Article
Biochemistry & Molecular Biology
Dhanamjai Penta, Priya Mondal, Jagadish Natesh, Syed Musthapa Meeran
Summary: The study demonstrates that diindolylmethane can enhance the efficacy of Centchroman in treating breast cancer by modulating drug efflux transporters, inhibiting cell proliferation, inducing apoptosis, and hindering stemness of cancer cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Jaeok Lee, Jiyeon Kang, Na-Yun Kwon, Aneesh Sivaraman, Ravi Naik, So-Young Jin, A. Reum Oh, Jae-Ho Shin, Younghwa Na, Kyeong Lee, Hwa-Jeong Lee
Summary: The inhibition of P-gp and BCRP by natural derivatives has shown promise in overcoming multidrug resistance in cancer chemotherapy, increasing the bioavailability of anticancer drugs and reducing drug resistance in cells. This approach could potentially be a useful clinical strategy.
Article
Agriculture, Dairy & Animal Science
Xiaoming Wang, Yue Wang, Ci Fang, Qianmei Gong, Jinhu Huang, Yujuan Zhang, Liping Wang
Summary: In this study, it was found that allicin could inhibit the expression and efflux function of ABC efflux transporters P-gp and BCRP in broilers, thereby increasing the plasma concentrations of their substrates.
Review
Biochemistry & Molecular Biology
Peter Szatmari, Eszter Ducza
Summary: ABC transporters are essential for drug efflux in the human body, with significant impact on pharmacokinetics and pharmacologic properties of drugs. P-gp and BCRP transporters, in particular, play a crucial role in barrier tissues. During pregnancy, placental and intestinal ABC transporters are of great importance for drug absorption and distribution. Their expression changes with gestational age and can affect the efficacy of various therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Tingting Zhao, Xuening Li, Yanwei Chen, Jie Du, Xiaodong Chen, Dalong Wang, Liyan Wang, Shan Zhao, Changyuan Wang, Qiang Meng, Huijun Sun, Kexin Liu, Jingjing Wu
Summary: Cancer patients are at high risk of thrombotic diseases, but anticoagulant therapy increases bleeding risks. This study explores the combination safety of rivaroxaban with tyrosine kinase inhibitors (TKIs) and finds significant drug-drug interactions in different combinations. Imatinib increases bleeding risks while sunitinib reduces therapeutic efficacy. Therefore, caution should be exercised in the coadministration of rivaroxaban and TKIs to avoid harmful interactions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lei Zhang, Biwei Ye, Yunfeng Lin, Yi-Dong Li, Jing-Quan Wang, Zhuo Chen, Feng-Feng Ping, Zhe-Sheng Chen
Summary: In this study, the researchers investigated the effect of the CDK4/6 inhibitor, ribociclib, on multidrug resistance (MDR) mediated by P-glycoprotein (P-gp) in human epidermoid carcinoma cells. They found that ribociclib increased the efficacy of a P-gp substrate drug, colchicine, by down-regulating the expression of P-gp and increasing its ATPase activity. Docking studies suggested that ribociclib interacted with the drug-substrate binding site of P-gp. Additionally, ribociclib inhibited the drug efflux activity of P-gp, leading to increased intracellular accumulation of doxorubicin. These findings suggest that ribociclib may be a potential agent for combined therapy in cancers with P-gp-mediated MDR.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Margarida L. F. Martins, Paniz Heydari, Wenlong Li, Alejandra Martinez-Chavez, Nikkie Venekamp, Maria C. Lebre, Luc Lucas, Jos H. Beijnen, Alfred H. Schinkel
Summary: This study investigated the impact of drug transporters and drug-metabolizing complex on the pharmacokinetics of ibogaine and its metabolites. The results showed that drug efflux and uptake transporters have a modest restricting effect on the systemic exposure and brain penetration of ibogaine, while drug-metabolizing complex had negligible impact on ibogaine pharmacokinetics.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Manasi S. Pote, Rajesh N. Gacche
Summary: This review provides updated information on the structure, function, and regulatory mechanisms of major multidrug resistance (MDR) related ATP binding cassette (ABC) transporters, which play a significant role in limiting the efficacy of anticancer drugs. The effects of modulators on the functions of ABC transporters such as P-glycoprotein, MRP1, and BCRP are discussed. Additionally, the potential use of these ABC transporter modulators in clinical practice to alleviate the emerging MDR crisis in cancer treatment is highlighted.
