Article
Chemistry, Analytical
Yu-Bin Su, Xu Zhao, Li-Jian Chen, Hai-Long Qian, Xiu-Ping Yan
Summary: The development of a novel theranostic nanoprobe for imaging-guided PDT is reported in this study. The nanoprobe integrates PLNP for autofluorescence-free bioimaging, TCPP for PDT, and AS1411 aptamer-contained DNA for specific binding to cancer cells. This work provides a new imaging-guided PDT nanoplatform for theranostics.
Article
Chemistry, Multidisciplinary
Zhanlin Zhang, Hui Yan, Bo Qiu, Pan Ran, Wenxiong Cao, Xinwei Jia, Kun Huang, Xiaohong Li
Summary: In this study, a therapeutic strategy was developed to integrate real-time optical imaging and simultaneous photodynamic therapy (PDT) of bacterial infections into persistent luminescence (PL) nanoparticles (NPs). The strategy enables precise imaging and non-antibiotic treatment of bacterial infections without causing side effects to normal tissues.
Review
Chemistry, Inorganic & Nuclear
Carlos F. G. C. Geraldes, M. Margarida C. A. Castro, Joop A. Peters
Summary: Mn(III) porphyrins show great potential as Gd-free MRI contrast agents due to their interesting redox properties and high affinity for tumor tissues. With applications in photothermal, photodynamic, and sonodynamic therapies, they are attractive for theranostics development. Their relative longitudinal relaxivity at typical clinical MRI field strengths is even higher than traditional Gd-based agents.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Jessica V. Moore, Matthew P. Wylie, Gavin P. Andrews, Colin P. McCoy
Summary: Antimicrobial resistance is a growing global concern, and the development of alternative antimicrobial agents and techniques is crucial. Antimicrobial photodynamic therapy (aPDT) is a promising alternative that uses visible light to destroy microbes. This study presents a convenient method to produce highly photoactive antimicrobial microparticles, which showed a size-dependent effect on antimicrobial activity. The incorporation of a cationic photosensitizer onto the microparticles resulted in significant bacterial reductions when irradiated with red light, without any leaching of the photosensitizer.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Madhura Murar, Lorenzo Albertazzi, Silvia Pujals
Summary: Nanomedicine utilizes nanotechnology for clinical applications and holds promise for improving cancer treatments. Personalized Medicine aims to match the most effective treatment to individual patients, and nanotheranostics, which combine therapy and diagnostic imaging, can help in treatment selection, monitoring response, and planning therapy.
Review
Pharmacology & Pharmacy
Xiaoxv Dong, Yawen Zeng, Zhiqin Zhang, Jing Fu, Longtai You, Yuanyuan He, Yang Hao, Zili Gu, Zhenfeng Yu, Changhai Qu, Xingbin Yin, Jian Ni, Luis J. Cruz
Summary: Photodynamic therapy using blue light can inhibit the proliferation of various cancer cells and has the potential to be an effective treatment for certain types of cancer.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Xiamin Cheng, Jing Gao, Yang Ding, Yao Lu, Qiancheng Wei, Dezhi Cui, Jiali Fan, Xiaoman Li, Ershu Zhu, Yongna Lu, Qiong Wu, Lin Li, Wei Huang
Summary: This review discusses the development of liposomes as versatile nano-carriers for drug delivery in order to overcome limitations of PDT and enhance therapeutic effects.
Review
Nanoscience & Nanotechnology
Jincong Yan, Tian Gao, Zhongzhong Lu, Jingbo Yin, Ye Zhang, Renjun Pei
Summary: Aptamers, short oligonucleotide sequences with selective binding abilities, have shown promise in improving controlled and accurate delivery of photosensitizers into tumor sites for enhanced photodynamic therapy. Modification of aptamers onto PSs or nanocarriers enables specific recognition and binding to tumor cells, resulting in superior therapeutic efficiency. The development of aptamer-targeted platforms for tumor therapy holds potential for synergistic treatment modalities like PDT, photothermal therapy, and chemotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Mengfei Hou, Wandi Chen, Junkai Zhao, Deshen Dai, Mo Yang, Changqing Yi
Summary: Fluorescence imaging-guided photodynamic therapy using TCPP@PEI/PGA nanoparticles was demonstrated in this study. The nanoparticles showed excellent water-solubility, biocompatibility, in vivo bioimaging capabilities, and effective tumor cell killing upon laser irradiation.
