Article
Biochemistry & Molecular Biology
Zhan Chen, Yan Lv, Lu He, Shunli Wu, Zhuang Wu
Summary: The study showed that decreased CDKL2 expression in ccRCC patients is closely associated with poor prognosis, suggesting it as a potential prognostic biomarker related to immune infiltrates.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Jiayi Li, Dongyan Cao
Summary: We developed two prognostic nomograms for predicting recurrence and long-term survival in patients with ovarian clear cell carcinoma (OCCC) after primary treatment, and validated them in patients from the same center. This tool, which uses variables specifically related to OCCC, was more accurate than the FIGO system, making it relatively easy to use in clinic for patient counseling, postoperative management, and follow-up for individual patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiangyu Li, Woonghee Kim, Kajetan Juszczak, Muhammad Arif, Yusuke Sato, Haruki Kume, Seishi Ogawa, Hasan Turkez, Jan Boren, Jens Nielsen, Mathias Uhlen, Cheng Zhang, Adil Mardinoglu
Summary: The study stratified ccRCC into three molecular subtypes using systems biology approach, developed biomarkers for patient classification and prognosis prediction, and identified potential drug targets. Mitotane, a repositioned drug targeting SOAT1, showed potential in treating ccRCC based on in vitro experiments.
Review
Oncology
Haixiang Shen, Jin Liu, Shiming Chen, Xueyou Ma, Yufan Ying, Jiangfeng Li, Weiyu Wang, Xiao Wang, Liping Xie
Summary: High expression of CD68+ TAMs and M2-TAMs are risk factors for poor prognosis in ccRCC patients. TAMs' high density is associated with advanced clinicopathological features in ccRCC. TAMs could be potential biomarkers for prognosis and novel targets for immunotherapy in ccRCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kaiwen Kong, Yuanyu Zhao, Leilei Xia, Hui Jiang, Mingjuan Xu, Jianming Zheng
Summary: The study identified B3GNT3 as a prognostic factor in pancreatic cancer and potentially related to immune cell infiltration. The expression of B3GNT3 was associated with clinical outcomes in pancreatic carcinoma and could serve as an immunotherapy target.
Article
Medicine, General & Internal
Jie Yang, Jiaxin Yang, Dongyan Cao, Ming Wu, Yang Xiang
Summary: This study investigated the association between malignant peritoneal cytology and survival outcomes in patients with stage I uterine serous or clear cell carcinoma who underwent primary staging surgery. The results showed that patients with malignant cytology had a higher likelihood of peritoneal recurrence and shorter time to relapse compared to those with negative cytology. Malignant cytology and serous histology were associated with worse progression-free survival and overall survival. This detrimental effect was more prominent in older patients, those with serous histology, stage IB disease, and those who received hysteroscopy as a diagnostic test.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Genetics & Heredity
Zhi Liu, Jun Zhang, Deyun Shen, Xuechun Hu, Zongpan Ke, I. Nyoman Ehrich Lister, Bungaran Sihombing
Summary: This study found that cytoskeleton-associated protein 2-like protein is upregulated in clear cell renal cell carcinoma tissues and may promote disease progression through multiple signaling pathways. It can serve as a prognostic marker and a potential treatment target in clear cell renal cell carcinoma.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Zijian Zhou, Jiajin Wu, Yuanyuan Yang, Peng Gao, Lujia Wang, Zhong Wu
Summary: This study found that hepcidin expression is upregulated in clear cell renal cell carcinoma (ccRCC) and is correlated with patient age, T stage, and pathologic stage. Hepcidin promoter methylation is significantly associated with poor clinical parameters and hepcidin may serve as an independent prognostic factor. Mechanistically, hepcidin is involved in immune-related and metabolism-related pathways.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Yang-Yu Huang, Xuan Liu, Shen-Hua Liang, Yu Hu, Guo-Wei Ma
Summary: This study aimed to investigate whether preoperative tumor biomarkers CEA and NSE could serve as independent predictors for postoperative prognosis in patients with TETs. The results showed that preoperative serum CEA levels and tumor size may be strong predictors of postoperative overall survival in patients with TETs.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Oncology
Dzenis Koca, Irinka Seraudie, Remy Jardillier, Claude Cochet, Odile Filhol, Laurent Guyon
Summary: The COL7A1 gene has been identified as a potential prognostic marker for ccRCC patients, capable of stratifying them into different risk groups.
