Article
Engineering, Environmental
Duo Zhang, Panithi Saktrakulkla, Rachel F. Marek, Hans-Joachim Lehmler, Kai Wang, Peter S. Thorne, Keri C. Hornbuckle, Michael W. Duffel
Summary: Serum samples from both rural and urban communities were analyzed for 74 sulfated metabolites of PCBs. The urban group showed significantly higher concentrations of PCB sulfates compared to the rural group. Several specific congeners contributed to the majority of the assessed PCB sulfates. The distribution of PCB sulfates differed from previous studies in the same communities. There were location and mother-child dyad-specific correlations.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Agricultural Engineering
Yun Hwan Park, Sang-Il Han, Byeolnim Oh, Hyun Soo Kim, Min Seo Jeon, Sok Kim, Yoon-E Choi
Summary: There is a growing interest in utilizing microalgae for industrial purposes due to concerns about petroleum depletion and sustainable energy sources. Despite the advantages of high biomass productivity and short culture periods, barriers such as high unit price need to be addressed. Co-producing primary and secondary metabolites from microalgae is essential, with induction methods available to promote the biosynthesis of secondary metabolites for industrial applications.
BIORESOURCE TECHNOLOGY
(2022)
Review
Food Science & Technology
Dan Xu, Mengyao Xue, Zhen Shen, Xiaowei Jia, Xuwen Hou, Daowan Lai, Ligang Zhou
Summary: Fungal phytotoxic secondary metabolites are toxic substances produced by fungi through biochemical reactions, with a high level of diversity in their properties. These metabolites are mainly isolated from phytopathogenic fungal species, with aromatic polyketides and sesquiterpenoids being the main phytotoxic compounds.
Article
Environmental Sciences
Yanlin Li, Christian M. Bako, Panithi Saktrakulkla, Hans-Joachim Lehmler, Keri C. Hornbuckle, Jerald L. Schnoor
Summary: This study investigated the uptake, translocation, and metabolism of MeO-PCBs in poplar plants, as well as the relationship between methoxy-PCBs, hydroxyl-PCBs, and PCB sulfates. Results showed that hydroxylated metabolites and sulfate metabolites of MeO-PCBs were identified in the plant, indicating a complex interconversion process. The formation of PCB sulfates was found to be predominant over the reverse reaction, the formation of hydroxyPCBs, providing new insights into the fate of MeO-PCBs in plants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Environmental Sciences
Martina Kolackova, Anna Janova, Marketa Dobesova, Monika Zvalova, Pavel Chaloupsky, Olga Krystofova, Vojtech Adam, Dalibor Huska
Summary: Proficient photosynthetic microalgae/cyanobacteria produce a remarkable amount of various biomolecules. Secondary metabolites (SM) represent high value products for global biotrend application. Production improvement can be achieved by nutritional, environmental, and physiological stress as a first line tools for their stimulation. However, deep understanding and connection of specific stress elucidator are missing. Hence, the present review summarizes recent evidence with an emphasis on the carotenoids, phenolic, and lessdiscussed compounds (glycerol, proline, mycosporins-like amino acids), highlighting the need to expand knowledge in this area using genome-editing tools and omics approaches.
ENVIRONMENTAL RESEARCH
(2023)
Review
Agriculture, Multidisciplinary
Josef L. Ranner, Sabrina Schalk, Cindy Martyniak, Martin Parniske, Caroline Gutjahr, Timo D. Stark, Corinna Dawid
Summary: This article provides an overview of the primary and secondary metabolites identified in Lotus japonicus to date. More than 600 metabolites are grouped into compound classes such as polyphenols, carbohydrates, organic acids and phosphates, lipids, amino acids, nitrogenous compounds, phytohormones, and additional defense compounds. Their physiological effects are briefly discussed, and the detection methods are explained. This review of the exisiting literature on Lotus japonicus metabolites provides a valuable basis for future metabolomics studies.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Ali Movahedi, Amir Almasi Zadeh Yaghuti, Hui Wei, Paul Rutland, Weibo Sun, Mohaddeseh Mousavi, Dawei Li, Zhuge Qiang
Summary: Populus trees face continuous environmental challenges throughout their life cycle, exhibiting various defenses including the production of secondary metabolites. While many of these metabolites have been functionally described, their overall functions are still not fully understood. Research indicates therapeutic effects and leads to further study of secondary metabolites and their biosynthesis in Populus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Bruno Cerra, Francesco Venturoni, Maria Souma, Giada Ceccarelli, Anna Maria Lozza, Daniela Passeri, Francesca De Franco, Ian R. Baxendale, Roberto Pellicciari, Antonio Macchiarulo, Antimo Gioiello
Summary: In this report, we describe our synthetic efforts in supporting the development of bile alcohol sulfate INT-767. We have successfully developed a large-scale preparation route and synthesized analogues. Through key reactions and the use of flow technology, we have overcome critical bottlenecks. The final synthetic route can be used to produce the desired amount of INT-767, and potential metabolites have been synthesized and evaluated.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Microbiology
Rosario Nicoletti, Anna Andolfi, Andrea Becchimanzi, Maria Michela Salvatore
Summary: Due to their widespread occurrence, fungi in the genus Penicillium are commonly found in association with insects. This symbiotic interaction has been investigated to explore their potential for ecofriendly pest control strategies. The assumption is that Penicillium species, known for producing bioactive secondary metabolites, may have entomopathogenic properties. This review paper examines the properties and potential applications of compounds from Penicillium fungi in insect pest management.
