Article
Biochemistry & Molecular Biology
Alvaro Baeza Garcia, Edwin Siu, Xin Du, Lin Leng, Blandine Franke-Fayard, Chris J. Janse, Shanshan W. Howland, Laurent Renia, Elias Lolis, Richard Bucala
Summary: Cerebral malaria, the deadliest complication of Plasmodium parasite infection, may be caused by neuroinflammation leading to cerebral edema and blood-brain barrier dysfunction. Plasmodium MIF can enhance inflammatory response by signaling through host MIF receptor CD74, contributing to the development of cerebral malaria. Studies using CD74 deficient hosts and PMIF deficient parasites suggest a potential mechanism for the onset of experimental cerebral malaria and liver stage Plasmodium development.
Article
Chemistry, Multidisciplinary
Wei Wei, Weijia Cheng, Wenhao Dai, Feng Lu, Yaru Cheng, Tingting Jiang, Zhenyu Ren, Yiting Xie, Jiahui Xu, Qun Zhao, Xianjun Yu, Yi Yin, Jian Li, Haifeng Dong
Summary: This study introduces a nanoparticle formulation of an antimalarial drug coated in a biomimetic membrane derived from brain microvascular endothelial cells and demonstrates its therapeutic efficacy in a mouse model of cerebral malaria, offering new insight into nanoparticle-based therapeutics for malaria and parasitic infections.
Article
Behavioral Sciences
Hu Luo, Xiaofang Li, Runyue Fan, Yuer Ruan, Liyin Qian, Yao Shen, Zizhen Si, Longhui Li, Yu Liu
Summary: This study investigated the effect of H3 receptor blockade on METH-induced cognitive impairment and the underlying mechanism. The results showed that METH exposure led to cognitive impairment and hippocampal apoptosis in mice, as well as increased H3 receptor protein levels in HT22 cells. However, treatment with the H3 receptor antagonist THIO improved METH-induced cognitive impairment and toxicity in both mice and HT22 cells. These findings suggest that THIO has a neuroprotective effect against METH-induced cognitive impairment and cell toxicity via the raf-MEK-ERK signaling pathway.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Neurosciences
Kevin M. Manz, Jennifer C. Becker, Carrie A. Grueter, Brad A. Grueter
Summary: The study reveals that stress-induced histamine signaling in the NAc recruits H-3 heteroreceptor signaling to shift thalamocortical input onto D1(+)-MSNs in the NAc. These findings provide novel insights into an understudied neuromodulatory system within the NAc and implicate histamine in stress-related physiological states.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Immunology
Jiangong Wang, Bin Liu, Fengjiao Sun, Yong Xu, Haiyun Luan, Meizi Yang, Chaoyun Wang, Tiantian Zhang, Zhenyu Zhou, Haijing Yan
Summary: This study found that inhibition of H3R reduced microglia activity and promoted a shift from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype in microglia, thereby attenuating lipopolysaccharide-induced neuroinflammation in mice. Additionally, inhibition of H3R rescued the impairments of neurogenesis and cognitive function caused by neuroinflammation. Mechanistically, the neuroprotective effects of H3R inhibition were mediated by histamine-dependent activation of H2R and reinforcement of CREB-CBP interaction, which led to increased release of anti-inflammatory cytokines and brain-derived neurotrophic factor, as well as decreased release of pro-inflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Kamil Mika, Malgorzata Szafarz, Marek Bednarski, Kamil Kuder, Katarzyna Szczepanska, Krzysztof Pociecha, Bartosz Pomierny, Katarzyna Kiec-Kononwicz, Jacek Sapa, Magdalena Kotanska
Summary: The study supports the use of active histamine H3 receptor ligands as new therapeutic agents for treating obesity. Compounds KSK-61 and KSK-63 are considered as leading structures due to their ability to slow weight gain and compensate for metabolic disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Ashley Castellanos-Jankiewicz, Omar Guzman-Quevedo, Valerie S. Fenelon, Philippe Zizzari, Carmelo Quarta, Luigi Bellocchio, Anne Tailleux, Julie Charton, Daniela Fernandois, Marcus Henricsson, Catherine Piveteau, Vincent Simon, Camille Allard, Sandrine Quemener, Valentine Guinot, Nathalie Hennuyer, Alessia Perino, Alexia Duveau, Marlene Maitre, Thierry Leste-Lasserre, Samantha Clark, Nathalie Dupuy, Astrid Cannich, Delphine Gonzales, Benoit Deprez, Gilles Mithieux, David Dombrowicz, Fredrik Backhed, Vincent Prevot, Giovanni Marsicano, Bart Staels, Kristina Schoonjans, Daniela Cota
Summary: Activation of hypothalamic TGR5 signaling reduces body weight and fat mass by promoting negative energy balance, counteracting diet-induced obesity. Conversely, downregulation of hypothalamic TGR5 expression may contribute to the development of obesity. These findings highlight the important role of hypothalamic TGR5 signaling in the pathophysiology of obesity.
