Article
Behavioral Sciences
Rahul Ranjan, Amitabh, Dipti N. Prasad, Ekta Kohli
Summary: The study showed that hypothermic preconditioning can prevent spatial memory deficit and neurodegeneration induced by HH, reduce oxidative stress, and restore hippocampal neuronal structure and spatial memory in rats.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Youngsun T. Cho, Flora Moujaes, Charles H. Schleifer, Martina Starc, Jie Lisa Ji, Nicole Santamauro, Brendan Adkinson, Antonija Kolobaric, Morgan Flynn, John H. Krystal, John D. Murray, Grega Repovs, Alan Anticevic
Summary: This study investigated how reward and loss impact spatial working memory precision and neural circuits in human subjects. The results showed that both reward and loss improved spatial working memory precision, with specific regions like precentral sulcus and intraparietal sulcus having increased BOLD signal related to better working memory precision. Conversely, areas straddling executive networks displayed decreased BOLD signal during incentivized working memory.
Article
Pharmacology & Pharmacy
Neetu Kushwah, Vishal Jain, Manisha Kadam, Rahul Kumar, Aastha Dheer, Dipti Prasad, Bhuvnesh Kumar, Nilofar Khan
Summary: The study showed that GBE improves memory impairment and reduces oxidative damage and apoptosis induced by HH. Additionally, GBE modulates the activity of small conductance calcium-activated potassium channels, reducing glutamate excitotoxicity and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Mikael Lundqvist, Scott L. Brincat, Jonas Rose, Melissa R. Warden, Timothy J. Buschman, Earl K. Miller, Pawel Herman
Summary: Working memory is achieved through interactions between beta and gamma oscillations, which allow the spatial flow of item-specific activity across the network. This spatial flow is independent of the detailed recurrent connectivity supporting the item-specific activity, and control-related information is stored in the spatial activity. Analysis of local field potentials and neuronal spiking confirms these predictions. Spatial computing can facilitate generalization and zero-shot learning by utilizing spatial component as an additional information encoding dimension.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Sihai Li, Christos Constantinidis, Xue-Lian Qi
Summary: The study investigated the roles of the dorsolateral prefrontal cortex and posterior parietal cortex in working memory, finding that neuronal activity can predict categorical judgments of information and deviations in firing rates reflect the contents of working memory.
Article
Biochemistry & Molecular Biology
Yang Yang, Sang-Min Lee, Fumiaki Imamura, Krishne Gowda, Shantu Amin, Richard B. Mailman
Summary: This study compared two different D-1 agonists and found that 2-methyldihydrexidine was more effective in enhancing cognition compared to CY208,243, based on its impact on neural activity and cognitive performance.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Craig W. Berridge, David M. Devilbiss, Andrea J. Martin, Robert C. Spencer, Rick L. Jenison
Summary: Goal-directed behavior relies on neuronal activity in the prefrontal cortex (PFC) and extended frontostriatal circuitry. Stress impairs frontostriatal-dependent cognition, but the underlying neural mechanisms are not well understood. This study investigated the effects of acute noise-stress on neural activity and connectivity within cognition-related frontostriatal circuitry in rats. The results showed that stress suppressed neuronal responses and disrupted neural coding and functional connectivity during a spatial working memory task, providing insights into the cognitive impairing effects of stress.
Article
Multidisciplinary Sciences
Dheeraj S. Roy, Ying Zhang, Tomomi Aida, Chenjie Shen, Keith M. Skaggs, Yuanyuan Hou, Morgan Fleishman, Olivia Mosto, Alyssa Weninger, Guoping Feng
Summary: A specific region of the anterior thalamic nuclei plays a key role in spatial working memory tasks in aged mice, and targeting this region may be more beneficial for cognitive functions with fewer unintended effects compared to direct manipulation of the prefrontal cortex. Activation of neurons or circuits in this region can improve working memory, while direct activation of prefrontal cortex neurons may lead to increased anxiety levels in aged mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Megan Roussy, Benjamin Corrigan, Rogelio Luna, Roberto A. Gulli, Adam J. Sachs, Lena Palaniyappan, Julio C. Martinez-Trujilio
Summary: The study found that LPFC neurons maintain robust and distinct neural codes for mnemonic and perceptual visuospatial representations during naturalistic vision, with animals using different behavioral strategies for working memory and perception tasks.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Noah Zarr, Joshua W. Brown
Summary: Despite advances in machine learning and neuroscience, the mechanisms behind problem-solving in the human brain remain unclear. This study applies engineering control theory to explore this question, presenting a neural model that can find solutions to various problems through localist learning. By combining computational neural modeling, human fMRI, and representational similarity analysis, the roles of several brain regions are reinterpreted as interacting mechanisms of a control theoretic system, offering new insights and potential for artificial general intelligence.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Shintaro Funahashi, Binbin Gao, Kazuyoshi Takeda, Yumiko Watanabe, Jinglong Wu, Tianyi Yan
Summary: Performing working memory tasks require maintenance and transformation of information. Delay-period activity recorded from prefrontal neurons showed a gradual change from sensory to motor information during the delay period. Individual prefrontal neurons were found to encode and adjust cue directions by referencing retinotopic or saccade-based coordinate frames. Manipulating the reference frame allows for the transformation of visual-to-motor information.
Article
Neurosciences
Xiaoyu Ma, Charles Zheng, Yenho Chen, Francisco Pereira, Zheng Li
Summary: The ability to perceive and locate spatial environments is crucial for animal survival. The medial prefrontal cortex (mPFC) has been implicated in spatially related behaviors, but its properties and how it is influenced by animal behavior are not well-defined. This study found that the population activity of mPFC neurons can predict animal locations, and this coding accuracy is higher in tasks involving working memory and reward-seeking.
Article
Neurosciences
Jia Wang, Shengnan Zhang, Tiaotiao Liu, Xuyuan Zheng, Xin Tian, Wenwen Bai
Summary: By recording local field potentials (LFPs) from the medial prefrontal cortex (mPFC) and mediodorsal thalamus (MD) while mice performed a spatial working memory task, the study found that elevated theta information flow from mPFC to MD plays an important role in successful memory retrieval.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Keshuang Li, Jinhao Yang, Benjamin Becker, Xianchun Li
Summary: This study evaluated the feasibility and maintenance of training the dorsolateral prefrontal cortex (DLPFC) using functional near-infrared spectroscopy neurofeedback (fNIRS-NF) to enhance spatial working memory (SWM) in healthy individuals. The results showed that feedback from the target channel significantly increased DLPFC activation and improved SWM and attention performance in the experimental group. Furthermore, increased DLPFC activation mediated the effects of fNIRS-NF treatment on better SWM performance.
Article
Psychology, Biological
Ashkan Farrokhi, Shiva Tafakori, Mohammad Reza Daliri
Summary: The interaction between oscillatory rhythms at different frequencies plays a crucial role in cognitive functions. This study focuses on the medial prefrontal cortex (mPFC) and reveals the dynamic phase-amplitude coupling between theta and high frequency oscillations (HFOs) in a spatial working memory task. The coupling emerges near the turning point and diminishes afterwards.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Behavioral Sciences
M. Wadhwa, S. Sahu, P. Kumari, H. Kauser, K. Ray, U. Panjwani
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Neurosciences
H. Kauser, S. Sahu, U. Panjwani
Article
Neurosciences
G. Chauhan, K. Ray, S. Sahu, K. Roy, V. Jain, M. Wadhwa, U. Panjwani, K. Kishore, S. B. Singh
Article
Neurosciences
