Journal
PHYSIOLOGY
Volume 29, Issue 5, Pages 314-324Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00069.2013
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Funding
- National Institutes of Health [DK-062471, NS-029728]
- Juvenile Diabetes Research Foundation [1-2007-605, 1-2008-710]
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Hypoglycemia poses a serious threat to the integrity of the brain, owing to its reliance on blood glucose as a fuel. Protecting against hypoglycemia is an extended network of glucose sensors located within the brain and in the periphery that serve to mediate responses restoring euglycemia, i.e., counterregulatory responses. This review examines the various glucose sensory loci involved in hypoglycemic detection, with a particular emphasis on peripheral glucose sensory loci and their contribution to hypoglycemic counterregulation.
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