Article
Critical Care Medicine
Shinji Katayanagi, Yasuhiro Setoguchi, Sayoko Kitagawa, Tsukasa Okamoto, Yasunari Miyazaki
Summary: The TOLLIP gene variants are associated with clinical features in patients with CHP, especially the GG genotype is correlated with rapid deterioration in lung function.
Article
Chemistry, Multidisciplinary
Yue Qin, Xiaoyu Zhang, Yanling Song, Bowen Zhong, Lu Liu, Dongdong Wang, Yahui Zhang, Wenqi Lu, Xinjia Zhao, Zhiqi Jia, Minmin Li, Lihua Zhang, Guangyan Qing
Summary: Using phage display technology, this study identified two cyclic peptide sequences that specifically bind to the terminal dodecapeptide sequence of SUMO1. The combination of these peptides and polyethylene terephthalate conical nanochannel films resulted in a highly sensitive nanochannel device for detecting SUMO1. This device shows promise for monitoring enzyme-catalyzed reactions and cellular imaging.
Article
Plant Sciences
Xiao-Ting Zheng, Caijuan Wang, Wenxiong Lin, Chufang Lin, Danlu Han, Qi Xie, Jianbin Lai, Chengwei Yang
Summary: This study reveals a general regulatory mechanism of SUMOylation in maintaining chloroplast protein importation during heat stress and provides detailed insights into the functional mechanisms of PSBR. It also provides clues for further investigation of protein modifications associated with plant organelles under stress conditions.
Article
Biochemistry & Molecular Biology
Ying Zhang, Xu Xu, Mengxin Hu, Xin Wang, Hanhua Cheng, Rongjia Zhou
Summary: SPATA33 is a novel autophagy mediator for mitophagy in testis, and it promotes mitochondrial degradation and mitophagy in male germline cells by binding VDAC2 and ATG16L1 to facilitate autophagosome formation.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Plant Sciences
Rekha Agrawal, Amrita Singh, Jitender Giri, Zoltan Magyar, Jitendra Kumar Thakur
Summary: Mediator subunit MED17 regulates root system architecture by establishing a link between the auxin and sucrose signaling pathways. Sucrose and auxin are important factors in root development, but the factors that connect their signaling pathways are poorly understood. This study reveals that MED17 plays a role in integrating the sugar and auxin signaling pathways in Arabidopsis, and it acts as a nodal point to connect sucrose and auxin signaling.
Article
Multidisciplinary Sciences
Victor M. Corral, Eric R. Schultz, Richard S. Eisenstein, Gregory J. Connell
Summary: TfR1 receptor plays a crucial role in regulating the steady-state TfR1 mRNA levels across different cell types, with the Roquin gene identified as a major mediator of TfR1 mRNA instability.
Article
Cell Biology
Runliu Wu, Jiao Liu, Nian Wang, Ling Zeng, Chunhua Yu, Feng Chen, Haichao Wang, Timothy R. Billiar, Jianxin Jiang, Daolin Tang, Rui Kang
Summary: This study identifies an unexpected role of aconitate decarboxylase 1 (ACOD1) in sepsis, showing that its accumulation in monocytes and macrophages leads to a robust proinflammation response through tumor necrosis factor signaling pathway. Additionally, the CDK2-ACOD1 axis is correlated with disease severity in sepsis patients.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Microbiology
Shih-Che Weng, Shin-Hong Shiao
Summary: This study investigated the impact of protein SUMOylation on dengue virus replication in A. aegypti. The findings suggest that protein SUMOylation plays an important role in dengue virus replication and transmission.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Ming-Gui Wang, Jing Wang, Jian-Qing He
Summary: This study found a significant association between two SNPs (rs5743867 and rs5743899) in the TOLLIP gene and susceptibility to HIV infection in a Chinese Han population. No significant association was found between MBL2 gene polymorphisms and HIV infection.
