PNPLA3 I148M variant in nonalcoholic fatty liver disease: Demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis

The Effect of PNPLA3 on Fibrosis Progression and Development of Hepatocellular Carcinoma: A Meta-analysis

(2014) Amit G Singal et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function

(2013) Piero Pingitore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy

(2013) M Swiderska-Syn et al.   GUT

Hedgehog pathway and pediatric nonalcoholic fatty liver disease

(2013) Marzena Swiderska-Syn et al.   HEPATOLOGY

Hepatic stellate cells hold the key to liver fibrosis

(2013) Katrina Ray   Nature Reviews Gastroenterology & Hepatology

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Convergent pathways that cause hepatic fibrosis in NASH

(2013) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

Adenosine 2A Receptor Antagonist Prevented and Reversed Liver Fibrosis in a Mouse Model of Ethanol-Exacerbated Liver Fibrosis

(2013) Dian J. Chiang et al.   PLoS One

Molecular dynamics simulation of PNPLA3 I148M polymorphism reveals reduced substrate access to the catalytic cavity

(2013) Yong-Ning Xin et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Diagnosis and management of non-alcoholic fatty liver disease and related metabolic disorders: Consensus statement from the Study Group of Liver and Metabolism, Chinese Society of Endocrinology (非酒精性脂肪性肝病与相关代谢紊乱诊疗共识--中华医学会内分泌学分会肝病与代谢学组)

(2013) Xin Gao et al.   Journal of Diabetes

Adiponutrin Functions as a Nutritionally Regulated Lysophosphatidic Acid Acyltransferase

(2012) Manju Kumari et al.   Cell Metabolism

The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology

(2012) Naga Chalasani et al.   GASTROENTEROLOGY

A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease

(2012) Shamsul Mohd Zain et al.   HUMAN GENETICS

Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans

(2011) K. Sevastianova et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Hedgehog signaling in cholangiocytes

(2011) Alessia Omenetti et al.   CURRENT OPINION IN GASTROENTEROLOGY

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

(2011) Silvia Sookoian et al.   HEPATOLOGY

Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease

(2011) Cynthia D. Guy et al.   HEPATOLOGY

Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study

(2011) Lynne E. Wagenknecht et al.   LIVER INTERNATIONAL

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption

(2010) Jaimie N Davis et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulin

(2010) Sharleen M. Rae-Whitcombe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of PNPLA3 on Liver Fat and Metabolic Profile in Hispanic Children and Adolescents

(2010) M. I. Goran et al.   DIABETES

I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents

(2010) Nicola Santoro et al.   HEPATOLOGY

PNPLA3variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease

(2010) Elizabeth K. Speliotes et al.   HEPATOLOGY

The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease

(2010) Yaron Rotman et al.   HEPATOLOGY

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

Specifically PNPLA3-Mediated Accumulation of Liver Fat in Obese Patients with Type 2 Diabetes

(2010) Jean-Michel Petit et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life

(2010) Stefano Romeo et al.   JOURNAL OF HEPATOLOGY

Variant adiponutrin (PNPLA3) represents a common fibrosis risk gene: Non-invasive elastography-based study in chronic liver disease

(2010) Marcin Krawczyk et al.   JOURNAL OF HEPATOLOGY

Hedgehog signaling in the liver

(2010) Alessia Omenetti et al.   JOURNAL OF HEPATOLOGY

Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes

(2010) Céline Dubuquoy et al.   JOURNAL OF HEPATOLOGY

A Common Variant in the PNPLA3 Gene is a Risk Factor for Non-Alcoholic Fatty Liver Disease in Obese Taiwanese Children

(2010) Yu-Cheng Lin et al.   JOURNAL OF PEDIATRICS

A feed-forward loop amplifies nutritional regulation of PNPLA3

(2010) Yongcheng Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis

(2009) Steve S. Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene

(2009) K. Kantartzis et al.   DIABETES

Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production

(2009) Alessia Omenetti et al.   HEPATOLOGY

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

(2009) Shaoqing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

(2009) Silvia Sookoian et al.   JOURNAL OF LIPID RESEARCH

A common variant in the adiponutrin gene influences liver enzyme values

(2009) B. Kollerits et al.   JOURNAL OF MEDICAL GENETICS

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes

(2008) Xin Yuan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease

(2008) Naga Chalasani et al.   JOURNAL OF HEPATOLOGY

Nonalcoholic fatty liver disease: Fig. 1.

(2008) Sandra K. Erickson   JOURNAL OF LIPID RESEARCH

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS