Article
Dentistry, Oral Surgery & Medicine
Yiting Li, Ken Lin, Xiaobin Ren, Jianguo Xu, Haiming Yuan, Li Bian, Yongwen He
Summary: This study found that activated fibroblasts can induce high expression of PD-L1 in tongue squamous cell carcinoma cells through the CCL25/CCR9/p-Akt axis, and promote immune escape of tumor cells by inhibiting T-cell proliferation and IFN-gamma secretion.
Article
Oncology
Wei Zheng, Jihua Yang, Juyi Wen, Junzhao Sun, Jing Wang, Xinhong Zhang, Xia Zhang, Xiangfei Zhao, Henghu Fang, Qi Zhu, Shanshan Wu, Zejun Lu, Heng Sun, Rugang Zhao, Siyuan Huai, Lipin Gao, Yongzhen Liu, Jingjiao Li, Gaowa Guan, Wei Yang, Yi Hu
Summary: This study demonstrates that ligustrazine can induce apoptosis in A549 cells through upregulation of the Fas and caspase-activating death receptor pathway expression.
TRANSLATIONAL CANCER RESEARCH
(2022)
Review
Cell Biology
Jiawei Xu, Yu Li, Meili Kang, Cuicui Chang, Hong Wei, Chi Zhang, Yuhua Chen
Summary: Cell death is a natural biological process that is classified into different types. Investigating the details of cell death is crucial for finding effective targets for disease treatments.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Cell Biology
Rekha Tripathi, Tanya Aggarwal, Frida A. Lindberg, Anna H. Klemm, Robert Fredriksson
Summary: SLC38A10 is a member of the SLC38 family and plays a role in regulating protein synthesis and cellular stress responses. The study reveals that SLC38A10 is also involved in glutamate homeostasis and mTOR signaling, and its deficiency may result in lower cholesterol levels, which could be implicated in neurodegenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Jiayang Cai, Zhang Ye, Yuanyuan Hu, Liguo Ye, Lun Gao, Yixuan Wang, Qian Sun, Shiao Tong, Shenqi Zhang, Liquan Wu, Ji'an Yang, Qianxue Chen
Summary: In this study, we found that fatostatin induces ferroptosis in glioblastoma by inhibiting the AKT/mTORC1/GPX4 signaling pathway. Fatostatin also inhibits cell proliferation and the EMT process through the AKT/mTORC1 signaling pathway. Additionally, we developed a p28-functionalized PLGA nanoparticle loaded with fatostatin, which can penetrate the blood-brain barrier and target GBM.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Xiaoming Sun, Yani Chen, Xiaoyang Tao, Wenzi Zhang, Xinyu Wang, Xianhui Wang, Zhihua Ruan, Zhuo Chen
Summary: This study confirms that INPP4B is often downregulated in glioma tissues and cells. INPP4B overexpression inhibits glioma cell proliferation, migration, apoptosis resistance, PD-L1 expression, and T cell suppression, while INPP4B silencing has the opposite effects. Additionally, INPP4B downregulates the PI3K/AKT signaling pathway to inhibit glioma cell proliferation, migration, and PD-L1 expression.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yalan Dai, Liqiong Yang, Abass Sakandar, Duoli Zhang, Fukuan Du, Xinyi Zhang, Linglin Zou, Yueshui Zhao, Jigang Wang, Zhenhua Zhang, Xu Wu, Mingxing Li, Xiao Ling, Lei Yu, Lishu Dong, Jing Shen, Zhangang Xiao, Qinglian Wen
Summary: This study investigates the role of immune escape encoding genes on the prognosis of breast cancer and predicts novel targeting agents. A prognostic model consisting of eleven immune escape related protein-coding genes is established and validated. Vemurafenib is identified as a potential targeted agent for breast cancer treatment by targeting the PI3K/AKT signaling pathway and suppressing the immune escape biomarker BCL2A1.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Nhu Thi Quynh Mai, Ulziituya Batjargal, Won-Seok Kim, Ji-Hoon Kim, Ji-Won Park, Ihn-Sil Kwak, Byoung-San Moon
Summary: Microplastics pose significant threats to marine organisms, especially mussels. In this study, the toxic effects of microspheres and microfibers on the gill and digestive gland of Mytilus galloprovincialis were compared. The results showed that microfibers had higher genotoxic effects on mussels compared to microspheres. During the acute phase, low concentrations of microplastics had minimal impact, but high concentrations led to structural damage and DNA breakage. In the chronic phase, the differences between the effects of microspheres and microfibers decreased over time. Mussels responded to the toxicity by triggering apoptotic responses and increasing energy metabolism.