Article
Immunology
Fan Zhang, DongBo Yuan, JuKun Song, WeiMing Chen, Wei Wang, GuoHua Zhu, Bin Hu, Xiaoyue Chen, Jianguo Zhu
Summary: HJURP is upregulated in ccRCC, associated with poor pathological features and poor prognosis in patients. It serves as a high-risk factor for ccRCC patients and is closely linked to multiple immune-related signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Chunxiu Yang, Jingjing Pang, Jian Xu, He Pan, Yueying Li, Huainian Zhang, Huan Liu, Shu-Yuan Xiao
Summary: Our study revealed that LRRK2 plays a crucial role in the tumorigenesis and progression of ccRCC, and may serve as a potential predictor and therapeutic target for this type of cancer. The up-regulation of LRRK2 in ccRCC was found to be correlated with DNA methylation and associated with a better prognosis in patients with ccRCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Vasilios Pergialiotis, Dimitrios Haidopoulos, Theano Christodoulou, Ioannis Rodolakis, Ioannis Prokopakis, Michalis Liontos, Alexandros Rodolakis, Nikolaos Thomakos
Summary: This study evaluated the prognostic factors of disease relapse and overall survival in patients with clear cell carcinoma (CCC) of the endometrium. It found that known predictors of survival rates in endometrioid carcinoma patients had moderate effect on CCC patients, except for the disease stage. Further research is needed to assess whether molecular profiling can help predict survival outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dermatology
R. Varaljai, S. Elouali, S. S. Lueong, K. Wistuba-Hamprecht, T. Seremet, J. T. Siveke, J. C. Becker, A. Sucker, A. Paschen, P. A. Horn, B. Neyns, B. Weide, D. Schadendorf, A. Roesch
Summary: This study demonstrates that high cfDNA concentration can serve as a biomarker for melanoma regardless of tumor genotype, providing information on tumor burden, risk of progression, and risk of death.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Immunology
Mancheng Gong, Yongxiang Li, Erlin Song, Miaoyuan Li, Shaopeng Qiu, Wenjing Dong, Runqiang Yuan
Summary: Our study found a correlation between OIP5 expression and immune cell infiltration level in ccRCC. Analysis based on RNA-seq data showed that OIP5 has an impact on immune activity. Additionally, OIP5 was associated with several immunomodulators and involved in multiple immune signaling pathways. We constructed a multiple-gene risk prediction signature, providing a potential target for immunotherapy in ccRCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yipeng Zhang, Yidong Liu, Jieni Zhu, Dan Xiao, Ping Xu, Cuiqing Ma, Chao Gao, Chuanjuan Lu
Summary: 3,4-Dihydroxybutyric acid (3,4-DHBA) is an important platform chemical with versatile applications, but traditional chemical production methods are environmentally unfriendly. This study developed a coculture system using Gluconobacter oxydans and Escherichia coli for efficient biosynthesis of 3,4-DHBA from xylose, achieving the highest reported titer and yield.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Physics, Applied
Ruoyu Zeng, Qi Zhao, Yijie Shen, Yidong Liu, Yuanjie Yang
Summary: This study examines the structural stability of open vortex beams (OVBs) and their potential applications in optical manipulation, optical metrology, etc., through a theoretical model and experimental validation.
APPLIED PHYSICS LETTERS
(2021)
Article
Genetics & Heredity
Mingzhu Huo, Yile Zhang, Senlin Shi, Hao Shi, Yidong Liu, Lingyun Zhang, Yanchi Wang, Wenbin Niu
Summary: This study examined nine patients with oocyte maturation arrest and identified nine pathogenic variants in five genes, including three novel variants. These findings expand the understanding of the gene variant spectrum and provide insights for genetic diagnosis and prediction of oocyte maturation arrest.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Yidong Liu, Emma Leary, Obai Saffaf, R. Frank Baker, Shuqun Zhang
Summary: In this study, the researchers found that Arabidopsis MAPK3 and MPK6 play important roles in plant immunity and growth/development. YDA, along with MAPKKK3 and MAPKKK5, serves as an upstream regulator of the MAPK cascade, regulating plant growth and development. The study also demonstrated the involvement of YDA in plant immune signaling, and the contribution of MAPKKK3 and MAPKKK5 to gamete function and embryogenesis.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Chuanhui Hao, Yidong Liu, Hongmei Zheng, Xu-bao Sun
Summary: This paper studies a practical scheme to reduce mutual coupling interference (MCI) between two extremely adjacent multiple input multiple output (MIMO) antenna elements. By using special two-dimensional metamaterial units, the surface wave interference is successfully suppressed. The proposed scheme is validated through experimental and simulation results, which show that the MCI of the antenna array is effectively reduced and exhibits good performance at the interested frequencies.
