Article
Plant Sciences
Denisa Langova, Maria Angelica Mera Cordoba, Rodrigo Sorrechia, Julie Hoova, Zdenek Svoboda, Renata Mikulikova, Marcos Antonio Correa, Rosemeire Cristina Linhari Rodrigues Pietro, Ivana Marova
Summary: This study investigates the antimicrobial effect of Achyrocline satureioides hydroalcoholic extract and its potential use in cosmetic preparations. The extract showed a beneficial effect on the growth and renewal of keratinocytes, with minimal fragrance allergens. It also exhibited a synergistic interaction with other cosmetic components, suggesting its potential as a natural antimicrobial alternative to commonly used preservatives.
Article
Pharmacology & Pharmacy
Lucelia Albarello Balestrin, Patricia Ines Back, Magno da Silva Marques, Gabriela de Moraes Soares Araujo, Mariana Correa Falkembach Carrasco, Matheus Monteiro Batista, Tony Silveira, Jamile Lima Rodrigues, Flavia Nathiely Silveira Fachel, Leticia Scherer Koester, Valquiria Linck Bassani, Ana Paula Horn, Cristiana Lima Dora, Helder Ferreira Teixeira
Summary: In this study, the wound healing activity of a hydrogel containing Achyrocline satureioides extract-loaded nanoemulsions was evaluated in vivo. The results showed that the formulation promoted wound healing by increasing angiogenesis, reducing inflammation, decreasing lipid damage, and improving re-epithelialization process in lesions.
Article
Chemistry, Organic
Shicheng Wang, Dongming Zhang, Jinhua Zhu, Hongdong Liu, Bin Li, Luqi Huang
Summary: Novel compounds were isolated from Achrocline satureioides, with 1 showing potential against Gram-negative bacteria, and both 1 and 2 having significant impact on H1299 cells. Compounds 3-7 exhibited moderate cancer cell lethality and significant anti-inflammatory activities.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Sara Elis Bianchi, Gabriela de Carvalho Meirelles, Victorya Benes Raabe, Kellen Cristhinia Borges de Souza, Valquiria Linck Bassani
Summary: Achyrocline satureioides, also known as marcela or macela, is a native species of the southeastern subtropical and temperate region of South America. It has been recognized in traditional medicine for its various biological activities such as digestive, antispasmodic, anti-inflammatory, antiviral, sedative, and hepatoprotective effects. The presence of phenolic compounds, including flavonoids, phenolic acids, and terpenoids, contribute to these activities. Technological advancements have led to the development of various phytopharmaceutical products, such as spray-dried powders, hydrogels, ointments, granules, films, nanoemulsions, and nanocapsules. The extracts and derivative products from A. satureioides have shown antioxidant, neuroprotective, antidiabetic, antiobesity, antimicrobial, anticancer, and obstructive sleep apnea syndrome effects, indicating its high potential for industrial applications.
Article
Biochemistry & Molecular Biology
Figueiredo Leite Gondim Cicera Natalia, Nalyda Pereira Carneiro Joara, Catarina Pereira Leite, Jacqueline Cosmo Andrade Pinheiro, Wanderlei do Amaral, Cicero Deschamps, Luiz Everson da Silva, Leite Sampaio Nadghia Figueiredo, Carvalho Gondim Goncalo Emanuel, Melo Coutinho Henrique Douglas
Summary: The study evaluated the phytochemical profile and antimicrobial potential of essential oils from Achyrocline satureioides, identifying alpha-pinene and (E)-caryophyllene as major active constituents. Synergistic effects were observed when the essential oil was combined with gentamicin and ampicillin against Staphylococcus aureus, as well as with gentamicin and norfloxacin against Escherichia coli. Additional research is needed to assess the toxicity of A. satureioides oil and its potential for therapeutic use in humans.
JOURNAL OF PLANT BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Adriana Maite Fernandez-Fernandez, Eliane Dumay, Francoise Lazennec, Ignacio Migues, Horacio Heinzen, Patricia Lema, Tomas Lopez-Pedemonte, Alejandra Medrano-Fernandez
Summary: The study demonstrates that ethanolic extracts of marcela have strong bioactive properties, while high-pressure technology has no or negative effects on the in vitro bioactivities of the extracts. TC7-cell studies show that marcela extracts have significant biological effects on cell monolayers.
Article
Engineering, Chemical
J. C. K. Monteiro Filho, R. A. F. Rodrigues
Summary: The study found that granules dried in desiccators maintained higher oil content over a 60-day period, while gelatin capsules reduced oil losses, which is expected to increase the shelf-life and maintain the biological activity of the preparations for pharmaceutical applications.