Punita Kumari, Hina Kauser, Meetu Wadhwa, Koustav Roy, Shahnawaz Alam, Surajit Sahu, Krishna Kishore, Koushik Ray, Usha Panjwani
Article
Neurosciences
Fanny Sandrine Martineau, Surajit Sahu, Vanessa Plantier, Emmanuelle Buhler, Fabienne Schaller, Lauriane Fournier, Genevieve Chazal, Hiroshi Kawasaki, Alfonso Represa, Francoise Watrin, Jean-Bernard Manent
Article
Neurosciences
Meetu Wadhwa, Garima Chauhan, Koustav Roy, Surajit Sahu, Satyanarayan Deep, Vishal Jain, Krishna Kishore, Koushik Ray, Lalan Thakur, Usha Panjwani
FRONTIERS IN CELLULAR NEUROSCIENCE
(2018)
Article
Neurosciences
Surajit Sahu, Hina Kauser, Koushik Ray, Krishna Kishore, Sanjeev Kumar, Usha Panjwani
EXPERIMENTAL NEUROLOGY
(2013)
Article
Neurosciences
H. Kauser, S. Sahu, S. Kumar, U. Panjwani
Article
Neurosciences
Vanessa Plantier, Francoise Watrin, Emmanuelle Buhler, Fanny Sandrine Martineau, Surajit Sahu, Jean-Bernard Manent, Ingrid Bureau, Alfonso Represa
Article
Clinical Neurology
Surajit Sahu, Emmanuelle Buhler, Jean-Christophe Vermoyal, Francoise Watrin, Alfonso Represa, Jean-Bernard Manent
Article
Biochemistry & Molecular Biology
Karen Runge, Remi Mathieu, Stephane Bugeon, Sahra Lafi, Corinne Beurrier, Surajit Sahu, Fabienne Schaller, Arthur Loubat, Leonard Herault, Stephane Gaillard, Emilie Pallesi-Pocachard, Aurelie Montheil, Andreas Bosio, Jill A. Rosenfeld, Eva Hudson, Kristin Lindstrom, Saadet Mercimek-Andrews, Lauren Jeffries, Arie van Haeringen, Olivier Vanakker, Audrey Van Hecke, Dina Amrom, Sebastien Kury, Chana Ratner, Reena Jethva, Candace Gamble, Bernard Jacq, Laurent Fasano, Gabriel Santpere, Belen Lorente-Galdos, Nenad Sestan, Antoinette Gelot, Sylvie Giacuzz, Sandra Goebbels, Alfonso Represa, Carlos Cardoso, Harold Cremer, Antoine de Chevigny
Summary: The transcription factor NEUROD2 plays a crucial role in cortical development, with its knockout leading to over-migration of cortical projection neurons, dysregulation of spine density and turnover, and increased intrinsic excitability. Dysfunctional NEUROD2 is also associated with neurodevelopmental disorders including autism spectrum disorders.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Yana van den Herrewegen, Thomas M. Sanderson, Surajit Sahu, Dimitri De Bundel, Zuner A. Bortolotto, Ilse Smolders
Summary: Astrocytes express a variety of GPCRs crucial for synaptic activity regulation. Activation of these receptors can lead to changes in intracellular Ca2+ levels, gliotransmitter release, and bidirectional neuron-astrocyte communication. Designer receptors exclusively activated by designer drugs (DREADDs) have been instrumental in uncovering the roles of astrocytes in both normal and pathological conditions. They offer a specific way to target astrocytic signaling pathways, although discrepancies in research findings still exist.
Article
Geriatrics & Gerontology
Maxime Vande Vyver, Louise Daeninck, Gino De Smet, Najat Aourz, Surajit Sahu, Sebastiaan Engelborghs, Kris Pauwels, Dimitri De Bundel, Ilse Smolders
Summary: We investigated the impact of A beta(1-42) oligomers on seizure susceptibility in mice and found no effect after intracerebral injection. Despite confirming the presence of A beta(1-42) oligomers, it remains unclear whether our findings or previous studies best represent the role of these oligomers in seizures in AD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Meeting Abstract
Neurosciences
I. Smolders, Y. Van den Herrewegen, S. Sahu, L. Nestor, D. De Bundel
Article
Psychology, Biological
Umit Yilmaz, Kevser Tanbek
Summary: This study investigated the effects of intracerebroventricular administration of Spexin on the hypothalamus-pituitary-thyroid axis and energy expenditure in rats. The results showed that Spexin reduced food consumption and body weight, increased thyroid hormones, and enhanced energy metabolism.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Kuei-Yu Chien, Yun-Ju Chen, Kuo-Jen Hsu, Chiao-Nan Chen
Summary: This study investigated the effects of a high-protein diet and high-intensity interval training on appetite and weight loss in obese middle-aged individuals. The results showed that consuming a high-protein drink and following a high-protein diet after exercise can reduce post-exercise appetite and the frequency of late-night snacking.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Melissa Alves Braga Oliveira, Ana Carolina Odebrecht Vergne de Abreu, Debora Barroggi Constantino, Andre C. Tonon, Antoni Diez-Noguera, Fernanda Gaspar Amaral, Maria Paz Hidalgo
Summary: Biological processes in living organisms exhibit strong rhythmicity and are regulated by internal timing systems. Understanding the influence of biological rhythms is crucial for experimental design and reporting.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Yanqun Cao, Hao Chen, Yinna Tan, Xu-Dong Yu, Chuli Xiao, Yin Li, James Reilly, Zhiming He, Xinhua Shu