Article
Psychiatry
Yongqian Wang, Xufeng Huang, Hongzhen Fan, Huimei An, Ting Ma, Qi Zhang, Wenxuan Zhao, Yajun Yun, Wenshuang Yang, Xiaolu Zhang, Zhiren Wang, Fude Yang
Summary: This study showed that high-dose betahistine can effectively improve cognitive function but not psychiatric symptoms in Chinese Han patients with schizophrenia. Betahistine (72 mg/d) was considered safe for use in these patients.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Xue Yang, Jiamin Liang, Ziyi Wang, Yuangang Su, Yunfei Zhan, Zuoxing Wu, Jing Li, Xuedong Li, Runfeng Chen, Jinmin Zhao, Jiake Xu, Qian Liu, Bo Zhou
Summary: This study found that sesamolin has the potential to treat osteoporosis by effectively inhibiting the formation of osteoclasts in vitro, attenuating bone loss through modulating multiple signaling pathways and gene expression, and demonstrating a preventive effect against bone loss induced by estrogen deficiency in vivo.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Lok-Yin Roy Wong, Jian Zheng, Kevin Wilhelmsen, Kun Li, Miguel E. Ortiz, Nicholas J. Schnicker, Andrew Thurman, Alejandro A. Pezzulo, Peter J. Szachowicz, Pengfei Li, Ruangang Pan, Klaus Klumpp, Fred Aswad, Justin Rebo, Shuh Narumiya, Makoto Murakami, Sonia Zuniga, Isabel Sola, Luis Enjuanes, David K. Meyerholz, Kristen Fortney, Paul B. McCray, Stanley Perlman
Summary: This article describes the research on therapeutic drugs against new variants of SARS-CoV-2. The study suggests that the elderly population is at higher risk during infection, and protecting aged animals from severe diseases can be achieved by inhibiting specific inflammatory pathways.
Article
Immunology
Hongxia Duan, Shuai Zhao, Jianquan Xiang, Chenhui Ju, Xuehui Chen, Irene Gramaglia, Xiyun Yan
Summary: The study found that endothelial CD146 plays a crucial role in experimental cerebral malaria, with its overexpression leading to the aggregation of infected red blood cells and lymphocytes, thereby disrupting BBB integrity. Deletion of endothelial CD146 or treatment with anti-CD146 antibody can prevent severe symptoms of cerebral malaria, and combined treatment with anti-CD146 antibody and antiparasitic drugs can improve cognition and memory in patients with cerebral malaria.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lin Xie, Ke Wen, Qian Li, Cong-Cong Huang, Jia-Le Zhao, Qi-Hang Zhao, Yun-Fei Xiao, Xiao-Hui Guan, Yi-Song Qian, Lu Gan, Ling-Fang Wang, Ke-Yu Deng, Hong-Bo Xin
Summary: This study demonstrates that CD38 deficiency can reduce lipid accumulation and suppress oxidative stress in mice with HFD-induced NAFLD by activating NAD/Sirtuins signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Virology
Jungang Chen, Jiao Song, Karlie Plaisance-Bonstaff, Shengyu Mu, Steven R. Post, Lu Dai, Zhiqiang Qin
Summary: Although KSHV has been found to cause various human cancers, including KS and PEL, the mechanisms of KSHV-induced tumorigenesis and virus-host interaction network are still not fully understood. Histamine, and its receptors, have been shown to play a role in allergic diseases. Previous data showed that histamine receptor antagonists can effectively inhibit KSHV replication. In this study, histamine treatment was found to promote cell proliferation and growth abilities of KSHV-infected cells, and affect the expression of inflammatory factors.
