Role of Epigenetics in Cardiac Development and Congenital Diseases

The Key Role of Epigenetics in Human Disease Prevention and Mitigation

(2018) Andrew P. Feinberg   NEW ENGLAND JOURNAL OF MEDICINE

The epicardium as a source of multipotent adult cardiac progenitor cells: Their origin, role and fate

(2018) Anke M. Smits et al.   PHARMACOLOGICAL RESEARCH

Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES

(2018) Martin J. Pfeiffer et al.   Nature Communications

Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

(2018) Ralf Gilsbach et al.   Nature Communications

NIPBL+/− haploinsufficiency reveals a constellation of transcriptome disruptions in the pluripotent and cardiac states

(2018) Jason A. Mills et al.   Scientific Reports

BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease

(2017) Joaquim Miguel Vieira et al.   Nature Communications

DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes

(2017) Stephan Nothjunge et al.   Nature Communications

Characterization of histone acylations links chromatin modifications with metabolism

(2017) Johayra Simithy et al.   Nature Communications

CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart

(2017) Melisa Gomez-Velazquez et al.   PLoS Genetics

Comparative DNA methylation and gene expression analysis identifies novel genes for structural congenital heart diseases

(2016) Marcel Grunert et al.   CARDIOVASCULAR RESEARCH

KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation

(2016) Siang-Yun Ang et al.   DEVELOPMENT

Chromatin Domains: The Unit of Chromosome Organization

(2016) Jesse R. Dixon et al.   MOLECULAR CELL

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing

(2016) Alejandro Sifrim et al.   NATURE GENETICS

Down syndrome and the complexity of genome dosage imbalance

(2016) Stylianos E. Antonarakis   NATURE REVIEWS GENETICS

Erratum: Organization and function of the 3D genome

(2016) Boyan Bonev et al.   NATURE REVIEWS GENETICS

Spatial organization of chromatin domains and compartments in single chromosomes

(2016) Siyuan Wang et al.   SCIENCE

On TADs and LADs: Spatial Control Over Gene Expression

(2016) Adriana Gonzalez-Sandoval et al.   TRENDS IN GENETICS

Rebalancing gene haploinsufficiency in vivo by targeting chromatin

(2016) Filomena Gabriella Fulcoli et al.   Nature Communications

DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy

(2016) Carolina M. Greco et al.   Nature Communications

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2

(2016) Sarah Cooper et al.   Nature Communications

Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells

(2016) Qi Chen et al.   Nature Communications

Physiological and pathological implications of 5-hydroxymethylcytosine in diseases

(2016) Jing Liang et al.   Oncotarget

Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects

(2016) Rosaysela Santos et al.   PLOS BIOLOGY

Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo

(2015) Maria Aurelia Ricci et al.   CELL

Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms

(2015) Lluis Morey et al.   Cell Stem Cell

RNA Sequencing of Mouse Sinoatrial Node Reveals an Upstream Regulatory Role for Islet-1 in Cardiac Pacemaker Cells

(2015) V. Vedantham et al.   CIRCULATION RESEARCH

Brg1 modulates enhancer activation in mesoderm lineage commitment

(2015) J. M. Alexander et al.   DEVELOPMENT

A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development

(2015) Sophie Payne et al.   DEVELOPMENTAL BIOLOGY

DNA methylation abnormalities in congenital heart disease

(2015) Clara Serra-Juhé et al.   Epigenetics

Kabuki syndrome genesKMT2DandKDM6A: functional analyses demonstrate critical roles in craniofacial, heart and brain development

(2015) Peter M. Van Laarhoven et al.   HUMAN MOLECULAR GENETICS

Transcription factor ISL1 is essential for pacemaker development and function

(2015) Xingqun Liang et al.   JOURNAL OF CLINICAL INVESTIGATION

Chromatin-Driven Behavior of Topologically Associating Domains

(2015) Filippo Ciabrelli et al.   JOURNAL OF MOLECULAR BIOLOGY

Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice

(2015) Rene C. Adam et al.   NATURE

Chromatin architecture reorganization during stem cell differentiation

(2015) Jesse R. Dixon et al.   NATURE

What are super-enhancers?

(2015) Sebastian Pott et al.   NATURE GENETICS

The Mediator complex: a central integrator of transcription

(2015) Benjamin L. Allen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies

(2015) J. Homsy et al.   SCIENCE

Genome-Wide Identification of MESP1 Targets Demonstrates Primary Regulation Over Mesendoderm Gene Activity

(2015) Benjamin Soibam et al.   STEM CELLS

Direct Nkx2-5 Transcriptional Repression of Isl1 Controls Cardiomyocyte Subtype Identity

(2015) Tatjana Dorn et al.   STEM CELLS

Perturbations of Heart Development and Function in Cardiomyocytes from Human Embryonic Stem Cells with Trisomy 21

(2015) Alexis Bosman et al.   STEM CELLS

Functional Insights into Chromatin Remodelling from Studies on CHARGE Syndrome

(2015) M. Albert Basson et al.   TRENDS IN GENETICS

A cohesin–OCT4 complex mediates Sox enhancers to prime an early embryonic lineage

(2015) Nesrine Abboud et al.   Nature Communications

NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets

(2015) Romaric Bouveret et al.   eLife

The Development of Septation in the Four-Chambered Heart

(2014) Robert H. Anderson et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

(2014) Suhas S.P. Rao et al.   CELL

DOT1L-mediated H3K79me2 modification critically regulates gene expression during cardiomyocyte differentiation

(2014) P Cattaneo et al.   CELL DEATH AND DIFFERENTIATION

Tbx1 Coordinates Addition of Posterior Second Heart Field Progenitor Cells to the Arterial and Venous Poles of the Heart

(2014) M. Sameer Rana et al.   CIRCULATION RESEARCH

TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field

(2014) A. Francou et al.   DEVELOPMENT

Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development

(2014) Lu Zhang et al.   DEVELOPMENTAL BIOLOGY

CHD7, the gene mutated in CHARGE syndrome, regulates genes involved in neural crest cell guidance

(2014) Yvonne Schulz et al.   HUMAN GENETICS

Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair

(2014) Karolin Klement et al.   JOURNAL OF CELL BIOLOGY

Topologically associating domains are stable units of replication-timing regulation

(2014) Benjamin D. Pope et al.   NATURE

Up and down in Down's syndrome

(2014) Benjamin D. Pope et al.   NATURE

Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development

(2014) Fabienne Lescroart et al.   NATURE CELL BIOLOGY

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

(2014) Philippe Chetaille et al.   NATURE GENETICS

CTCF: an architectural protein bridging genome topology and function

(2014) Chin-Tong Ong et al.   NATURE REVIEWS GENETICS

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease

(2014) Ralf Gilsbach et al.   Nature Communications

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development

(2014) Sonia Stefanovic et al.   Nature Communications

Cardiac Cell Lineages that Form the Heart

(2014) S. M. Meilhac et al.   Cold Spring Harbor Perspectives in Medicine

Early patterning and specification of cardiac progenitors in gastrulating mesoderm

(2014) W Patrick Devine et al.   eLife

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites

(2013) Jian Yan et al.   CELL

Architectural Protein Subclasses Shape 3D Organization of Genomes during Lineage Commitment

(2013) Jennifer E. Phillips-Cremins et al.   CELL

HCN4 Dynamically Marks the First Heart Field and Conduction System Precursors

(2013) Xingqun Liang et al.   CIRCULATION RESEARCH

Tbx18 regulates development of the epicardium and coronary vessels

(2013) San-Pin Wu et al.   DEVELOPMENTAL BIOLOGY

CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in mice

(2013) Yuelong Liu et al.   HUMAN MOLECULAR GENETICS

Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor

(2013) Tien Peng et al.   NATURE

Charting a dynamic DNA methylation landscape of the human genome

(2013) Michael J. Ziller et al.   NATURE

De novo mutations in histone-modifying genes in congenital heart disease

(2013) Samir Zaidi et al.   NATURE

A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells

(2013) Daniela Später et al.   NATURE CELL BIOLOGY

Architectural cohesin

(2013) Kim Baumann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Brief Report: Oct4 and Canonical Wnt Signaling Regulate the Cardiac Lineage Factor Mesp1 Through a Tcf/Lef-Oct4 Composite Element