DRUG DISCOVERY TODAY
(2023)
Article
Pharmacology & Pharmacy
Alejandra Martinez-Chavez, Jelle Broeders, Maria C. Lebre, Matthijs T. Tibben, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel
Summary: The pharmacokinetics of the promising anticancer drug milciclib is influenced by various transporters and drug-metabolizing enzymes, with ABCB1 and ABCG2 cooperatively limiting its brain penetration.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chao-Yun Cai, Qiu-Xu Teng, Megumi Murakami, Suresh V. Ambudkar, Zhe-Sheng Chen, Vijaya L. Korlipara
Summary: A series of 22 quinazolinamine derivatives with potent inhibitory activities on BCRP and P-gp were synthesized. Compound 22 was identified as a dual BCRP and P-gp inhibitor, while compound 33 showed BCRP inhibitory activity. These compounds changed the localization of BCRP and P-gp, inhibiting the efflux of anticancer drugs by the two ABC transporters. Compounds 22 and 33 also stimulated ATP hydrolysis, increasing the accumulation of mitoxantrone in BCRP-overexpressing cells.
Article
Toxicology
Rogelio Recio-Vega, Sandra Hernandez-Gonzalez, Gladis Michel-Ramirez, Edgar Olivas-Calderon, R. Clark Lantz, A. Jay Gandolfi, Mary Kay Amistadi
Summary: Chronic arsenic exposure can lead to genetic polymorphisms in different proteins, increasing levels of arsenic metabolism and being associated with an increased risk of lung cancer.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Oncology
Danijela Mandic, Lana Nezic, Ljiljana Amdzic, Natasa Vojinovic, Radoslav Gajanin, Miroslav Popovic, Jugoslav Deri, Milena Todorovic Balint, Jelena Dumanovic, Zoran Milovanovic, Jelica Grujic-Milanovic, Ranko Skrbic, Vesna Jacevic
Summary: This study aimed to investigate whether the coexpression of ABC transporters and survivin was associated with the response to R-CHOP treatment in DLBCL patients. The results showed that DLBCL might harbor molecular signatures such as MRP1/ABCC1, survivin, and BCRP/ABCC2 overexpression that can predict resistance to R-CHOP.
Article
Biochemistry & Molecular Biology
Prabhu Thirusangu, Upasana Ray, Sayantani Sarkar Bhattacharya, Derek B. Oien, Ling Jin, Julie Staub, Nagarajan Kannan, Julian R. Molina, Viji Shridhar
Summary: PFKFB3 is an important enzyme in glycolysis that is overexpressed in many human cancers. Its high expression promotes glycolysis and survival in cancer stem cells, while inhibition of PFKFB3 can reduce proliferation, spheroid formation, chemotherapy resistance, and invasion/migration in SCLC cells.
Article
Radiology, Nuclear Medicine & Medical Imaging
Thi Xuan Mai Tran, Soyeoun Kim, Huiyeon Song, Eunhye Lee, Boyoung Park
Summary: Breast density changes over time are associated with breast cancer risk in both premenopausal and postmenopausal women. Continuous increase in breast density increases the future risk of breast cancer, while continuous decrease in breast density is associated with a lower risk.
Article
Biochemistry & Molecular Biology
Kamila Siedlecka-Kroplewska, Agata Wronska, Zbigniew Kmiec
Summary: Acute myeloid leukemia is characterized by uncontrolled proliferation of abnormal myeloid progenitor cells. Despite recent advances in treatment, prognosis remains poor, driving the search for new chemotherapeutics. Piceatannol shows promise as a chemotherapeutic agent for leukemia, but its use may be associated with the risk of multidrug resistance, suggesting the need for combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Federico Sizzano, Sebastiano Collino, Ornella Cominetti, Daniela Monti, Paolo Garagnani, Rita Ostan, Chiara Pirazzini, Maria Giulia Bacalini, Daniela Mari, Giuseppe Passarino, Claudio Franceschi, Alessio Palini
MEDIATORS OF INFLAMMATION
(2018)
Article
Geriatrics & Gerontology
Rita Ostan, Daniela Monti, Daniela Mari, Beatrice Arosio, Davide Gentilini, Evelyn Ferri, Giuseppe Passarino, Francesco De Rango, Patrizia D'Aquila, Stefano Mariotti, Renato Pasquali, Flaminia Fanelli, Laura Bucci, Claudio Franceschi, Giovanni Vitale
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2019)
Article
Nutrition & Dietetics
