Article
Pediatrics
Sule Gokce, Burce Emine Dortkardesler, Ali Yurtseven, Zafer Kurugol
Summary: The study demonstrated that the liquid herbal drug preparation from the root extracts of Pelargonium sidoides is effective in improving symptoms of uncomplicated URTIs, especially in reducing cough frequency and sneezing. Effective administration of the extract within the first 24 hours of symptom onset provided significant improvement in symptom burden.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Otorhinolaryngology
Aleksandar Peric, Sandra Vezmar Kovacevic, Aleksandra Barac, Aneta V. Peric, Danilo Vojvodic
Summary: This study compared the effects of EPs 7630 and roxithromycin on ABRS patients and found that roxithromycin showed better improvement in nasal symptoms and endoscopic findings than EPs 7630.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2021)
Article
Immunology
Vitoria Paixao, Ewin B. Almeida, Jonatas B. Amaral, Tamaris Roseira, Fernanda R. Monteiro, Roberta Foster, Adriane Sperandio, Marcelo Rossi, Gislene R. Amirato, Carlos A. F. Santos, Renier S. Pires, Fabyano B. Leal, Edison L. Durigon, Danielle B. L. Oliveira, Rodolfo P. Vieira, Mauro Vaisberg, Juliana M. B. Santos, Andre L. L. Bachi
Summary: The study showed that L-glutamine supplementation can modulate the cytokine profile in saliva and increase levels of secretory immunoglobulin A, both total and specific to the influenza virus vaccine, in physically active elderly subjects.
Article
Allergy
Philippe Gevaert, Kit Wong, Lauren A. Millette, Tara F. Carr
Summary: Immunoglobulin E (IgE) plays a key role in both allergic and non-allergic airway diseases. Understanding its role as a unifying component of upper and lower airway diseases is important for diagnosis and treatment.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Environmental Sciences
Joanna Orysiak, John Fitzgerald, Jadwiga Malczewska-Lenczowska, Konrad Witek, Jan Gajewski, Agnieszka Zembron-Lacny, Barbara Morawin, Dariusz Sitkowski
Summary: The study found no significant correlation between vitamin D levels and mucosal/systemic immunity or upper respiratory tract infection episodes.
ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jong-Yeup Kim, Inseok Ko, Dong-Kyu Kim, Myeong Sang Yu
Summary: This study found that adenotonsillectomy does not alter the frequency of upper airway infections in children. There were no significant differences in the incidence of acute pharyngitis, rhinosinusitis, or otitis media between the adenotonsillectomy group and control group from postoperative year 1 to year 9. The hospital visits for these diseases gradually decreased over time in both groups.
Review
Biology
Antonio Cicchella, Claudio Stefanelli, Marika Massaro
Summary: This review clarifies the relationship between heavy training and upper respiratory tract infections (URTI), providing evidence on the impact of nutrition, sleep, and stress management on athlete immunity. It also highlights the complex interaction between physiological and psychological factors in influencing the immune system response in heavily trained athletes.
Article
Infectious Diseases
Joana Ferreira, Ana Isabel Placido, Vera Afreixo, Ines Ribeiro-Vaz, Fatima Roque, Maria Teresa Herdeiro
Summary: This study aimed to characterize the adverse drug reactions (ADR) of the most commonly used antibiotics for upper airway infections in Portugal. The results showed that serious ADR were more likely to occur in female patients and those aged between 18 and 64. Health professionals were the main reporters of suspected serious ADR. Skin and gastrointestinal issues were the prevalent types of ADR.
Article
Immunology
Pablo J. Bertrand, Yaneisi Vazquez, Andrea A. Beckhaus, Liliana A. Gonzalez, Ana Maria Contreras, Marcela Ferres, Oslando Padilla, Claudia A. Riedel, Alexis M. Kalergis, Susan M. Bueno
Summary: The study suggests that IL-8 and IL-33 are significantly increased in lower respiratory tract infections caused by RSV and could be potential biomarkers for clinical severity in children with LRTIs.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Microbiology
L. C. Rijsbergen, M. M. Lamers, A. D. Comvalius, R. W. Koutstaal, D. Schipper, W. P. Duprex, B. L. Haagmans, R. D. de Vries, R. L. de Swart
Summary: This study compared the replicative fitness and cytokine responses of HRSV-A and HRSV-B strains in disease-relevant cell culture models. The results showed that subgroup A viruses disseminated and replicated faster than subgroup B viruses, suggesting that subgroup A viruses may cause more severe disease in infants. Additionally, airway organoids cultured at air-liquid interface were demonstrated to be a valuable model for studying HRSV infection ex vivo and for further research into factors influencing HRSV disease severity.
