Single-molecule assays for investigating protein misfolding and aggregation

Microsecond folding experiments and simulations: a match is made

(2013) M. B. Prigozhin et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Single-molecule approaches to prion protein misfolding

(2013) Hao Yu et al.   Prion

Single-Particle Characterization of Aβ Oligomers in Solution

(2012) Erik C. Yusko et al.   ACS Nano

Two Different Binding Modes of α-Synuclein to Lipid Vesicles Depending on its Aggregation State

(2012) Tobias Högen et al.   BIOPHYSICAL JOURNAL

Tracking UNC-45 Chaperone-Myosin Interaction with a Titin Mechanical Reporter

(2012) Christian M. Kaiser et al.   BIOPHYSICAL JOURNAL

The Conformational Ensembles of α-Synuclein and Tau: Combining Single-Molecule FRET and Simulations

(2012) Abhinav Nath et al.   BIOPHYSICAL JOURNAL

Protein Folding Drives Disulfide Formation

(2012) Pallav Kosuri et al.   CELL

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Methamphetamine binds to α-synuclein and causes a conformational change which can be detected by nanopore analysis

(2012) Omid Tavassoly et al.   FEBS LETTERS

Nanomechanical properties of single amyloid fibrils

(2012) K K M Sweers et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Effect of electrostatics on aggregation of prion protein Sup35 peptide

(2012) Alexander M Portillo et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Specific and Nonspecific Effects of Glycosylation

(2012) Christopher R. Ellis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Techniques for monitoring protein misfolding and aggregation in vitro and in living cells

(2012) Simpson Gregoire et al.   KOREAN JOURNAL OF CHEMICAL ENGINEERING

Function and Dysfunction of α-Synuclein: Probing Conformational Changes and Aggregation by Single Molecule Fluorescence

(2012) Adam J. Trexler et al.   MOLECULAR NEUROBIOLOGY

The physics of life: one molecule at a time

(2012) M. C. Leake   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Effect of Spermidine on Misfolding and Interactions of Alpha-Synuclein

(2012) Alexey V. Krasnoslobodtsev et al.   PLoS One

Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes

(2012) Felix Schmidt et al.   PLoS One

Nanopore analysis

(2012) Claudia A. Madampage et al.   Prion

Single-molecule observation of helix staggering, sliding, and coiled coil misfolding

(2012) Z. Xi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct observation of multiple misfolding pathways in a single prion protein molecule

(2012) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy landscape analysis of native folding of the prion protein yields the diffusion constant, transition path time, and rates

(2012) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid Folding of DNA into Nanoscale Shapes at Constant Temperature

(2012) J.-P. J. Sobczak et al.   SCIENCE

Molecular level insight into intra-solvent interaction effects on protein stability and aggregation

(2011) Diwakar Shukla et al.   ADVANCED DRUG DELIVERY REVIEWS

Information Content in Fluorescence Correlation Spectroscopy: Binary Mixtures and Detection Volume Distortion

(2011) Jonathan D. Lam et al.   ANALYTICAL CHEMISTRY

Nanopore Analysis of β-Amyloid Peptide Aggregation Transition Induced by Small Molecules

(2011) Hai-Yan Wang et al.   ANALYTICAL CHEMISTRY

Signal-Pair Correlation Analysis of Single-Molecule Trajectories

(2011) Armin Hoffmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single particle analysis of tau oligomer formation induced by metal ions and organic solvents

(2011) Benedikt Bader et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Single-Molecule Atomic Force Microscopy Force Spectroscopy Study of Aβ-40 Interactions

(2011) Bo-Hyun Kim et al.   BIOCHEMISTRY

Protein folding at single-molecule resolution

(2011) Allan Chris M. Ferreon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Physical Properties of Polymorphic Yeast Prion Amyloid Fibers

(2011) Carlos E. Castro et al.   BIOPHYSICAL JOURNAL

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Phosphorylation as a Tool To Modulate Aggregation Propensity and To Predict Fibril Architecture

(2011) Nathalie M. Valette et al.   CHEMBIOCHEM

Recent advances in single-molecule detection on micro- and nano-fluidic devices

(2011) Chang Liu et al.   ELECTROPHORESIS

Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis

(2011) Marco Duering et al.   HUMAN MOLECULAR GENETICS

A Diversity of Assembly Mechanisms of a Generic Amyloid Fold

(2011) Timo Eichner et al.   MOLECULAR CELL

Single-molecule fluorescence reveals sequence-specific misfolding in multidomain proteins

(2011) Madeleine B. Borgia et al.   NATURE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing

(2011) Yann Gambin et al.   NATURE METHODS

Controlling protein translocation through nanopores with bio-inspired fluid walls

(2011) Erik C. Yusko et al.   Nature Nanotechnology

Experimental validation of free-energy-landscape reconstruction from non-equilibrium single-molecule force spectroscopy measurements

