Article
Multidisciplinary Sciences
Tanyaluck Kampoun, Pimpisid Koonyosying, Jetsada Ruangsuriya, Parichat Prommana, Philip J. Shaw, Sumalee Kamchonwongpaisan, Hery Suwito, Ni Nyoman Tri Puspaningsih, Chairat Uthaipibull, Somdet Srichairatanakool
Summary: This study found that the antimalarial compound C3 and iron chelators have similar antimalarial effects and inhibit the action of iron ions on dihydroartemisinin (DHA). The results suggest that drugs with inhibitory effects on the Fd/FNR redox system should be avoided as partner drugs for DHA in combination therapy.
Article
Pharmacology & Pharmacy
Xuelian Cheng, Jingjing Li, Limei Feng, Songwei Feng, Xiao Wu, Yongming Li
Summary: The study identifies HRGs as potential biomarkers for patients with refractory TACE and provides a novel immunological perspective for developing personalized therapies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Guifang Gan, Zhaopeng Shi, Chengfang Shangguan, Jieying Zhang, Yuan Yuan, Lei Chen, Weiren Liu, Biao Li, Songshu Meng, Wujun Xiong, Jun Mi
Summary: The study demonstrates that 3-HAA sensitizes HCC cells to sorafenib by upregulating phosphatases, indicating it as a promising molecule for HCC therapy.
Review
Immunology
Sihang Yu, Lei Zhou, Jiaying Fu, Long Xu, Buhan Liu, Yuanxin Zhao, Jian Wang, Xiaoyu Yan, Jing Su
Summary: There is increasing evidence showing the crucial role of the immune microenvironment, particularly the polarization state and function of macrophages, in the development of hepatocellular carcinoma. Tumor-derived exosomes in hepatocellular carcinoma act as information carriers and regulate the physiological state of cells in the microenvironment, thus controlling cancer progression. This review focuses on the role of exosome content in disease outcomes at different stages of hepatitis B virus/hepatitis C virus-induced hepatocellular carcinoma, and explores the mechanism by which macrophages contribute to hepatocellular carcinoma formation and the regulation of macrophage functions by the heterogeneity of exosome loading. The application prospects of exosome-based targeted drug delivery in immunotherapy research on hepatocellular carcinoma are also summarized.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yun Liu, Hao Zhuang, Fang Cao, Jie Li, Yan Guo, Jun Zhang, Qiang Zhao, Yuanyuan Liu
Summary: High expression of Shc3 was observed in patients with chemoresistant and recurrent HCCs. Shc3 overexpression increased MDR1/P-glycoprotein expression and reduced HCC cell sensitivity to doxorubicin and sorafenib. This study suggests a potential strategy to target the Shc3 pathway in conjunction with systemic chemotherapy for improved clinical treatment of HCC.
CELL DEATH & DISEASE
(2021)
Review
Oncology
GuoYun Wang, GaiXiang Luo, MeiJing Zhao, HuiLai Miao
Summary: This article discusses the research progress on exosomes in the development of hepatocellular carcinoma, tumor microenvironment, treatment resistance, and immunosuppression. Understanding the pathogenesis and identifying early diagnostic markers are crucial for diagnosing and treating HCC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Shuang Li, Limin Chen
Summary: Exosomes are extracellular vesicles that play important roles in cell-to-cell communication and can be stably present in various body fluids. They have a unique double-layer saclike structure and reflect the characteristics of their host cells. Exosomes derived from hepatocellular carcinoma cells show heterogeneity in their cargo. Additionally, exosomes are capable of efficiently delivering cargoes to target cells, which significantly impact HCC progression, including tumor occurrence, development, metastasis, immune regulation, and drug resistance. Previous studies have demonstrated wide applications of exosomes in the diagnosis and treatment of HCC. This review discusses recent findings on the significant roles of exosomes in HCC, focusing on their effects and underlying mechanisms in regulating HCC progression and their potential clinical value as biomarkers and therapeutic targets.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Songpeng Yang, Shu Yang, Hongying Zhang, Hui Hua, Qingbin Kong, Jiao Wang, Yangfu Jiang