Article
Allergy
Christian Rosas-Salazar, Zheng-Zheng Tang, Meghan H. Shilts, Kedir N. Turi, Qilin Hong, Derek A. Wiggins, Christian E. Lynch, Tebeb Gebretsadik, James D. Chappell, R. Stokes Peebles, Larry J. Anderson, Suman R. Das, Tina Hartert
Summary: The study found that the upper respiratory tract (URT) microbiome during RSV ARI in infancy is associated with the acute local immune response, disease severity, and number of wheezing episodes in the fourth year of life. The diversity of the URT microbiome is related to the course of RSV ARI, and there are complex interactions between the URT microbiome and the immune system.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Seyedehzarifeh Jazaeri, Adam M. Goldsmith, Caitlin R. Jarman, Julie Lee, Marc B. Hershenson, Toby C. Lewis
Summary: The study compared nasal cytokine responses after natural rhinovirus infections in controls and children with asthma. The results showed that natural rhinovirus infection leads to robust type II and III interferon responses in both controls and patients with asthma.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2021)
Review
Otorhinolaryngology
Erick Yuen, David A. Gudis, Nicholas R. Rowan, Shaun A. Nguyen, Rodney J. Schlosser
Summary: This review summarizes the key characteristics of respiratory viruses that hold global significance, focusing on SARS-CoV-2. Despite significant progress in understanding the epidemiology and pathogenesis of various respiratory viruses, efficacious vaccines and antiviral treatments remain elusive for most respiratory viruses. Rhinologists continue to play a crucial role on the front-lines of pandemics associated with respiratory viruses.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2021)
Article
Otorhinolaryngology
C-C Lin, Y-P Wang, C-H Chiu, Y-K Sun, M-W Lin, I-S Tzeng
Summary: This study found that the molecular signalling involved in upper airway remodelling is enhanced in patients with obstructive sleep apnoea, leading to more severe inflammation and increased protein expression.
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2022)
Article
Mechanics
Hang Yi, Qingsheng Wang, Yu Feng
Summary: The study highlights the importance of using an appropriate non-Newtonian fluid model for accurate simulation of mucus transport, as simplifying mucus as a Newtonian fluid may lead to inaccuracies. Intense coughing can enhance mucus clearance efficiency in COPD upper airways, but there is a risk of mucus accumulation and obstruction in cases of insufficient cough intensity.
Article
Immunology
Juliana de Melo Batista dos Santos, Jonatas Bussador do Amaral, Carolina Nunes Franca, Fernanda Rodrigues Monteiro, Anuska Marcelino Alvares-Saraiva, Sandra Kalil, Edison Luiz Durigon, Danielle Bruna Leal Oliveira, Silvia Sanches Rodrigues, Debora Heller, Eliane Aparecida Rosseto Welter, Joao Renato Rebello Pinho, Rodolfo P. Vieira, Andre Luis Lacerda Bachi
Summary: This study investigated the mucosal immune response of mild/moderate symptom COVID-19 patients' upper airway two months after SARS-CoV-2 infection and compared it with a control group of non-COVID-19 healthy individuals. The results showed that individuals with SIgA had higher levels of various cytokines, indicating the importance of immune response in maintaining mucosal immunity in COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Andrey Sladkevicius Vidal, Natasha Ferraz de Campos Reis, Beatriz Helena Pizarro De Lorenzo, Anuska Marcelino Alvares-Saraiva, Patricia Xander, Ronni Romulo Novaes Brito
Summary: B-1 lymphocytes are a subtype of B cells that have different functional and phenotypic features. Chronic stress can affect the activation and differentiation of B-1 cells, leading to a more myeloid profile but lower phagocytic capacity.
