Article
Pharmacology & Pharmacy
Frank Adu-Nti, Xu Gao, Jia-Min Wu, Jing Li, Javed Iqbal, Riaz Ahmad, Xin-Ming Ma
Summary: This study found that Osthole (OST) can improve ovariectomy-induced cognitive impairment, alleviate anxiety and depression-like behaviors, and reverse alterations in hippocampal protein levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Joanna Rojek, Matthew R. Tucker, Sara C. Pinto, Michal Rychlowski, Malgorzata Lichocka, Hana Soukupova, Julita Nowakowska, Jerzy Bohdanowicz, Gabriela Surmacz, Malgorzata Gutkowska
Summary: Research shows that mutations in the gene encoding the beta-subunit of RGT in Arabidopsis plants severely disrupt female gametogenesis, leading to decreased internal transport of auxin and significant developmental arrest in a portion of the female gametophytes. These findings suggest that Rab-dependent vesicular transport is crucial for communication between the sporophyte and the developing female gametophyte.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Endocrinology & Metabolism
Rebecca V. Mountain, Audrie L. Langlais, Dorothy Hu, Roland Baron, Christine W. Lary, Katherine J. Motyl
Summary: Social isolation is a significant psychosocial stress and public health concern, especially among older adults. Prior to the COVID-19 pandemic, researchers have already been concerned about the increasing epidemic of loneliness. This study aimed to investigate the effects of social isolation on bone loss in male and female mice.
Article
Biochemistry & Molecular Biology
Wen-jun Jiang, Zan Zhou, Yan-ping Wang, Wa Gao, Li Li, Jun-qiang Si
Summary: Noise exposure leads to hearing loss in mice, accompanied by swelling of the cochlear stria vascularis, migration of pericytes, leakage of the blood labyrinth barrier, increased oxidative stress levels in the stria vascularis, and reduced expression of PGC-1 alpha.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Environmental Sciences
Lucila Alvarez-Barrera, Juan Jose Rodriguez-Mercado, Rodrigo Anibal Mateos-Nava, Nydia Angelica Ocampo-Aguilera, Mario Agustin Altamirano-Lozano
Summary: This study found that administration of V2O4 to pregnant mice during the organogenesis period resulted in maternal and embryo-fetal toxicity, as well as external abnormalities in the offspring. The fetuses showed reduced ossification of cranial bones, corresponding to head injuries observed in the external assessment.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Beat Moeckli, Thuy-Vy Pham, Florence Slits, Samuel Latrille, Andrea Peloso, Vaihere Delaune, Graziano Oldani, Stephanie Lacotte, Christian Toso
Summary: A short-term treatment with FGF21 has a long-term effect on female fertility in mice, raising safety concerns for FGF21 analogs currently in clinical development. Future clinical trials should include assessments of reproductive health outcomes.
Article
Audiology & Speech-Language Pathology
Celia Zhang, Henry J. Adler, Senthilvelan Manohar, Richard Salvi, Wei Sun, Mengxiao Ye, Bo Hua Hu
Summary: Sex differences play an important role in the development of sensorineural hearing loss in inner ear disorders. Gal-3 deficiency exacerbates age-related cochlear degeneration and auditory dysfunction in female mice.
Article
Neurosciences
Rui Guo, Yang Li, Jiao Liu, Shusheng Gong, Ke Liu
Summary: The study found significant impairment of social memory in mice with hearing loss, but no significant differences were seen in tests such as novel object recognition, Morris water maze, and locomotion in the open field. Therefore, the study demonstrates that hearing input is required for the formation of social memory, and hearing stimuli play an important role in the development of normal cognitive ability.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ivan Banovac, Lovorka Grgurevic, Viktorija Rumenovic, Slobodan Vukicevic, Igor Erjavec
Summary: Bone morphogenetic protein 3 (Bmp3) deletion was found to affect skeleton development until adulthood, leading to increased cortical and trabecular bone parameters in young and adult mice of both sexes, while delayed mineralization of the epiphyseal growth plate was observed in adult Bmp3(-/-) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Samantha M. Estacio, Madalyn M. Thursby, Noel C. Simms, Vanessa A. Orozco, Jessica P. Wu, Alyssa A. Miawotoe, Whitney W. Worth, Claire B. Capeloto, Kyla Yamashita, Kayla R. Tewahade, Katherine B. Saxton
Summary: This study developed a laboratory mouse model to examine the impact of food insecurity on food consumption, stress coping mechanisms, exploratory behavior, and memory. Results showed that exposure to food insecurity led to differences in food consumption patterns, active coping mechanisms, and memory in the mice. These findings could inform research on the effects of food insecurity on health in elderly individuals.
