Article
Endocrinology & Metabolism
Da-Young Jeong, Shin-Hye Kim, Moon Young Seo, Sin Young Kang, Mi Jung Park
Summary: The prevalence of hypercholesterolemia and hyper-LDL-cholesterolemia increased, while that of hypo-HDL-cholesterolemia decreased among Korean adolescents over the recent 12 years. The overall prevalence of dyslipidemia showed only a modest decline in boys and a stable trend in girls. Further studies are needed to explain these trends and possible associations with lifestyle factors.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Jill Dybiec, Wiktoria Baran, Bartlomiej Dabek, Piotr Fularski, Ewelina Mlynarska, Ewa Radzioch, Jacek Rysz, Beata Franczyk
Summary: This review focuses on the treatment approach for dyslipidemias, emphasizing the importance of normalizing these parameters to enhance patients' overall quality of life. Through an extensive analysis of clinical trials, this review identifies diseases that require alternative treatment strategies, particularly familial hypercholesterolemia. The primary objective of this review is to consolidate existing information on drugs with the potential to revolutionize dyslipidemia management significantly. Among these promising pharmaceuticals, alirocumab, bempedoic acid, antisense oligonucleotides, angiopoietin-like protein inhibitors, apolipoprotein C-III (APOC3) inhibitors, lomitapide, and cholesterol ester transfer protein (CETP) inhibitors are highlighted. This review outlines the future landscape of dyslipidemia treatment, envisioning a more tailored and effective therapeutic approach to address this widespread medical concern.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Linda C. Zuurbier, Joep C. Defesche, Albert Wiegman
Summary: The genetic screening program for familial hypercholesterolemia in the Netherlands, which ran from 1994 to 2014, identified at least 1500 cases annually and continued despite government funding cuts. The program led to the development of more sophisticated diagnostic tools, clinical collaborations, and new molecular-based treatments for FH patients. Additionally, the screening expanded to include other heritable dyslipidemias, utilizing a diagnostic next-generation sequencing panel that identified more patients prone to cardiovascular diseases and provided more personalized treatment options. The NGS output also revealed a more complex dyslipidemic landscape than originally thought, highlighting continuous progress and the importance of genetics in dyslipidemia.
Article
Endocrinology & Metabolism
Jie Wang, Qi Sun, Yu An, Jia Liu, Song Leng, Guang Wang
Summary: This study found that elevated remnant cholesterol is associated with a higher risk of hypertension in the Chinese population, especially among individuals with diabetes. However, with ideal management of remnant cholesterol, glucose, and other cardiovascular risk factors, the risk of hypertension can be minimized for diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Liu Shi, Dongmei Zhang, Jianqing Ju, Anlu Wang, Tianyi Du, Xuanye Chen, Yewen Song, Zhuye Gao, Hao Xu
Summary: In the general US adult population, remnant cholesterol (RC) is associated with hypertension beyond LDL-C levels. Elevated RC levels are linked to a higher prevalence of hypertension, independent of BMI, LDL-C, HDL-C, or triglycerides.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Peripheral Vascular Disease
Tracie K. Lin, Thomas C. Dispenza
Summary: Through an overview of childhood cholesterol screening, summarizing historical and contemporary guidelines and collating evidence of low adherence to current guidelines, we argue that novel approaches to universal cholesterol screening in childhood are warranted. We call for new and universal pediatric cholesterol screening guidelines.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Article
Medicine, General & Internal
Amy L. Peterson, Matthew Bang, Robert C. Block, Nathan D. Wong, Dean G. Karalis
Summary: Many physicians do not conduct cascade screening and are less likely to screen individuals with family history of known HeFH, compared to those with high cholesterol or premature ASCVD family history. Most physicians are willing to screen pediatric patients but only a few are willing to start treatment at recommended ages. Further education is needed to improve the diagnosis and treatment of HeFH.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Ambika P. Ashraf, Bhuvana Sunil, Vaneeta Bamba, Emily Breidbart, Preneet Cheema Brar, Stephanie Chung, Anshu Gupta, Aditi Khokhar, Seema Kumar, Marissa Lightbourne, Manmohan K. Kamboj, Ryan S. Miller, Nivedita Patni, Vandana Raman, Amy S. Shah, Don P. Wilson, Brenda Kohn
