Article
Endocrinology & Metabolism
Sandhya Nair, Sonam Hatkar, Anushree Patil, Suchitra Surve, Beena Joshi, Nafisa Balasinor, Meena Desai
Summary: A study on 374 healthy Indian women established reference intervals for serum RANKL, OPG, RANKL/OPG ratio, CTX, and PINP, providing valuable information for the diagnosis and management of osteoporosis in this population.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Endocrinology & Metabolism
Helene Tietze, Veronika Pott, Nele Kanzelmeyer, Nima Memaran, Ulrich Baumann, Charlotte Mindermann, Adriana Suhlrie, Jens Drube, Anette Melk, Anibh M. Das, Dirk Schnabel, Dieter Haffner, Maren Leifheit-Nestler
Summary: This study provides LMS-based continuous pediatric reference percentiles for sRANKL, OPG, and sRANKL/OPG ratio, allowing calculation of standardized patient z-scores to assess bone modeling in children.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Francesco Squadrito, Egidio Imbalzano, Michelangelo Rottura, Vincenzo Arcoraci, Giovanni Pallio, Antonino Catalano, Marco Atteritano, Natasha Irrera, Federica Mannino, Giovanni Squadrito, Mario Vaccaro, Pierangela Irrera, Igor Pirrotta, Alessandra Bitto
Summary: This study examined the effects of genistein on bone loss in postmenopausal women with glucocorticoid-induced osteoporosis (GIO). The results showed that genistein can increase bone mineral density and may serve as an additional therapeutic option for patients with GIO.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Sandhya Nair, Hetal Bhadricha, Anushree Patil, Suchitra Surve, Beena Joshi, Nafisa Balasinor, Meena Desai
Summary: This study aimed to investigate the impact of single nucleotide polymorphisms (SNPs) in OPG and RANKL genes on bone mineral density (BMD) in Indian women. The results revealed that SNPs rs2073618 and rs3102735 in the OPG gene may influence BMD at the spine in Indian women. However, no association was observed between SNPs in the RANKL gene and BMD.
Article
Endocrinology & Metabolism
Zofia Ostrowska, Malgorzata Morawiecka-Pietrzak, Wojciech Pluskiewicz, Elzbieta Swietochowska, Joanna Strzelczyk, Karolina Golabek, Jadwiga Gazdzicka, Katarzyna Ziora
Summary: Based on recent studies, there is a correlation between chemerin, bone metabolism, and the OPG/RANK/RANKL system in girls with anorexia nervosa. Chemerin acts as a coordinator and may contribute to the loss of bone mass in these patients.
ENDOKRYNOLOGIA POLSKA
(2022)
Article
Pediatrics
Riham Eid, Maha Abdelsalam, Aya Ahmed Fathy, Hadil M. M. Abolenein, Eman Bakr Elmarghany, Aya Ahmed El-Hanafy, Nashwa Hamdy, Dina Salama Abd-Elmagid, Nermeen A. A. Niazy, Dina M. M. Abd-El Ghaffar
Summary: This study aims to investigate the effects of OPG gene polymorphisms and serum levels of OPG and RANKL on bone mineral density (BMD) in children with JIA. The results suggest that rs2073617 TT genotype and T allele, as well as RANKL/OPG ratio, may be determinants of decreased BMD in JIA. These findings highlight the importance of frequent monitoring of BMD and controlling disease activity in JIA children to preserve long-term bone health.
PEDIATRIC RHEUMATOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Benediktus Yudo Leksono, Muhammad Nur Cahyanto, Endang Sutriswati Rahayu, Rini Yanti, Tyas Utami
Summary: This study found that Indonesian indigenous LAB could enhance the antioxidant properties of black soy milk during fermentation. All strains were able to increase the antioxidant activity and isoflavone aglycone content of black soy milk.
FERMENTATION-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
C. A. Nava-Valdivia, J. M. Ponce-Guarneros, A. M. Saldana-Cruz, E. G. Corona-Sanchez, M. Ramirez-Villafana, E. E. Perez-Guerrero, J. D. Murillo-Saich, B. Contreras-Haro, M. L. Vazquez-Villegas, F. Gonzalez-Ponce, D. Bonilla-Lara, H. Jacobo-Cuevas, J. D. Centeno-Valadez, G. Echeverria-Gonzalez, S. Cerpa-Cruz, M. F. Alcaraz-Lopez, E. G. Cardona-Munoz, M. Salazar-Paramo, L. Gonzalez-Lopez, J. I. Gamez-Nava
Summary: This study aimed to assess the correlation between FRAX and serum bone turnover markers in RA patients. The results showed that high levels of sRANKL and sRANKL/OPG ratio were associated with an increased risk of fractures, while high serum SOST levels were linked to a lower risk of fractures.