CELL DEATH DISCOVERY
(2023)
Article
Neurosciences
Peng Ding, Wei Chen, Xiaodi Yan, Jinxiang Zhang, Cheng Li, Guangming Zhang, Yongqiang Wang, Yonghua Li
Summary: The study reveals that BMPER acts as a neuroprotective hormone in alleviating ischemic brain injury through the Smad3/Akt/Nrf2 pathway, showing potential therapeutic strategies for stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Heba S. Omar, Osama Ahmed Ibrahim, Maha Gomaa Sayed, Eman Mohammed Faruk, Hanan Fouad, Miriam Safwat
Summary: This study aims to validate the association between PCOS and PI3K/AKT pathway target genes miRNA486-5p and miRNA483-5p, and evaluate the effects of metformin on the pathogenesis of PCOS. Real-time PCR analysis showed a significant decrease in miRNA486-5p and miRNA483-5p in PCOS patients, with a significant negative correlation between these miRNAs and PI3K and ERK. Treatment with metformin upregulated these miRNAs, downregulated PI3K/AKT target genes, and improved insulin resistance and hormonal imbalance in PCOS.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Fisheries
Chang Ding, Xu Shi, Yalin Guan, Xiaojing Li
Summary: Exposure to DON can cause neutrophil death by activating CYP450s/ROS signal, inhibiting the RI3K/AKT pathway, inducing apoptosis and necroptosis, in a dose-dependent manner. These findings offer new insights into the toxicological effects of mycotoxins.
Article
Biochemistry & Molecular Biology
Nannan Liu, Xinxiu Jiang, Leiming Guo, Chuchu Zhang, Meimei Jiang, Zhuoran Sun, Yizheng Zhang, Wunan Mi, Jiehan Li, Yang Fu, Feng Wang, Lingling Zhang, Yingjie Zhang
Summary: This study reports the most frequent genetic alterations of the TP53 gene in human cancer and explores how mutant p53 activates AKT by inhibiting PHLPP2, thereby suppressing immune response and promoting tumor growth. The findings provide an important basis for the clinical treatment of patients with mutant p53, particularly in the context of immunotherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pathology
Hui Li, Jie Liu, Yiqin Lai, Sha Huang, Liang Zheng, Nanfen Fan
Summary: LINC01559 promotes CRC by sponging miR-1343-3p to modulate the PARP1/PTEN/AKT pathway, offering a new idea for CRC therapeutic treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Cell Biology
Yiyang Sun, Lingling Zhang, Zhuoqing Fang, Dingyu Liu, Min Shao, Yujie Liu, Bing Liao, Ying Jin
Summary: The PRPF8 gene is essential for the survival of human embryonic stem cells (hESCs). Knockdown of PRPF8 induces p53 accumulation and activates the p53 pathway, leading to apoptosis in hESCs. PRPF8 regulates alternative splicing of PIRH2 to maintain p53 pathway activity and hESC survival.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Genetics & Heredity
Kerong Chen, Zhiling Yan, Xudong Dong, Yan Liang, Yueting Yao, Shao Zhang, Weipeng Liu, Chuanyin Li, Yufeng Yao, Li Shi
Summary: Polymorphisms in miRNA genes (rs107822 in miR-219a and rs2292832 in miR-149) are associated with cervical cancer risk, but not with cervical intraepithelial neoplasia.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Yun Xiao, Juan Tang, Hui Guo, Yixia Zhao, Rong Tang, Song Ouyang, Qiuming Zeng, Chad A. Rappleye, Murugesan V. S. Rajaram, Larry S. Schlesinger, Lijian Tao, Gordon D. Brown, Wallace Y. Langdon, Belinda T. Li, Jian Zhang
Article
Immunology
