Luan, Yingmei Xu, Yubin Zhang, Ruiyan Li
Summary: This study found that Demethyleneberberine (DMB), a natural product from the rhizome of Coptis chinensis, possesses anti-inflammatory and immunoregulatory activities. It can alleviate ulcerative colitis (UC) and inhibit TLR4-mitochondria signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Yuxin Dai, Qiulu Lu, Peiyi Li, Junyu Zhu, Jiaxin Jiang, Tong Zhao, Yue Hu, Kang Ding, Min Zhao
Summary: This study aimed to investigate the mechanism of Xianglian Pill (XLP) in treating ulcerative colitis (UC) induced by dextran sulfate sodium (DSS). The results showed that XLP treated UC by regulating the TLR4/MyD88/NF-kappa B signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Juan F. Burgueno, Julia Fritsch, Eddy E. Gonzalez, Kevin S. Landau, Ana M. Santander, Irina Fernandez, Hajar Hazime, Julie M. Davies, Rebeca Santaolalla, Matthew C. Phillips, Sophia Diaz, Rishu Dheer, Nivis Brito, Judith Pignac-Kobinger, Ester Fernandez, Gregory E. Conner, Maria T. Abreu
Summary: Chronic colonic inflammation can lead to dysplasia and cancer. Activation of TLR4 is associated with up-regulation of DUOX2 and NOX1, leading to increased epithelial production of H2O2, promoting colorectal tumor formation.
Article
Environmental Sciences
Yadong Zhou, Fafu Dou, Huwei Song, Tao Liu
Summary: In this study, the protective effect of wogonin on ulcerative colitis was investigated. It was found that wogonin has anti-inflammatory properties and can inhibit oxidative damage. The molecular mechanisms underlying its anti-inflammatory effects were also explored.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Immunology
Maryam Ghasemi-Dehnoo, Hossein Amini-Khoei, Zahra Lorigooini, Maryam AnjomShoa, Elham Bijad, Mahmoud Rafieian-Kopaei
Summary: The study found that syringic acid significantly reduced inflammatory and apoptotic gene expressions in rats with UC, improved colon tissue damage, decreased oxidative stress and inflammation, and increased antioxidant capacity.
INFLAMMOPHARMACOLOGY
(2023)
Article
Medical Laboratory Technology
Yiyi Xie, Tingting Zhuang, Ying Ping, Yingzhi Zhang, Xuchu Wang, Pan Yu, Xiuzhi Duan
Summary: It has been found that high levels of Systemic immune-inflammation index (SII) are associated with poor outcomes in ulcerative colitis (UC) patients. Our study confirmed that SII levels were significantly elevated in UC patients and closely correlated with disease activity, showing high diagnostic capacity for active UC.
CLINICA CHIMICA ACTA
(2021)
Article
Chemistry, Medicinal
Jinfen Chen, Pengde Lu, Jiayue Liu, Li Yang, Yiyang Li, Yanling Chen, Yitao Wang, Jianbo Wan, Yonghua Zhao
Summary: The administration of 20(S)-PDS from Panax notoginseng showed anti-inflammatory effects and ameliorated experimental colitis by blocking the binding of HMGB1 to TLR4.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biophysics
Yanan Wang, Yanan Li, Lingyun He, Baiping Mao, Sian Chen, Vanessa Martinez, Xiaoling Guo, Xian Shen, Baohua Liu, Chao Li
Summary: The study found that the esterified alginate-curcumin conjugate exhibited effective anti-inflammatory effects in Raw 264.7 cells, and after oral administration in animals, the majority reached the colon rapidly and released curcumin, effectively reducing colonic inflammation and tissue damage. The curcumin release triggered by commensal flora shows great potential for ulcerative colitis treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Oncology
Ping Zhang, Le Su, Feifan Ma, Xiuyu Ji, Yue Su, Qiulin Yue, Chen Zhao, Song Zhang, Xin Sun, Lin Zhao
Summary: This study evaluated the effect of weilan gum oligosaccharide (WLGO) on a mouse model of ulcerative colitis (UC). The results showed that WLGO significantly alleviated UC symptoms, restored mucosal integrity, and reduced inflammatory cytokine levels.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Plant Sciences
Jiajia Zhao, Rui Wu, Panhong Wei, Ziyan Ma, Heying Pei, Jingwen Hu, Feiyan Wen, Li Wan
Summary: The therapeutic effect and molecular mechanisms of Piper wallichii extract on DSS-induced ulcerative colitis in mice were investigated. The extract improved the symptoms of ulcerative colitis mice by enhancing intestinal barrier function, regulating inflammatory factors, and modulating the immune system. The TLR4/NF-Kappa B/COX-2 signaling pathway was found to be involved in the anti-inflammatory effect of Piper wallichii extract.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Immunology
Hiroshi Nakase, Noriko Sato, Naomi Mizuno, Yoshiko Ikawa
Summary: Ulcerative colitis (UC) is specifically affected by genetic alterations, environmental factors, microbiota, and mucosal immune dysregulation, leading to a lack of response in 30%-55% of patients to current therapies. The expression levels of cytokines associated with treatment depend on disease stage and patient characteristics, suggesting that future targeted therapies should focus on these differences and individual cytokine profiles.