Article
Chemistry, Multidisciplinary
Mariana Gonzalez, Lucia Cavallo, Eliana Budelli, Sofia Barrios, Nicolas Perez, Patricia Lema, Horacio Heinzen
Summary: This study investigated the use of ultrasound assisted extraction (UAE) to improve the aqueous extraction of bioactive compounds from marcela. The results showed that UAE significantly increased the antioxidant capacity and total polyphenol content of the extracts. Ultrasound application accelerated the extraction of hydroxycinnamic acids, while higher temperatures resulted in a more diverse compound profile.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Article
Parasitology
Rafaela Regina Fantatto, Ana Carolina de Souza Chagas, Yousmel Aleman Gainza, Flavio Augusto Sanches Politi, Leonardo Mendes de Souza Mesquita, Wagner Vilegas, Humberto Ribeiro Bizzo, Ilio Montanari Junior, Rosemeire Cristina Linhari Rodrigues Pietro
Summary: Although Brazilian livestock is highly productive, the losses caused by parasites still greatly limit these activities. This study evaluated the anthelmintic and acaricidal activities of the ethanolic extract and essential oil from Achyrocline satureioides against important endo and ectoparasites in sheep and cattle. The results showed high efficacy and significant inhibition against the parasites.
EXPERIMENTAL PARASITOLOGY
(2022)
Article
Entomology
Rafaela Regina Fantatto, Yousmel Aleman Gainza, Amanda Figueiredo, Rodrigo Sorrechia, Ana Carolina de Souza Chagas, Rosemeire Cristina Linhari Rodrigues Pietro
Summary: This study evaluated the activity of extracts from A. satureioides and the fungus B. bassiana against R. microplus. The results showed that the combination of the extract and fungus enhanced their effectiveness and caused mortality in ticks. The larval immersion test was found to be the most effective evaluation method. The results with A. satureioides associated with the fungus are considered promising and offer new perspectives for future product development.
EXPERIMENTAL AND APPLIED ACAROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nathalia Stark Pedra, Kirley Marques Canuto, Ana Sheila de Queiroz Souza, Paulo Riceli Vasconcelos Ribeiro, Natalia Pontes Bona, Roberto Ramos-Sobrinho, Priscila Oliveira de Souza, Roselia Maria Spanevello, Elizandra Braganhol
Summary: Endophytic fungus Biscogniauxia sp. was isolated from the medicinal plant Achyrocline satureioides, and its secondary metabolites were evaluated for their cytotoxic properties in a human melanoma cell line (A375). A total of 17 secondary metabolites, including polyketide derivatives, terpenoids, and isocoumarins, were identified. The purified F-DCM fraction significantly inhibited the viability and proliferation of melanoma cells and induced apoptosis/necrosis and cell cycle arrest. Biscogniauxia sp. of A. satureioides has the potential to be a valuable source of compounds with therapeutic applications.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Instruments & Instrumentation
Eduarda Doneda, Sara Elis Bianchi, Vanessa Pittol, Taina Kreutz, Juliete Nathali Scholl, Irene L. Ibanez, Candelaria Bracalente, Hebe Duran, Fabricio Figueiro, Fabio Klamt, Valquiria Linck Bassani
Summary: The natural 3-O-methylflavonoid 3-O-methylquercetin (3OMQ) isolated from Achyrocline satureioides exhibited cytotoxic activity against melanoma cells and was incorporated into hydrogels for topical treatment. The formulation showed permeation/retention in all skin layers and a significant accumulation at the replication site of melanoma cells, demonstrating potential for topical management of melanoma.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Microbiology
Natalia Tonello, Diana Pimentel Betancurt, Carlos Leonel Huallpa, Juan Miguel Marioli, Marcela Beatriz Moressi, Maria de las Mercedes Oliva, Fabiana D'Eramo
Summary: This study evaluated the antimicrobial activity of Achyrocline satureioides extract and isolated compounds against Paenibacillus larvae. Four known compounds were isolated and found to have significant inhibitory and bactericidal effects against the bacteria. The study also showed that the antimicrobial efficacy of the extract is dependent on the presence of all compounds.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lucelia Albarello Balestrin, Taina Kreutz, Flavia Nathiely Silveira Fachel, Juliana Bidone, Nicolly Espindola Gelsleichter, Leticia Scherer Koester, Valquiria Linck Bassani, Elizandra Braganhol, Cristiana Lima Dora, Helder Ferreira Teixeira
Summary: The study investigated the effects of ASE-loaded nanoemulsions (NEASE) on HaCaT cells, showing positive impacts on cell viability, death by necrosis, migration, and irritant potential. NEASE was found to increase cell migration at low concentrations.
Article
Chemistry, Medicinal
Daniel Garcia, Ya-ni Wu, Marcos Roberto Furlan, Danial Hassani, Muhammad Khalid, Danfeng Huang, Lin Chau Ming
Summary: The study analyzed the dry biomass, volatile oil contents, and chemical substances of the first Brazilian variety of Achyrocline satureioides (CPQBA 2) under different organic fertilizer levels and plant spacing schemes. The results showed that specific combinations of organic fertilizer treatment and spacing could increase the biomass yield of branches and inflorescences, as well as the volatile oil content. The study identified 30 substances in the volatile oil, with alpha-pinene being the major component. These agronomic management practices could be beneficial for producers looking to cultivate a local variety of A. satureioides (CPQBA 2).
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2021)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.