Kaivon Assani, Chandra L. Shrestha, Frank Robledo-Avila, Murugesan V. Rajaram, Santiago Partida-Sanchez, Larry S. Schlesinger, Benjamin T. Kopp
JOURNAL OF IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Malathi Talari, Tapan Kumar Singh Nayak, Vasundhara Kain, Phanithi Prakash Babu, Parimal Misra, Kishore V. L. Parsa
MOLECULAR IMMUNOLOGY
(2017)
Article
Immunology
Jessica M. Mates, Zhili Yao, Alana M. Cheplowitz, Ozan Suer, Gary S. Phillips, Jesse J. Kwiek, Murugesan V. S. Rajaram, Jonghan Kim, John M. Robinson, Latha P. Ganesan, Clark L. Anderson
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Soma Behera, Bandish Kapadia, Vasundhara Kain, Neeraja P. Alamuru-Yellapragada, Vachana Murunikkara, Sireesh T. Kumar, Phanithi Prakash Babu, Sriram Seshadri, Prasad Shivarudraiah, Jagadheshan Hiriyan, Narmadha Reddy Gangula, Subbareddy Maddika, Parimal Misra, Kishore V. L. Parsa
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Multidisciplinary Sciences
Navneet Bung, Sobhitha Surepalli, Sriram Seshadri, Sweta Patel, Saranya Peddasomayajula, Lalith Kumar Kummari, Sireesh T. Kumar, Phanithi Prakash Babu, Kishore V. L. Parsa, Rajamohan Reddy Poondra, Gopalakrishnan Bulusu, Parimal Misra
SCIENTIFIC REPORTS
(2018)
Article
Chemistry, Medicinal
Rajnikanth Sunke, Ramudu Bankala, B. Thirupataiah, E. V. V. Shivaji Ramarao, Jetta Sandeep Kumar, Hari Maduri Doss, Raghavender Medishetti, Pushkar Kulkarni, Ravi Kumar Kapavarapu, Mahaboobkhan Rasool, Jayesh Mudgal, Jessy E. Mathew, Gautham G. Shenoy, Kishore V. L. Parsa, Manojit Pal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Immunology
William P. Lafuse, Murugesan V. S. Rajaram, Qian Wu, Juan Moliva, Jordi B. Torrelles, Joanne Turner, Larry S. Schlesinger
JOURNAL OF IMMUNOLOGY
(2019)
Article
Immunology
Qian Wu, Austin Hossfeld, Abigail Gerberick, Noushin Saljoughian, Charu Tiwari, Smriti Mehra, Latha Prabha Ganesan, Daniel J. Wozniak, Murugesan V. S. Rajaram
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Cell Biology
Noushin Saljoughian Esfahani, Qian Wu, Naresh Kumar, Latha Prabha Ganesan, William P. Lafuse, Murugesan V. S. Rajaram
Summary: Aging affects the phenotype and function of cardiac immune cells, leading to immune dysregulation and cardiac electrical dysfunction during infection in aged mice.
Review
Pharmacology & Pharmacy
Keerthana Balamurugan, Kanika Chandra, S. Sai Latha, M. Swathi, Manjunath B. Joshi, Parimal Misra, Kishore V. L. Parsa
Summary: This review summarizes the role and regulation mechanisms of PHLPPs in metabolic tissues, and discusses their potential as therapeutic targets.
DRUG DISCOVERY TODAY
(2022)
Article
Biochemical Research Methods
Keerthana Balamurugan, Raghavender Medishetti, Pallavi Rao, K. Rahul Varma, Kiranam Chatti, Kishore V. L. Parsa
Summary: The report describes an approach to generate a zebrafish larval model of lipid accumulation and provides detailed steps on experimental procedures and data analysis methods.
Article
Biochemistry & Molecular Biology
Neeraja P. Alamuru-Yellapragada, Bandish Kapadia, Kishore V. L. Parsa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Neeraja P. Alamuru-Yellapragada, Sanghamitra Vundyala, Soma Behera, Kishore V. L. Parsa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Tapan Kumar Singh Nayak, Neeraja P. Alamuru-Yellapragada, Kishore V. L. Parsa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)