Summary: Berbamine and ouabain synergize with sorafenib to inhibit hepatocellular carcinoma cells growth by activating p38MAPK and EGFR-ERK pathways. The combination of sorafenib with berbamine or ouabain synergistically inhibits both sorafenib-naive and sorafenib-resistant hepatocellular carcinoma cells growth, induces cell death, and significantly inhibits hepatocellular carcinoma xenografts growth in vivo. Targeting Na+/K+-ATPase represents a novel strategy to potentiate the anti-hepatocellular carcinoma effects of sorafenib.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Cell Biology
Fan Pan, Xin-Rong Lin, Li-Ping Hao, Xiao-Yuan Chu, Hai-Jun Wan, Rui Wang
Summary: Hepatocellular carcinoma (HCC) is the 6th most prevalent cancer globally, and m6A modification may play a role in its pathogenesis. METTL3, a key methyltransferase, is involved in the carcinogenesis and progression of HCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Jia Zheng, Zhihong Yang, Yanlei Li, Li Yang, Ruili Yao
Summary: AKR1C3, highly expressed in sorafenib-resistant patients, promotes HCC cell proliferation and acute sorafenib resistance through AKT phosphorylation. Targeting AKR1C3 may be a promising therapeutic strategy to overcome sorafenib resistance in HCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniel Mendanha, Joana Vieira de Castro, Joana Moreira, Bruno M. Costa, Honorina Cidade, Madalena Pinto, Helena Ferreira, Nuno M. Neves
Summary: This study evaluated three chalcone derivatives and found that one of them exhibited the most potent anticancer effects in GBM cell lines, successfully reducing the invasion and proliferation capacity of tumor cells; furthermore, this compound was encapsulated into liposomes to retain its strong in vitro growth inhibitory effect, making it a promising starting point for new drug treatments for GBM.
Article
Medicine, Research & Experimental
Shuhua Wei, Fenghua Wei, Mengyuan Li, Yuhan Yang, Jingwen Zhang, Chunxiao Li, Junjie Wang
Summary: Sorafenib, a multi-kinase inhibitor, has been approved for cancer treatment, especially hepatocellular carcinoma (HCC). However, many cancer patients acquire drug resistance to sorafenib in subsequent treatment, and the immunological mechanisms behind this resistance are still unclear. This review focuses on the immunoregulatory effects of sorafenib on the tumor microenvironment, the potential immunological mechanisms of therapeutic resistance, and the combination of sorafenib with immunotherapy to improve efficacy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Cui Tang, Shixiong Qiu, Wenying Mou, Jinming Xu, Peijun Wang
Summary: The transcription factor HOXB13 is involved in the occurrence, progression, and drug resistance of various cancers. This study revealed that HOXB13 is up-regulated in hepatocellular carcinoma (HCC) tissues and promotes the multiplication, metastasis, and drug resistance of HCC cells. The mechanism involves the activation of PIMREG transcription by HOXB13, which in turn regulates the expression of cell cycle and DNA repair-related factors. These findings provide insights into the role of HOXB13 in HCC and its potential as a target for HCC treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Cell Biology
Siqi Zhao, Wubin Zheng, Chao Yu, Gaoxin Xu, Xinyi Zhang, Chao Pan, Yongheng Feng, Kunxing Yang, Jin Zhou, Yong Ma
Summary: Cell death is crucial in the development of multicellular organisms and degenerative diseases. Ferroptosis, a distinct form of cell death mediated by iron-dependent lipid peroxidation, has been found to be involved in various diseases, including HCC. Recent advances have shed light on the specific mechanisms of ferroptosis in HCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Environmental
Huimin Lin, Qing Xu, Fang Zhang, Hualan Wu, Ben Hu, Guimei Chen, Xiaohua Ban, Xiaohui Duan, Meng Yu
Summary: Induction of tumor stemness is a key factor in acquired drug-resistance during traditional treatments. Sorafenib, an anti-angiogenic drug, has been the first-line treatment for hepatocellular carcinoma (HCC), but drug resistance remains a challenge. Upregulation of hypoxia-inducible factors (HIFs) by sorafenib contributes to acquired stemness-related drug resistance in HCC. To overcome this, piceatannol (PCT) was used to form a carrier-free nanomedicine (FPSN) with sorafenib and Fe3+ via chelation bonding, which showed potential in overcoming drug resistance in HCC by targeting HIFs and neovascularization blockade.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.
