Article
Biochemistry & Molecular Biology
Malena Rabenau, Benjamin Dillberger, Madeline Guenther, Sylvia Krippner, Veronika Butterweck, Georg Boonen, Juergen Drewe, Gunter P. Eckert, Carsten Culmsee
Summary: The study suggests that Cimicifuga racemosa extract Ze 450 exerts protective effects against cell damage through regulating mitochondrial activity and metabolic shift. The protection against ferroptosis is achieved by inhibiting complex I activity in mitochondria and modulating cMyc and HIF1α, independent of estrogen receptor activation and effects of metformin.
Article
Biology
E. I. T. de Assis, V. A. N. Azevedo, M. F. de Lima Neto, F. C. Costa, L. R. F. M. Paulino, P. A. A. Barroso, M. H. T. Matos, A. P. O. do Monte, M. A. M. Donato, C. A. Peixoto, A. N. Godinho, J. M. O. Freire, A. L. P. Souza, J. R. V. Silva, A. W. B. Silva
Summary: The present study aimed to investigate the protective effects of Cimicifuga racemosa (L.) Nutt extract (CIMI) on dexamethasone-induced adverse effects in cultured mouse ovaries. The results showed that CIMI prevented the deleterious effects of dexamethasone on ovarian morphology, follicular ultrastructure, and mRNA expression of Bax, Bcl-2, and Caspase-3.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Plant Sciences
Hui Jia, Xinying Wang, Wenwu Liu, Xiaochun Qin, Bei Hu, Qun Ma, Chongning Lv, Jincai Lu
Summary: Cimicifuga dahurica has a long history in treating breast cancer and its root extract, CREE, exhibits significant anti-breast cancer activity by inhibiting cell proliferation, migration, and invasion, as well as promoting apoptosis. The study provides compelling evidence for further research and development of C. dahurica.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Chrysoula Boutari, Panagiotis D. Pappas, Theodoros D. Theodoridis, Dimitrios Vavilis
Summary: This article reviews the role of Humanin (HN) in insulin resistance and diabetes treatment, as well as its potential application in age-related diseases such as Alzheimer's disease.
WORLD JOURNAL OF DIABETES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Rafaella Milla Nunes Pimenta, Alexandre Henrique dos Reis-Prado, Sabrina de Castro Oliveira, Juliana Goto, Leopoldo Cosme-Silva, Luciano Tavares Angelo Cintra, Francine Benetti
Summary: This systematic review evaluated the influence of diabetes mellitus (DM) on the response of the pulp tissue and in the pulp cells behaviour. The results indicated that DM may increase inflammation/degeneration and mineralization in the pulp tissue while reducing cell proliferation. Further analyses in human pulp are important to provide stronger evidence.
Article
Food Science & Technology
Haibo Zhou, Sen Zhang, Lianghua Chen, Yimei Liu, Luhong Shen, Jiuliang Zhang
Summary: Gardenia has been highly valued as a food herbal medicine due to its bioactive compounds, but the mechanism underlying its hypoglycemic effect is unknown. This study evaluated the effect of gardenia extracts on type 2 diabetes and compared the efficacy of different purified fragments. The results showed that geniposide had a better inhibitory effect on T2DM in animal experiments, while crocin I had a better effect in vitro. These findings suggest potentially different mechanisms between geniposide and crocin I in treating T2DM.
Article
Biochemistry & Molecular Biology
Inge Everaert, Thibaux Van der Stede, Jan Stautemas, Maxime Hanssens, Cleo van Aanhold, Hans Baelde, Lynn Vanhaecke, Wim Derave
Summary: This study investigated the effects of anserine or carnosine supplementation on BTBR ob/ob mice, showing that anserine supplementation can increase circulating and kidney anserine levels in diabetic mice, but is not able to attenuate the development of T2D or diabetic nephropathy.
Article
Geriatrics & Gerontology
Haoran Wang, Zihan Zhu, Junnan Wu, Hongbin Wang, Li Gao, Jianhua Xiao
Summary: The study showed that T2DM combined with OA can exacerbate the aging of articular cartilage, and high concentration glucose can accelerate the degradation and aging of cartilage.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Orthopedics
Zengxin Jiang, Chang Jiang, Lixia Jin, Zixian Chen, Zhenzhou Feng, Xiaoxing Jiang, Yuanwu Cao
Summary: In this study, the effects of high glucose levels on human and rat nucleus pulposus cell senescence were investigated. It was found that exposure to high glucose concentrations promoted nucleus pulposus cell senescence and increased senescence-related secretion phenotype. Bioinformatics analysis identified hub genes involved in cell cycle activities and cell senescence in nucleus pulposus cells. The results suggest that appropriate blood glucose control may be key to preventing intervertebral disc degeneration in diabetic patients.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Medicine, Research & Experimental
Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen
Summary: This study aims to find a new potential method and mechanism for the treatment of DM. The findings suggest that alfuzosin can improve oxidative stress, glycative stress, and insulin resistance. In a HFD/STZ-induced diabetic mouse model, alfuzosin reduces fasting blood glucose and improves insulin sensitivity, and it achieves this by activating PGK1 to stimulate the AKT signaling pathway.
Article
Plant Sciences
Yaoxing Dou, Gaoxiang Ai, Ronglei Huang, Ziwei Huang, Yucui Li, Yuhong Liu, Jianhui Xie, Jiannan Chen, Ziren Su
Summary: The study found that OBB effectively improved hyperglycemia, dyslipidemia, and insulin resistance, enhanced oral glucose tolerance, and maintained glucose metabolism homeostasis, partially through promoting the activation of the PI3K/Akt and AMPK pathways mediated by HO-1. These data suggest that OBB, as a novel HO-1 agonist, has the potential to be a promising candidate drug for diabetes management, and support the therapeutic role of HO-1 induction in diabetes, paving the way for translational research.
Review
Biochemistry & Molecular Biology
Lina T. Al Kury, Aya Abdoh, Kamel Ikbariah, Bassem Sadek, Mohamed Mahgoub
Summary: Diabetes mellitus (DM) is a chronic metabolic condition characterized by persistent hyperglycemia. Monoterpenes, compounds extracted from plants, have various biological and medicinal effects and can potentially be used to treat different diseases. They also have the ability to modulate enzymes and proteins involved in diabetes. Research suggests that monoterpenes can serve as lead compounds for developing effective hypoglycemic agents.
Article
Endocrinology & Metabolism
Gyeong-Jin Cheon, Heon-Seok Park, Eun-Young Lee, Min Jung Kim, Young-Hye You, Marie Rhee, Ji-Won Kim, Kun-Ho Yoon
Summary: This study demonstrates the accelerated differentiation and immune-tolerant properties of neonatal porcine pancreatic cell clusters (NPCCs) through in vitro chemical treatment and microencapsulation. The differentiated NPCCs showed increased insulin-positive cells and improved transplant efficacy in diabetic mice without immune rejection.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Environmental Sciences
Jingyu Duan, Yangqi Zhao, Feilong Pei, Wenhao Deng, Liangliang He, Chengdian Rao, Yutong Zhai, Chunping Zhang
Summary: Swietenine, a compound isolated from Swietenia macrophylla, was found to protect HepG2 cells from oxidative injury induced by H2O2 through the AKT/Nrf2/HO-1 pathway. In addition, it improved lipid deposition and inhibited oxidative stress in the liver of type 2 diabetic mice.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Yue Sun, Ya-ping Bai, De-guo Wang, Yu-jie Xing, Teng Zhang, Wen Wang, Si-min Zhou, Jin-han Cheng, Wei-wei Chang, Xiang Kong, Xin-ming Yao, Li-qun Guo
Summary: Metformin treatment exerts a protective effect against beta-cell damage in patients with T2DM by modulating ferroptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Marie Febvre-James, Valerie Lecureur, Olivier Fardel
INFLAMMATION RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Jessica Dietrich, Magdalena Schindler, Alfonso Lampen, Albert Braeuning, Stefanie Hessel-Pras
CHEMICO-BIOLOGICAL INTERACTIONS
(2020)
Article
Nutrition & Dietetics
Anne Christin Meyer-Gerspach, Juergen Drewe, Wout Verbeure, Carel W. le Roux, Ludmilla Dellatorre-Teixeira, Jens F. Rehfeld, Jens J. Holst, Bolette Hartmann, Jan Tack, Ralph Peterli, Christoph Beglinger, Bettina K. Wolnerhanssen
Summary: Xylitol can stimulate gut hormone secretion, slow down gastric emptying rates, have no effect on blood lipids, and have minimal impact on blood glucose and insulin, making it a suitable candidate for sugar replacement.
Article
Endocrinology & Metabolism
Bettina K. Wolnerhanssen, Juergen Drewe, Wout Verbeure, Carel W. le Roux, Ludmilla Dellatorre-Teixeira, Jens F. Rehfeld, Jens J. Holst, Bolette Hartmann, Jan Tack, Ralph Peterli, Christoph Beglinger, Anne C. Meyer-Gerspach
Summary: The study demonstrated a dose-dependent effect of the natural sweetener erythritol in stimulating gut hormone release and slowing gastric emptying. There was no impact on blood glucose, insulin, or other blood markers, and all doses were well tolerated.