BMC INFECTIOUS DISEASES
(2021)
Article
Microbiology
Junping Li, Libin Liang, Li Jiang, Qian Wang, Xia Wen, Yuhui Zhao, Pengfei Cui, Yaping Zhang, Guangwen Wang, Qibing Li, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Yongping Jiang, Liling Liu, Hualan Chen, Chengjun Li
Summary: Our study demonstrates the vital role of PB1 K612 SUMOylation in the pathogenesis and transmission of IAVs, providing a potential target for anti-influenza therapies. The SUMOylation at K612 is crucial for PB1 to efficiently bind viral RNA, facilitating the transcription and replication of the viral genome.
Article
Plant Sciences
Valentin Hammoudi, Bas Beerens, Martijs J. Jonker, Tieme A. Helderman, Georgios Vlachakis, Marcel Giesbers, Mark Kwaaitaal, Harrold A. van den Burg
Summary: SUMO plays a critical role in plant thermoresilience and longevity, particularly at 28 degrees Celsius. Mutants with reduced levels of SUMO1/2 exhibit thermolethality at 28 degrees Celsius, but not due to autoimmunity. The role of SUMO in thermoresilience is distinct from its requirement in thermomorphogenesis.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Behavioral Sciences
Aspen Gustin, Shaghayegh Navabpour, Kayla Farrell, Kiley Martin, Jessica DuVall, W. Keith Ray, Richard F. Helm, Timothy J. Jarome
Summary: The study reveals a sex-specific role for protein SUMOylation in the amygdala during fear memory formation. Females show increased targeting of individual proteins by SUMOylation following fear conditioning, while males do not. These findings expand our understanding of how protein SUMOylation contributes to fear memory formation in a gender-specific manner.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Immunology
Sambasivan Venkatasubramanian, Robyn Pryor, Courtney Plumlee, Sarah B. Cohen, Jason D. Simmons, Alexander J. Warr, Andrew D. Graustein, Aparajita Saha, Thomas R. Hawn, Kevin B. Urdahl, Javeed A. Shah
Summary: TOLLIP, as a central regulator of innate immune signaling pathways, plays a role in dendritic cell (DC) function and adaptive immune responses. TOLLIP deficiency in DCs leads to impaired maturation and activation of T cells, contributing to increased susceptibility to tuberculosis.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Plant Sciences
Haiwei Shuai, Tingting Chen, Tanja Wlk, Wilfried Rozhon, Maria J. Pimenta Lange, Tobias Sieberer, Theo Lange, Brigitte Poppenberger
Summary: Brassinosteroids Enhanced Expression (BEE) subfamily proteins CES and BEEs in Arabidopsis thaliana promote the expression of different BR-responsive genes, including cold-responsive genes. Over-expression of CES in Arabidopsis enhances fruit growth and cold stress tolerance. This study investigated the effects of over-expressing CES in the fruit crop Solanum lycopersicum (tomato).
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Jiao Liu, Yang Liu, Yuan Wang, Rui Kang, Daolin Tang
Summary: This study found that cuproptotic cells release HMGB1 to initiate inflammation. Mechanistically, copper accumulation-induced ATP depletion activates AMPK to promote HMGB1 phosphorylation, resulting in increased release. Inhibiting AMPK activation reduces cuproptosis and HMGB1 release. Cuproptotic cells deficient in HMGB1 show reduced production of inflammatory cytokines. Thus, HMGB1 is a key mediator of sterile inflammation initiated by cuproptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Rexhep Durmo, Benedetta Donati, Louis Rebaud, Anne Segolene Cottereau, Alessia Ruffini, Maria Elena Nizzoli, Sabino Ciavarella, Maria Carmela Vegliante, Christophe Nioche, Michel Meignan, Francesco Merli, Annibale Versari, Alessia Ciarrocchi, Irene Buvat, Stefano Luminari
Summary: In this study, we evaluated the prognostic role of the largest distance between two lesions (Dmax) defined by positron emission tomography (PET) in newly diagnosed classical Hodgkin Lymphoma (cHL) patients. We found that Dmax was independently associated with progression free survival (PFS), and differences in Dmax were associated with variations in the expression of microenvironmental components. Therefore, Dmax can serve as a novel prognostic factor for cHL patients.