Article
Endocrinology & Metabolism
Judith M. Swart, David R. Grattan, Sharon R. Ladyman, Rosemary S. E. Brown
Summary: Maternal interactions with offspring are rewarding for female mice, and lactogenic hormones play a role in the rewarding effect of pups.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Behavioral Sciences
Inyeong Choi, Kristian Beedholm, Vibeke S. Dam, Seong-Ho Bae, Donald J. Noble, Sandra M. Garraway, Christian Aalkjaer, Ebbe Boedtkjer
Summary: Deletion of the NBCn1 gene leads to reduced locomotor activity in mice by affecting their exploratory behaviors or emotionality. The deletion also causes hearing loss, but its effect on vision varies between different lines of knockout mice.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Environmental Sciences
Mingjun Yang, Fang Tian, Shimin Tao, Minjie Xia, Yuzhu Wang, Jingying Hu, Bin Pan, Zhouzhou Li, Renzhen Peng, Haidong Kan, Yanyi Xu, Weihua Li
Summary: This study found that chronic exposure to PM2.5 can lead to follicular dysplasia, which is associated with hormone modulation and inflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Xuhong Zhang, Xiaoyu Wang, Hong Zhu, Dongyan Zhang, Jinbo Chen, Yingying Wen, Yanqing Li, Le Jin, Chen Xie, Dongyu Guo, Ting Luo, Jianping Tong, Yudong Zhou, Ye Shen
Summary: Artificial light is crucial for modern life, but it can have negative effects on health. Exposure to short wavelength artificial light during early development in mice delays the development of the visual pathway and impairs neuronal structure and neurotransmitter function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Otorhinolaryngology
Anna-Lena Moennich, Sebastian Strieth, Andrea Bohnert, Benjamin Philipp Ernst, Tobias Rader
Summary: The aim of this study was to develop the German Hearing in Noise Test (HINT) with a female speaker and compare it with the norms of male speech tests. Results showed that the norms for the HINT with a female speaker are comparable to the norms with a male speaker.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Anesthesiology
Der-Sheng Han, Cheng-Han Lee, Yih-Dar Shieh, Chu-Ting Chang, Min-Hsuan Li, Ya-Cherng Chu, Jaw-Lin Wang, Ke-Vin Chang, Shing-Hong Lin, Chih-Cheng Chen
Summary: The study found that dextrose injections can reduce mechanical hypersensitivity in a mouse model of fibromyalgia. The effectiveness of this treatment depends on the type of injectant, dose, and volume, but not on osmolarity. The antinociceptive effects are mediated through the activation of ASIC1a and substance P signaling pathways in muscle afferents. This study provides insights into the mechanism of action of dextrose prolotherapy in noninflammatory muscle pain and potential treatments for other chronic pain conditions.
Article
Anesthesiology
Wei-Hsiang Hsu, Der-Sheng Han, Wei-Chi Ku, Yen-Ming Chao, Chih-Cheng Chen, Yun-Lian Lin
Summary: This study identified potential biomarkers in fibromyalgia patients, which could differentiate between pain and soreness symptoms in FM patients. These biomarkers shed light on the underlying pathological mechanisms, offering insights for more effective diagnosis and therapy for FM.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Engineering, Civil
Luobing Dong, Honghao Gao, Weili Wu, Qiwen Gong, Nemera Chala Dechasa, Yanfei Liu
Summary: In this paper, a dependence-aware edge intelligent function offloading scheme for 6G-based Internet of Vehicle (IoV) is proposed. The traditional intelligent transportation applications are split into different chains of intelligent functions, which can be offloaded to edge servers for processing. Two algorithms are designed to achieve the optimal assignment of intelligent functions, and experiments show that the algorithms are fast.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Review
Cell Biology
Yu-Chia Chuang, Chih-Cheng Chen
Summary: This article discusses mechanosensitive ion channels and their role in mechanotransduction. These channels are capable of converting different forms of mechanical force into electrical signals through variant gating models. Additionally, the article introduces another model for channel activation, which involves channels being opened through force tethering. The research also focuses on cytoskeletal proteins and the extracellular matrix involved in mechanotransduction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jormay Lim, Ya-Cherng Chu, Hsiao-Hsin Tai, Andy Chien, Shao-Shiang Huang, Chih-Cheng Chen, Jaw-Lin Wang
Summary: This study quantified the optimal ultrasound dosage and long-term effects of transcranial ultrasound treatments for brain diseases. It was found that transcranial ultrasound promotes the increase of neural progenitors and this effect lasts at least a week, unaffected by auditory toxicity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Acoustics
Ya-Cherng Chu, Jormay Lim, Andy Chien, Chih-Cheng Chen, Jaw-Lin Wang
Summary: This review examines the effects of ultrasound on mechanosensitive channels (MSCs), summarizes the conditions for ultrasound activation of these channels, and explores the biological effects of ultrasound in therapeutic applications. The findings suggest that only a limited number of MSCs are activated by ultrasound, and provide insights into the ion channels and molecular mechanisms involved. These results contribute to the design of more effective ultrasound stimulation devices.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Cell Biology
Pei-Rung Wu, Shang-Yin Chiang, Robert Midence, Wen-Chao Kao, Chun-Lun Lai, I-Cheng Cheng, Shen-Ju Chou, Chih-Cheng Chen, Chih-Yang Huang, Ruey-Hwa Chen
Summary: Patients with mutations in the WDR4 gene exhibit cerebellar atrophy and gait phenotypes, but the underlying mechanisms have not been explored. This study reveals a crucial role of Wdr4 in cerebellar development. Deficiency of Wdr4 in granule neuron progenitors (GNPs) leads to reduced foliation, smaller external and internal granular layers, compromised Purkinje neuron organization, and smaller molecular layer, resulting in locomotion defects.
