Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels

Comparative Molecular Dynamics Study of Human Islet Amyloid Polypeptide (IAPP) and Rat IAPP Oligomers

(2013) Guizhao Liang et al.   BIOCHEMISTRY

Cations as Switches of Amyloid-Mediated Membrane Disruption Mechanisms: Calcium and IAPP

(2013) Michele F.M. Sciacca et al.   BIOPHYSICAL JOURNAL

pH-Dependent Conformational Ensemble and Polymorphism of Amyloid-β Core Fragment

(2013) Weixin Xu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Familial Alzheimer’s Disease Osaka Mutant (ΔE22) β-Barrels Suggest an Explanation for the Different Aβ1–40/42 Preferred Conformational States Observed by Experiment

(2013) Hyunbum Jang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Probing Structural Features of Alzheimer’s Amyloid-β Pores in Bilayers Using Site-Specific Amino Acid Substitutions

(2012) Ricardo Capone et al.   BIOCHEMISTRY

Effects of Point Substitutions on the Structure of Toxic Alzheimer’s β-Amyloid Channels: Atomic Force Microscopy and Molecular Dynamics Simulations

(2012) Laura Connelly et al.   BIOCHEMISTRY

Probing ion channel activity of human islet amyloid polypeptide (amylin)

(2012) Jun Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Toxicity of Amyloid ß Oligomers

(2012) Li Na Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Atomic Force Microscopy and MD Simulations Reveal Pore-Like Structures of All-d-Enantiomer of Alzheimer’s β-Amyloid Peptide: Relevance to the Ion Channel Mechanism of AD Pathology

(2012) Laura Connelly et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective

(2011) Jeffrey R. Brender et al.   ACCOUNTS OF CHEMICAL RESEARCH

Heterogeneous Triangular Structures of Human Islet Amyloid Polypeptide (Amylin) with Internal Hydrophobic Cavity and External Wrapping Morphology Reveal the Polymorphic Nature of Amyloid Fibrils

(2011) Jun Zhao et al.   BIOMACROMOLECULES

Effects of cholesterol on pore formation in lipid bilayers induced by human islet amyloid polypeptide fragments: A coarse-grained molecular dynamics study

(2011) Weixin Xu et al.   PHYSICAL REVIEW E

Polymorphic Structures of Alzheimer's β-Amyloid Globulomers

(2011) Xiang Yu et al.   PLoS One

Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems

(2010) Sara M. Butterfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Polymorphism of Human Islet Amyloid Polypeptide (hIAPP) Oligomers Highlights the Importance of Interfacial Residue Interactions

(2010) Jun Zhao et al.   BIOMACROMOLECULES

β-Barrel Topology of Alzheimer's β-Amyloid Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Convergence Among Diverse, Toxic β-Sheet Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Interactions of Aβ25−35 β-Barrel-like Oligomers with Anionic Lipid Bilayer and Resulting Membrane Leakage: An All-Atom Molecular Dynamics Study

(2010) Zhongwen Chang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Truncated  -amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

(2010) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Misfolded Amyloid Ion Channels Present Mobile β-Sheet Subunits in Contrast to Conventional Ion Channels

(2009) Hyunbum Jang et al.   BIOPHYSICAL JOURNAL

K3 Fragment of Amyloidogenic β2-Microglobulin Forms Ion Channels: Implication for Dialysis Related Amyloidosis

(2009) Mirela Mustata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Induction of Negative Curvature as a Mechanism of Cell Toxicity by Amyloidogenic Peptides: The Case of Islet Amyloid Polypeptide

(2009) Pieter E. S. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloidogenesis Abolished by Proline Substitutions but Enhanced by Lipid Binding

(2009) Ping Jiang et al.   PLoS Computational Biology

Das Amyloid der Langerhansschen Inseln und seine Beziehung zum Diabetes mellitus* 1

(2008) H.-M. Schneider et al.   DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

(2008) M. F. M. Engel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New structures help the modeling of toxic amyloidß ion channels

(2008) Hyunbum Jang et al.   TRENDS IN BIOCHEMICAL SCIENCES