Article
Biochemistry & Molecular Biology
Beata Lemli, Peter Vilmanyi, Eszter Fliszar-Nyul, Balazs Zoltan Zsido, Csaba Hetenyi, Lajos Szente, Miklos Poor
Summary: This study investigated the interactions between Alternaria mycotoxins and albumins and cyclodextrins. The results showed that these substances can form stable complexes, with cyclodextrins showing stronger binding affinity for the mycotoxins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Marcelo D. Catarino, Rita Silva-Reis, Amina Chouh, Sonia Silva, Susana S. Braga, Artur M. S. Silva, Susana M. Cardoso
Summary: This article provides an overview of Sargassum seaweeds, one of the largest and most diverse genus of brown seaweeds, comprising around 400 taxonomically accepted species. Many species of this genus have long been used in human culture for food, feed, and folk medicine. Besides their high nutritional value, these seaweeds are also rich in natural antioxidant compounds, such as polyphenols, carotenoids, meroterpenoids, and phytosterols. These compounds have important applications in various fields, including agriculture, food, and health, and can be used for product preservation, cosmetics, and crop production improvement.
Review
Biochemistry & Molecular Biology
Meijie Xu, Ziwei Huang, Wangjie Zhu, Yuanyuan Liu, Xuelian Bai, Huawei Zhang
Summary: Fungal microbes, particularly Fusarium spp., have been identified as a prolific source of secondary metabolites (SMs) with diverse chemical structures and broad-spectrum antimicrobial properties. A thorough literature search and data analysis revealed the discovery of 185 antimicrobial natural products derived from Fusarium strains by the end of 2022. These substances exhibit various antimicrobial effects, including antibacterial, antifungal, antiviral, and antiparasitic activities. Furthermore, suggestions for future research on efficient discovery of novel bioactive SMs from Fusarium strains are proposed.
Review
Agronomy
Ana Bendejacq-Seychelles, Stephanie Gibot-Leclerc, Jean-Philippe Guillemin, Gregory Mouille, Christian Steinberg
Summary: This study discusses the diversity of fungal secondary metabolites that are phytotoxic to weeds and the methods commonly used to extract, characterize, identify and exploit them for weed management. The 183 phytotoxic fungal secondary metabolites identified in this review have different toxic effects on plants, including inhibition of germination, root and vegetative growth, and tissue and organ alterations. The biochemical characterization of these metabolites requires specialized knowledge and tools, as well as toxicity tests and effectiveness evaluations in laboratory and field conditions.
PEST MANAGEMENT SCIENCE
(2023)
Review
Microbiology
Guodong Song, Zhibin Zhang, Xuenan Niu, Du Zhu
Summary: Microsphaeropsis fungi are known for their production of secondary metabolites with potential medicinal value. This paper presents a systematic analysis of the secondary metabolites synthesized by Microsphaeropsis reported between 1980 and 2023, identifying 49 novel compounds among the 112 reported. A concise summary of their diverse biological activities is provided.
Review
Environmental Sciences
Reda Ben Mrid, Bouchra Benmrid, Jawhar Hafsa, Hassan Boukcim, Mansour Sobeh, Abdelaziz Yasri
Summary: Increasing crop productivity while reducing the use of chemical fertilizers and pesticides is a major challenge that scientists are addressing by focusing on plant and microbial-based solutions to sustain the agricultural sector in a cost-effective and eco-friendly manner. Biostimulants and bioprotectants have gained interest for their ability to improve plant growth and yield, as well as reduce the impact of abiotic and biotic stresses. Microbial-based biostimulants and bioprotectants have been shown to positively impact cropping systems through various mechanisms, ultimately leading to better crop growth and yields.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)