DIABETES OBESITY & METABOLISM
(2021)
Article
Chemistry, Medicinal
Maren Blosa, Julia Uricher, Sabine Nebel, Catherine Zahner, Veronika Butterweck, Jurgen Drewe
Summary: The study confirmed the effectiveness of P. hybridus leaf extract Ze 339 for treating early allergic and late inflammatory symptoms of allergic rhinitis. Both patients and physicians were highly satisfied with the treatment outcomes and concept, with good tolerability noted.
Article
Pharmacology & Pharmacy
Christoph Helma, Verena Schoening, Juergen Drewe, Philipp Boss
Summary: Analysis of a new Salmonella mutagenicity dataset using various machine learning algorithms revealed distinct performance of different chemical compounds in different models, with some types of compounds showing higher positive mutagenicity predictions and others lower predictions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Malena Rabenau, Benjamin Dillberger, Madeline Guenther, Sylvia Krippner, Veronika Butterweck, Georg Boonen, Juergen Drewe, Gunter P. Eckert, Carsten Culmsee
Summary: The study suggests that Cimicifuga racemosa extract Ze 450 exerts protective effects against cell damage through regulating mitochondrial activity and metabolic shift. The protection against ferroptosis is achieved by inhibiting complex I activity in mitochondria and modulating cMyc and HIF1α, independent of estrogen receptor activation and effects of metformin.
Article
Biochemistry & Molecular Biology
Jurgen Drewe, Ernst Kuesters, Felix Hammann, Matthias Kreuter, Philipp Boss, Verena Schoening
Summary: The AMPK plays a critical role in regulating important cellular functions and activation of AMPK is beneficial in various diseases. Machine learning algorithms can accurately predict AMPK activators, making them useful tools for rapid screening and identification of potential compounds.
Article
Virology
Lorena Urda, Matthias Heinrich Kreuter, Juergen Drewe, Georg Boonen, Veronika Butterweck, Thomas Klimkait
Summary: The CO2 extract Ze 339 of Petasites hybdridus, along with its active compounds isopetasin and neopetasin, have shown potent antiviral activity against SARS-CoV-2 replication. This discovery may provide a new direction for the treatment of COVID-19.
Article
Medicine, General & Internal
Christoph Driessen, Christoph Noppen, Georg Boonen, Juergen Drewe
Summary: Low-dose interferon-alpha 2a treatment may be a viable alternative to cytoreductive therapy for high-risk polycythemia vera patients, compared to hydroxyurea or regularly dosed interferon.
CLINICAL CASE REPORTS
(2021)
Article
Plant Sciences
Juergen Drewe, Georg Boonen, Carsten Culmsee
Summary: Cimicifuga extracts alleviate menopausal symptoms and age-related metabolic changes by modulating the AMP-activated protein kinase.
Article
Biochemistry & Molecular Biology
Valentine Bordier, Fabienne Teysseire, Frank Senner, Gotz Schlotterbeck, Jurgen Drewe, Christoph Beglinger, Bettina K. Wolnerhanssen, Anne Christin Meyer-Gerspach
Summary: The study aimed to assess the absorption and metabolization of erythritol and xylitol in the human body. The results showed that erythritol absorption was dose-dependent and saturable, while xylitol had very low absorption. Furthermore, erythritol was metabolized into erythronate, while xylitol was not. Further research is needed to determine the implications of erythritol metabolization into erythronate for human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Hendrik Bussmann, Hanns Haberlein, Georg Boonen, Juergen Drewe, Veronika Butterweck, Sebastian Franken
Summary: This study found that the St. John's wort extract Ze 117 has an effect on the lateral mobility of SNAP-tagged beta 1-adrenergic receptors in the plasma membrane of C6 cells. Treatment with Ze 117 decreased the mobility of the receptors and increased receptor confinement. These findings suggest that Ze 117 may have therapeutic potential for depression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
M. Guenther, M. Rabenau, V. Butterweck, J. Drewe, G. Boonen, C. Culmsee
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lea S. Blaser, Urs Duthaler, Jamal Bouitbir, Anne B. Leuppi-Taegtmeyer, Evangelia Liakoni, Reto Dolf, Michael Mayr, Jurgen Drewe, Stephan Krahenbuhl, Manuel Haschke
Summary: The study found that short-term use of metamizole or naproxen has no significant effect on renal function in healthy subjects on a low sodium diet, but reduces the renal excretion of 6-keto-prostaglandin F1 alpha. Pharmacokinetic analysis showed that at clinically effective doses, both 4-MAA and naproxen inhibit COX-mediated renal prostacyclin synthesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.