BIOMED RESEARCH INTERNATIONAL
(2021)
Review
Medicine, Research & Experimental
Vlad Pop, Andrada Parvu, Alexandra Craciun, Anca Daniela Farcas, Gheorghe Tomoaia, Anca Bojan
Summary: Multiple myeloma is a bone marrow neoplasia that is incurable and has increasing incidence. Bone disease in MM has severe repercussions on patients' quality of life. This article analyzes markers of bone destruction and risk factors for severe bone damage in MM.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Endocrinology & Metabolism
Mei Li, Qun Cheng, Ya-nan Huo, Ai-jun Chao, Liang He, Qing-yun Xue, Jin Xu, Shi-gui Yan, Hui Jin, Zhen-lin Zhang, Jian-hua Lin, Xiao-lan Jin, You-jia Xu, Feng Liu, Wei-bo Xia
Summary: This study demonstrates that Yigu (R) is clinically as effective and safe as Aclasta (R) in the treatment of postmenopausal women with osteoporosis in China.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Medicine, General & Internal
Agnieszka Jura-Poltorak, Anna Szeremeta, Krystyna Olczyk, Aleksandra Zon-Giebel, Katarzyna Komosinska-Vassev
Summary: This study demonstrated that anti-TNF-alpha therapy in combination with methotrexate can improve bone metabolism in female patients with RA, leading to a decrease in bone resorption and an increase in bone formation levels. The findings suggest that markers such as PINP and CTX-I may be useful indicators of the effectiveness of TNF-alpha therapy in RA patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medical Laboratory Technology
Yiduo Zhang, Xiaocui Huang, Chao Li, Jing Zhang, Xingnan Yu, Ye Li, Wenjie Zhou, Fan Yu
Summary: Bone turnover markers are crucial in pediatric medicine, as they can aid in the diagnosis and prognosis of bone metabolic disorders.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Biotechnology & Applied Microbiology
Saeedeh Hosseini Hooshiar, Mohammad Tobeiha, Sadegh Jafarnejad
Summary: Bone remodeling involves resorption and formation, with the RANKL/RANK/OPG pathway being a crucial mechanism affecting bone turnover. Soy isoflavones impact the RANKL/OPG ratio, leading to improved bone metabolism and reduced bone resorption. Further research is needed to fully understand the efficacy of isoflavones on the RANKL/RANK/OPG pathway and their potential as a treatment target for bone disorders.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Jeshica Bulsara, Arun Soni, Pragati Patil, Kripa Halpati, Sonal Desai, Sanjeev Acharya
Summary: This study investigated the enhancement of bioactivity of soy isoflavones (SIF) by Bacillus coagulans (B. coagulans). Animal experiments showed that the combination of SIF and B. coagulans restored hormone balance, reduced oxidative stress, improved the menstrual cycle, and enhanced ovarian physiology. The study also revealed that a higher dose of B. coagulans was more effective in alleviating symptoms of polycystic ovarian syndrome (PCOS).
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Chemistry, Multidisciplinary
Fei Huang, Xiaoyu Zhang, Wenhui Li, Yuting Zhao, Qixuan Mu, Xinhui Wang, Yuefei Wang
Summary: This study investigated the misuse of Scutellariae Radix (SR), steamed Scutellariae Radix (SSR), and wine Scutellariae Radix (WSR) in the market using an UPLC-PDA method. The presence of β-glucuronidase in raw Scutellariae Radix (RSR) samples was identified, leading to the production of baicalein (BN) and wogonin (WN). By evaluating the different capacities of β-glucuronidase in the tested samples, this study provided the first scientific evidence to distinguish RSR from SSR and WSR.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Giacomo Picciolo, Federica Mannino, Natasha Irrera, Letteria Minutoli, Domenica Altavilla, Mario Vaccaro, Giacomo Oteri, Francesco Squadrito, Giovanni Pallio
Summary: The study evaluated the anti-inflammatory and anti-oxidant effects of flavocoxid in an in vitro model of oral mucositis. The results showed that flavocoxid can reduce the expression of inflammatory proteins, decrease oxidative stress, and suppress oral mucositis inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Cesarina Giallongo, Ilaria Dulcamare, Daniele Tibullo, Vittorio Del Fabro, Nunzio Vicario, Nunziatina Parrinello, Alessandra Romano, Grazia Scandura, Giacomo Lazzarino, Concetta Conticello, Giovanni Li Volti, Angela Maria Amorini, Giuseppe Musumeci, Michelino Di Rosa, Francesca Polito, Rosaria Oteri, M'hammed Aguennouz, Rosalba Parenti, Francesco Di Raimondo, Giuseppe A. Palumbo
Summary: In multiple myeloma, mesenchymal stromal cells (MSCs) promote tumor growth and provide metabolic support to plasma cells (PCs) through mitochondrial transfer. Myeloma MSCs rely less on mitochondrial metabolism compared to healthy MSCs and are more prone to delivering mitochondria to myeloma cells. Additionally, PCs induce the expression of connexin 43 (CX43) in MSCs, leading to the activation of CXCL12 and the stimulation of its receptor CXCR4 on myeloma cells, promoting mitochondrial transfer. These findings suggest that the CXCL12/CXCR4 axis mediates intercellular communication in the myeloma niche.