HEMATOLOGICAL ONCOLOGY
(2022)
Article
Oncology
Mila Gugnoni, Gloria Manzotti, Emanuele Vitale, Elisabetta Sauta, Federica Torricelli, Francesca Reggiani, Mariaelena Pistoni, Simonetta Piana, Alessia Ciarrocchi
Summary: The study revealed the impaired expression of OVOL2 in ATC and its transcriptional inhibition of the RHO GTPase pathway, leading to the suppression of EMT, cytoskeleton dynamics, and mitosis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Letter
Oncology
Emanuele Vitale, Elisabetta Sauta, Mila Gugnoni, Federica Torricelli, Veronica Manicardi, Alessia Ciarrocchi
CANCER COMMUNICATIONS
(2022)
Article
Oncology
Giuseppa De Luca, Giannamaria Cerruti, Sonia Lastraioli, Romana Conte, Adalberto Ibatici, Nikki Di Felice, Fortunato Morabito, Paola Monti, Gilberto Fronza, Serena Matis, Monica Colombo, Sonia Fabris, Alessia Ciarrocchi, Antonino Neri, Paola Menichini, Manlio Ferrarini, Paolo Nozza, Franco Fais, Giovanna Cutrona, Mariella Dono
Summary: The use of Next Generation Sequencing (NGS) in CLL patients revealed a high frequency of subclonal TP53 mutations. Precise identification of these mutations during the disease is necessary to prevent treatment failures.
HEMATOLOGICAL ONCOLOGY
(2022)
Article
Hematology
Elisa Taiana, Cecilia Bandini, Vanessa Katia Favasuli, Domenica Ronchetti, Ilaria Silvestris, Noemi Puccio, Katia Todoerti, Silvia Erratico, Domenica Giannandrea, Niccolo Bolli, Nicola Amodio, Alessia Ciarrocchi, Raffaella Chiaramonte, Yvan Torrente, Roberto Piva, Antonino Neri
Summary: Long non-coding RNA NEAT1 is deregulated in multiple myeloma patients and its silencing negatively affects MM cell proliferation and viability, indicating a role in DNA damage repair. NEAT1 overexpression provides oncogenic and prosurvival advantages, especially in stressful conditions like nutrient starvation or hypoxia. NEAT1 is involved in various DNA damage repair processes through the regulation of essential PS proteins and the molecular axis of ATM and DNA-PK kinase proteins.
Article
Oncology
Teresa Rossi, Raffaella Zamponi, Mattea Chirico, Maria Elena Pisanu, Egidio Iorio, Federica Torricelli, Mila Gugnoni, Alessia Ciarrocchi, Mariaelena Pistoni
Summary: The study demonstrated that BET inhibitors increased ATGL expression and lipolytic function in triple-negative breast cancer cells, leading to reduced intracellular lipid content and inhibition of tumor cell proliferation and induction of cell death through the modulation of mitochondrial dynamics.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Alberto D'Angelo, Huseyin Kilili, Robert Chapman, Daniele Generali, Ingeborg Tinhofer, Stefano Luminari, Benedetta Donati, Alessia Ciarrocchi, Riccardo Giannini, Roberto Moretto, Chiara Cremolini, Filippo Pietrantonio, Navid Sobhani, Debora Bonazza, Robert Prins, Seung Geun Song, Yoon Kyung Jeon, Giuseppina O. Pisignano, Mattia K. Cinelli, Stefan K. Bagby, Araxi O. K. Urrutia
Summary: The immune system plays a key role in cancer development. By using NanoString-based gene profiling, this study identifies transcriptional changes in immune cell-related genes that are associated with disease prognosis, providing valuable insights for clinical applications.
Article
Marine & Freshwater Biology
Annalaura Mancia, Luigi Abelli, Giorgia Palladino, Marco Candela, Tyrone Lucon-Xiccato, Cristiano Bertolucci, Maria Cristina Fossi, Matteo Baini, Cristina Panti
Summary: This study aimed to assess the combined effects of microplastics and environmental contaminants on zebrafish health and behavior. The results showed that exposure to microplastics and pollutants can have negative effects on zebrafish, with greater impacts observed from environmentally exposed microplastics.
