Article
Pediatrics
Carme Alejandre, Carmina Guitart, Monica Balaguer, Isabel Torrus, Sara Bobillo-Perez, Francisco Jose Cambra, Iolanda Jordan
Summary: The study evaluated the use of procalcitonin (PCT) and C-reactive protein (CRP) for diagnosing bacterial infection in bronchiolitis patients. Procalcitonin showed better accuracy in diagnosing invasive bacterial infection (IBI), such as sepsis and pneumonia, compared to CRP. This highlights the importance of using PCT as a predictive biomarker to distinguish bronchiolitis patients with IBI, potentially reducing unnecessary antibiotic use.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Immunology
Yuting Chen, Jiran Shen, Hui Yang, Shanshan Xu, Yubo Ma, Faming Pan
Summary: The study found that serum PCT and CRP levels were significantly increased in SLE patients with bacterial infections. PCT had better diagnostic performance than CRP, with a higher positive likelihood ratio, making it a good rule-in marker. CRP testing may result in a high false-positive rate due to low positive likelihood ratio.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Infectious Diseases
Yingli Liu, Xiaoli Zhang, Tianfang Yue, Yanlai Tang, Zhiyong Ke, Yu Li, Xuequn Luo, Libin Huang
Summary: This study aims to evaluate the diagnostic performance of C-reactive protein (CRP) and procalcitonin (PCT) in differentiating invasive fungal infection (IFI) from bacterial bloodstream infections in immunocompromised children. The results demonstrate that high levels of CRP combined with low PCT can effectively differentiate IFI from bacterial bloodstream infections.
Article
Infectious Diseases
Claire Y. Mason, Tanmay Kanitkar, Charlotte J. Richardson, Marisa Lanzman, Zak Stone, Tabitha Mahungu, Damien Mack, Emmanuel Q. Wey, Lucy Lamb, Indran Balakrishnan, Gabriele Pollara
Summary: This study found that patients with community-acquired pneumonia (CAP) had higher baseline white cell counts and C-reactive protein levels, as well as a greater decrease in CRP upon hospital admission compared to COVID-19 patients. A multivariate logistic regression model incorporating WCC and CRP changes could distinguish bacterial co-infection and differentiate between CAP and COVID-19.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Clinical Neurology
Yan Chen, Zhanghua Yin, Xiaohui Gong, Jing Li, Wenhua Zhong, Liqin Shan, Xiaoping Lei, Qian Zhang, Qin Zhou, Youyan Zhao, Chao Chen, Yongjun Zhang
Summary: The study developed a sequential algorithm integrating clinical and laboratory parameters to stratify the risk of BM in neonates, showing excellent predictive performance and proving to be helpful for clinicians in decision-making related to LP.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Infectious Diseases
Raquel Carbonell, Silvia Urgeles, Melina Salgado, Alejandro Rodriguez, Luis Felipe Reyes, Yuliv. Fuentes, CristianC. Serrano, Ederl. Caceres, Maria Bodi, Ignacio Martin-Loeches, Jordi Sole-Violan, Emili Diaz, Josep Gomez, Sandra Trefler, Montserrat Vallverdu, Josefa Murcia, Antonio Albaya, Ana Loza, Lorenzo Socias, Juan Carlos Ballesteros, Elisabeth Papiol, Lucia Vina, Susana Sancho, Mercedes Nieto, M. Del, Carmen Lorente, Oihane Badallo, Virginia Fraile, Fernando Armestar, Angel Estella, Paula Abanses, Isabel Sancho, Neus Guasch, Gerard Moreno
Summary: Procalcitonin (PCT) and C-Reactive Protein (CRP) have poor ability to predict bacterial respiratory coinfection in COVID-19 patients. However, baseline PCT values <0.3ng/mL can be used to rule out bacterial coinfection, while PCT >= 0.50ng/mL may predict worsening outcomes.
JOURNAL OF INFECTION
(2022)
Article
Multidisciplinary Sciences
Meirav Mor, Meital Paz, Lisa Amir, Itzhak Levy, Oded Scheuerman, Gilat Livni, Claire Guetta-Oz, Sivan Yochpaz, Ron Berant, Rama Schwartz, Omer Niv, Dana Singer, Shai Ashkenazi, Yehezkel Waisman
Summary: A host-protein score (BV score) combining the levels of TRAIL, IP-10, and CRP was developed to distinguish between bacterial and viral infection. The study found that the BV score has the potential to aid diagnostic process and could potentially correct the physician's diagnosis and reduce error rate.