Article
Biochemistry & Molecular Biology
Caterina Oriana Aragona, Antonio Giovanni Versace, Carmelo Ioppolo, Daniela La Rosa, Rita Lauro, Maria Concetta Tringali, Simona Tomeo, Guido Ferlazzo, William Neal Roberts, Alessandra Bitto, Natasha Irrera, Gianluca Bagnato
Summary: This review discusses recent advancements in the treatment of systemic sclerosis-associated interstitial lung disease, including new molecular targets and approved drugs to slow disease progression. The focus is on personalized treatment strategies based on emerging pathogenic features of the disease.
Article
Endocrinology & Metabolism
Giuseppe Giuffrida, Valeria D'Argenio, Francesco Ferrau, Vito Alessandro Lasorsa, Francesca Polito, Federica Aliquo, Marta Ragonese, Oana Ruxandra Cotta, Ylenia Alessi, Rosaria Oteri, Federica Di Maggio, Alessio Asmundo, Petronilla Daniela Romeo, Federica Spagnolo, Lucio Pastore, Filippo Flavio Angileri, Mario Capasso, Salvatore Cannavo, M'Hammed Aguennouz
Summary: The study found that there are complex epigenetic modifications, mainly methylation and miRNA activity, in pituitary adenomas. Nonfunctioning tumors (NFPAs) showed higher methylation levels compared to GH-omas, with 178 differentially methylated regions (DMRs) mainly located in noncoding and intronic sequences. Additionally, the study identified three hypermethylated genes involved in tumorigenesis processes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Gianluca Bagnato, Antonio Giovanni Versace, Daniela La Rosa, Alberta De Gaetano, Egidio Imbalzano, Marianna Chiappalone, Carmelo Ioppolo, William Neal Roberts, Alessandra Bitto, Natasha Irrera, Alessandro Allegra, Giovanni Pioggia, Sebastiano Gangemi
Summary: Autologous hematopoietic stem cell transplantation has shown improved outcomes in the treatment of severe systemic sclerosis, but there are still challenges such as accurate patient selection and pre-transplant analysis.
Article
Chemistry, Medicinal
Ida Ceravolo, Federica Mannino, Natasha Irrera, Letteria Minutoli, Vincenzo Arcoraci, Domenica Altavilla, Gian Maria Cavallini, Salvatore Guarini, Francesco Squadrito, Giovanni Pallio
Summary: FECD is a common genetic eye disease, and oxidative stress plays a key role in its pathogenesis, while PDRN may protect corneal endothelial cells through its antioxidant, anti-inflammatory, and antiapoptotic properties.
Correction
Endocrinology & Metabolism
Herbert Marini, Francesca Polito, Elena B. Adamo, Alessandra Bitto, Francesco Squadrito, Salvatore Benvenga
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Alfredo Campenni, M'hammed Aguennouz, Massimiliano Siracusa, Angela Alibrandi, Francesca Polito, Rosaria Oteri, Sergio Baldari, Rosaria Maddalena Ruggeri, Luca Giovanella
Summary: About 30% of patients with papillary thyroid cancer (PTC) experience persistent or recurrent disease within 10 years after initial treatment. However, the measurement of serum thyroglobulin (Tg) is unreliable in the presence of anti-thyroglobulin antibodies (TgAb). This pilot study investigated the potential of circulating miRNA as valuable biomarkers for the early detection of persistent disease in TgAb-positive PTC patients. The findings indicate that serum miRNA kinetics may provide additional and independent information for the early detection of persistent disease in PTC patients with uninformative Tg results.