(2013) Yongqing Li et al.   STEM CELLS

Signaling and Transcriptional Networks in Heart Development and Regeneration

(2013) B. G. Bruneau   Cold Spring Harbor Perspectives in Biology

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

Embryological origin of the endocardium and derived valve progenitor cells: From developmental biology to stem cell-based valve repair

(2012) Michel Pucéat   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endocardial Cells Form the Coronary Arteries by Angiogenesis through Myocardial-Endocardial VEGF Signaling

(2012) Bingruo Wu et al.   CELL

Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome

(2012) Tom Sexton et al.   CELL

Asymmetric Fate of the Posterior Part of the Second Heart Field Results in Unexpected Left/Right Contributions to Both Poles of the Heart

(2012) Jorge N. Domínguez et al.   CIRCULATION RESEARCH

Lineage Tree for the Venous Pole of the Heart

(2012) Fabienne Lescroart et al.   CIRCULATION RESEARCH

Islet1 Derivatives in the Heart Are of Both Neural Crest and Second Heart Field Origin

(2012) Kurt A. Engleka et al.   CIRCULATION RESEARCH

Growth of the developing mouse heart: An interactive qualitative and quantitative 3D atlas

(2012) Bouke A. de Boer et al.   DEVELOPMENTAL BIOLOGY

Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart

(2012) Andy Wessels et al.   DEVELOPMENTAL BIOLOGY

Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning

(2012) Vasanth Vedantham et al.   DEVELOPMENTAL BIOLOGY

Tbx5-Hedgehog Molecular Networks Are Essential in the Second Heart Field for Atrial Septation

(2012) Linglin Xie et al.   DEVELOPMENTAL CELL

Distinct Compartments of the Proepicardial Organ Give Rise to Coronary Vascular Endothelial Cells

(2012) Tamar C. Katz et al.   DEVELOPMENTAL CELL

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

(2012) Matthew A. Deardorff et al.   NATURE

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Conditional Ablation of Ezh2 in Murine Hearts Reveals Its Essential Roles in Endocardial Cushion Formation, Cardiomyocyte Proliferation and Survival

(2012) Li Chen et al.   PLoS One

Role of Chd7 in Zebrafish: A Model for CHARGE Syndrome

(2012) Shunmoogum A. Patten et al.   PLoS One

Linking epithelial-to-mesenchymal-transition and epigenetic modifications

(2012) Sonja C. Stadler et al.   SEMINARS IN CANCER BIOLOGY

Insights from Cardiac Development Relevant to Congenital Defects and Adult Clinical Anatomy

(2012) Robert H. Anderson et al.   Journal of Cardiovascular Translational Research

Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling

(2012) Yuichiro Arima et al.   Nature Communications

Transcriptional Control in Cardiac Progenitors: Tbx1 Interacts with the BAF Chromatin Remodeling Complex and Regulates Wnt5a

(2012) Li Chen et al.   PLoS Genetics

Mechanisms of T-box gene function in the developing heart

(2011) F. Greulich et al.   CARDIOVASCULAR RESEARCH

Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart

(2011) Aibin He et al.   CIRCULATION RESEARCH

UTX, a Histone H3-Lysine 27 Demethylase, Acts as a Critical Switch to Activate the Cardiac Developmental Program

(2011) Seunghee Lee et al.   DEVELOPMENTAL CELL

The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation

(2011) Ita Costello et al.   NATURE CELL BIOLOGY

Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart

(2011) A. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The sinus venosus progenitors separate and diversify from the first and second heart fields early in development

(2010) Mathilda T.M. Mommersteeg et al.   CARDIOVASCULAR RESEARCH

Ash2l interacts with Tbx1 and is required during early embryogenesis

(2010) Jason Z Stoller et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis

(2010) Gabriel E. Zentner et al.   HUMAN MOLECULAR GENETICS

Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart

(2010) Sandra Puskaric et al.   HUMAN MOLECULAR GENETICS

Differential Roles of Transcriptional Mediator Subunits in Regulation of Multidrug Resistance Gene Expression in Saccharomyces cerevisiae