Summary: Pediatric endocrinologists play a crucial role in early intervention for dyslipidemia in children, with different treatment strategies needed for various cases. Timely identification and management are extremely important for preventing cardiovascular disease in at-risk youth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Medicine, General & Internal
Juliette M. Schefelker, Amy L. Peterson
Summary: This review emphasizes the importance of screening and treating pediatric dyslipidemia, especially due to the significant risk factors for cardiovascular disease in childhood. Identifying abnormalities through universal cholesterol screening and initiating lifestyle modifications are crucial in reducing future cardiovascular risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Peripheral Vascular Disease
Ibra S. Fancher, Irena Levitan
Summary: The goal of this review is to highlight the mechanisms driving hypercholesterolemia-mediated endothelial dysfunction, specifically focusing on cholesterol-protein interactions and their impact on cellular cholesterol and vascular endothelial function. The review describes key approaches used to determine the effects of cholesterol-protein interactions in mediating endothelial dysfunction under dyslipidemic conditions.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Article
Medicine, General & Internal
Jianxin Li, Mengyao Liu, Fangchao Liu, Shufeng Chen, Keyong Huang, Jie Cao, Chong Shen, Xiaoqing Liu, Ling Yu, Yingxin Zhao, Huan Zhang, Shujun Gu, Liancheng Zhao, Ying Li, Dongsheng Hu, Jianfeng Huang, Dongfeng Gu, Xiangfeng Lu
Summary: This cohort study investigates the association between age, genetic risk score, and annual rates of blood lipid changes in Chinese adults. The results suggest that age and polygenic risk are both associated with blood lipid changes, and these associations differ between male and female participants. The findings emphasize the importance of precision management of lipid levels for individuals at high genetic risk and in the critical age window.
Article
Medicine, Research & Experimental
Masoumeh Asgari, Iraj Salehi, Kamal Ranjbar, Maryam Khosravi, Ebrahim Zarrinkalam
Summary: This study evaluated the effects of exercise training and Crataegus persica extract on myocardial ischemia-reperfusion-induced kidney injury in diabetic rats. The results showed that interval training and Crataegus persica treatment decreased renal damage, improved insulin sensitivity and renal function in these rats.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Jinwei Gao, Zheng Wang, Zhangzhang Ye
Summary: This study examined the effectiveness of madder as a medicine to treat ischemia-reperfusion injury. The results showed that madder treatment can effectively reduce the area of myocardial infarction, restore arterial blood flow velocity and myocardial contractility, and inhibit the expression of inflammatory factors, autophagy factors, and apoptosis factors in mice. Madder treatment can also alleviate myocardial ischemia-reperfusion injury in mice and inhibit the occurrence of inflammatory response by inhibiting the activity of the NF-kappa B pathway.
MEDIATORS OF INFLAMMATION
(2023)
Article
Nutrition & Dietetics
Jacksaint Saintila, Laura E. Baquedano-Santana, Yaquelin E. Calizaya-Milla, Cristian Ramos-Vera, Antonio Serpa Barrientos, Renzo F. Carranza-Esteban
Summary: For university teachers, the frequency of breakfast consumption is associated with cardiometabolic risk. Skipping breakfast can have detrimental effects on cardiometabolic health. Promoting the benefits of breakfast is of great public health interest.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Youhyun Song, Hye Sun Lee, Goeun Park, Sang-Wook Kang, Ji Won Lee
Summary: This study aimed to investigate the risk of dyslipidemia in patients with thyroid cancer (TC) compared to the general population without TC. The results showed no significant difference in dyslipidemia risk between TC patients and the general population, both in prospective and retrospective analyses.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Chemistry, Medicinal
Levy Munguia, Miguel Ortiz, Cristian Gonzalez, Andres Portilla, Eduardo Meaney, Francisco Villarreal, Nayelli Najera, Guillermo Ceballos
Summary: Skeletal muscle is a dynamic tissue, and its mitochondria play a major role in various biological processes. Flavonoids, as polyphenolic compounds, have the potential to modulate mitochondrial myopathy. Research suggests that flavonoids may have positive effects on skeletal muscle structure and function.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Obstetrics & Gynecology