AUTOIMMUNITY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Jiuxi Liu, Jiapei Cai, Peng Fan, Xue Dong, Naisheng Zhang, Jiandong Tai, Yongguo Cao
Summary: Salidroside, a glycoside extracted from Rhodiola rosea L., was found to ameliorate dextran sulfate sodium (DSS)-induced colitis by modulating the gut microbiota. Salidroside treatment inhibited colitis symptoms in mice, including colon length, histology, disease activity index (DAI) score, and macrophage levels in the intestine. In a fecal microbiota transplantation (FMT) study, fecal samples from Salidroside-treated mice significantly alleviated colitis symptoms in recipient mice, indicating the importance of gut microbiota in the therapeutic effect. Salidroside and FMT both influenced the structure and abundance of the gut microbiota, with decreased relative abundance of Turicibacter, Alistipes, Romboutsia, and increased relative abundance of Lactobacillus. The anti-inflammatory effect of Salidroside was dependent on the presence of gut microbiota, as evidenced by its disappearance in antibiotic-treated mice. Salidroside could be a promising functional food for colitis treatment.
Article
Immunology
Maryam Ranjbar Bushehri, Nahid Babaei, Hadi Esmaeili Gouvarchin Ghaleh, Gholamreza Khamisipour, Gholamreza Farnoosh
Summary: This study investigates the anti-inflammatory effects of peiminine on ulcerative colitis. The results demonstrate that peiminine treatment can alleviate inflammatory manifestations, reduce intestinal tissue damage, and affect gene expression. Peiminine holds potential as a therapeutic adjunct for the management of ulcerative colitis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Atieh Yaghoubi, Saeid Amel Jamehdar, Mohammad Reza Akbari Eidgahi, Kiarash Ghazvini
Summary: This study found that melittin peptide, alone or in combination with sulfasalazine, significantly cured clinical ulcerative colitis and attenuated inflammation and tissue damage in colon tissue. Furthermore, this peptide had an antioxidant effect by disrupting the oxidant/antioxidant balance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hayley Muendlein, Wilson M. Connolly, Zoie Magri, David Jetton, Irina Smirnova, Alexei Degterev, Siddharth Balachandran, Alexander Poltorak
Summary: ZBP1 is known for its role in cell death, but it also promotes inflammatory responses to bacterial lipopolysaccharide or double-stranded RNA. ZBP1 facilitates the delivery and ubiquitination of RIPK1, sustaining the activation of inflammatory signaling cascades. This finding highlights the crucial role of ZBP1 in regulating both bacterial and viral responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Letter
Gastroenterology & Hepatology
Anjan Dhar, Bu'Hussain Hayee, Emma Wesley, William Stableforth, Shaji Sebastian
Article
Dentistry, Oral Surgery & Medicine
Erni Marlina, Richard N. Goodman, Valeria Mercadante, Martina Shephard, Roddy McMillan, Tim Hodgson, Rachel Leeson, Stephen Porter, Julie A. Barber, Stefano Fedele, Andrew M. Smith
Summary: This study evaluated the clinical effects of probiotic VSL#3 in individuals with symptomatic oral lichen planus. The results showed that VSL#3 was safe and well tolerated, but did not demonstrate significant changes in pain, disease activity, quality of life, serum/salivary CXCL10, or oral microbial composition compared to placebo. Further research is needed to confirm these preliminary findings.
