期刊
PHOTOCHEMISTRY AND PHOTOBIOLOGY
卷 87, 期 1, 页码 32-44出版社
WILEY
DOI: 10.1111/j.1751-1097.2010.00832.x
关键词
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资金
- Scientific Grant Agency [1/0225/08, 1/0018/09]
- Research and Development Agency of the Slovak Republic [APVV-0055-07, SK-AT-0016-08]
Novel 7-substituted 6-oxo-6,9-dihydro[1,2,5]selenadiazolo[3,4-h] quinoline (SeQ(1-6)) and 8-substituted 9-oxo-6,9-dihydro[1,2,5] selenadiazolo[3,4-f]quinoline derivatives (SeQN(1-5)) with R-7, R-8 = H, COOC2H5, COOCH3, COOH, COCH3 or CN were synthesized and their spectral characteristics were obtained by UV/Vis spectroscopy. Ultraviolet A photoexcitation of the selenadiazoloquinolones in dimethylsulfoxide or acetonitrile resulted in the formation of paramagnetic species coupled with molecular oxygen activation generating the superoxide radical anion or singlet oxygen, evidenced by electron paramagnetic resonance spectroscopy. The cytotoxic/photocytotoxic impact of selenadiazoloquinolones on murine and human cancer cell lines was demonstrated using the derivative SeQ5 (with R-7 = COCH3).
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