Article
Endocrinology & Metabolism
Zhenhong Pan, Yan Yang, Jingjing Zhang
Summary: Combining DPP-IV inhibitors with insulin therapy in patients with type 2 diabetes mellitus significantly improves glycemic control without increasing the risk of hypoglycemia, adverse events, or serious adverse events compared to insulin treatment alone.
JOURNAL OF DIABETES
(2021)
Review
Neurosciences
A. Young Sim, Sumit Barua, Jong Youl Kim, Yong-ho Lee, Jong Eun Lee
Summary: Alzheimer's disease (AD) is characterized by memory loss and cognitive decline, and has been linked to type 2 diabetes mellitus (T2DM). The pathophysiological relationship between the two diseases involves factors such as amyloid plaques accumulation and oxidative stress, with potential therapeutic drugs including DPP-4 inhibitors and SGLT2 inhibitors.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Xu Liu, Yang Liu, Hongzhong Liu, Haiyan Li, Jianhong Yang, Pei Hu, Xinhua Xiao, Dongyang Liu
Summary: Imigliptin and alogliptin, after 13 days of treatment, were shown to decrease glycemic levels by improving beta-cell function. Comparing OMM with HOMA or SUIT results, glucose stimulation may be more sensitive for detecting changes in beta-cell function.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kazushi Yamamoto, Masashi Yamashita, Masataka Oda, Vindy Tjendana Tjhin, Hiroyuki Inagawa, Gen-Ichiro Soma
Summary: This study confirms that oral administration of lipopolysaccharide (LPS) does not worsen type 2 diabetes mellitus (T2DM) and investigates the possible mechanisms. Oral LPS administration for 8 weeks suppresses abnormal glucose tolerance, insulin resistance, and T2DM progression in KK/Ay mice. In addition, the expression of insulin signaling-related factors is upregulated in adipose tissues, where an increase in adiponectin expression is observed for the first time with oral LPS administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiaodong Ge, Xiaoyu He, Zhenshan Lin, Yuxian Zhu, Xiaoqin Jiang, Liyuan Zhao, Feng Zeng, Ligen Chen, Wei Xu, Tingting Liu, Zhigang Chen, Chao Zhao, Ying Huang, Bin Liu
Summary: By modifying the structure of luteolin, the compounds DAGL and DAGL · Cr were found to improve hyperglycemia in T2DM mice. They achieved this by improving pancreatic islet function, regulating serum and liver biochemical indicators, repairing damaged tissues, and regulating the PI3K/AKT-1 signaling pathway. Moreover, DAGL and DAGL · Cr also regulated the structure of the intestinal microbiota and increased the content of short-chain fatty acids (SCFA) in the feces, alleviating the symptoms of hyperglycemia in T2DM mice.
Article
Medicine, Research & Experimental
Teresa Mezza, Pietro Manuel Ferraro, Gianfranco Di Giuseppe, Simona Moffa, Chiara M. A. Cefalo, Francesca Cinti, Flavia Impronta, Umberto Capece, Giuseppe Quero, Alfredo Pontecorvi, Andrea Mari, Sergio Alfieri, Andrea Giaccari
Summary: This study aimed to verify the acute effect of reduced beta cell mass on the development of hyperglycemia. The research found that reduced first-phase insulin secretion and glucose sensitivity were predictors of eventual development of impaired glucose tolerance and diabetes. Thus, these functional alterations may play a key role in the pathogenesis of type 2 diabetes (T2DM).
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Camille E. Powe, Miriam S. Udler, Sarah Hsu, Catherine Allard, Alan Kuang, Alisa K. Manning, Patrice Perron, Luigi Bouchard, William L. Lowe, Denise Scholtens, Jose C. Florez, Marie-France Hivert
Summary: This study identified genetic and physiological pathways that differ between gestational diabetes mellitus (GDM) and type 2 diabetes (T2D), confirming that GDM is a distinct metabolic disorder.
Article
Medicine, Research & Experimental
Benedikt Dietz, Juergen Machann, Vaibhav Agrawal, Martin Heni, Patrick Schwab, Julia Dienes, Steffen Reichert, Andreas L. Birkenfeld, Hans-Ulrich Haering, Fritz Schick, Norbert Stefan, Andreas Fritsche, Hubert Preissl, Bernhard Schoelkopf, Stefan Bauer, Robert Wagner
Summary: The study indicated that diabetes can be detected through whole-body MRI without additional data, with visceral fat playing a crucial role in diabetes classification. The model identified a high-risk group with increased risk for future diabetes and microalbuminuria.
Article
Endocrinology & Metabolism
Shihao Hu, Yuzhi Lu, Andrea Tura, Giovanni Pacini, David Z. D'Argenio
Summary: Glucose effectiveness, the ability of glucose to regulate glucose utilization and production in the body, plays a significant role in maintaining normal blood sugar levels. Hierarchical statistical analysis revealed that individuals with type 2 diabetes had a decreased glucose effectiveness compared to non-diabetic individuals. This finding suggests that glucose effectiveness could be a potential marker for glucose metabolism disorders and a target for diabetes treatment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Ravi Retnakaran, Jiajie Pu, Alexandra Emery, Stewart B. Harris, Sonja M. Reichert, Hertzel C. Gerstein, Natalia McInnes, Caroline K. Kramer, Bernard Zinman
Summary: Induction with short-term insulin therapy followed by maintenance with metformin can stabilize beta-cell function in early type 2 diabetes. The study found that initial reversibility of beta-cell dysfunction and preserved hepatic insulin sensitivity are associated with sustained stabilization of beta-cell function.