Article
Physiology
Anamei Silva-Reis, Maysa Alves Rodrigues Brandao-Rangel, Renilson Moraes-Ferreira, Thiago Gibson Goncalves-Alves, Victor Hugo Souza-Palmeira, Helida Cristina Aquino-Santos, Andre Luis Lacerda Bachi, Luis Vicente Franco de Oliveira, Rodrigo Alvaro Brandao Lopes-Martins, Iranse Oliveira-Silva, Regiane Albertini, Claudio Ricardo Frison, Rodolfo P. Vieira
Summary: This study investigated the effects of combined physical exercise on lung function and immune response in non-obese, overweight, and obese grade I women. The results showed that combined physical exercise improved lung function and mechanics in obese grade I women and reduced pro-fibrotic IGF-1 levels while increasing anti-fibrotic Klotho levels.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Priscila Larcher Longo, Rita de Cassia de Aquino, Sandra Regina Mota Ortiz, Roque Santos de Oliveira, Aline Gavioli, Jonatas Bussador do Amaral, Fernanda Rodrigues Monteiro, Raquel Riyuzo de Almeida Franco, Giovana Rebonatti Mereu, Andre Luis Lacerda Bachi, Alexandre Jose Bancher de Lima, Gilberto Candido Laurentino, Marta Ferreira Bastos
Summary: Physical distancing measures during the COVID-19 pandemic had negative impacts on the health of older women in Brazil, leading to increased BMI, reduced physical activity level, and unhealthy eating habits. The changes in diet and gut microbiota are likely contributors to these effects.
FRONTIERS IN NUTRITION
(2022)
Article
Physiology
Daniel Carneiro de Carvalho, Francisco Antonio Helfenstein Fonseca, Maria Cristina de Oliveira Izar, Ana Luiza Pereira Assuncao Silveira, Izabela Dorota Tuleta, Jonatas Bussador do Amaral, Lucas Melo Neves, Andre Luis Lacerda Bachi, Carolina Nunes Franca
Summary: This study found that regardless of the treatment received, there was an increase in the number of classical monocytes and a decrease in the number of non-classical monocytes in patients after 6 months of acute myocardial infarction. The percentage of intermediate monocytes was consistently higher. The treatment had no significant effect on the expression of CCR2, CCR5, and CX3CR1 on monocytes. In conclusion, after 6 months of treatment, the inflammatory phenotype of monocytes persisted in the patients.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Immunology
Sara Coelho Rangel, Michelly Damasceno da Silva, Amanda Lopes da Silva, Juliana de Melo Batista dos Santos, Lucas Melo Neves, Ana Pedrosa, Fernanda Monteiro Rodrigues, Caio dos Santos Trettel, Guilherme Eustaquio Furtado, Marcelo Paes de Barros, Andre Luis Lacerda Bachi, Camila Malta Romano, Luiz Henrique Da Silva Nali
Summary: This review summarizes the multiple roles of Human Endogenous Retroviruses (HERVs) in the human genome and their involvement in various diseases. HERVs, derived from ancient exogenous retroviral infections, play critical roles in physiological activities but their reactivation is linked to several diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Lucenda A. A. Felipe, Andre L. L. Bachi, Miria C. Oliveira, Sandra M. B. P. Moreira, Joao Pedro R. Afonso, Maria E. M. Lino, Vitoria Paixao, Carlos H. M. Silva, Rodolfo P. P. Vieira, Sergio Vencio, Elias I. I. Jirjos, Carlos A. A. Malheiros, Giuseppe Insalaco, Wilson R. Freitas Junior, Luis V. F. Oliveira
Summary: This study conducted Roux-en-Y gastric bypass surgery on 32 severely obese women with metabolic syndrome and examined the changes in plasma biochemical parameters and systemic inflammatory status before and after the surgery. The results demonstrated significant improvement in anthropometric measurements and blood biochemical parameters after the surgery, indicating the benefits of Roux-en-Y gastric bypass surgery for severely obese patients.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Review
Endocrinology & Metabolism
Caio dos Santos Trettel, Bruno Rocha de Avila Pelozin, Marcelo Paes Barros, Andre Luis Lacerda Bachi, Pedro Gabriel Senger Braga, Cesar Miguel Momesso, Guilherme Eustaquio Furtado, Pedro Afonso Valente, Edilamar Menezes Oliveira, Eef Hogervorst, Tiago Fernandes
Summary: Human beings' sedentary lifestyle is not beneficial to health, and exercise can promote pathways through exerkines to optimize individual health and quality of life, providing protective effects against aging and noncommunicable diseases. However, the molecular mechanisms and interorgan crosstalk underlying the beneficial effects of exercise, particularly in relation to exerkine irisin, remain poorly understood.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Ariane Nardy, Camila Tussato Soares Camargo, Yasmim Faustina Castro de Oliveira, Fernanda Cristina da Silva, Millena Soares de Almeida, Fernanda Rodrigues Monteiro, Brenda Rodrigues Silva, Jonatas Bussador do Amaral, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Guilherme Pereira Scagion, Vanessa Nascimento Chalup, Erika Donizetti Candido, Andressa Simoes Aguiar, Neil Ferreira Novo, Marina Tiemi Shio, Carolina Nunes Franca, Luiz Henrique da Silva Nali, Andre Luis Lacerda Bachi
Summary: This study investigated the impact of IFN-lambda-3 polymorphism on specific IgG responses for COVID-19 in older adults seropositive for CMV. The results suggested that both CMV seropositivity and the homozygosis for allele 1 (C/C) in IFN-lambda-3 gene can negatively impact the antibody response to COVID-19 infection and vaccination in older adults.