(2010) Puja Shahi et al.   MOLECULAR BIOLOGY OF THE CELL

Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression

(2010) Sara A. Miller et al.   MOLECULAR CELL

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

Chromatin regulation by Brg1 underlies heart muscle development and disease

(2010) Calvin T. Hang et al.   NATURE

The changing epidemiology of congenital heart disease

(2010) Teun van der Bom et al.   Nature Reviews Cardiology

Development of the Endocardium

(2010) Ian S. Harris et al.   PEDIATRIC CARDIOLOGY

skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration

(2010) C. Y. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome Territories

(2010) T. Cremer et al.   Cold Spring Harbor Perspectives in Biology

CHD7 Targets Active Gene Enhancer Elements to Modulate ES Cell-Specific Gene Expression

(2010) Michael P. Schnetz et al.   PLoS Genetics

Tbx20 Interacts With Smads to Confine Tbx2 Expression to the Atrioventricular Canal

(2009) Reena Singh et al.   CIRCULATION RESEARCH

Epicardium and Myocardium Separate From a Common Precursor Pool by Crosstalk Between Bone Morphogenetic Protein– and Fibroblast Growth Factor–Signaling Pathways

(2009) Bram van Wijk et al.   CIRCULATION RESEARCH

Tbx1 Regulates Proliferation and Differentiation of Multipotent Heart Progenitors

(2009) Li Chen et al.   CIRCULATION RESEARCH

Endocardial cells are a distinct endothelial lineage derived from Flk1+ multipotent cardiovascular progenitors

(2009) Andrew M. Misfeldt et al.   DEVELOPMENTAL BIOLOGY

Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns

(2009) M. P. Schnetz et al.   GENOME RESEARCH

Physical Interaction between TBX5 and MEF2C Is Required for Early Heart Development

(2009) T. K. Ghosh et al.   MOLECULAR AND CELLULAR BIOLOGY

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf–Hirschhorn syndrome

(2009) Keisuke Nimura et al.   NATURE

Dosage Effects of Cohesin Regulatory Factor PDS5 on Mammalian Development: Implications for Cohesinopathies

(2009) Bin Zhang et al.   PLoS One

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Tetralogy of Fallot as a Model to Study Cardiac Progenitor Cell Migration and Differentiation During Heart Development

(2009) Valentina Di Felice et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium

(2008) Bin Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms

(2008) Vania Parelho et al.   CELL

Mesp1 Acts as a Master Regulator of Multipotent Cardiovascular Progenitor Specification

(2008) Antoine Bondue et al.   Cell Stem Cell

Mesp1 Coordinately Regulates Cardiovascular Fate Restriction and Epithelial-Mesenchymal Transition in Differentiating ESCs

(2008) R. Coleman Lindsley et al.   Cell Stem Cell

A Caudal Proliferating Growth Center Contributes to Both Poles of the Forming Heart Tube

(2008) Gert van den Berg et al.   CIRCULATION RESEARCH

Formation of the Sinus Node Head and Differentiation of Sinus Node Myocardium Are Independently Regulated by Tbx18 and Tbx3

(2008) Cornelia Wiese et al.   CIRCULATION RESEARCH

Atrial myocardium derives from the posterior region of the second heart field, which acquires left-right identity as Pitx2c is expressed

(2008) D. Galli et al.   DEVELOPMENT

Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity

(2008) Qing Ma et al.   DEVELOPMENTAL BIOLOGY

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development

(2008) Meenakshi Maitra et al.   DEVELOPMENTAL BIOLOGY

Endocardial Brg1 Represses ADAMTS1 to Maintain the Microenvironment for Myocardial Morphogenesis

(2008) Kryn Stankunas et al.   DEVELOPMENTAL CELL

Cooperative interaction ofNkx2.5andMef2ctranscription factors during heart development

(2008) Joshua W. Vincentz et al.   DEVELOPMENTAL DYNAMICS

Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression

(2008) S. A. Miller et al.   GENES & DEVELOPMENT

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Genesis and Regulation of the Heart Automaticity

(2008) Matteo E. Mangoni et al.   PHYSIOLOGICAL REVIEWS