Araceli Montoya-Estrada, Daniela B. Veruete-Bedolla, Jose Romo-Yanez, Guillermo F. Ortiz-Luna, Arturo Arellano-Eguiluz, Nayelli Najera, Guillermo Ceballos, Nayeli Goreti Nieto-Velazquez, Ma. Abel Ramos-Valencia, Norma Carino-Mancilla, Norma L. Valdez-Rodriguez, Arturo Flores-Pliego, Aurora Espejel-Nunez, Enrique Reyes-Munoz
Summary: In postmenopausal women, those with metabolic syndrome have higher oxidative stress markers, while those without metabolic syndrome have lower oxidative stress markers.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andres Portilla-Martinez, Miguel Angel Ortiz-Flores, Eduardo Meaney, Francisco Villarreal, Nayelli Najera, Guillermo Ceballos
Summary: (-)-Epicatechin (EC), a flavonoid widely distributed in plants, has been shown to have diverse beneficial effects. This study demonstrates that EC acts as a biased agonist by recruiting β-arrestin to activate the APLN receptor. However, the effects of EC are so varied that it cannot be solely described by the activation of specific receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Moises Bustamante-Pozo, Israel Ramirez-Sanchez, Alejandra Garate-Carrillo, Bruce Ito, Viridiana Navarrete, Moises Haro, Ricardo Garcia, Nancy Carson, Guillermo Ceballos, Francisco Villarreal
Summary: This study found that (-)-epicatechin (Epi) can reduce cardiac fibrosis in an aged, female rat model of pre-heart failure with preserved ejection fraction (pre-HFpEF), while also decreasing levels of oxidative stress markers and proinflammatory/profibrotic cytokines.
JOURNAL OF MEDICINAL FOOD
(2022)
Review
Biochemistry & Molecular Biology
La Gil-Acevedo, Guillermo Ceballos, Yd Torres-Ramos
Summary: Preeclampsia is a pregnancy-specific syndrome with unknown causes. Lipid metabolism is altered in preeclampsia, leading to risks for both the mother and the fetus. Lipoperoxidation is the main process of lipid damage, generating toxic substances that cause reduced vasodilation and endothelial dysfunction. Neonates of mothers with preeclampsia are at increased risk of cardiovascular diseases, mental retardation, and metabolic diseases.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Pediatrics
Silvia Romero-Maldonado, Diana Mercedes Soriano-Becerril, Perla Karina Garcia-May, Enrique Reyes-Munoz, Eudoxia Georgina Munoz-Ortiz, Sandra Carrera-Muinos, Martha Lucia Granados-Cepeda, Jorge Arturo Cardona-Perez, Elsa Castro-Millan, Enrique Segura-Cervantes, Guillermo Ceballos, Araceli Montoya-Estrada
Summary: The study suggests that oropharyngeal administration of colostrum can increase serum IgA concentration, shorten the time to complete enteral feeding and reach birth weight, and reduce the total days of hospitalization in premature newborns.
FRONTIERS IN PEDIATRICS
(2022)
Review
Plant Sciences
German Chamorro-Cevallos, Maria Angelica Mojica-Villegas, Yuliana Garcia-Martinez, Salud Perez-Gutierrez, Eduardo Madrigal-Santillan, Nancy Vargas-Mendoza, Jose A. Morales-Gonzalez, Jose Melesio Cristobal-Luna
Summary: The use of medicinal plants in Mexico is crucial for treating diseases among the economically vulnerable population, but there are potential risks of teratogenic effects from certain plants, especially affecting the nervous system and axial skeleton. Research shows that approximately 0.22% of Mexican plants have teratogenic effects, indicating a need for more evaluation in this area.
Article
Chemistry, Multidisciplinary
Angelica Perez-Juarez, Jose Leopoldo Aguilar-Faisal, Araceli Posadas-Mondragon, Jose Angel Santiago-Cruz, Cornelio Barrientos-Alvarado, Maria Angelica Mojica-Villegas, German Alberto Chamorro-Cevallos, Jose A. Morales-Gonzalez
Summary: This study evaluated the protective properties of Spirulina against ethanol-induced toxicity. The administration of Spirulina extract restored the biochemical and histopathological changes caused by ethanol, and regulated antioxidant enzyme levels.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Andres Portilla-Martinez, Miguel Ortiz-Flores, Isabel Hidalgo, Cristian Gonzalez-Ruiz, Eduardo Meaney, Guillermo Ceballos, Nayelli Najera
Summary: Despite the development of vaccines and drugs for COVID-19, there are still too many obstacles to implementing a fully accessible plan for prevention and therapy. Therefore, it is necessary to explore nutraceutical/pharmaceutical drugs as potential preventives/treatments. Flavonoids, particularly amentoflavone, show promise as multitarget inhibitors of SARS-CoV-2 non-structural proteins.