CHINESE CHEMICAL LETTERS
(2022)
Review
Engineering, Biomedical
Xiao-Qiang Wang, Wenjing Wang, Mengyun Peng, Xian-Zheng Zhang
Summary: Free radicals, traditionally seen as harmful, can also have beneficial applications in health due to their unique electronic structure. Their properties like high reactivity and conversion ability make them attractive for biomedical applications.
Review
Pharmacology & Pharmacy
Rajkumar Sekar, Nagaraj Basavegowda, Saktishree Jena, Santhoshkumar Jayakodi, Pandian Elumalai, Amballa Chaitanyakumar, Prathap Somu, Kwang-Hyun Baek
Summary: This review discusses the recent developments in doped CNDs for cancer therapy, including their preparations, properties, imaging, and therapeutic applications.
Article
Biophysics
Na An, Yao Zhang, Han Sheng Lu, Shuang Long Tang, Yan Gao, Xiao Hui Li, Chong Shen Guo
Summary: This study established a cancer theranostic method by using laser-induced breakdown spectroscopy (LIBS)-mediated synergistic photothermal/photodynamic therapy. PEGylated cobalt phosphate nanoparticles with strong near-infrared absorbance, high photothermal conversion efficiency, and reactive oxygen species generation effect were used for tumor localization and treatment. The LIBS imaging system provided fast, real-time analysis and imaging, facilitating precise tumor treatment by monitoring the distribution of nanoparticles.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Medicine, Research & Experimental
Conor C. Horgan, Mads S. Bergholt, Anika Nagelkerke, May Zaw Thin, Isaac J. Pence, Ulrike Kauscher, Tammy L. Kalber, Daniel J. Stuckey, Molly M. Stevens
Summary: This article presents an alternative nanoparticle-free theranostic approach based on Raman spectroscopy and photodynamic therapy, which offers significant advantages and application prospects in clinical cancer treatment.
Review
Medicine, Research & Experimental
Paromita Sarbadhikary, Blassan P. George, Heidi Abrahamse
Summary: Photodynamic Therapy (PDT) has emerged as a promising alternative in cancer diagnosis and treatment, utilizing light-induced activation of photosensitizers to kill cancer cells. PDT offers advantages such as minimal invasiveness and spatio-temporal control, with proper planning of parameters being crucial for efficacy. The design of PS formulations for imaging-guided PDT has shown promising potential, with recent advances in activatable phototheranostic agents enhancing the specificity of treatment.
Review
Chemistry, Inorganic & Nuclear
Demei Sun, Xuesong Feng, Xinyuan Zhu, Youfu Wang, Jinghui Yang
Summary: Metal organic cages (MOCs) with precise and tunable nano structures show great potential in cancer therapy. Their diverse functions and ultrasmall size make them excellent nanoagents for different anticancer strategies, demonstrating outstanding anticancer performances.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Engineering, Environmental
A. Lesar, G. Begic, N. Malatesti, I. Gobin
Review
Biochemical Research Methods
Jordon Sandland, Ross W. Boyle
BIOCONJUGATE CHEMISTRY
(2019)
Review
Biochemistry & Molecular Biology
Dario Matulja, Karlo Wittine, Nela Malatesti, Sylvain Laclef, Maris Turks, Maria Kolympadi Markovic, Gabriela Ambrozic, Dean Markovic
CURRENT MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Inorganic & Nuclear
Jordon Sandland, Huguette Savoie, Ross W. Boyle, Benjamin S. Murray
INORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Christopher S. Wilson, Timothy J. Prior, Jordon Sandland, Huguette Savoie, Ross W. Boyle, Benjamin S. Murray
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Andrija Lesar, Martina Muskovic, Gabrijela Begic, Martin Loncaric, Dijana Tomic Linsak, Nela Malatesti, Ivana Gobin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Jordon Sandland, Huguette Savoie, Ross W. Boyle, Benjamin S. Murray
Summary: In this study, the RAPTA complex was successfully immobilized onto biologically inert polyacrylamide nanoparticles, resulting in a significant decrease in the effective concentration of ruthenium required for a near identical biological effect on cell viability. This conjugation of the RAPTA metallodrug to nanoparticle carriers demonstrated the potential for controlled cell activity and enhanced efficiency in cancer treatment.
Review
Biochemistry & Molecular Biology
Ivana Ratkaj, Martina Muskovic, Nela Malatesti
Summary: Controlling hypoxia levels is crucial in PDT for melanoma and head and neck cancers, with oxygen self-supply systems and vascular targeting being important methods. The use of angiogenesis inhibitors has shown somewhat less success than expected and requires further investigation. The combination of PDT with immunotherapy using multifunctional nanoparticles appears to be the most promising for achieving a complete and lasting antitumor effect.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Martina Muskovic, Iva Cavar, Andrija Lesar, Martin Loncaric, Nela Malatesti, Ivana Gobin
Summary: Three cationic tripyridylporphyrins showed different stability and singlet oxygen production in waters of varying hardness, but all demonstrated effectiveness against L. pneumophila adhesion, biofilm formation, and destruction in micromolar concentrations. However, higher water hardness generally decreased the PDI activity of all porphyrins at different biofilm growth stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Igor Jurak, Maja Cokaric Brdovcak, Lara Djakovic, Ivana Bertovic, Klaudia Knezevic, Martin Loncaric, Antonija Jurak Begonja, Nela Malatesti
Summary: This study demonstrates that activated TMPyP3-C17H35 can effectively inhibit HSV-1 replication and can be further developed as a potential novel treatment and used as a model for studying photodynamic antimicrobial chemotherapy.
Review
Chemistry, Medicinal
Martina Muskovic, Rafaela Pokrajac, Nela Malatesti
Summary: Photodynamic therapy (PDT) is a form of phototherapy that requires light, a photosensitiser, and oxygen to create cytotoxic species for destroying cancer cells and pathogens. The combination of two photosensitising agents in PDT aims to enhance the therapeutic effects, reduce toxicity, and improve drug loading and singlet oxygen production. This approach can target multiple organelles, induce immune responses, and generate reactive oxygen species for anticancer and antimicrobial effects.
Article
Multidisciplinary Sciences
Martina Muskovic, Matej Planinic, Antonela Crepulja, Marko Lusic, Marin Glad, Martin Loncaric, Nela Malatesti, Ivana Gobin
Summary: With the increasing threat of multidrug-resistant strains of bacteria spreading into the environment and drinking water, there is a need to discover effective methods for treating municipal wastewater. Photodynamic inactivation (PDI) may be a way to stop the spread of antibiotic-resistant genes by combining a photosensitiser and light to generate reactive species that react with bacteria. This study investigated the effect of TMPyP3, a photosensitiser, on MDR strains of Pseudomonas aeruginosa and Klebsiella pneumoniae in tap water and municipal wastewater, and found significant toxicity and PDI effect after activation with violet-blue light.
Review
Engineering, Chemical
Martina Muskovic, Ivana Gobin, Nela Malatesti
Summary: Research suggests that current water disinfection methods are not effectively controlling opportunistic premise plumbing pathogens (OPPPs). Photodynamic inactivation (PDI), a method that utilizes photosensitizers, light, and oxygen, shows promise in combating these pathogens, but further research and development are needed.
Article
Water Resources
Ivona Viduka, Gabrijela Begic, Nela Malatesti, Ivana Gobin