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS
(2022)
Article
Food Science & Technology
Mingyue Zhao, Fengxian Tang, Wenchao Cai, Yidong Liu, Chunhui Shan
Summary: This study investigated the impact of hot brewing, room temperature brewing, and cold brewing on Apocynum venetum tea. The results showed that hot brewing is the best method for producing high-quality A. venetum tea, while cold brewing resulted in tea with a unique color and aroma. The brewing conditions affected the physicochemical indexes, functional components, antioxidant activity, and aroma compounds of the tea.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Microbiology
Yidong Liu, Wenxuan Sun, Liting Ma, Rong Xu, Chunyu Yang, Ping Xu, Cuiqing Ma, Chao Gao
Summary: Given the intrinsic and potential resistance of Pseudomonas aeruginosa to antibiotics, it is crucial to develop new therapeutic options for infections caused by this bacterium. Bacterial metabolic pathways are being explored as potential targets for new antibiotics. This study investigates the metabolic mechanisms of glycerol and its intermediate glycerol 3-phosphate (G3P) in P. aeruginosa PAO1. The results reveal the importance of G3P homeostasis for the growth and virulence factor production of P. aeruginosa PAO1. The enzyme GlpD, involved in G3P catabolism, is identified as a potential therapeutic target for the prevention and treatment of P. aeruginosa infections.
Article
Computer Science, Information Systems
Yidong Liu, Xihong Chen, Dizhe Yuan, Denghua Hu
Summary: This paper presents a novel nonlinear frequency domain equalization algorithm for SC-FDE systems. The algorithm improves the classical iterative block decision feedback equalization (IBDFE) algorithm by replacing ZF equalization with MMSE equalization and eliminating the iteration of the correlation factor. Delta estimation is also applied to improve equalization accuracy. Simulation results show that the performance of the novel algorithm is better or the complexity is lower than the IBDFE algorithm with similar complexity or performance.
Article
Optics
Jiadian Yan, Jun Yao, Yidong Liu, Yuanjie Yang
Summary: Newton's rings are interference patterns consisting of concentric rings, commonly observed in classic optics experiments. In this study, we demonstrate the generation of generalized Newton's rings using vortex beams. Unlike conventional Newton's rings, the generalized ones exhibit spiral arms instead of concentric rings, accompanied by fork-shaped dislocations. Notably, the number of spiral arms and dislocations corresponds to the topological charge of the incident vortex beams. Experimental results confirm our theoretical predictions. This novel interference pattern can be utilized for measuring the topological charge of vortex beams.
Article
Andrology
Yanping Huang, Wei Liu, Yidong Liu, Ming Zhang, Xiangguo Lv, Kai Hu, Shiran Xu, Mujun Lu
Summary: Glycated serum albumin (GSA) decreases the expression of phosphorylated connexin 43 (p-Cx43) in the corpus cavernosum of rats. This effect might be related to the decreased phosphorylation of p-eNOS, p-PI3K, and p-Akt, as well as the downregulation of phosphorylation at the S368 site.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2022)
Article
Surgery
Chengjiang Liu, Yidong Liu, Boyuan Ma, Mengmeng Zhou, Xinyan Zhao, Xuanhao Fu, Shunli Kan, Wei Hu, Rusen Zhu
Summary: Anterior cervical discectomy and fusion (ACDF) is a common surgery for cervical diseases, with low infection rates and rare involvement of adjacent segments. Tuberculosis (TB) is a common infectious disease that rarely affects the cervical spine. Here, we report a case of tuberculosis infection in adjacent segments after ACDF for the first time.
FRONTIERS IN SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Yunzhe Jiang, Yidong Liu, Sylvain Grosjean, Volodymyr Bon, Patrick Hodapp, Anemar Bruno Kanj, Stefan Kaskel, Stefan Braese, Christof Woell, Lars Heinke
Summary: In this research, we achieved a directed responsive behavior of light-induced deformation by assembling light-powered molecules into a surface-mounted metal-organic framework film. The molecular extension changes were multiplied at the mesoscopic scale and transferred to the macroscopic scale, resulting in the bending of a cantilever and performing work.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Electrical & Electronic
Liu Yidong, Jia Zhentang
Summary: The article describes an improved particle swarm optimization camera parameter calibration method that dynamically adjusts the inertia weight of the group and adapts the optimal particle variation to improve calibration accuracy and search ability. Experimental results show that the algorithm has advantages.
LASER & OPTOELECTRONICS PROGRESS
(2022)
Review
Medicine, General & Internal
Chengjiang Liu, Yidong Liu, Boyuan Ma, Mengmeng Zhou, Xinyan Zhao, Xuanhao Fu, Shunli Kan, Wei Hu, Rusen Zhu
Summary: Spinal cord injury is a severe injury to the central nervous system, resulting in permanent loss of motor, sensory, and autonomic functions below the level of injury. Secondary injury impairs mitochondrial function and exacerbates the damage. Therapeutic strategies aimed at preserving mitochondrial function show promise but are still underexplored.
Article
Clinical Neurology
Hu Wei, Kan Shunli, Jiang Zehua, Zhang Tengfei, Liu Yidong, Zhu Rusen
Summary: This study retrospectively analyzed 8 cases of ASD cervical spondylopathy treated with ACCF, and showed significant improvements in clinical outcomes with the use of self-locking stand-alone cage. The method was considered reliable and effective in terms of JOA and NDI scores, as well as cervical alignment correction.
TURKISH NEUROSURGERY
(2021)