(2011) Amar Nath Gupta et al.   Nature Physics

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide

(2011) Priyanka Narayan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quantifying heterogeneity and conformational dynamics from single molecule FRET of diffusing molecules: recurrence analysis of single particles (RASP)

(2011) Armin Hoffmann et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Locating the Barrier for Folding of Single Molecules under an External Force

(2011) Olga K. Dudko et al.   PHYSICAL REVIEW LETTERS

Transmission of prions within the gut and towards the central nervous system

(2011) Gianfranco Natale et al.   Prion

Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

(2011) L. I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Complex Folding Network of Single Calmodulin Molecules

(2011) J. Stigler et al.   SCIENCE

Alteration of the α-Synuclein Folding Landscape by a Mutation Related to Parkinson’s Disease

(2010) Allan Chris M. Ferreon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Measurement of the Attachment and Assembly of Small Amyloid-β Oligomers on Live Cell Membranes at Physiological Concentrations Using Single-Molecule Tools

(2010) Suman Nag et al.   BIOPHYSICAL JOURNAL

Early Aggregation Steps in α-Synuclein as Measured by FCS and FRET: Evidence for a Contagious Conformational Change

(2010) Sangeeta Nath et al.   BIOPHYSICAL JOURNAL

Single Molecule Characterization of α-Synuclein in Aggregation-Prone States

(2010) Adam J. Trexler et al.   BIOPHYSICAL JOURNAL

Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing

(2010) Juliane Winkler et al.   EMBO JOURNAL

Assays for α-synuclein aggregation

(2010) Lise Giehm et al.   METHODS

Nanoprobing of α-synuclein misfolding and aggregation with atomic force microscopy

(2010) Junping Yu et al.   Nanomedicine-Nanotechnology Biology and Medicine

The folding cooperativity of a protein is controlled by its chain topology

(2010) Elizabeth A. Shank et al.   NATURE

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Optical trapping with high forces reveals unexpected behaviors of prion fibrils

(2010) Jijun Dong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Full distance-resolved folding energy landscape of one single protein molecule

(2010) J. C. M. Gebhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The propagation of prion-like protein inclusions in neurodegenerative diseases

(2010) Michel Goedert et al.   TRENDS IN NEUROSCIENCES

Converse modulation of toxic α-synuclein oligomers in living cells by N′-benzylidene-benzohydrazide derivates and ferric iron

(2009) Andreas S. Hillmer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Determination of the Oligomer Size of Amyloidogenic Protein β-Amyloid(1–40) by Single-Molecule Spectroscopy

(2009) Hao Ding et al.   BIOPHYSICAL JOURNAL

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

Experimental determination of upper bound for transition path times in protein folding from single-molecule photon-by-photon trajectories

(2009) H. S. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monitoring the earliest amyloid-β oligomers via quantized photobleaching of dye-labeled peptides

(2008) Kyle D. Dukes et al.   ANALYTICAL BIOCHEMISTRY

Single-Molecule Studies of Protein Folding

(2008) Alessandro Borgia et al.   Annual Review of Biochemistry

Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences

(2008) Huan-Xiang Zhou et al.   Annual Review of Biophysics

Protein aggregation kinetics, mechanism, and curve-fitting: A review of the literature

(2008) Aimee M. Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Nanomechanical Properties of Human Prion Protein Amyloid as Probed by Force Spectroscopy

(2008) Dragomir N. Ganchev et al.   BIOPHYSICAL JOURNAL

Pathogenic Mutations Shift the Equilibria of α-Synuclein Single Molecules towards Structured Conformers

(2008) Marco Brucale et al.   CHEMBIOCHEM

Protein folding studied by single-molecule FRET

(2008) Benjamin Schuler et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein-DNA chimeras for single molecule mechanical folding studies with the optical tweezers

(2008) Ciro Cecconi et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Single Particle Characterization of Iron-induced Pore-forming α-Synuclein Oligomers

(2008) Marcus Kostka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Misfolding: Single Molecule AFM Force Spectroscopy Study

(2008) Junping Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

Early Stages for Parkinson’s Development: α-Synuclein Misfolding and Aggregation

(2008) Junping Yu et al.   Journal of Neuroimmune Pharmacology

Unfolded Protein and Peptide Dynamics Investigated with Single-Molecule FRET and Correlation Spectroscopy from Picoseconds to Seconds†

(2008) Daniel Nettels et al.   JOURNAL OF PHYSICAL CHEMISTRY B

AFM-based force spectroscopy measurements of mature amyloid fibrils of the peptide glucagon

(2008) Mingdong Dong et al.   NANOTECHNOLOGY

A practical guide to single-molecule FRET

(2008) Rahul Roy et al.   NATURE METHODS

Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy

(2008) Keir C Neuman et al.   NATURE METHODS

Theory, analysis, and interpretation of single-molecule force spectroscopy experiments

(2008) O. K. Dudko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct characterization of amyloidogenic oligomers by single-molecule fluorescence

(2008) A. Orte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level

(2008) Massimo Sandal et al.   PLOS BIOLOGY