Article
Anesthesiology
Yang Ren, Yinhui Zhou, Zerong You, Hao Deng, William R. Kem, Jianren Mao, Wei Zhang, J. A. Jeevendra Martyn
Summary: This study found that morphine exacerbates burn injury-site pain and microglia activation, while GTS-21 alleviates morphine-induced pain and microglia activation in burn injury.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Review
Plant Sciences
Sarada D. Tetali, Satyabrata Acharya, Aditya B. Ankari, Vadthyavath Nanakram, Agepati S. Raghavendra
Summary: Withania somnifera, commonly known as Indian ginseng, has been extensively used in Ayurveda for various health benefits. Metabolomic studies have shown that the metabolite profiles of W. somnifera vary depending on plant parts collected, developmental stage, season, and geographical location. The use of sophisticated techniques like LC-MS, GC-MS, HPTLC, and NMR has facilitated the discovery of new metabolites and comprehensive metabolomic profiles.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kriti Kalpana, Shen Yap, Moriya Tsuji, Akira Kawamura
Summary: This study reveals that Withaferin A can selectively attenuate the pro-inflammatory signaling triggered by endotoxin without impairing other immunological pathways, providing a new conceptual framework to understand the safe immune-boosting effect of Withania somnifera and possibly other medicinal plants. The findings also open new opportunities for the development of safe immunotherapeutic agents, such as vaccine adjuvants.
Review
Plant Sciences
Neetu Singh, S. S. Yadav, Amrender Singh Rao, Abhishek Nandal, Sanjiv Kumar, S. A. Ganaie, B. Narasihman
Summary: Withania somnifera, also known as Ashwagandha, has been traditionally used as an important medicinal herb with various health benefits, including anti-cancer properties. The plant contains alkaloids, steroids, flavonoids, phenolics, and other compounds that contribute to its therapeutic potential in treating different types of cancers.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Hamad H. H. Alanazi, Elyasa Elfaki
Summary: Withania somnifera (Ashwagandha) is a botanical drug with various therapeutic effects, such as anti-inflammatory, antioxidant, anticancer, antidiabetic, and anti-asthmatic properties. It promotes immunomodulatory effects and plays a significant role in immunological diseases by regulating cytokines, increasing T-cell proliferation, and enhancing macrophage functions. This review focuses on the latest therapeutic effects of Ashwagandha on various diseases through immunomodulation, as well as its chemical properties and immunomodulatory role in type 2 allergic diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Agricultural Engineering
T. M. Anandakumar, Devendra Kumar, B. Shivanna, Rakesh Kumar
Summary: This study aimed to determine the physical properties of ashwagandha seeds for designing and developing seed sowing equipment. The results showed significant differences in diameter, sphericity, and gravimetric properties among different cultivars, which can be helpful for agricultural engineers in designing seed handling tools and machines.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Plant Sciences
Devesh Tewari, Vikas Chander, Archana Dhyani, Sanjeev Sahu, Pawan Gupta, Pooja Patni, Lindsay S. Kalick, Anupam Bishayee
Summary: This review provides a comprehensive insight into the anticancer effects of Ashwagandha (W. somnifera) and the mechanistic attributes of its bioactive phytocompounds. It also presents updated information on clinical studies related to cancer, safety evaluation, and opportunities for chemical modifications of withanolides.
Review
Chemistry, Medicinal
John M. M. Macharia, Zsolt Kaposztas, Raposa L. L. Bence
Summary: Research into tumorigenic pathways can contribute to the development of new cancer therapies and shed light on the regulatory mechanisms employed by cancer cells. Our study evaluated the medicinal properties of Withania somnifera L. and its potential in CRC management. We found that W. somnifera L. possesses active compounds that exhibit antiproliferation, apoptosis-inducing, oxidative stress-reducing, COX-2 downregulating, targeted cytotoxic, antiangiogenic, and antimigratory effects on cancer cells. Further research is needed to determine the optimal concentrations for clinical use in CRC management.
Article
Chemistry, Multidisciplinary
Iman A. Mohammed A. Ali, Hazim Ismail AL-Ahmed, Ali Ben Ahmed
Summary: The synthesis of selenium nanoparticles (Se NPs) from the aqueous extract of Withania somnifera roots has been confirmed. The Se NPs have shown promising potential in improving sperm efficacy and antioxidant defense mechanisms.
APPLIED SCIENCES-BASEL
(2023)
Article
Plant Sciences
Valeria Itzel Reyes-Perez, Vinicio Granados-Soto, Manuel Rangel-Grimaldo, Myrna Deciga-Campos, Rachel Mata
Summary: Zinagrandinolide E (ZGE) is an elemanolide derived from Zinnia grandiflora with analgesic properties, showing anti-inflammatory and antiallodynic effects. The study revealed that ZGE is more effective in reducing tactile allodynia than inflammation, and acts through multiple targets such as the opioidergic, serotoninergic, and GABAergic systems.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Agricultural Engineering
Lakee Sharma, Bipin Maurya, Saurabh Pandey, Krishna Kumar Rai, Shashi Pandey-Rai
Summary: In this study, a MYB transcription factor WsMYB34 from Withania somnifera was identified and found to play a role in plant development and stress tolerance. In-silico analysis and comparative microarray analysis revealed the potential of WsMYB34 in regulating the expression of secondary metabolite-related genes and enhancing abiotic stress tolerance in plants.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Pharmacology & Pharmacy
Akash Saggam, Kirti Limgaokar, Swapnil Borse, Preeti Chavan-Gautam, Santosh Dixit, Girish Tillu, Bhushan Patwardhan
Summary: This review highlights the potential of Ashwagandha in managing COVID-19, showcasing its immunomodulatory, anti-inflammatory, and organ protective properties. It proposes Ashwagandha as a therapeutic adjuvant for COVID-19 management and suggests the need for further systematic studies to fully realize its potential.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Vivek K. Kashyap, Godwin Peasah-Darkwah, Anupam Dhasmana, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan
Summary: This review highlights the potential of Withania somnifera (WS) as an anticancer and immunomodulatory molecule. Several preclinical studies have shown that WS can prevent or slow the progression of cancer originating from various organs. However, stability, bioavailability, and target specificity are major obstacles in the application of WS for cancer therapy.
Review
Plant Sciences
Pulok K. Mukherjee, Subhadip Banerjee, Sayan Biswas, Bhaskar Das, Amit Kar, C. K. Katiyar
Summary: Withania somnifera, commonly known as Ashwagandha, has been used in Ayurvedic medicine for over 3000 years and has been found to have potential therapeutic effects for a wide range of diseases. The plant contains important chemical constituents with various pharmacological activities, and clinical trials have demonstrated its efficacy in treating conditions such as anxiety, impotence, cancer, and cardiovascular diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Praveen Kumar, Rohit Sharma, Neha Garg
Summary: Dysregulated inflammatory responses play a significant role in cancer initiation and progression. Withania somnifera has been shown to inhibit cancer cell proliferation and reduce inflammation. However, the underlying molecular mechanisms of its anti-inflammatory effects in cancer need further investigation.
Article
Neurosciences
Michela Rosas, Simona Porru, Marta Sabariego, Maria Antonietta Piludu, Osvaldo Giorgi, Maria G. Corda, Elio Acquas
PSYCHOPHARMACOLOGY
(2018)
Article
Geochemistry & Geophysics
Daniela Medas, Carlo Meneghini, Francesca Podda, Costantino Floris, Mariano Casu, Maria Antonietta Casu, Elodia Musu, Giovanni De Giudici
AMERICAN MINERALOGIST
(2018)
Article
Neurosciences
Giulia Costa, Marcello Serra, Nicholas Pintori, Maria Antonietta Casu, Mary Tresa Zanda, Daniela Murta, Maria Antonietta De Luca, Nicola Simola, Liana Fattore
Article
Pharmacology & Pharmacy
Francesca Felicia Caputi, Laura Rullo, Elio Acquas, Roberto Ciccocioppo, Sanzio Candeletti, Patrizia Romualdi
PHARMACOLOGICAL RESEARCH
(2019)
Article
Psychology, Biological
Marta Sabariego, Michela Rosas, Maria Antonietta Piludu, Elio Acquas, Osvaldo Giorgi, Maria G. Corda
PHYSIOLOGY & BEHAVIOR
(2019)
Article
Biochemistry & Molecular Biology
Gabriele Murineddu, Battistina Asproni, Paola Corona, Sandra Piras, Paolo Lazzari, Stefania Ruiu, Laura Legnani, Lucio Toma, Gerard A. Pinna
Article
Neurosciences
Andrea Diana, Maria Collu, Maria Antonietta Casu, Ignazia Mocci, Miguel Aguilar-Santelises, Maria Dolores Setzu
