Article
Oncology
Jean Pierre Jabbour, Giulia Ciotti, Giacomo Maestrini, Mattia Brescini, Chiara Lisi, Claudia Ielo, Gianfranco La Pietra, Cristina Luise, Costantino Riemma, Massimo Breccia, Gregorio Antonio Brunetti, Ida Carmosino, Roberto Latagliata, Giacomo Salvatore Morano, Maurizio Martelli, Corrado Girmenia
Summary: This study confirms the utility of procalcitonin and C-reactive protein as predictors of Gram-negative bloodstream infection in hematological febrile outpatients. Procalcitonin shows a higher discriminative value in differentiating the cause of fever and ruling out GN-BSI compared to C-reactive protein, providing a potential tool for tailored prompt antimicrobial therapy.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Immunology
Yuting Chen, Jiran Shen, Hui Yang, Shanshan Xu, Yubo Ma, Faming Pan
Summary: The study found that serum PCT and CRP levels were significantly increased in SLE patients with bacterial infections. PCT had better diagnostic performance than CRP, with a higher positive likelihood ratio, making it a good rule-in marker. CRP testing may result in a high false-positive rate due to low positive likelihood ratio.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pediatrics
Carme Alejandre, Carmina Guitart, Monica Balaguer, Isabel Torrus, Sara Bobillo-Perez, Francisco Jose Cambra, Iolanda Jordan
Summary: The study evaluated the use of procalcitonin (PCT) and C-reactive protein (CRP) for diagnosing bacterial infection in bronchiolitis patients. Procalcitonin showed better accuracy in diagnosing invasive bacterial infection (IBI), such as sepsis and pneumonia, compared to CRP. This highlights the importance of using PCT as a predictive biomarker to distinguish bronchiolitis patients with IBI, potentially reducing unnecessary antibiotic use.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Infectious Diseases
Yingli Liu, Xiaoli Zhang, Tianfang Yue, Yanlai Tang, Zhiyong Ke, Yu Li, Xuequn Luo, Libin Huang
Summary: This study aims to evaluate the diagnostic performance of C-reactive protein (CRP) and procalcitonin (PCT) in differentiating invasive fungal infection (IFI) from bacterial bloodstream infections in immunocompromised children. The results demonstrate that high levels of CRP combined with low PCT can effectively differentiate IFI from bacterial bloodstream infections.
Article
Infectious Diseases
Owen Richards, Philip Pallmann, Charles King, Yusuf Cheema, Charlotte Killick, Emma Thomas-Jones, Jessica Harris, Catherine Bailey, Tamas Szakmany
Summary: The study revealed a significant association between an increase in PCT levels and the occurrence of secondary bacterial infection in critically ill COVID-19 patients, suggesting the potential usefulness of PCT measurement in predicting such infections.
Article
Integrative & Complementary Medicine
Liping Fan, Xiaoge Ding
Summary: This study investigated the potential of procalcitonin (PCT) levels and the C-reactive protein/ procalcitonin (CRP/PCT) ratio as markers for distinguishing between infectious and neoplastic fever in febrile patients with malignant tumors. The results showed that both PCT and CRP/PCT were sensitive markers for identifying infection, with CRP/PCT demonstrating higher specificity compared to PCT. The findings suggest that CRP/PCT may be more valuable than PCT in distinguishing between infectious fever and neoplastic fever in cancer patients.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Medicine, General & Internal
Jooyoung Cho, Seri Jeong, Jong-Han Lee
Summary: This study found a positive association between the procalcitonin to C-reactive protein ratio and 90-day mortality in ischemic stroke patients. This suggests that the PC ratio may be a useful marker for predicting mortality after stroke.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Eun-Hwa Lee, Kyoung-Hwa Lee, Young-Goo Song, Sang-Hoon Han
Summary: C-reactive protein (CRP) or procalcitonin (PCT) alone have limitations in the early detection of infection or inflammation. Interleukin (IL)-6 has been assessed recently, and this study reveals considerable discrepancies among CRP, PCT, and IL-6 levels. Relying solely on CRP tests may lead to misinterpretation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Claire Y. Mason, Tanmay Kanitkar, Charlotte J. Richardson, Marisa Lanzman, Zak Stone, Tabitha Mahungu, Damien Mack, Emmanuel Q. Wey, Lucy Lamb, Indran Balakrishnan, Gabriele Pollara
Summary: This study found that patients with community-acquired pneumonia (CAP) had higher baseline white cell counts and C-reactive protein levels, as well as a greater decrease in CRP upon hospital admission compared to COVID-19 patients. A multivariate logistic regression model incorporating WCC and CRP changes could distinguish bacterial co-infection and differentiate between CAP and COVID-19.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Meirav Mor, Meital Paz, Lisa Amir, Itzhak Levy, Oded Scheuerman, Gilat Livni, Claire Guetta-Oz, Sivan Yochpaz, Ron Berant, Rama Schwartz, Omer Niv, Dana Singer, Shai Ashkenazi, Yehezkel Waisman
Summary: A host-protein score (BV score) combining the levels of TRAIL, IP-10, and CRP was developed to distinguish between bacterial and viral infection. The study found that the BV score has the potential to aid diagnostic process and could potentially correct the physician's diagnosis and reduce error rate.
