Article
Cardiac & Cardiovascular Systems
Nada Joe Melhem, Mouna Chajadine, Ingrid Gomez, Kiave-Yune Howangyin, Marion Bouvet, Camille Knosp, Yanyi Sun, Marie Rouanet, Ludivine Laurans, Olivier Cazorla, Mathilde Lemitre, Jose Vilar, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Jean-Sebastien Hulot, Jacques Callebert, Jean-Marie Launay, Jeremy Fauconnier, Jean-Sebastien Silvestre, Soraya Taleb
Summary: The study suggests that IDO could be a potential therapeutic target in acute myocardial infarction, as its deficiency limits cardiac injury and dysfunction after MI, with endothelial cell-specific deletion of IDO showing improvement in cardiac function and reduction in adverse ventricular remodeling.
Review
Biochemistry & Molecular Biology
Akande Rouchidane Eyitayo, Mathilde Gonin, Hubert Arokium, Stephen Manon
Summary: BCL-2 family members are key regulators of apoptotic cell death in mammals. Studying their ectopic expression in yeast provides valuable insights into their function and regulation mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Liang Zhao, Lulu Sun, Xiafei Li, Tian Lu, Yuxue Pan, Pengchong Du
Summary: This study elucidated the cardioprotective mechanism of genipin and demonstrated its potential for treating ischemic heart failure.
Article
Pharmacology & Pharmacy
Genlong Xue, Xiaolei Yang, Ge Zhan, Xin Wang, Jinghan Gao, Yong Zhao, Xinying Wang, Jiatian Li, Zhenwei Pan, Yunlong Xia
Summary: This study demonstrates that the SGLT2 inhibitor empagliflozin can improve post-myocardial infarction electrophysiological remodeling and reduce the occurrence of ventricular arrhythmia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Minh Quang Duong, Rudy Gadet, Isabelle Treilleux, Stephane Borel, Adrien Nougarede, Olivier Marcillat, Philippe Gonzalo, Ivan Mikaelian, Nikolay Popgeorgiev, Ruth Rimokh, Germain Gillet
Summary: Overexpression of Bcl-2 proteins like Bcl2L10 is linked to chemotherapy resistance and poor survival in several types of cancer. A particular SNP (rs2231292) in the BCL2L10 gene has been found to lower resistance to chemotherapy, leading to improved survival in acute leukemia and colorectal cancer patients. This study investigated the impact of this SNP in breast cancer, finding that individuals with the Nrh-R isoform of Bcl2L10 had higher sensitivity to cell death induction and potentially better outcomes.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Lijia Zhang, Lifang Lv, Nan Zheng, Ruotong Li, Rui Yang, Tianyu Li, Yingnan Li, Yingqi Liu, Hongwei Luo, Xuelian Li, Yuhong Zhou, Hongli Shan, Bing Bai, Haihai Liang
Summary: Sox4 plays a role in promoting cardiomyocyte apoptosis during myocardial infarction by regulating Bim expression, and silencing Sox4 can attenuate cardiomyocyte apoptosis, suggesting it as a potential therapeutic target for MI.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Peng Yu, Shuai Song, Xiaokai Zhang, Shujun Cui, Gang Wei, Zihang Huang, Linqi Zeng, Ting Ni, Aijun Sun
Summary: This study revealed the regulatory mechanism of APA in post-MI HF and identified the potential therapeutic effect of the APA-regulated gene AVEN in treating HF.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pharmacology & Pharmacy
Hong Zhang, Zongwei Guo, Yafei Guo, Ziqian Wang, Yao Tang, Ting Song, Zhichao Zhang
Summary: The research showed that the transfer of Bim between Bcl-2-like protein and Hsp70 underlies the crosstalk in mitochondrial apoptosis pathway, leading to apoptosis in cancer cell lines by inhibiting free Bim and facilitating oncogenic client AKT folding and activation.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Yongpan Huang, Bin He, Chong Song, Xian Long, Jianbin He, Yansong Huang, Lijing Liu
Summary: This study evaluated the protective effects of oxymatrine (OMT) in myocardial injury caused by type 2 diabetes mellitus. Diabetic rats were treated with OMT orally for 8 weeks, and the results showed that OMT alleviated myocardial injury by reducing blood glucose and oxidative stress and promoting the expression of antioxidative enzymes and the Nrf2/HO-1 pathway.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Pharmacology & Pharmacy
Zhiyu He, Xiaojun Zeng, Deke Zhou, Peiying Liu, Dunzheng Han, Lingling Xu, Tong Bu, Jinping Wang, Mengmeng Ke, Xiudi Pan, Yipeng Du, Hao Xue, Dongfeng Lu, Bihui Luo
Summary: This study identifies the novel ability of lncRNA Chaer in regulating cardiomyocyte apoptosis by promoting phosphorylation of AMPK in acute myocardial infarction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Liangpeng Li, Wenbin Fu, Xue Gong, Zhi Chen, Luxun Tang, Dezhong Yang, Qiao Liao, Xuewei Xia, Hao Wu, Chao Liu, Miao Tian, Andi Zeng, Lin Zhou, Pedro A. Jose, Ken Chen, Wei Eric Wang, Chunyu Zeng
Summary: The study aims to investigate the role of GRK4 in the pathogenesis and progression of myocardial infarction (MI). Results showed that GRK4 expression was increased in the heart after MI, and overexpression of GRK4 aggravated cardiac infarction and dysfunction while specific gene knockout ameliorated these effects. GRK4 inhibited autophagy and promoted cardiomyocyte apoptosis, effects mediated by HDAC4 phosphorylation and a decrease in beclin-1 expression, leading to greater impairment of cardiac function in MI patients carrying the GRK4 A486V variant.
EUROPEAN HEART JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Niu Liu, Yingni Zhu, Wei Song, Wujing Ren, Zhenjun Tian
Summary: This study characterized the temporal expression of ALCAT1 in post-myocardial infarction (MI) and demonstrated that aerobic exercise can reverse the upregulation of ALCAT1, reduce oxidative stress and apoptosis in MI rats.
Article
Biochemistry & Molecular Biology
Raluca Maria Boteanu, Viorel-Iulian Suica, Elena Uyy, Luminita Ivan, Aurel Cerveanu-Hogas, Razvan Gheorghita Mares, Maya Simionescu, Alexandru Schiopu, Felicia Antohe
Summary: This study investigates the effects of S100A9 blockade on the biological processes during recovery after myocardial infarction (MI). The results suggest that blockade of S100A9 regulates the expression of proteins involved in leukocyte cell-cell adhesion, muscle cell apoptosis, cardiac muscle hypertrophy, and other biological processes. It prevents compensatory hypertrophy and reduces post-ischemic stress in the heart.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Alakananda Basu
Summary: The interplay between apoptosis and senescence is crucial in cancer development, and targeting the Bcl-2 family proteins could be a promising strategy for cancer therapy. Therapy-induced senescence (TIS), induced by chemotherapeutic agents, has been controversial in its effect on therapeutic outcome. Clearance of senescent cells and overcoming their pro-survival mechanisms are important challenges in cancer treatment. This review article discusses recent literature on the role of the Bcl-2 family proteins in apoptosis and senescence, and the progress and limitations in targeting them for cancer therapy.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Carter K. Fairchild, Konstantinos V. Floros, Sheeba Jacob, Colin M. Coon, Madhavi Puchalapalli, Bin Hu, Hisashi Harada, Mikhail G. Dozmorov, Jennifer E. Koblinski, Steven C. Smith, Gregory Domson, Joel D. Leverson, Andrew J. Souers, Naoko Takebe, Hiromichi Ebi, Anthony C. Faber, Sosipatros A. Boikos
Summary: Synovial sarcoma is a type of soft-tissue sarcoma with limited treatment options and poor prognosis. Research has shown that targeting both the pro-survival proteins BCL-2 and MCL-1 in combination therapy has proven to be effective in cell culture and animal models, suggesting potential for clinical trials.
