Challenges in animal modelling of mesenchymal stromal cell therapy for inflammatory bowel disease

Mesenchymal stem cells and conditioned medium avert enteric neuropathy and colon dysfunction in guinea pig TNBS-induced colitis

(2014) Ainsley M. Robinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis

(2014) Shipeng Dang et al.   Autophagy

Mesenchymal Stem Cells Use IDO to Regulate Immunity in Tumor Microenvironment

(2014) W. Ling et al.   CANCER RESEARCH

Transplantation of human umbilical mesenchymal stem cells attenuates dextran sulfate sodium-induced colitis in mice

(2014) Yan Lin et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Translational research and efficacy of biologics in Crohn's disease: a cautionary tale

(2014) Keil Auer et al.   Expert Review of Clinical Immunology

IDO-Independent Suppression of T Cell Effector Function by IFN- -Licensed Human Mesenchymal Stromal Cells

(2014) R. Chinnadurai et al.   JOURNAL OF IMMUNOLOGY

A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents

(2014) Puneet Kaur Randhawa et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

(2014) Ying Wang et al.   NATURE IMMUNOLOGY

Do Cryopreserved Mesenchymal Stromal Cells Display Impaired Immunomodulatory and Therapeutic Properties?

(2014) Guido Moll et al.   STEM CELLS

Impaired Proliferative Potential of Bone Marrow Mesenchymal Stromal Cells in Patients with Myelodysplastic Syndromes Is Associated with Abnormal WNT Signaling Pathway

(2014) Konstantia Pavlaki et al.   STEM CELLS AND DEVELOPMENT

Actin Cytoskeletal Disruption following Cryopreservation Alters the Biodistribution of Human Mesenchymal Stromal Cells In Vivo

(2014) Raghavan Chinnadurai et al.   Stem Cell Reports

Thalidomide corrects impaired mesenchymal stem cell function in inducing tolerogenic DCs in patients with immune thrombocytopenia

(2013) J. Ma et al.   BLOOD

A Phase 2 Study of Allogeneic Mesenchymal Stromal Cells for Luminal Crohn's Disease Refractory to Biologic Therapy

(2013) Geoffrey M. Forbes et al.   Clinical Gastroenterology and Hepatology

Use of Mesenchymal Stem Cells (MSC) in Chronic Inflammatory Fistulizing and Fibrotic Diseases: a Comprehensive Review

(2013) Jan Voswinkel et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Stem cell therapy in inflammatory bowel disease

(2013) Welmoed K. van Deen et al.   CURRENT OPINION IN GASTROENTEROLOGY

Mesenchymal stromal cells for organ transplantation

(2013) Martin J. Hoogduijn et al.   Current Opinion in Organ Transplantation

Immunological characterization of multipotent mesenchymal stromal cells—The International Society for Cellular Therapy (ISCT) working proposal

(2013) Mauro Krampera et al.   CYTOTHERAPY

The peculiar biology of mouse mesenchymal stromal cells—oxygen is the key

(2013) Veena Krishnappa et al.   CYTOTHERAPY

The mesenchymal stromal cells dilemma—does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?

(2013) Jacques Galipeau   CYTOTHERAPY

Inflammatory Bowel Disease: Dysfunction of Autophagy?

(2013) Michael Scharl et al.   DIGESTIVE DISEASES

Human Umbilical Cord Blood Mesenchymal Stem Cells Reduce Colitis in Mice by Activating NOD2 Signaling to COX2

(2013) Hyung–Sik Kim et al.   GASTROENTEROLOGY

MSCs: science and trials

(2013) Donald G Phinney et al.   NATURE MEDICINE

Human Umbilical Cord-Derived Mesenchymal Stem Cells Downregulate Inflammatory Responses by Shifting the Treg/Th17 Profile in Experimental Colitis

(2013) Liren Li et al.   PHARMACOLOGY

Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjogren syndrome

(2012) J. Xu et al.   BLOOD

Pre-treatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis

(2012) Hongye Fan et al.   Cellular & Molecular Immunology

Gene Expression Profile Reveals Abnormalities of Multiple Signaling Pathways in Mesenchymal Stem Cell Derived from Patients with Systemic Lupus Erythematosus

(2012) Yu Tang et al.   Clinical & Developmental Immunology

Adoptive transfer of mesenchymal stromal cells accelerates intestinal epithelium recovery of irradiated mice in an interleukin-6-dependent manner

(2012) Moïra François et al.   CYTOTHERAPY

Autologous Expanded Adipose-Derived Stem Cells for the Treatment of Complex Cryptoglandular Perianal Fistulas

(2012) M.D. Herreros et al.   DISEASES OF THE COLON & RECTUM

Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks

(2012) Martina Perše et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The gut microbiota in IBD

(2012) Chaysavanh Manichanh et al.   Nature Reviews Gastroenterology & Hepatology

Intraperitoneal but Not Intravenous Cryopreserved Mesenchymal Stromal Cells Home to the Inflamed Colon and Ameliorate Experimental Colitis

(2012) Morgana T. L. Castelo-Branco et al.   PLoS One

Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Mice Trinitrobenzene Sulfonic Acid (TNBS)-Induced Colitis

(2011) Lu Liang et al.   CELL TRANSPLANTATION

Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-γ licensing

(2011) Moïra François et al.   CYTOTHERAPY

New therapies for inflammatory bowel disease: from the bench to the bedside

(2011) Silvio Danese   GUT

Human MSC Suppression Correlates With Cytokine Induction of Indoleamine 2,3-Dioxygenase and Bystander M2 Macrophage Differentiation

(2011) Moïra François et al.   MOLECULAR THERAPY

Pretreatment with Interferon-γ Enhances the Therapeutic Activity of Mesenchymal Stromal Cells in Animal Models of Colitis

(2011) Marjolijn Duijvestein et al.   STEM CELLS

Human Bone Marrow and Adipose Tissue Mesenchymal Stem Cells: A User's Guide

(2010) Federico Mosna et al.   STEM CELLS AND DEVELOPMENT

Regulatory T-Cell Generation and Kidney Allograft Tolerance Induced by Mesenchymal Stem Cells Associated With Indoleamine 2,3-Dioxygenase Expression

(2010) Wei Ge et al.   TRANSPLANTATION

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)

(2010) Caitlyn G. Whittem et al.   Jove-Journal of Visualized Experiments

Phenotypical/functional characterization of in vitro-expanded mesenchymal stromal cells from patients with Crohn's disease

(2009) Maria Ester Bernardo et al.   CYTOTHERAPY

Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis

(2009) Lianhua Bai et al.   GLIA

Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis

(2009) E Gonzalez-Rey et al.   GUT

Allogeneic Mesenchymal Stem Cells for Treatment of Experimental Autoimmune Encephalomyelitis

(2009) Moutih Rafei et al.   MOLECULAR THERAPY

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression

(2009) Guangwen Ren et al.   STEM CELLS

Blockade of adenosine A2Breceptors ameliorates murine colitis

(2008) V L Kolachala et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide

(2008) Guangwen Ren et al.   Cell Stem Cell

Is the Th1/Th2 paradigm of immune regulation applicable to IBD?

(2008) Ivan J. Fuss   INFLAMMATORY BOWEL DISEASES

Topical Implantation of Mesenchymal Stem Cells Has Beneficial Effects on Healing of Experimental Colitis in Rats

(2008) Y. Hayashi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS