Journal
PHOTOCHEMISTRY AND PHOTOBIOLOGY
Volume 87, Issue 1, Pages 32-44Publisher
WILEY
DOI: 10.1111/j.1751-1097.2010.00832.x
Keywords
-
Categories
Funding
- Scientific Grant Agency [1/0225/08, 1/0018/09]
- Research and Development Agency of the Slovak Republic [APVV-0055-07, SK-AT-0016-08]
Ask authors/readers for more resources
Novel 7-substituted 6-oxo-6,9-dihydro[1,2,5]selenadiazolo[3,4-h] quinoline (SeQ(1-6)) and 8-substituted 9-oxo-6,9-dihydro[1,2,5] selenadiazolo[3,4-f]quinoline derivatives (SeQN(1-5)) with R-7, R-8 = H, COOC2H5, COOCH3, COOH, COCH3 or CN were synthesized and their spectral characteristics were obtained by UV/Vis spectroscopy. Ultraviolet A photoexcitation of the selenadiazoloquinolones in dimethylsulfoxide or acetonitrile resulted in the formation of paramagnetic species coupled with molecular oxygen activation generating the superoxide radical anion or singlet oxygen, evidenced by electron paramagnetic resonance spectroscopy. The cytotoxic/photocytotoxic impact of selenadiazoloquinolones on murine and human cancer cell lines was demonstrated using the derivative SeQ5 (with R-7 = COCH3).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available