Summary: There is evidence to suggest that chronic stress impacts neurochemical homeostasis and contributes to mental disorders. This study investigates the therapeutic potential of p-coumaric acid (p-CA), a natural compound found in vegetables and fruits, against stress-associated mental disorders. The findings suggest that p-CA could alleviate cognitive deficits and depression-like behavior in mice exposed to chronic restraint stress (CRS) by regulating the PKA-CREB-BDNF signaling pathway.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Mai O. Spaulding, Jessica R. Hoffman, Grace C. Madu, Magen N. Lord, Caroline Soares Iizuka, Kevin P. Myers, Emily E. Noble
Summary: Food insecurity is associated with obesity and disordered eating behaviors. Studying a rodent model, researchers found that adolescent food insecurity may increase susceptibility to obesity and altered eating behaviors during adulthood.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
K. Oberman, B. L. van Leeuwen, M. Nabben, J. E. Villafranca, R. G. Schoemaker
Summary: The present study investigated the post-operative complications and therapeutic potential of J147 in male Zucker rats, and found that J147 treatment had positive effects on behavioral and metabolic parameters, but did not affect neuroinflammation. The results suggest that a combination of acute and chronic J147 treatment may be optimal for treatment.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Mathieu Cournoyer, Alice Maldera, Alexandre-Charles Gauthier, Fabien Dal Maso, Marie-Eve Mathieu
Summary: This article provides a comprehensive view of the literature on the effect of different odors on physical activity through a systematic review. It was found that pleasant odors have a positive impact on participants' physical activity. However, better methodological consistency is needed in studies to produce more meaningful results.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Gabriel R. Gilmore, Jeff Dyche
Summary: This study examined sleep, sleep/wake regularity, and cognition in college students diagnosed with depression and using serotonergic antidepressants, comparing them to those without a depression diagnosis. The results showed that students using antidepressants had slightly longer wake after sleep onset and lower sleep efficiency, but these differences were likely not noticed by the participants. There were no differences in sleep regularity or cognition between the two groups.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Erica A. Cross, Kim L. Huhman, H. Elliott Albers
Summary: Social stress plays a significant role in the development of neuropsychiatric disorders and can lead to behavioral deficits such as social withdrawal. This study investigates the impact of social stress on social reward in Syrian hamsters. The results show that subordinate and socially defeated males have reduced motivation for social interactions compared to dominant males. Additionally, winning males exhibit greater activation in the mesolimbic dopamine system compared to losers. In females, there were no differences in social entries between winners and losers, but winning females display more activation in the NAc shell.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Daniel A. R. Cabral, Maria L. M. Rego, Eduardo B. Fontes, Vagner D. O. Tavares
Summary: This study examined the association between body mass index (BMI) and negative emotional states (NES) in men with substance use disorders (SUD) undergoing treatment. The findings showed a positive correlation between BMI and stress, anxiety, and depression. These results suggest that reducing body fat accumulation may contribute to improving mental health in individuals with SUD during recovery.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Elizabeth Agbor Epse Muluh, Jessica C. McCormack, Yunfan Mo, Michael Garratt, Mei Peng
Summary: This PROSPERO pre-registered systematic review and meta-analysis evaluated the olfactory and gustatory changes in pregnant individuals. The meta-analysis revealed that pregnant individuals performed poorer in odour identification, rated olfactory stimuli to be more intense during the second and third trimester, and had increased pleasantness for sweet taste in the first trimester. No major difference was observed in terms of gustatory functions between pregnant and non-pregnant subjects.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Renee Spiteri Douglas, Mackenzie R. Hartley, J. Renee Yang, Tamara B. Franklin
Summary: The expression of Hdac2 in the hippocampus is associated with social status, while the expression of closely related genes Hdac1 and HDAC2 protein is not associated with social rank in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2024)