AQUATIC TOXICOLOGY
(2023)
Article
Cell Biology
Mila Gugnoni, Eugenia Lorenzini, Italo Faria do Valle, Daniel Remondini, Gastone Castellani, Federica Torricelli, Elisabetta Sauta, Benedetta Donati, Moira Ragazzi, Francesco Ghini, Simonetta Piana, Alessia Ciarrocchi, Gloria Manzotti
Summary: This study validated specific gene signatures in the transition from differentiated thyroid carcinoma (DTC) to anaplastic thyroid cancer (ATC) and identified the E2F7 gene as a key player in this process. Down-regulation of E2F7 reduced the aggressiveness of ATC cells.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Margherita Cortini, Francesca Macchi, Francesca Reggiani, Emanuele Vitale, Maria Veronica Lipreri, Francesca Perut, Alessia Ciarrocchi, Nicola Baldini, Sofia Avnet
Summary: The pathogenesis of osteosarcoma relies on complex interactions between cancer cells and extracellular matrix (ECM) proteins. Understanding these interactions and ECM composition is important for predicting cancer response to chemotherapy and identifying alternative therapeutic targets. This study aims to generate a 3D model that mimics the tumor microenvironment and investigate the role of ECM deposition in chemotherapy response. The findings suggest that targeting ECM proteins may improve outcomes for chemoresistant tumors.
Article
Oncology
Chiara Vasco, Ambra Rizzo, Chiara Cordiglieri, Elena Corsini, Emanuela Maderna, Emilio Ciusani, Andrea Salmaggi
Summary: Metastasis refers to the spread of a tumor from its original site to other parts of the body. This study focused on brain metastasis and used an in vitro model to investigate the ability of breast and lung tumor cells to cross the blood-brain barrier, as well as the expression of adhesion molecules. The study also found that vesicles released by tumor cells can induce cell death in endothelial cells.
Review
Oncology
Angela Lauriola, Pierpaola Davalli, Gaetano Marverti, Spartaco Santi, Andrea Caporali, Domenico D'Arca
Summary: Immunotherapy uses the body's immune system to fight against cancer, and it has greatly improved patient outcomes for several types of tumors. However, many patients have not yet benefited from this treatment. Combination strategies targeting different cellular pathways are predicted to play a key role in cancer immunotherapy. This review discusses the effects of tumor cell death and immune system engagement on oxidative stress and ubiquitin ligase pathways, as well as combinations of immunotherapies and immunomodulatory targets. The importance of imaging techniques for monitoring tumor responses and side effects is also highlighted.
Article
Cell Biology
Federica Torricelli, Elisabetta Sauta, Veronica Manicardi, Vincenzo Dario Mandato, Andrea Palicelli, Alessia Ciarrocchi, Gloria Manzotti
Summary: This study identified potential drug candidates for high-risk endometrial cancer using a computational drug repurposing approach.
Article
Biology
Michela Sgarzi, Martina Mazzeschi, Spartaco Santi, Elisa Montacci, Tito Panciera, Enea Ferlizza, Cinzia Girone, Alessandra Morselli, Valerio Gelfo, Rikke Sofie Kuhre, Carola Cavallo, Sabrina Valente, Gianandrea Pasquinelli, Balazs Gyorffy, Gabriele D'Uva, Donatella Romaniello, Mattia Lauriola
Summary: This study reveals that overactivation of MET disrupts the perinuclear actin cap by inhibiting YAP1, leading to changes in nuclear shape and cell motility.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Azzurra Sargenti, Simone Pasqua, Marco Leu, Laura Dionisi, Giuseppe Filardo, Brunella Grigolo, Daniele Gazzola, Spartaco Santi, Carola Cavallo
Summary: Articular cartilage lacks regenerative capabilities and current treatments only provide temporary pain relief. Tissue engineering approaches, such as 3D culture systems and spheroids derived from mesenchymal stromal cells, have shown promise in regenerating functional tissues. This study investigated the assembly and chondrogenic differentiation capacity of adipose stromal cells in spheroids for cartilage repair. The spheroids exhibited differentiation towards the chondrogenic lineage and expressed specific cartilaginous markers that correlated with their mass density, indicating a critical point of maturation. Spheroids generated with chips were suggested as a promising tool for generating cartilage organoids for preclinical/clinical applications, including personalized therapy.
BIOENGINEERING-BASEL
(2023)