JOURNAL OF MOLECULAR MODELING
(2022)
Article
Immunology
Selma Alin Somilleda-Ventura, Ruth Mery Lopez-Mayorga, Eduardo Meaney-Mendiolea, Angel Ivan Orlando Rubio-Gayosso, Hector Javier Perez-Cano, Guillermo Manuel Ceballos-Reyes, Virgilio Lima-Gomez
Summary: The study aimed to investigate the effect of (-)-Epicatechin administered alone or simultaneously with topical Ketorolac on the relative expression of GFAP and the response of Nrf2 in a mouse model with induced hyperglycemia. The results showed that GFAP and Nrf2 decreased in the groups that received treatments alone or simultaneous for 8 weeks, with a higher concentration of Nrf2 when GFAP decreased. The findings suggest a protective effect of Ketorolac and (-)-Epicatechin in limiting preclinical retinal damage caused by inflammation in hyperglycemia.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Levy Munguia, Nayelli Najera, Felipe de Jesus Martinez, Dylan Diaz-Chiguer, Fiacro Jimenez-Ponce, Miguel Ortiz-Flores, Francisco Villarreal, Guillermo Ceballos
Summary: COVID-19 can lead to intense systemic inflammation and a prothrombotic state, causing rapid and disproportionate deterioration of lung function. An observation study found that certain biomarkers are highly correlated with the severity of the disease, and elevated levels of Syndecan-1 are associated with severe cases of COVID-19. Preserving glycocalyx integrity may be a potential treatment for COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Justina P. Nguyen, Israel Ramirez-sanchez, Alejandra Garate-Carrillo, Viridiana Navarrete-Yanez, Rommel A. Carballo-Castaneda, Guillermo Ceballos, Aldo Moreno-Ulloa, Francisco Villarreal
Summary: In this study, we characterized the long-term changes in cardiac structure and function in a mouse model of aging and type 2 diabetes mellitus (T2D) induced by a high-fat diet and streptozotocin. We also explored the effects of the intersection of both conditions on plasma metabolomics, as well as the roles of oxidative stress, arginase activity, and pro-inflammatory cytokines.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Miguel Ortiz-Flores, Marcos Gonzalez-Perez, Andres Portilla, Marvin A. Soriano-Ursua, Javier Perez-Duran, Araceli Montoya-Estrada, Guillermo Ceballos, Nayelli Najera
Summary: By employing in silico tools, this study identified the most probable targets for five aromatic boronic acid derivatives and demonstrated their anticancer properties. In vitro analysis revealed that phenanthren-9-yl boronic acid and 6-hydroxynaphthalen-2-yl boronic acid possess cytotoxic properties at sub-micromolar concentrations. In conclusion, through in silico approaches and in vitro analysis, two boronic acid derivatives with potential anticancer activity were identified.
Article
Biochemistry & Molecular Biology
Javier Perez-Duran, Aglae Luna, Andres Portilla, Pamela Martinez, Guillermo Ceballos, Miguel angel Ortiz-Flores, Juan Mario Solis-Paredes, Nayelli Najera
Summary: Breast cancer is a global public health problem, and current chemotherapy has significant adverse effects. (-)-Epicatechin (EC), a flavonoid found in plants, has been shown to have beneficial effects on skeletal muscle and the cardiovascular system without adverse effects. Recent experiments have also demonstrated that EC has an antitumor effect in a murine breast cancer model.
Article
Medicine, General & Internal
Yolanda Martinez-Marroquin, Alejandra Meaney, Virginia Samaniego-Mendez, Nayelli Najera, Guillermo Ceballos, Carlos Fernandez-Barros, Eduardo Meaney
Summary: The study examines the TG/HDL-c ratio as a cardiovascular risk marker in a middle-class urban Mexican population. The Lindavista score (LS) is developed based on multiple variables and shows correlation with high-risk categories. Compared to the ACC ASCVD system, the TG/HDL-c ratio provides more accurate assessment of high-risk categories.
JOURNAL OF CLINICAL MEDICINE
(2023)