Correction
Nutrition & Dietetics
Pietro Antonuccio, Herbert Ryan Marini, Antonio Micali, Carmelo Romeo, Roberta Granese, Annalisa Retto, Antonia Martino, Salvatore Benvenga, Salvatore Cuzzocrea, Daniela Impellizzeri, Rosanna Di Paola, Roberta Fusco, Raimondo Maximilian Cervellione, Letteria Minutoli
Review
Biochemistry & Molecular Biology
Herbert Ryan Marini, Federica Bellone, Antonino Catalano, Giovanni Squadrito, Antonio Micali, Domenico Puzzolo, Jose Freni, Giovanni Pallio, Letteria Minutoli
Summary: Cadmium (Cd) poses a risk to public health due to its non-biodegradability and long half-life in the body. Cd mainly targets the kidneys and accumulates there. Studies have shown that Cd exposure can lead to bone fragility, not only through direct toxic effects on bone mineralization but also due to renal failure. Further research has revealed the molecular pathways through which Cd induces serious kidney damage, including lipid peroxidation, inflammation, programmed cell death, and hormonal imbalances. Chronic kidney disease (CKD) is associated with dysbiosis, and recent studies have highlighted the altered composition and functions of gut microbiota in CKD. Considering the strong connection between diet and CKD management, nutraceuticals found in Mediterranean diet can be a safe therapeutic strategy for Cd-induced kidney damage and contribute to the prevention and treatment of CKD.
Article
Biochemistry & Molecular Biology
Federica Mannino, Giovanni Pallio, Chiara Imbesi, Alessandro Scarfone, Domenico Puzzolo, Antonio Micali, Jose Freni, Francesco Squadrito, Alessandra Bitto, Letteria Minutoli, Natasha Irrera
Summary: The present study evaluated the effects of beta-Caryophyllene (BCP) on Cd-induced neurotoxicity. The results showed that BCP treatment reduced ROS production, increased Nrf2 expression, and protected cells from death. BCP also regulated the apoptosis pathway and reduced the increase of pro-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Herbert Ryan Marini, Bianca Arianna Facchini, Raffaele di Francia, Jose Freni, Domenico Puzzolo, Liliana Montella, Gaetano Facchini, Alessandro Ottaiano, Massimiliano Berretta, Letteria Minutoli
Summary: In cases of cellular injury, excessive production of reactive oxygen species (ROS) can lead to various conditions, including cancerogenesis. Glutathione (GSH), the most abundant thiol-containing antioxidant, is crucial for restoring redox homeostasis. The conjugation of GSH with xenobiotics, such as anti-cancer drugs, can either reduce their harmful effects or enhance their toxicity. Further studies are needed to better understand the relationship between GSH and cancer. The use of GSH should only be considered under medical supervision, taking into account the appropriate timing and setting, as self-prescribed GSH lacks strong scientific evidence for its efficacy in reducing toxicity.
Review
Oncology
Valentina Urzi Brancati, Letteria Minutoli, Herbert Ryan Marini, Domenico Puzzolo, Alessandro Allegra
Summary: Multiple myeloma (MM) is a difficult-to-treat malignant disease characterized by the proliferation of plasma cells in the bone marrow. This review analyzes the presence of neoantigens in MM patients and evaluates their potential as prognostic factors or therapeutic targets. The use of neoantigen treatment strategies and bispecific, trispecific, and conjugated antibodies for MM treatment are discussed. The utilization of CAR-T in relapsed and refractory patients is also examined.
Article
Biochemistry & Molecular Biology
Michele Scuruchi, Federica Mannino, Chiara Imbesi, Giovanni Pallio, Giovanna Vermiglio, Gianluca Bagnato, Letteria Minutoli, Alessandra Bitto, Francesco Squadrito, Natasha Irrera
Summary: Cardiac fibrosis is characterized by abnormal deposition of extracellular matrix proteins, myofibroblast differentiation, and collagen deposition stimulated by TGF-beta activation. Biglycan (BGN) plays a key role in matrix assembly and the control of cardiac fibroblast phenotype. Adenosine receptors (ARs), particularly A(2AR), may stimulate fibrotic damage through collagen production, and A(2AR) modulation could be an effective therapeutic option to reduce fibrotic processes in heart remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Gianluca Bagnato, Egidio Imbalzano, Caterina Oriana Aragona, Carmelo Ioppolo, Pierpaolo Di Micco, Daniela La Rosa, Francesco Costa, Antonio Micari, Simona Tomeo, Natalia Zirilli, Angela Sciacqua, Tommaso D'Angelo, Irene Cacciola, Alessandra Bitto, Natasha Irrera, Vincenzo Russo, William Neal Roberts, Sebastiano Gangemi, Antonio Giovanni Versace
Summary: New-onset atrial fibrillation is common in COVID-19 patients and is associated with increased IL-6 serum levels and early mortality.
MEDICINA-LITHUANIA
(2022)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.