Article
Immunology
Eliane Aparecida Rosseto-Welter, Silvia Sanches Rodrigues, Amanda Braga de Figueiredo, Carolina Nunes Franca, Danielle Bruna Leal Oliveira, Andre Luis Lacerda Bachi, Jonatas Bussador do Amaral, Ricardo Andreotti Siqueira, Laiz Camerao Bento, Ana Paula da Silva, Nydia Strachman Bacal, Carlos Eduardo dos Santos Ferreira, Cristovao Luis Pitangueira Mangueira, Joao Renato Rebello Pinho
Summary: This study aimed to investigate the cellular and humoral immune responses in individuals who received the CoronaVac vaccine followed by a booster with the Pfizer vaccine. Results showed an increase in gamma interferon-type cellular response after the first CoronaVac dose, while neutralizing and IgG antibody levels only rose after the second dose and decreased after 90 and 180 days. The booster with the Pfizer vaccine significantly enhanced both cellular and humoral responses. Participants with lower humoral immune responses had a higher number of double-negative and senescent T cells, as well as increased pro-inflammatory cytokines levels.
Meeting Abstract
Cardiac & Cardiovascular Systems
P. G. Senger Braga, T. M. Tavoni, R. V. Baroni, M. N. Aldin, M. J. N. N. Alves, G. A. Rocha, A. L. L. Bachi, C. E. Negrao, M. W. Vaisberg, F. R. Freitas, A. M. Figueiredo Neto, N. R. T. Damasceno, R. C. Maranhao
EUROPEAN HEART JOURNAL
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
P. G. S. Braga, T. M. Tavoni, R. V. Baroni, F. R. Freitas, M. C. Guido, M. J. N. N. Alves, G. A. Rocha, A. L. L. Bachi, C. E. Negrao, M. W. Vaisberg, R. C. Maranhao
Article
Health Care Sciences & Services
Kizzy Cezario, Carlos Andre Freitas dos Santos, Clineu de Mello Almada Filho, Gislene Rocha Amirato, Vitoria da Paixao, Ewin Barbosa Almeida, Jonatas Bussador do Amaral, Adriana Caldo-Silva, Nuno Pimenta, Antonio Rodrigues Sampaio, Pedro Teques, Fernanda Monteiro Rodrigues, Carolina Nunes Franca, Andre Luis Lacerda Bachi
Summary: This study investigated the effects of COVID-19-induced social isolation on the metabolic parameters and functional physical capacity of older women. The findings revealed that one year of social isolation resulted in increased levels of creatinine and triglycerides, longer time to perform gait speed and time-up-and-go tests, and reduced muscle strength and estimated creatinine clearance in older women.
Article
Sport Sciences
Cesar Miguel Momesso Santos, Jonatas Bussador Amaral, Marcelo Rossi, Rodolfo Paula Vieria, Cesar Cavinato Cal Abad, Andre Luis Lacerda Bachi
Summary: Triathlon racing under extreme conditions has significant effects on metabolic and immune/inflammatory responses, including changes in blood glucose, lipid profiles, and cytokine levels.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2022)
Article
Health Care Sciences & Services
Edson Ramuth, Sylvia Ramuth, Tamaris R. R. Pavao, Kimberlly B. Biacchi, Andre L. L. Bachi
Summary: The effectiveness of the scientific 4 Phases Method in promoting weight loss, reducing BMI, and waist circumference was investigated. The results showed significant reductions in these measures, particularly when combining a ketogenic diet and health coach assistance.
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.
