Article
Chemistry, Applied
Jiawei Chen, Qing Meng, Bo Jiang, Jingjing Chen, Tao Zhang, Licheng Zhou
Summary: Alginate, a low-cost polysaccharide found in seaweeds, is considered a sustainable gum source for dietary fiber. Partially degraded alginate products may enhance the hypoglycemic effect, especially mannuronate-rich PDA4, suggesting potential implications for development as dietary fiber with hypoglycemic activity.
Article
Biology
Josep Marti-Solans, Aina Borve, Paul Bump, Andreas Hejnol, Timothy Lynagh
Summary: Nervous systems use ligand-gated ion channels (LGICs) for rapid chemosensation and intercellular signaling. Acid-sensing ion channels (ASICs), a type of LGICs found in vertebrate neurons, emerged earlier than previously thought and were likely an innovation in bilaterian animals. The earliest ASICs were probably expressed in the peripheral nervous system before being incorporated into the brain during the evolution of certain deuterostomes and xenacoelomorphs. The loss of ASICs in certain model organisms can be explained by the loss of peripheral cells in their lineage.
Article
Multidisciplinary Sciences
Phebe Verbrugghe, Jon Brynjolfsson, Xingjun Jing, Inger Bjorck, Frida Hallenius, Anne Nilsson
Summary: The gut bacterium Prevotella copri has shown to lower blood glucose levels in mice and healthy humans, making it a potential probiotic for obesity and type 2 diabetes. The study confirmed the hypoglycemic effect of live P. copri in mice and found that pasteurization further enhanced its ability to improve glucose tolerance, with no major adverse effects detected in the treated groups compared to controls.
SCIENTIFIC REPORTS
(2021)
Review
Biochemical Research Methods
Junxia Wang, Ziyi Lu, Ruisi Cai, Hanqi Zheng, Jicheng Yu, Yuqi Zhang, Zhen Gu
Summary: This paper presents an overview of state-of-the-art microneedle-based detection and sensing systems. Firstly, the designs of microneedle devices based on extraction mechanisms are summarized, including different geometries and materials of microneedles. Secondly, the targets of equipment-assisted microneedle detections are discussed, revealing the current performance and potential scenarios of these microneedles. Thirdly, the trend towards highly integrated sensors is elaborated by emphasizing the sensing principles (colorimetric, fluorometric and electronic manner). Finally, the key challenges and future development perspectives are discussed.
Review
Biotechnology & Applied Microbiology
Ahmad Yaser Alhaddad, Hussein Aly, Hoda Gad, Abdulaziz Al-Ali, Kishor Kumar Sadasivuni, John-John Cabibihan, Rayaz A. Malik
Summary: This review summarizes the recent advancements in blood glucose monitoring utilizing novel sensing technologies over the past five years, including wearable devices, non-invasive sensors, and machine learning algorithms for predicting blood glucose trends.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ming Lv, Qingqing Liang, Xiaofang He, Xiaocui Du, Yuhan Liu, Yan Liu, Chongye Fang
Summary: This study investigated the hypoglycemic effect and mechanism of D. officinale leaves. The results showed that D. officinale leaves significantly lowered blood glucose levels in mice on a high-fat diet, potentially by activating the insulin signaling pathway. Further examination revealed that the >3 kDa ethanol-soluble fraction of D. officinale leaves played a major role in lowering blood glucose.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Sayani Mukherjee, Silje Skrede, Martha Haugstoyl, Miguel Lopez, Johan Ferno
Summary: Obesity is associated with chronic inflammation, caused by excessive nutrient intake leading to adipose tissue expansion and cellular stress. In addition to adipose tissue macrophages, other organs such as the liver, muscle, and pancreas also show pro-inflammatory activation. Pro-inflammatory signaling in the central nervous system is involved in appetite dysregulation and metabolic disturbances.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Beatriz Isabel Garcia-Martinez, Mirna Ruiz-Ramos, Jose Pedraza-Chaverri, Edelmiro Santiago-Osorio, Victor Manuel Mendoza-Nunez
Summary: Resveratrol has the potential to improve glucose and insulin levels in patients with type 2 diabetes, with significant improvement in glucose observed at doses of 500-1000 mg/day, and improvement in insulin seen at doses lower than 500 mg/day or greater than 1000 mg/day.
