Journal
PHYSIOLOGY
Volume 25, Issue 5, Pages 304-310Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00016.2010
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Funding
- Dutch Organization for Scientific Research (NWO)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [R01 1AR-053897]
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR053897] Funding Source: NIH RePORTER
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Nebulin is a giant protein and a constituent of the skeletal muscle sarcomere. The name of this protein refers to its unknown (i.e., nebulous) function. However, recent rapid advances reveal that nebulin plays important roles in the regulation of muscle contraction. When these functions of nebulin are compromised, muscle weakness ensues, as is the case in patients with nemaline myoptahy.
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