Editorial Material
Gastroenterology & Hepatology
James B. Maurice, Andrew Rochford, Sarah Marshall, Shaji Sebastian, Anjan Dhar, Bu'Hussain Hayee
FRONTLINE GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Thomas Joshua Pasvol, Stuart Bloom, Anthony Walter Segal, Greta Rait, Laura Horsfall
Summary: The study found that long-term use of combined oral contraceptive pills increases the risk of developing inflammatory bowel disease, while progestogen-only pills do not increase the risk of Crohn's disease but may have a modest association with ulcerative colitis. There was no clear association between parenteral progestogen-only contraception and inflammatory bowel disease.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Gastroenterology & Hepatology
Rosemary Haddock, Rabia de Latour, Keith Siau, Bu'Hussain Hayee, Swapna Gayam
Summary: Climate change is a global emergency that requires policy changes to address industry emissions. The healthcare industry, particularly gastroenterology, has a large and growing carbon footprint due to its reliance on industry. To effectively reduce the field's carbon footprint, serious commitment from the industry is necessary, along with clear guidelines and regulations to control healthcare-related industry emissions and improve sustainability. This narrative review aims to provide practical suggestions for achieving greater sustainability at each step of the supply chain.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Elsa L. S. A. van Liere, Ahmed B. Bayoumy, Chris J. J. Mulder, Ben Warner, Bu Hayee, Bilal A. Mateen, Jonathan D. Nolan, Nanne K. H. de Boer, Simon H. C. Anderson, Azhar R. Ansari
Summary: In this study, the first-line low-dose azathioprine-allopurinol co-therapy (LDAA) showed a higher clinical benefit and lower treatment failure rate compared to first-line azathioprine monotherapy (AZAm) in IBD patients without metabolite monitoring. LDAA may be considered as a standard first-line immunosuppressive therapy for improving long-term effectiveness and safety in IBD patients.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Klaus Metter, Patrick Aepli, Franz Ludwig Dumoulin, Bu'Hussain Hayee, Karl-Ernst Grund, Guenter Farin, Remus Frei
Summary: The study evaluated the technical feasibility and safety of newly designed devices for en bloc resection of lesions measuring 20-40 mm, demonstrating relative technical ease and high efficacy in the procedure.
Article
Gastroenterology & Hepatology
Xianyong Gui, Alina Bazarova, Rocio Del Amor, Michael Vieth, Gert de Hertogh, Vincenzo Villanacci, Davide Zardo, Tommaso Lorenzo Parigi, Elin Synnove Royset, Uday N. Shivaji, Melissa Anna Teresa Monica, Giulio Mandelli, Pradeep Bhandari, Silvio Danese, Jose G. Ferraz, Bu'Hussain Hayee, Mark Lazarev, Adolfo Parra-Blanco, Luca Pastorelli, Remo Panaccione, Timo Rath, Gian Eugenio Tontini, Ralf Kiesslich, Raf Bisschops, Enrico Grisan, Valery Naranjo, Subrata Ghosh, Marietta Iacucci
Summary: Histological remission is emerging as a key treatment target in UC, and the development of a simple histological index PHRI showed high correlation with endoscopic activity and clinical outcomes. A deep learning AI system based on PHRI accurately predicted histological remission and differentiated active from quiescent UC, with promising sensitivity, specificity, and accuracy results.
Article
Gastroenterology & Hepatology
Jonathon J. Graham, Sujit Mukherjee, Muhammad Yuksel, Rebeca Sanabria Mateos, Tengfei Si, Zhenlin Huang, Xiahong Huang, Hadil Abu Arqoub, Vishal Patel, Mark McPhail, Yoh Zen, Nigel Heaton, Maria Serena Longhi, Michael A. Heneghan, Rodrigo Liberal, Diego Vergani, Giorgina Mieli-Vergani, Yun Ma, Bu'Hussain Hayee
Summary: The study found that the gut homing hypothesis is not the primary driver of PSC, and aberrant recruitment of gut-derived T cells to the liver is also seen in other chronic liver diseases. This finding provides a new understanding of the pathogenesis of PSC and CLD.