Article
Environmental Sciences
Ziquan Lv, Zhi Tang, Suli Huang, Xiaoxiao Hu, Changfeng Peng, Yuhua Chen, Guangnan Liu, Ying Chen, Tingting Cao, Cuilan Hou, Xinyi Wei, Yuebin Ke, Xuan Zou, Huaicai Zeng, Yajie Guo
Summary: This study found that long-term exposure to BPF can significantly improve glucose metabolism and enhance insulin sensitivity in mice fed a high-fat diet.
Article
Chemistry, Multidisciplinary
Tianyu Shu, Kai Wang, Xuewu Zhang
Summary: In this study, biological enzymolysis of Sacha inchi meal (SIM) protein was performed, and the resulting hydrolysates were evaluated for antioxidant and hypoglycemic activities. The hydrolysates showed high scavenging rates of free radicals and significant inhibition of dipeptidyl peptidase (DPP-IV). Furthermore, the hydrolysates significantly increased glucose consumption in insulin-resistant cells. Therefore, SIM protein hydrolysates have potential applications in functional food and pharmaceutical development.
APPLIED SCIENCES-BASEL
(2023)
Article
Engineering, Electrical & Electronic
Yuyang Sun, Helena Cano-Garcia, Efthymios Kallos, Fergus O'Brien, Adeyemi Akintonde, Diana-Elena Motei, Oana Ancu, Richard William Alexander Mackenzie, Panagiotis Kosmas
Summary: By combining multiple sensor data with machine learning techniques, we have developed an accurate fully noninvasive glucose monitoring model. The model achieved high prediction accuracy on a dataset of clinical subjects and holds promise for practical applications in glucose monitoring.
IEEE SENSORS JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Nadtinan Promphet, Chusak Thanawattano, Chatchai Buekban, Thidarut Laochai, Pranee Rattanawaleedirojn, Krisana Siralertmukul, Pranut Potiyaraj, Juan P. Hinestroza, Nadnudda Rodthongkum
Summary: This paper reports an electrochemical sensing device based on a cotton-thread electrode for real-time and simultaneous detection of sweat glucose and sweat lactate. The cotton thread surfaces are modified to enhance liquid adsorption, bioreceptor immobilization, and sensor performance while minimizing irritation and allergies on the wearer's skin. The modified thread electrodes are characterized and amperometry is carried out for electrochemical characterization. A customized circuit and digital readout are integrated with the thread electrodes for real-time and simultaneous detection. The device provides linear ranges and detection limits for glucose and lactate, and can effectively distinguish between a normal individual and one with a diabetic condition. This platform opens up new possibilities for noninvasive and real-time detection of other sweat biomarkers.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Physics, Multidisciplinary
Saeedeh Barzegar-Parizi, Amir Ebrahimi
Summary: A metallic perfect electromagnetic absorber with a simple design that achieves a very narrow resonance bandwidth and perfect absorption amplitude at terahertz frequencies is presented. The absorber can also be used as a sensor to detect the refractive index of different materials and the concentration of glucose with high sensitivity and figure-of-merit.
Article
Plant Sciences
Adolfo Andrade-Cetto, Fernanda Espinoza-Hernandez, Gerardo Mata-Torres, Sonia Escandon-Rivera
Summary: This study confirmed the traditional use of E. longifolium and A. firma as hypoglycemic agents in a hyperglycemic animal model for the first time. Both plants exhibited a significant hypoglycemic effect and inhibited enzymes involved in glucose metabolism in vitro.
Article
Endocrinology & Metabolism
Shana O. Warner, Abby M. Wadian, Marta Smith, Ben Farmer, Yufei Dai, Nicole Sheanon, Dale S. Edgerton, Jason J. Winnick
Summary: The study illustrates that elevated liver glycogen content enhances hormonal responses to insulin-induced hypoglycemia, but this enhancement does not occur in the absence of hypoglycemia in the brain. The results suggest that information from the liver regarding glycogen availability is integrated in the brain to optimize the counterregulatory response.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