CELL DEATH & DISEASE
(2023)
Article
Health Care Sciences & Services
Hsiao-Yen Chiu, I-Wen Su, Yu-Wen Yu, Yi-Chen Chen, Chih-Cheng Chen, Jiann-Her Lin
Summary: This study aimed to investigate the prevalence and impacts of soreness or sng on the outcome of LSS. The results showed that soreness or sng had substantial clinical impacts on the outcome of LSS, indicating the need for independent assessment.
Article
Clinical Neurology
Der-Sheng Han, Cheng-Han Lee, Yih-Dar Shieh, Ke-Vin Chang, Shing-Hong Lin, Ya-Cherng Chu, Jaw-Lin Wang, Chih-Cheng Chen
Summary: Therapeutic ultrasound has analgesic effects against chronic muscle pain by activating ASIC3-containing channels and releasing substance P in muscle afferents.
Article
Computer Science, Cybernetics
Qiufen Ni, Jianxiong Guo, Weili Wu, Huan Wang
Summary: This article focuses on the community partition problem in social networks and formulates it as a combinatorial optimization problem. Continuous greedy algorithms and discrete implementations are proposed to solve the upper and lower bound problems, achieving a good approximation ratio. The effectiveness and advantages of the proposed method are demonstrated through experiments on real datasets.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Immunology
Chia-Wei Liou, Sin-Jhong Cheng, Tzu-Ting Lai, Yu-Hsuan Tsai, Che-Wei Chien, Yu-Lun Kuo, Shih-Hsuan Chou, Cheng-Chih Hsu, Wei-Li Wu
Summary: Social novelty, a cognitive process crucial for strategic interaction among animals based on prior experiences, is modulated by the commensal microbiome in the gut through various routes, including microbe-derived metabolite signaling. Short-chain fatty acids (SCFAs), metabolites produced by bacterial fermentation in the gastrointestinal tract, have been found to affect host behavior. This study demonstrates that the direct delivery of SCFAs into the brain disrupts social novelty through specific neuronal populations, specifically the CaMKII-labeled neurons in the BNST.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Physiology
Cheng-Han Lee, Chih-Cheng Chen
Summary: This review explores why proprioceptors, which are non-nociceptive, low-threshold mechanosensory neurons that monitor muscle contraction and body position, express several proton-sensing ion channels and receptors.
EXPERIMENTAL PHYSIOLOGY
(2023)
Review
Physiology
Yi-Chen Lin, Cheng-Han Lee, Jia-Ying Sung, Chih-Cheng Chen
Summary: Although ASICs are primarily responsible for sensing tissue acidosis, they are also involved in neurosensory mechanotransduction. However, their role as mechanically gated ion channels has not been confirmed using conventional mechanoclamp approaches. Instead, they are involved in the tether model of mechanotransduction, gated by tethering elements. New methods have been developed to investigate the roles of ASIC3 and ASIC1a in neurosensory mechanotransduction.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuan-Ren Cheng, Chih-Hung Chi, Cheng-Han Lee, Shing-Hong Lin, Ming-Yuan Min, Chih-Cheng Chen
Summary: The physiological response of proprioceptors to fatigue- and muscle-acidosis-related disturbances is still unclear. The effect of mild acidosis on the mechanosensitivity of dorsal root ganglia (DRG) neurons was investigated, revealing that acidification had an inhibitory effect on mechanosensitive currents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Tzu-Ting Lai, Chia-Wei Liou, Yu-Hsuan Tsai, Yuan-Yuan Lin, Wei-Li Wu
Summary: Psychological stress is a global issue that affects a significant portion of the global population and increases the risk of psychiatric disorders. Recent evidence suggests that the gut microbiota plays a role in regulating stress and associated behavior. The microbiota can modulate stress response through the regulation of intestinal glucocorticoids and the autonomic nervous system. This review provides insight into the pathways by which gut microbes impact stress signaling, brain circuits, and ultimately the host's behavior.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