Review
Medicine, Research & Experimental
Yousef M. Abdulrazzaq, Salim M. A. Bastaki, Ernest Adeghate
Summary: The human histamine H3 receptor plays a regulatory role in histamine synthesis and release in the brain, affecting processes such as cognition, sleep, and homoeostasis. H3 receptor antagonists have the potential to be important in the treatment of disorders related to cognition, sleep, oxidative stress, inflammation, and glucose homoeostasis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Yi-Hsuan Su, Jin-Yuarn Lin
Summary: This study compared the anti-allergic inflammation potential of five terpenoid compounds and found that menthone showed the most promising results. Further experiments in mice showed that menthone supplementation alleviated allergic asthma symptoms by regulating airway inflammation, immune balance, and gene expression related to inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Virology
Piet Maes, Sergey V. Alkhovsky, Yiming Bao, Martin Beer, Monica Birkhead, Thomas Briese, Michael J. Buchmeier, Charles H. Calisher, Remi N. Charrel, Il Ryong Choi, Christopher S. Clegg, Juan Carlos de la Torre, Eric Delwart, Joseph L. DeRisi, Patrick L. Di Bello, Francesco Di Serio, Michele Digiaro, Valerian V. Dolja, Christian Drosten, Tobiasz Z. Druciarek, Jiang Du, Hideki Ebihara, Toufic Elbeaino, Rose C. Gergerich, Amethyst N. Gillis, Jean-Paul J. Gonzalez, Anne-Lise Haenni, Jussi Hepojoki, Udo Hetzel, Thien Ho, Ni Hong, Rakesh K. Jain, Petrus Jansen van Vuren, Qi Jin, Miranda Gilda Jonson, Sandra Junglen, Karen E. Keller, Alan Kemp, Anja Kipar, Nikola O. Kondov, Eugene V. Koonin, Richard Kormelink, Yegor Korzyukov, Mart Krupovic, Amy J. Lambert, Alma G. Laney, Matthew LeBreton, Igor S. Lukashevich, Marco Marklewitz, Wanda Markotter, Giovanni P. Martelli, Robert R. Martin, Nicole Mielke-Ehret, Hans-Peter Muehlbach, Beatriz Navarro, Terry Fei Fan Ng, Marcio Roberto Teixeira Nunes, Gustavo Palacios, Janusz T. Paweska, Clarence J. Peters, Alexander Plyusnin, Sheli R. Radoshitzky, Victor Romanowski, Pertteli Salmenpera, Maria S. Salvato, Helene Sanfacon, Takahide Sasaya, Connie Schmaljohn, Bradley S. Schneider, Yukio Shirako, Stuart Siddell, Tarja A. Sironen, Mark D. Stenglein, Nadia Storm, Harikishan Sudini, Robert B. Tesh, Ioannis E. Tzanetakis, Mangala Uppala, Olli Vapalahti, Nikos Vasilakis, Peter J. Walker, Guoping Wang, Liping Wang, Yanxiang Wang, Taiyun Wei, Michael R. Wiley, Yuri I. Wolf, Nathan D. Wolfe, Zhiqiang Wu, Wenxing Xu, Li Yang, Zuokun Yang, Shyi-Dong Yeh, Yong-Zhen Zhang, Yazhou Zheng, Xueping Zhou, Chenxi Zhu, Florian Zirkel, Jens H. Kuhn
ARCHIVES OF VIROLOGY
(2018)
Correction
Multidisciplinary Sciences
Corina Monagin, Blanca Paccha, Ning Liang, Sally Trufan, Huiqiong Zhou, De Wu, Bradley S. Schneider, Aleksei Chmura, Jonathan H. Epstein, Peter Daszak, Changwen Ke, Peter M. Rabinowitz
Article
Multidisciplinary Sciences
Corina Monagin, Blanca Paccha, Ning Liang, Sally Trufan, Huiqiong Zhou, De Wu, Bradley S. Schneider, Aleksei Chmura, Jonathan H. Epstein, Peter Daszak, Changwen Ke, Peter M. Rabinowitz
Review
Biochemistry & Molecular Biology
Chayma El Khamlichi, Flora Reverchon-Assadi, Nadege Hervouet-Coste, Lauren Blot, Eric Reiter, Severine Morisset-Lopez
Article
Virology
Joseph Diffo, Valantine Ngum Ndze, Nkom Felix Ntumvi, Jean-Michel Takuo, Moctar M. M. Mouiche, Ubald Tamoufe, Julius Nwobegahay, Matthew LeBreton, Amethyst Gillis, Bradley S. Schneider, Joseph M. Fair, Corina Monagin, David J. McIver, Damien O. Joly, Nathan D. Wolfe, Edward M. Rubin, Christian E. Lange
ARCHIVES OF VIROLOGY
(2019)
Article
Microbiology