Article
Microbiology
Lihe Che, Zedong Wang, Na Du, Liang Li, Yinghua Zhao, Kaiyu Zhang, Quan Liu
Summary: This study retrospectively analyzed the data of 373 HFRS patients in northeastern China and found that serum ferritin and procalcitonin are closely associated with the severity and mortality of HFRS, making them promising predictors. C-reactive protein, on the other hand, can effectively assess bacterial co-infection in HFRS.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Jiakun Song, Yurong Lu
Summary: This study aimed to identify rapid and accurate early diagnostic indicators for intra-abdominal infection after general surgery. The combination of CRP, PCT, TNF alpha, and IL6 showed higher predictive efficiency for complicated IAIs among surgical patients compared to individual indicators on postoperative days 1 and 3. These composite indicators can serve as predictors with high sensitivity and specificity for postoperative abdominal infectious complications.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Infectious Diseases
Raquel Carbonell, Silvia Urgeles, Melina Salgado, Alejandro Rodriguez, Luis Felipe Reyes, Yuliv. Fuentes, CristianC. Serrano, Ederl. Caceres, Maria Bodi, Ignacio Martin-Loeches, Jordi Sole-Violan, Emili Diaz, Josep Gomez, Sandra Trefler, Montserrat Vallverdu, Josefa Murcia, Antonio Albaya, Ana Loza, Lorenzo Socias, Juan Carlos Ballesteros, Elisabeth Papiol, Lucia Vina, Susana Sancho, Mercedes Nieto, M. Del, Carmen Lorente, Oihane Badallo, Virginia Fraile, Fernando Armestar, Angel Estella, Paula Abanses, Isabel Sancho, Neus Guasch, Gerard Moreno
Summary: Procalcitonin (PCT) and C-Reactive Protein (CRP) have poor ability to predict bacterial respiratory coinfection in COVID-19 patients. However, baseline PCT values <0.3ng/mL can be used to rule out bacterial coinfection, while PCT >= 0.50ng/mL may predict worsening outcomes.
JOURNAL OF INFECTION
(2022)
Article
Pediatrics
Nagwan Y. Saleh, Hesham M. Aboelghar, Mohamed I. Garib, Mohammed S. Rizk, Asmaa A. Mahmoud
Summary: This study evaluated serum concentrations of pancreatic stone protein (PSP), copeptin, and apolipoprotein A-V (APOA5) as biomarkers for the diagnosis and prognosis of pediatric sepsis. The results showed that PSP, copeptin, and APOA5 were significantly higher in septic patients compared to healthy controls. PSP and copeptin were associated with non-survival, while APOA5 was inversely related. These biomarkers have potential diagnostic value for pediatric sepsis but are inadequate for predicting mortality.
PEDIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Yan Chen, Zhanghua Yin, Xiaohui Gong, Jing Li, Wenhua Zhong, Liqin Shan, Xiaoping Lei, Qian Zhang, Qin Zhou, Youyan Zhao, Chao Chen, Yongjun Zhang
Summary: The study developed a sequential algorithm integrating clinical and laboratory parameters to stratify the risk of BM in neonates, showing excellent predictive performance and proving to be helpful for clinicians in decision-making related to LP.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)