Article
Geochemistry & Geophysics
Maria Enrica Boi, Daniela Medas, Giuliana Aquilanti, Gianluigi Bacchetta, Giovanni Birarda, Giovanna Cappai, Ilaria Carlomagno, Maria Antonietta Casu, Alessandra Gianoncelli, Carlo Meneghini, Martina Piredda, Francesca Podda, Marco Porceddu, Valentina Rimondi, Lisa Vaccari, Giovanni De Giudici
Article
Clinical Neurology
Simona Porru, Riccardo Maccioni, Valentina Bassareo, Alessandra T. Peana, John D. Salamone, Merce Correa, Elio Acquas
JOURNAL OF PSYCHOPHARMACOLOGY
(2020)
Article
Substance Abuse
Simona Porru, Laura Lopez-Cruz, Carla Carratala-Ros, John D. Salamone, Elio Acquas, Merce Correa
Summary: The study showed that caffeine potentiated the stimulating effects of ethanol after the first administration, but did not counteract its suppressive or ataxic effects. Additionally, the results revealed that caffeine had less activating effects in ethanol-sensitized animals.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Giovanni Birarda, Carla Buosi, Francesca Caridi, Maria Antonietta Casu, Giovanni De Giudici, Letizia Di Bella, Daniela Medas, Carlo Meneghini, Martina Pierdomenico, Anna Sabbatini, Artur Surowka, Lisa Vaccari
Summary: The fate of plastic in oceans and its interaction with marine organisms were investigated through analysis of (bio)polymers and microplastics in selected benthic foraminiferal species using FTIR microscopy. The findings suggest that plastic-related molecules and debris may enter a biogeochemical cycle and affect ecosystems, potentially influencing the biomineralization process in foraminifera.
ENVIRONMENTAL POLLUTION
(2021)
Article
Clinical Neurology
Riccardo Maccioni, Filippo Cottiglia, Elias Maccioni, Giuseppe Talani, Enrico Sanna, Valentina Bassareo, Sanjay B. Kasture, Elio Acquas
Summary: The study found that the long alkyl-chain ferulic acid ester (DF) in Withania somnifera has anxiolytic effects similar to benzodiazepines, but without typical motor, cognitive, and motivational side effects. Additionally, DF did not potentiate ethanol-induced depressant activity.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Valentina Bassareo, Roberto Frau, Riccardo Maccioni, Pierluigi Caboni, Cristina Manis, Alessandra T. Peana, Rossana Migheli, Simona Porru, Elio Acquas
Summary: The addictive potential of ethanol is triggered by the activation of DA neurons in the pVTA projecting to the ipsilateral AcbSh, leading to an increase in DA release. The generation of salsolinol in the pVTA is responsible for the increase in AcbSh DA release via mu OR stimulation, providing grounds for developing preventive and therapeutic strategies.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Riccardo Maccioni, Marcello Serra, Jacopo Marongiu, Filippo Cottiglia, Elias Maccioni, Valentina Bassareo, Micaela Morelli, Sanjay B. Kasture, Elio Acquas
Summary: This study found that the docosanyl ferulate (DF) component of Withania somnifera Dunal (WSE) has different effects than WSE on the acquisition and expression of ethanol- and morphine-induced conditioned place preference (CPP). Additionally, both WSE and DF can prevent the phosphorylation of extracellular signal-regulated kinase (pERK) in the nucleus accumbens shell (AcbSh) induced by ethanol and morphine. These results highlight subtle but critical differences for the role of GABA(A) receptors in the mechanism by which WSE affects ethanol- and morphine-dependent behavioral and molecular/cellular responses, and suggest the potential use of WSE and DF for controlling different components of drug addiction.
PSYCHOPHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Francesca Pettinau, Barbara Pittau, Alessandro Orru
Summary: This study developed a paper microzone colorimetric assay embedded on a 3D printed support for quantifying total protein content in different biological matrices and foods. The optimized assay showed accurate results with a low limit of detection and high accuracy. The bioanalytical feasibility was demonstrated in various samples, and this method could have significant impacts in protein quantification technology for quality control analysis and pre-clinical laboratory analysis.
ANALYTICAL METHODS
(2023)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.