Article
Gastroenterology & Hepatology
Laurent Peyrin-Biroulet, Ailsa Hart, Peter Bossuyt, Millie Long, Matthieu Allez, Pascal Juillerat, Alessandro Armuzzi, Edward Loftus, Elham Ostad-Saffari, Astrid Scalori, Young S. Oh, Swati Tole, Akiko Chai, Jennifer Pulley, Stuart Lacey, William J. Sandborn
Summary: This study evaluated the efficacy and safety of etrolizumab in patients with moderately to severely active ulcerative colitis who had been previously treated with anti-TNF agents. The results showed that etrolizumab significantly improved remission rates at week 14 compared to placebo, but there was no significant difference between the two groups in remission rates at week 66.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Silvio Danese, Severine Vermeire, Geert D'Haens, Julian Panes, Axel Dignass, Fernando Magro, Maciej Nazar, Manuela Le Bars, Marjolein Lahaye, Lioudmila Ni, Ivana Bravata, Frederic Lavie, Marco Daperno, Milan Lukas, Alessandro Armuzzi, Mark Lowenberg, Daniel R. Gaya, Laurent Peyrin-Biroulet
Summary: In patients with moderate-to-severe active Crohn's disease, a treat-to-target strategy with early endoscopy, biomarker monitoring, and dose intensification did not result in significantly better endoscopic outcomes at week 48 compared to a clinically driven maintenance strategy.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Silvio Danese, Jean-Frederic Colombel, Milan Lukas, Javier P. Gisbert, Geert D'Haens, Bu'hussain Hayee, Remo Panaccione, Hyun-Soo Kim, Walter Reinisch, Helen Tyrrell, Young S. Oh, Swati Tole, Akiko Chai, Kirsten Chamberlain-James, Meina Tao Tang, Stefan Schreiber
Summary: This study compared the safety and efficacy of etrolizumab and infliximab in patients with moderately to severely active ulcerative colitis. While etrolizumab did not show statistical superiority for the primary endpoint, it performed similarly to infliximab from a clinical viewpoint.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Aki Kawakami, Makoto Tanaka, Lee Meng Choong, Reiko Kunisaki, Shin Maeda, Ingvar Bjarnason, Bu'Hussain Hayee
Summary: Medication adherence among patients with ulcerative colitis in Japan was higher than that of patients in the United Kingdom. This study highlights culturally sensitive medication-taking behaviors in Japanese and UK patients with ulcerative colitis.
PATIENT PREFERENCE AND ADHERENCE
(2022)
Article
Gastroenterology & Hepatology
Olga Maria Nardone, Alina Bazarova, Pradeep Bhandari, Rosanna Cannatelli, Marco Daperno, Jose Ferraz, Martin Goetz, Xianyong Gui, Bu Hayee, Gert De Hertogh, Mark Lazarev, Ji Li, Adolfo Parra-Blanco, Luca Pastorelli, Remo Panaccione, Vincenzo Occhipinti, Timo Rath, Samuel C. L. Smith, Uday N. Shivaji, Gian Eugenio Tontini, Michael Vieth, Vincenzo Villanacci, Davide Zardo, Raf Bisschops, Ralf Kiesslich, Subrata Ghosh, Marietta Iacucci
Summary: This study investigated the importance of combined endoscopic-histologic remission in predicting clinical outcomes in ulcerative colitis patients. The results showed that at 12 months, there was no significant difference in predicting specified clinical outcomes between endoscopic remission alone and combined endoscopic-histologic remission, but UCEIS combined with histology showed a significant advantage. More studies with specific therapeutic interventions are needed to confirm these findings.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Polychronis Pavlidis, Deepak Joshi, Yasser El Sherif, Ben Warner, Shraddha Gulati, James Alexander, Gemma Cross, Tracy Dew, Hadil Abu Arqoub, John Devlin, Michael Heneghan, Patrick Dubois, Ingvar Bjarnason, Nick Powell, Bu'Hussain Hayee
Summary: This study investigates the correlation between fecal calprotectin (fCAL) and inflammatory bowel disease (IBD) and biliary disease, and finds that fCAL may serve as a marker for biliary inflammation in primary sclerosing cholangitis associated IBD (PSC-IBD).
FRONTLINE GASTROENTEROLOGY
(2022)
