Molecular dynamics simulation of PNPLA3 I148M polymorphism reveals reduced substrate access to the catalytic cavity

Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization

(2012) Yibing Shan et al.   CELL

A systematic analysis of heart transcriptome highlights divergent cardiovascular disease pathways between animal models and humans

(2011) Yuqi Zhao et al.   Molecular BioSystems

Effects of point mutations in pVHL on the binding of HIF-1α

(2011) Carmen Domene et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

A feed-forward loop amplifies nutritional regulation of PNPLA3

(2010) Yongcheng Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene

(2009) K. Kantartzis et al.   DIABETES

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

(2009) A. Kotronen et al.   DIABETOLOGIA

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

(2009) S Romeo et al.   INTERNATIONAL JOURNAL OF OBESITY

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

(2009) Shaoqing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

(2009) Silvia Sookoian et al.   JOURNAL OF LIPID RESEARCH

Variant in PNPLA3 is associated with alcoholic liver disease

(2009) Chao Tian et al.   NATURE GENETICS

The Universal Protein Resource (UniProt) in 2010

(2009)   NUCLEIC ACIDS RESEARCH

Genetic Variance in the Adiponutrin Gene Family and Childhood Obesity

(2009) Lovisa E. Johansson et al.   PLoS One

Fully Automated Molecular Mechanics Based Induced Fit Protein−Ligand Docking Method

(2008) Jürgen Koska et al.   Journal of Chemical Information and Modeling

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Functional protein divergence in the evolution of Homo sapiens

(2008) Nuria Lopez-Bigas et al.   GENOME BIOLOGY