NATURE COMMUNICATIONS
(2023)
Review
Endocrinology & Metabolism
Markku Laakso, Lilian Fernandes Silva
Summary: Statins are commonly used to prevent cardiovascular disease events, but they also increase the risk of type 2 diabetes. These two diseases share common genetic and environmental factors. Studies have confirmed the association between statin treatment and type 2 diabetes, and the purpose of this review is to summarize the important findings and describe the mechanisms behind the increased risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
Sophie Welsch, Virginie Mailleux, Priscilla le Hardy de Beaulieu, Nadejda Ranguelov, Nathalie Godefroid, Annie Robert, Xavier Stephenne, Isabelle Scheers, Raymond Reding, Etienne M. Sokal, Philippe A. Lysy
Summary: This study retrospectively analyzed the risk factors of hyperglycemia in children who underwent liver or renal transplantation and prospectively evaluated the changes in glucose metabolism in a subset of children. The study found that the use of glucocorticoids and acute events were associated with the occurrence of hyperglycemia. The study suggests the importance of early detection of glucose intolerance-related markers in pediatric liver and renal transplantation.
FRONTIERS IN PEDIATRICS
(2023)
Article
Plant Sciences
Jinni Meng, Yafei Zhu, Huixia Ma, Xiaobo Wang, Qipeng Zhao
Summary: Traditional Chinese medicine (TCM) has been shown to be effective and safe in treating diabetic cognitive dysfunction (DCD), mainly by improving insulin resistance, microvascular dysfunction, abnormal gut microbiota composition, and inflammation. More in vivo, in vitro, and clinical trials are needed to further understand the quality markers of TCM in DCD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Shuang Hua, Qianying Liu, Jufei Li, Mengqi Fan, Kaixuan Yan, Dewei Ye
Summary: Type 2 diabetes mellitus is a global health issue with no cure yet. Beta-Klotho plays a crucial role in glucose metabolism regulation and there are ongoing efforts to develop pharmacological compounds targeting it.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Endocrinology & Metabolism
Shigenori Hiruma, Fumika Shigiyama, Naoki Kumashiro
Summary: This study compared the effects of SGLT2 inhibitors and DPP-4 inhibitors on ectopic fat accumulation and tissue-specific insulin sensitivity. The results showed that empagliflozin significantly improved hepatic steatosis compared with sitagliptin, and this may protect against subsequent hepatic insulin resistance. Therefore, early administration of SGLT2 inhibitors is preferable for T2D patients with NAFLD.
DIABETES OBESITY & METABOLISM
(2023)
Letter
Substance Abuse
Dhirendra Narain Sinha, Deeksha Bhartiya, Amit Kumar, Harpreet Singh, Ravi Mehrotra
NICOTINE & TOBACCO RESEARCH
(2017)
Article
Medicine, Legal
Deeksha Bhartiya, Amit Kumar, Jasmine Kaur, Suchitra Kumari, Amitesh Kumar Sharma, Dhirendra N. Sinha, Harpreet Singh, Ravi Mehrotra
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2018)
Review
Endocrinology & Metabolism
Sudhanshu Kumar Bharti, Supriya Krishnan, Ashwini Kumar, Awanish Kumar
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2018)
Article
Immunology
Amit Kumar, Deeksha Bhartiya, Jasmine Kaur, Suchitra Kumari, Harpreet Singh, Deepika Saraf, Dhirendra Narain Sinha, Ravi Mehrotra
INDIAN JOURNAL OF MEDICAL RESEARCH
(2018)
Article
Medicine, Research & Experimental
Sudhir Kumar Jaiswal, Neeraj Kumar Sharma, Sudhanshu Kumar Bharti, Supriya Krishnan, Amit Kumar, Om Prakash, Prashant Kumar, Awanish Kumar, Ashok Kumar Gupta
CURRENT MOLECULAR MEDICINE
(2018)
Article
Multidisciplinary Sciences
Jasmine Kaur, Arun Sharma, Amit Kumar, Deeksha Bhartiya, Dhirendra Narain Sinha, Suchitra Kumari, Ruchika Gupta, Ravi Mehrotra, Harpreet Singh
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Aditya Verma, Arnab Nayek, Amit Kumar, Ruchi Singh, Poonam Salotra
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2020)
Article
Microbiology
Mohammad Sajid, Sonal Srivastava, Amit Kumar, Anuj Kumar, Harpreet Singh, Mausumi Bharadwaj
Summary: Smokeless tobacco products contain diverse microbial populations that may contribute to carcinogen synthesis. The bacterial communities in moist STPs are highly diverse, with core bacterial genera such as Acinetobacter, Bacillus, and Prevotella being significantly abundant. Products with elevated moisture levels harbor rich bacterial diversity, with Qiwam showing the highest level of genes associated with nitrogen metabolism and other potentially carcinogenic processes.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Computer Science, Information Systems
Aditya Bharti, Supriya Krishnan, Sudhanshu Kumar Bharti
Summary: The article highlights the challenges faced by global healthcare settings in responding to pandemics and reveals how the global digital ecosystem can manage crises through transparent information sharing via the Internet of Things and utilizing artificial intelligence and blockchain technologies in a cross-disciplinary collaborative manner.
FRONTIERS IN BLOCKCHAIN
(2021)
Article
Pharmacology & Pharmacy
Ashwini Kumar, Sudhanshu Kumar Bharti, Awanish Kumar
ISTANBUL JOURNAL OF PHARMACY
(2020)
Review
Peripheral Vascular Disease
Sahul Bharti, Bhavneet Bharti
AMERICAN JOURNAL OF HYPERTENSION
(2018)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.
