Glycoengineering in plants for the development of N-glycan structures compatible with biopharmaceuticals

Plant species and organ influence the structure and subcellular localization of recombinant glycoproteins

(2013) Elsa Arcalis et al.   PLANT MOLECULAR BIOLOGY

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

(2012) Darius Ghaderi et al.   Biotechnology & Genetic Engineering Reviews

N-Glycosylation and N-Glycan Moieties of CTB Expressed in Rice Seeds

(2012) Hiroyuki Kajiura et al.   MOLECULAR BIOTECHNOLOGY

N-glycan maturation is crucial for cytokinin-mediated development and cellulose synthesis inOryza sativa

(2012) Wahyu Indra Duwi Fanata et al.   PLANT JOURNAL

Plant-made pharmaceuticals: Leading products and production platforms

(2011) Matthew Paul et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Pivotal trial with plant cell-expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease

(2011) A. Zimran et al.   BLOOD

Mechanisms and principles of N-linked protein glycosylation

(2011) Flavio Schwarz et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Production of active human glucocerebrosidase in seeds of Arabidopsis thaliana complex-glycan-deficient (cgl) plants

(2011) Xu He et al.   GLYCOBIOLOGY

Plant-based rapid production of recombinant subunit hemagglutinin vaccines targeting H1N1 and H5N1 influenza

(2011) Yoko Shoji et al.   Human vaccines & immunotherapeutics

Reduced Immunogenicity ofArabidopsis hgl1MutantN-Glycans Caused by Altered Accessibility of Xylose andcoreFucose Epitopes

(2011) Heidi Kaulfürst-Soboll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-N-Acetylhexosaminidases HEXO1 and HEXO3 Are Responsible for the Formation of PaucimannosidicN-Glycans inArabidopsis thaliana

(2011) Eva Liebminger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Antibody Fragments with a Controlled N-Glycosylation Pattern and Induction of Endoplasmic Reticulum-Derived Vesicles in Seeds of Arabidopsis

(2011) A. Loos et al.   PLANT PHYSIOLOGY

Advances in plant molecular farming

(2010) Olawole O. Obembe et al.   BIOTECHNOLOGY ADVANCES

Post-translational modifications of protein biopharmaceuticals

(2010) Gary Walsh   DRUG DISCOVERY TODAY

Plant glycans: friend or foe in vaccine development?

(2010) Dirk Bosch et al.   Expert Review of Vaccines

In PlantaProtein Sialylation through Overexpression of the Respective Mammalian Pathway

(2010) Alexandra Castilho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biopharmaceutical benchmarks 2010

(2010) Gary Walsh   NATURE BIOTECHNOLOGY

Plant-specific glycosylation patterns in the context of therapeutic protein production

(2010) Véronique Gomord et al.   PLANT BIOTECHNOLOGY JOURNAL

The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza

(2010) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Flipping Lipids: Why an’ What’s the Reason for?

(2009) Sumana Sanyal et al.   ACS Chemical Biology

The Recognition Motif of the Glycoprotein-Folding Sensor Enzyme UDP-Glc:Glycoprotein Glucosyltransferase†

(2009) Kiichiro Totani et al.   BIOCHEMISTRY

Cotranslational and Posttranslational N-Glycosylation of Polypeptides by Distinct Mammalian OST Isoforms

(2009) Catalina Ruiz-Canada et al.   CELL

Expression systems for therapeutic glycoprotein production

(2009) Yves Durocher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Hetero-oligomeric interactions between early glycosyltransferases of the dolichol cycle

(2009) C. Noffz et al.   GLYCOBIOLOGY

Carbohydrate analysis throughout the development of a protein therapeutic

(2009) Elizabeth Higgins   GLYCOCONJUGATE JOURNAL

Class I  -Mannosidases Are Required for N-Glycan Processing and Root Development in Arabidopsis thaliana

(2009) E. Liebminger et al.   PLANT CELL

A Plant-Derived Recombinant Human Glucocerebrosidase Enzyme—A Preclinical and Phase I Investigation

(2009) David Aviezer et al.   PLoS One

Specific transbilayer translocation of dolichol-linked oligosaccharides by an endoplasmic reticulum flippase

(2009) Sumana Sanyal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of Mouse Sialyltransferase Genes: Their Evolution and Diversity

(2008) Shou TAKASHIMA   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Novel Controlled-Release Lemna-Derived IFN-α2b (Locteron): Pharmacokinetics, Pharmacodynamics, and Tolerability in a Phase I Clinical Trial

(2008) Leo G.J. De Leede et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Effects of glycosylation on the stability of protein pharmaceuticals

(2008) Ricardo J. Solá et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

(2008) B. L. Cantarel et al.   NUCLEIC ACIDS RESEARCH

Influenza virus-like particles produced by transient expression inNicotiana benthamianainduce a protective immune response against a lethal viral challenge in mice

(2008) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

(2008) Richard Strasser et al.   PLANT BIOTECHNOLOGY JOURNAL

Construction of a Functional CMP-Sialic Acid Biosynthesis Pathway in Arabidopsis

(2008) A. Castilho et al.   PLANT PHYSIOLOGY

Salt tolerance of Arabidopsis thaliana requires maturation of N-glycosylated proteins in the Golgi apparatus

(2008) J. S. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is the Drought Over for Pharming?

(2008) J. Kaiser   SCIENCE

Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza

(2008) Yoko Shoji et al.   VACCINE