Article
Immunology
Sara Francisco, Alicia Arranz, Javier Merino, Carmen Punzon, Rosario Perona, Manuel Fresno
Summary: The study found that TLR2 ligands activate MAPKs p38 and ERK earlier in macrophages, leading to higher levels of IL-10/IL-12 and IL-10/TNF-alpha ratios compared to TLR4 ligand LPS. Early TLR2-mediated p38 induction contributes to high IL-10 production, likely suppressing host Th1 response against certain pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Guangyu Liu, Yan Zhang, Sansheng Han, Wei Zhuang, Jie Lv, Mengyao Han, Ling Xie, Xiangrui Jiang, Chun Wang, Kaidireya Saimaier, Jingshan Shen, Changsheng Du
Summary: Autoimmune hepatitis (AIH) can lead to irreversible liver damage such as fibrosis, cirrhosis, and hepatocellular carcinoma. The study used a mouse model to investigate the effect of the artemisinin derivative TPN10466 on AIH. It was found that TPN10466 inhibited the production of IFN-gamma by T cells and reduced the severity of AIH by regulating lymphocyte function and number in the liver. The treatment also suppressed T-cell responses through the inhibition of JNK, ERK, and p38 pathways. These findings suggest that TPN10466 has potential as a therapeutic agent for AIH.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Environmental Sciences
Ping Kuang, Hengmin Cui, Li Yu
Summary: This study investigated the mechanism of fluorosis on the growth system using qRT-PCR and WB methods. The results showed that NaF inhibited the proliferation and development of splenic cells and activated the Ras-Raf-MEK-ERK signaling pathway. However, it failed to activate ERK, leading to the disruption of cell regulation and suppressed spleen development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Dae-Kyum Kim, Jin-Won Huh, Hyeonseung Yu, Yeji Lee, Yongxin Jin, Un-Hwan Ha
Summary: This study investigated the impact of DnaJ on IL-1 beta expression in macrophages and found that DnaJ modulates macrophages to secrete IL-1 beta by activating NF-kappa B and MAPK signaling pathways. ERK was identified as a positive mediator for IL-1 beta expression, while p38 acted as a negative mediator. Furthermore, the reciprocal actions of MAPKs were found to regulate the activation of inflammasome-related molecules. The study also explored the involvement of CD91/CD40 in ERK signaling-mediated IL-1 beta production from DnaJ-treated macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Ying Wei, Sichen Ren, Jian Wang, Yanling Wang, Yanfei Cui, Miao Tian, Ruilin Wang, Honghong Liu, Yanling Zhao
Summary: DHE alleviated dyspepsia, inflammatory infiltration, and tissue damage induced by IDO through the ERK and p38 signaling pathways rather than the JNK pathway.
Article
Immunology
Ruijie Dong, Zhenyi Xue, Guangyue Fan, Na Zhang, Chengzhi Wang, Guangliang Li, Yurong Da
Summary: Pin1 regulates NLRP3 inflammasome activation through the p38 MAPK signaling pathway in mice, impacting shock mortality and organ damage. Lack of Pin1 reduces NLRP3 inflammasome activation and secretion of inflammatory cytokines, suggesting Pin1 as a potential target for treating inflammatory diseases such as septic shock.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Yingyu Zhou, Tomohiro Takano, Xuyang Li, Yimei Wang, Rong Wang, Zhangliang Zhu, Masaru Tanokura, Takuya Miyakawa, Satoshi Hachimura
Summary: Beta-elemene regulates the balance of proinflammatory cytokines in mouse white adipose tissue through MAPK signaling, affecting the imbalance of M1-M2 macrophages and inhibiting the phosphorylation of MAPK pathways. These results suggest that beta-elemene may be a potential therapeutic medicine for macrophage-mediated chronic diseases.