Article
Medicine, General & Internal
Matteo Vassallo, Celine Michelangeli, Roxane Fabre, Sabrina Manni, Pierre L. Genillier, Nicolas Weiss, Elea Blanchouin, Laurence Saudes, Regis Kaphan, Annick Puchois, Christian Pradier, Nathalie Montagne
Summary: This study evaluated the roles of PCT and CRP in febrile cancer patients with solid tumors, identifying cut-off values to distinguish between infection and cancer-associated fever. PCT and CRP/PCT ratio can serve as valuable markers for ruling out infection in these patients.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Nathan Shapiro, Michael R. Filbin, Peter C. Hou, Michael C. Kurz, Jin H. Han, Tom P. Aufderheide, Michael A. Ward, Michael S. Pulia, Robert H. Birkhahn, Jorge L. Diaz, Teena L. Hughes, Manya R. Harsch, Annie Bell, Catalina Suarez-Cuervo, Robert Sambursky
Summary: This study aimed to investigate a rapid diagnostic test that can differentiate bacterial and viral etiology of acute respiratory infections by measuring myxovirus resistance protein A (MxA) and C-reactive protein (CRP) in finger-stick blood. The results showed that the diagnostic test demonstrated high sensitivity and specificity, providing useful information for clinicians in assessing the bacterial or viral cause of acute respiratory infection symptoms.
Article
Infectious Diseases
Owen Richards, Philip Pallmann, Charles King, Yusuf Cheema, Charlotte Killick, Emma Thomas-Jones, Jessica Harris, Catherine Bailey, Tamas Szakmany
Summary: The study revealed a significant association between an increase in PCT levels and the occurrence of secondary bacterial infection in critically ill COVID-19 patients, suggesting the potential usefulness of PCT measurement in predicting such infections.
Article
Medicine, General & Internal
Eun-Hwa Lee, Kyoung-Hwa Lee, Young-Goo Song, Sang-Hoon Han
Summary: C-reactive protein (CRP) or procalcitonin (PCT) alone have limitations in the early detection of infection or inflammation. Interleukin (IL)-6 has been assessed recently, and this study reveals considerable discrepancies among CRP, PCT, and IL-6 levels. Relying solely on CRP tests may lead to misinterpretation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Emma J. Kooistra, Miranda van Berkel, Noortje F. van Kempen, Celine R. M. van Latum, Niklas Bruse, Tim Frenzel, Maarten J. W. van den Berg, Jeroen A. Schouten, Matthijs Kox, Peter Pickkers
Summary: Cessation of dexamethasone in critically ill COVID-19 patients leads to a rebound increase in PCT and CRP levels unrelated to secondary bacterial infections. Immunomodulatory treatment with dexamethasone and tocilizumab significantly reduces the value of PCT and CRP for detecting secondary infections in COVID-19 patients.
Article
Mathematical & Computational Biology
Yan Zhang, Mei La, Jihong Sun, Mimi Chen, Dandan Liu, Xiaolin Liu, Yating Kang
Summary: This study investigates the clinical values and implications for the prognosis of procalcitonin (PCT) combined with C-reactive protein (hs-CRP) in patients with bacterial bloodstream infection. The results suggest that PCT and hs-CRP levels are correlated with prognostic outcomes, with the combination of PCT and hs-CRP showing the highest accuracy.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Review
Infectious Diseases
B. Leticia Fernandez-Carballo, Camille Escadafal, Emily MacLean, Anokhi J. Kapasi, Sabine Dittrich
Summary: This study aimed to evaluate host biomarkers that can distinguish bacterial from non-bacterial causes of AFI, finding that most studies focused on protein, hematology, RNA, and metabolite biomarkers. Results showed a high overall risk of bias for most biomarkers, but some showed good sensitivity/specificity in blood samples. Most of the well-performing biomarkers identified are well-known, with a few new biomarkers showing promise, but further high-quality studies are needed to confirm these findings.
JOURNAL OF INFECTION
(2021)
Article
Chemistry, Multidisciplinary
Jae-Hwan Oh, Jung-Hyuk Kwon, Hye-Hyun Kim, Jeewon Lee
Summary: This study aims to develop an advanced one-step immunoassay for quick and accurate diagnosis of sepsis by measuring PCT concentration in patient sera. By attaching multiple anti-PCT antibodies (IgGs) to a modified hepatitis B virus (HBV) capsid surface to construct a 3D probe, hook effect-free and PCT concentration-dependent optical signals were successfully generated.