Fulvia Farabegoli, Marzia Govoni, Enzo Spisni, Alessio Papi
Article
Nutrition & Dietetics
Agnes A. M. Berendsen, Ondine van de Rest, Edith J. M. Feskens, Aurelia Santoro, Rita Ostan, Barbara Pietruszka, Anna Brzozowska, Agnieszka Stelmaszczyk-Kusz, Amy Jennings, Rachel Gillings, Aedin Cassidy, Aurelie Caille, Elodie Caumon, Corinne Malpuech-Brugere, Claudio Franceschi, Lisette C. P. G. M. de Groot
Article
Biochemistry & Molecular Biology
R. Fabbri, M. Macciocca, R. Vicenti, G. Caprara, M. P. Piccinni, R. Paradisi, P. Terzano, A. Papi, R. Seracchioli
BIOSCIENCE REPORTS
(2019)
Review
Endocrinology & Metabolism
Claudio Franceschi, Rita Ostan, Stefano Mariotti, Daniela Monti, Giovanni Vitale
Article
Oncology
L. Franchini, G. Ercolani, R. Ostan, M. Raccichini, A. Samolsky-Dekel, M. B. Malerba, A. Melis, S. Varani, R. Pannuti
SUPPORTIVE CARE IN CANCER
(2020)
Article
Multidisciplinary Sciences
Fabio Vivarelli, Donatella Canistro, Silvia Cirillo, Alessio Papi, Enzo Spisni, Andrea Vornoli, Clara M. Della Croce, Vincenzo Longo, Paola Franchi, Sandra Filippi, Marco Lucarini, Cristina Zanzi, Francesca Rotondo, Antonello Lorenzini, Silvia Marchionni, Moreno Paolini
SCIENTIFIC REPORTS
(2019)
Article
Nutrition & Dietetics
Isabelle Bourdel-Marchasson, Rita Ostan, Sophie C. Regueme, Alessandro Pinto, Florence Pryen, Zoubida Charrouf, Patrizia A. d'Alessio, Claire Roubaud Baudron, Florent Guerville, Jessica Durrieu, Lorenzo M. Donini, Claudio Franceschi, Luzia Valentini
Article
Health Care Sciences & Services
Silvia Varani, Rita Ostan, Luca Franchini, Giacomo Ercolani, Raffaella Pannuti, Guido Biasco, Eduardo Bruera
Summary: During the COVID-19 emergency, home PCPs showed lower burnout frequency and higher level of personal accomplishment compared to 2016. However, the risk for psychological morbidity was significantly higher during the pandemic.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2021)
Article
Oncology
Veronica Zavagli, Melania Raccichini, Rita Ostan, Giacomo Ercolani, Luca Franchini, Silvia Varani, Raffaella Pannuti
Summary: This study investigated the prevalence of unmet needs reported by family caregivers (FCs) of cancer patients in home palliative care, and whether these needs change with their demographic characteristics and the patients' functional abilities. The results showed that cancer caregiving is burdensome and FCs require more support and attention.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Rita Ostan, Giuseppe Gambino, Italo Malavasi, Gianluca Ronga, Maria Solipaca, Michela Spunghi, Silvia Varani, Raffaella Pannuti, Enrico Ruggeri
Summary: This study evaluated the impact of naloxegol therapy on the quality of life of advanced cancer patients in a home palliative care setting. The results showed that naloxegol therapy was effective in improving constipation, enhancing quality of life, and reducing pain in these patients.
Article
Nutrition & Dietetics
Enrico Ruggeri, Rita Ostan, Silvia Varani, Raffaella Pannuti, Guido Biasco
Summary: This study investigates the impact of home artificial nutrition on the nutritional and performance status of cancer patients. The results indicate that home artificial nutrition can improve energy balance, body weight, and performance status in eligible patients.
Article
Health Policy & Services
Rita Ostan, Silvia Varani, Francesco Pannuti, Raffaella Pannuti, Guido Biasco, Eduardo Bruera
Summary: This study aims to characterize the clinical and demographic characteristics of advanced cancer patients at the inception point and explore their association with the intensity of care during the last month of life. The results indicate that patient age, performance status, and symptoms are associated with the intensity of end-of-life care. This study highlights the disparities in home palliative care for advanced cancer patients.
PALLIATIVE & SUPPORTIVE CARE
(2023)
Review
Biochemistry & Molecular Biology
Aurelia Santoro, Rita Ostan, Marco Candela, Elena Biagi, Patrizia Brigidi, Miriam Capri, Claudio Franceschi
CELLULAR AND MOLECULAR LIFE SCIENCES
(2018)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.