COMMUNICATIONS BIOLOGY
(2022)
Article
Immunology
Madhuparna Nandi, Mitterrand Muamba Moyo, Sakina Orkhis, Jeanne Masunga Faida Mobulakani, Marc-Andre Limoges, Fjolla Rexhepi, Marian Mayhue, Anny Armas Cayarga, Gisela Cofino Marrero, Subburaj Ilangumaran, Alfredo Menendez, Sheela Ramanathan
Summary: Interleukin-15 (IL-15) regulates immune cell activity by forming a trimeric complex with IL-15Rα, but can also signal through the IL-15Rβγ(c) dimer. IL-15 deficiency results in the inability to control bacterial infections, while mice lacking IL-15Rα are able to effectively clear pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiayan Zhang, Yafang Zha, Yuheng Jiao, Yanyan Li, Jian Wang, Song Zhang
Summary: Fibrosis is a crucial factor contributing to cardiac dysfunction after myocardial infarction (MI). This study investigated the function of a protein called OTUD7B in cardiac fibrosis and identified its underlying mechanism. The researchers found that OTUD7B expression is downregulated in a MI rat model and in cultured cardiac fibroblasts under hypoxic conditions and TGF-beta 1 treatment. They also discovered that OTUD7B regulates the phosphorylation of FAK and ERK/P38 MAPK, leading to decreased expression of alpha-SMA and collagen I, both markers of fibrosis. This suggests that OTUD7B could be a potential therapeutic target for fibrosis after MI.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Immunology
Walaa Yehia Abdelzaher, Seham A. Abdel-Gaber, Michael Atef Fawzy, Abdel Hamid Sayed Abo Bakr Ali, Mina Ezzat Attya, Ayman Geddawy
Summary: Atorvastatin may protect against cyclophosphamide-induced thyroid injury by regulating the JNK/ERK/p38-MAPK signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Qi Yan, Linxin Pan, Shunli Qi, Fang Liu, Zhen Wang, Cheng Qian, Lijian Chen, Jian Du
Summary: The up-regulation of RNF2 in liver fibrosis enhances HSC activation and exerts fibrogenic effects by inhibiting the ERK/p38 signaling pathway induced by TGF-beta 1. The inhibition of RNF2 may be a promising therapeutic target for liver fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ryota Hashimoto, Hiroshi Koide, Youichi Katoh
Summary: Lipopolysaccharide (LPS) is an endotoxin that induces acute inflammatory response by activating macrophages to produce nitric oxide (NO) through the RAS-RAF-MEK-ERK signaling cascade. This study showed that the combination of LPS and MEK inhibitors enhanced NO production and mortality in mice with LPS-induced inflammation. The MEK inhibitor enhanced IL-12 expression and synergistically induced NO production with TNF-alpha, contributing to the increased mortality rate.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Ling Liu, Yihao Xing, Mengyao Cao, Jinglei Xu, Jingjing Chen
Summary: JS-K induces apoptosis in hepatocellular carcinoma cells by activating JNK and p38 MAPK and inhibiting the Raf/MEK/ERK signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Balaji Kyathegowdanadoddi Srinivas, Madhu Chakkere Shivamadhu, Shankar Jayarama
Summary: This study aimed to purify lectin from the sap of Musa acuminate pseudostem and investigate its apoptotic and angiogenic mechanisms in both in-vitro and in-vivo models. The findings suggest that the lectin possesses significant anticancer potential by inducing apoptosis and suppressing neoangiogenesis in cancer cells and animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medicine, Research & Experimental
Walaa Yehia Abdelzaher, Haitham Ahmed Bahaa, Reham Elkhateeb, Medhat Atta, Michael Atef Fawzy, Amira F. Ahmed, Remon Roshdy Rofaeil
Summary: This study aimed to evaluate the effect of the phosphodiesterase 5 inhibitor, sildenafil (Sild), on cyclophosphamide (CYC)-induced placental injury in rats. The results showed that Sild significantly improved the oxidative stress, inflammation, and apoptosis caused by CYC.
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.