Genomewide RNAi screen identifies protein kinase Cβ and new members of mitogen-activated protein kinase pathway as regulators of melanoma cell growth and metastasis

Protein Kinase C-β-Dependent Activation of NF-κB in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo

(2013) Gloria Lutzny et al.   CANCER CELL

TGF-β Effects on Prostate Cancer Cell Migration and Invasion Are Mediated by PGE2through Activation of PI3K/AKT/mTOR Pathway

(2013) BaoHan T. Vo et al.   ENDOCRINOLOGY

Synergy between enzastaurin doxorubicin in inducing melanoma apoptosis

(2013) Simona Romano et al.   Pigment Cell & Melanoma Research

Melanoma Cells Use Thy-1 (CD90) on Endothelial Cells for Metastasis Formation

(2012) Kathleen Schubert et al.   AMERICAN JOURNAL OF PATHOLOGY

Resistance patterns with tyrosine kinase inhibitors in melanoma

(2012) Reinhard Dummer et al.   CURRENT OPINION IN ONCOLOGY

Selumetinib (AZD6244; ARRY-142886) in the treatment of metastatic melanoma

(2012) Sapna P Patel et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Chemical Genetic Identification of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development

(2012) Sila K. Ultanir et al.   NEURON

Regulation of cell cycle checkpoint kinase WEE1 by miR-195 in malignant melanoma

(2012) A Bhattacharya et al.   ONCOGENE

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Specifying protein kinase C functions in melanoma

(2012) Mitchell F. Denning   Pigment Cell & Melanoma Research

The Protein Kinase C Inhibitor Enzastaurin Exhibits Antitumor Activity against Uveal Melanoma

(2012) Xinqi Wu et al.   PLoS One

Modulators of Prostate Cancer Cell Proliferation and Viability Identified by Short-Hairpin RNA Library Screening

(2012) Kimberly Brown Dahlman et al.   PLoS One

Novel Immunotherapeutic Agents and Small Molecule Antagonists of Signalling Kinases for the Treatment of Metastatic Melanoma

(2011) Nagendra Natarajan et al.   DRUGS

Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1

(2011) Deresa Lee et al.   EMBO REPORTS

The Adaptor-associated Kinase 1, AAK1, Is a Positive Regulator of the Notch Pathway

(2011) Neetu Gupta-Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Receptor tyrosine kinases and their activation in melanoma

(2011) David J. Easty et al.   Pigment Cell & Melanoma Research

Genomic Screening with RNAi: Results and Challenges

(2010) Stephanie Mohr et al.   Annual Review of Biochemistry

EGFR tyrosine kinases inhibitors in cancer treatment: in vitro and in vivo evidence

(2010) Anna Elisa Quatrale   Frontiers in Bioscience-Landmark

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Functional alterations in protein kinase C beta II expression in melanoma

(2010) John P. Voris et al.   Pigment Cell & Melanoma Research

Protein Kinase Cβ Is an Effective Target for Chemoprevention of Colon Cancer

(2009) Alan P. Fields et al.   CANCER RESEARCH

Dermal Fibroblasts Promote the Migration of Dendritic Cells

(2009) Anja Saalbach et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

E2F1 in Melanoma Progression and Metastasis

(2009) Vijay Alla et al.   JNCI-Journal of the National Cancer Institute

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

(2009) Renee D. Paulsen et al.   MOLECULAR CELL

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

V600EBRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

(2009) C. A. Pratilas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth

(2008) Julia Schultz et al.   CELL RESEARCH

JNK supports survival in melanoma cells by controlling cell cycle arrest and apoptosis

(2008) Vasileia-Ismini Alexaki et al.   Pigment Cell & Melanoma Research

Quality Assessment for Short Oligonucleotide Microarray Data

(2008) Julia Brettschneider et al.   TECHNOMETRICS