Article
Hematology
Buelent Altinsoy, Ibrahim Ilker Oz, Tacettin Ornek, Fatma Erboy, Hakan Tanriverdi, Firat Uygur, Nejat Altintas, Figen Atalay, Muege Meltem Tor
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2017)
Article
Cardiac & Cardiovascular Systems
Firat Uygur, Hakan Tanriverdi, Ziyaeddin Aktop, Fatma Erboy, Bulent Altinsoy, Murat Damar, Figen Atalay
Article
Cell Biology
Firat Uygur, Hakan Tanriverdi, Murat Can, Tacettin Ornek, Fatma Erboy, Bulent Altinsoy, Figen Atalay, Murat Damar, Furuzan Kokturk, Meltem Tor
MEDIATORS OF INFLAMMATION
(2016)
Article
Public, Environmental & Occupational Health
Guven Celebi, Nihal Piskin, Arzum Celik Beklevic, Yurdagul Altunay, Aysegul Salci Keles, Mehmet Ali Tuz, Bulent Altinsoy, Demet Haciseyitoglu
AMERICAN JOURNAL OF INFECTION CONTROL
(2020)
Article
Cardiac & Cardiovascular Systems
Mertol Gokce, Bulent Altinsoy, Ozcan Piskin, Burak Bahadir
Summary: This study compared the diagnostic efficacy and safety of VATS and AVATS in patients with undiagnosed exudative pleural effusions, finding no significant difference in diagnostic test performance between the two groups. The AVATS group had a shorter duration time of operation compared to the VATS group, and a relatively shorter length of hospital stay.
JOURNAL OF CARDIOTHORACIC SURGERY
(2021)
Article
Virology
Sevim Karakas Celik, Gunes Cakmak Genc, Nihal Piskin, Bilgehan Acikgoz, Bulent Altinsoy, Basak Kurucu Issiz, Ahmet Dursun
Summary: In this study, the polymorphisms of ACE gene I/D, ACE2 receptor gene rs2106809, and rs2285666 were not significantly associated with the severity of COVID-19 infection in the study population. While ACE2 receptor gene expression may influence susceptibility to COVID-19, there is no current evidence linking ACE or ACE2 gene polymorphisms directly to COVID-19 severity. Individual differences in COVID-19 severity might be influenced by epigenetic mechanisms of ACE2 receptor gene expression or variations in other genes involved in COVID-19 pathogenesis.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Peripheral Vascular Disease
Ozcan Piskin, Bulent Altinsoy, Cagdas Baytar, Bengu Gulhan Aydin, Dilek Okyay, Gamze Kucukosman, Keziban Bollucuoglu, Alkim Gizem Yilmaz, Hilal Ayoglu
Summary: This prospective study evaluated the effectiveness of US-guided PECS I blocks on postoperative analgesia after TIVAP insertion. The results showed that PECS-1 significantly reduced the use of paracetamol in the first 24 hours postoperatively and resulted in lower pain scores at 1, 4, and 12 hours compared to the infiltration anesthesia group.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Cardiac & Cardiovascular Systems
Ozcan Piskin, Mertol Gokce, Bulent Altinsoy, Cagdas Baytar, Bengu Gulhan Aydin, Rahsan Dilek Okyay, Gamze Kucukosman, Keziban Bollucuoglu, Hilal Ayoglu
Summary: Ultrasound-guided continuous erector spinae plane block provides effective analgesia for postoperative pain in video-assisted thoracoscopic surgery, reducing opioid consumption and related side effects.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Genetics & Heredity
Gunes Cakmak Genc, Sevim Karakas Celik, Busra Yilmaz, Nihal Piskin, Bulent Altinsoy, Ahmet Dursun
Summary: This study investigates the relationship between variants of interleukin 1 receptor antagonist (IL1RN), interleukin 17A (IL17A), and interleukin 17F (IL17F) genes and the severity of COVID-19. The findings reveal a significant association between the IL17A rs2275913 variant and COVID-19 severity. Haplotype frequency distributions of IL17F rs763780/rs2397084 and a combination of IL17F rs763780/rs2397084/IL17A rs2275913 also show a significant relationship with COVID-19 severity. Therefore, these variants may serve as predictive markers for the clinical course and potential immunomodulatory treatment options in COVID-19.
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
(2023)
Article
Medicine, Legal
Sadik Toprak, Emine Yilmaz Can, Bulent Altinsoy, John Hart, Zekeriya Dogan, Mustafa Ozcetin
Summary: The study developed an objective tool to evaluate sarin exposure from brief and unstructured social media videos, and validated the new questionnaire through standardized procedures. The Video Score Questionnaire showed good internal reliability and validity for analyzing sarin attacks.
FORENSIC SCIENCES RESEARCH
(2022)
Review
Respiratory System
Ceyda Anar, Oguzhan Okutan, Aysun Sengul, Onur Yazici, Bulent Altinsoy
EURASIAN JOURNAL OF PULMONOLOGY
(2020)
Meeting Abstract
Respiratory System
Muge Meltem Tor, Bulent Altinsoy, Fatma Erboy
EUROPEAN RESPIRATORY JOURNAL
(2017)
Meeting Abstract
Respiratory System
Fatma Erboy, Bulent Altinsoy, Muge Meltem Tor, Figen Atalay
EUROPEAN RESPIRATORY JOURNAL
(2017)
Article
Medicine, General & Internal
Ozcan Piskin, Bulent Altinsoy, Murat Cimencan, Bengu Gulhan Aydin, Dilek Okyay, Gamze Kucukosman, Oge Tascilar, Selda Sarikaya, Hilal Ayoglu
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2017)