Tony Li, Placide Mbala-Kingebeni, Samia N. Naccache, Julien Theze, Jerome Bouquet, Scot Federman, Sneha Somasekar, Guixia Yu, Claudia Sanchez-San Martin, Asmeeta Achari, Bradley S. Schneider, Anne W. Rimoin, Andrew Rambaut, Justus Nsio, Prime Mulembakani, Steve Ahuka-Mundeke, Jimmy Kapetshi, Oliver G. Pybus, Jean-Jacques Muyembe-Tamfum, Charles Y. Chiu
JOURNAL OF CLINICAL MICROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Anthony Guillemain, Yousra Laouarem, Laetitia Cobret, Dora Stefok, Wanyin Chen, Solal Bloch, Amina Zahaf, Lauren Blot, Flora Reverchon, Thierry Normand, Martine Decoville, Catherine Grillon, Elisabeth Traiffort, Severine Morisset-Lopez
Article
Biochemistry & Molecular Biology
Wissem Deraredj Nadim, Shalina Hassanaly, Helene Benedetti, Claudine Kieda, Catherine Grillon, Severine Morisset-Lopez
Summary: Research has shown that neurofibromin (Nf1) plays a significant role in melanogenesis by regulating the interaction between MC1R and melanocytes. The GAP activity of Nf1 is crucial for modulating intracellular signaling pathways involved in melanogenesis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Elisabeth Traiffort, Severine Morisset-Lopez, Mireille Moussaed, Amina Zahaf
Summary: Motor neurons and their axons reaching the skeletal muscle have long been considered the primary targets of degeneration in ALS, but recent research suggests that glial cells, particularly oligodendrocytes, also play a significant role. Oligodendrocytes are now recognized to be critically involved in axonal injury and are affected by toxic effects of degenerative neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chayma El Khamlichi, Laetitia Cobret, Jean-Michel Arrang, Severine Morisset-Lopez
Summary: This study reveals the presence of spontaneous H3R dimers not only in transfected cells and rodent brains, but also in transfected cortical neurons, with the receptor able to adopt a range of allosteric conformations from inactive to active states.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Florestan Courant, Marion Maravat, Wanyin Chen, David Gosset, Lauren Blot, Nadege Hervouet-Coste, Vincent Sarou-Kanian, Severine Morisset-Lopez, Martine Decoville
Summary: This study demonstrates the role of serotonin 5-HT7 receptor as a tumor suppressor gene in gliomas, which can restore metabolic biomarkers and characteristic markers of signaling pathways associated with tumor growth.
Article
Agriculture, Dairy & Animal Science
Esraa Razzaq Hassan, Abdullah O. Alhatami, Husam Muhsen Abdulwahab, Bradly S. Schneider
Summary: This study demonstrates that broiler chickens may be a potential source for the spread of multidrug-resistant Salmonella and extended-spectrum beta-lactamase (ESBL) genes in poultry production. Therefore, continuous monitoring of these genes is crucial to prevent the spread of resistant strains in the food chain and to protect public health.
Article
Biochemistry & Molecular Biology
Marylene Bertrand, Frederic Szeremeta, Nadege Hervouet-Coste, Vincent Sarou-Kanian, Celine Landon, Severine Morisset-Lopez, Martine Decoville
Summary: This study used a Drosophila glioma model to investigate metabolic disturbances associated with glioma and identified the involvement of the 5-HT7R in glioma development. The study provides valuable insights into the metabolic pathways and potential treatment targets for glioma.
Review
Neurosciences
Wissem Deraredj Nadim, Viorel Simion, Helene Benedetti, Chantal Pichon, Patrick Baril, Severine Morisset-Lopez
CURRENT NEUROPHARMACOLOGY
(2017)
Review
Neurosciences
Viorel Simion, Wissem Deraredj Nadim, Helene Benedetti, Chantal Pichon, Severine Morisset-Lopez, Patrick Baril
CURRENT NEUROPHARMACOLOGY
(2017)