Involvement of vacuolar H+-ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720

CTLA-4 and PD-1/PD-L1 Blockade: New Immunotherapeutic Modalities with Durable Clinical Benefit in Melanoma Patients

(2013) P. A. Ott et al.   CLINICAL CANCER RESEARCH

FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system

(2013) FV Pereira et al.   Clinics

Protein phosphatase 2A: a target for anticancer therapy

(2013) Danilo Perrotti et al.   LANCET ONCOLOGY

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3

(2013) F Lai et al.   Cell Death & Disease

PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma

(2013) Yan Ye et al.   Nature Communications

FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma

(2012) Lapo Alinari et al.   Autophagy

An update in the structure, function, and regulation of V-ATPases: the role of the C subunit

(2012) M Pérez-Sayáns et al.   BRAZILIAN JOURNAL OF BIOLOGY

The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance

(2012) D. Wroblewski et al.   CARCINOGENESIS

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

(2012) Sahar A. Saddoughi et al.   EMBO Molecular Medicine

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

(2012) Lin Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma

(2012) A. Estrada-Bernal et al.   NEURO-ONCOLOGY

Targeting sphingosine kinase-1 to inhibit melanoma

(2012) SubbaRao V. Madhunapantula et al.   Pigment Cell & Melanoma Research

Bioenergetics Failure and Oxidative Stress in Brain Stem Mediates Cardiovascular Collapse Associated with Fatal Methamphetamine Intoxication

(2012) Faith C. H. Li et al.   PLoS One

Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress

(2012) K H Tay et al.   Cell Death & Disease

FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells

(2011) Craig T. Wallington-Beddoe et al.   Autophagy

Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules

(2011) S. Pyne et al.   CANCER RESEARCH

NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling

(2011) Sharon Biton et al.   CELL

Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma

(2011) Hany A. Omar et al.   HEPATOLOGY

FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy

(2010) Ning Zhang et al.   Autophagy

Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT+ Cancers

(2010) K. G. Roberts et al.   CANCER RESEARCH

FTY720 (Fingolimod) Sensitizes Prostate Cancer Cells to Radiotherapy by Inhibition of Sphingosine Kinase-1

(2010) D. Pchejetski et al.   CANCER RESEARCH

The PI3K Pathway As Drug Target in Human Cancer

(2010) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

Contrasting Effects of Nutlin-3 on TRAIL- and Docetaxel-Induced Apoptosis Due to Upregulation of TRAIL-R2 and Mcl-1 in Human Melanoma Cells

(2010) H.-Y. Tseng et al.   MOLECULAR CANCER THERAPEUTICS

Molecular circuits of solid tumors: prognostic and predictive tools for bedside use

(2010) Charles Ferté et al.   Nature Reviews Clinical Oncology

Understanding Melanoma Signaling Networks as the Basis for Molecular Targeted Therapy

(2009) Keiran S.M. Smalley   JOURNAL OF INVESTIGATIVE DERMATOLOGY

FTY720 Induces Apoptosis in Hepatocellular Carcinoma Cells through Activation of Protein Kinase C   Signaling

(2008) J.-H. Hung et al.   CANCER RESEARCH

TNFα and reactive oxygen species in necrotic cell death

(2008) Michael J Morgan et al.   CELL RESEARCH

Downregulating sphingosine kinase-1 for cancer therapy

(2008) Olivier Cuvillier   EXPERT OPINION ON THERAPEUTIC TARGETS