Review
Chemistry, Inorganic & Nuclear
Xuezhao Li, Xing Zhao, Wen Wang, Zhuolin Shi, Yangming Zhang, Qingqing Tian, Yougang Yao, Cheng He, Chunying Duan
Summary: The development of highly efficient and minimally toxic agents with targeting abilities toward tumor tissues is an ongoing area of research in the fight against cancer. Different from the mononuclear and multinuclear metallodrug complexes, impressively, the unique supramolecular coordination complexes (SCCs) have shown great superiority in cancer treatment. Over the last decades, significant progress has been made in the design and synthesis of novel SCCs for intensive cancer therapy.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Inorganic & Nuclear
Robin Vinck, Albert Gandioso, Pierre Burckel, Bruno Saubamea, Kevin Cariou, Gilles Gasser
Summary: Four new ruthenium(II) polypyridyl complexes were synthesized and their properties were studied. It was found that these complexes could self-assemble into nanoparticles and accumulate in lysosomes upon internalization by cells. Conjugation with biotin increased cellular uptake but did not increase phototoxicity. However, these complexes showed high phototoxicity upon irradiation at long wavelengths (645-670 nm) and self-assembling behavior, making them promising for the development of new lysosome-targeted photosensitizers for photodynamic therapy.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Utpal Das, Priyankar Paira
Summary: The phototoxic nature of drugs in photo activated chemotherapy (PACT) has great importance in the selective treatment of diseases. This study synthesized a phototoxic anticancer agent by incorporating ruthenium(II) and iridium(III) metals into a biologically active 2,2'-biquinoline moiety. The complexes, RuBQ and IrBQ, showed significant toxicity towards HeLa and MCF-7 cancer cell lines under visible light due to the production of singlet oxygen.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Enrique Ortega-Forte, Anna Rovira, Marta Lopez-Corrales, Alba Hernandez-Garcia, Francisco Jose Ballester, Eduardo Izquierdo-Garcia, Mireia Jorda-Redondo, Manel Bosch, Santi Nonell, Maria Dolores Santana, Jose Ruiz, Vicente Marchan, Gilles Gasser
Summary: Photodynamic therapy (PDT) is a promising cancer treatment method, but it is limited by its oxygen dependency and poor tissue penetration of some photosensitizers (PSs) activatable with short wavelengths. In this study, a novel hypoxia-active PS with operability in the near-infrared (NIR) region was developed, which showed high photoactivity toward cancer cells even under hypoxic environments. This strategy could potentially pave the way for the development of novel NIR- and hypoxia-active Ru(ii)-based theragnostic PSs.
Article
Chemistry, Inorganic & Nuclear
Urszula K. Komarnicka, Sandra Koziel, Agnieszka Skorska-Stania, Agnieszka Kyziol, Francesco Tisato
Summary: In this study, new complexes based on ruthenium(II) and iridium(III) with phosphine ligands and phenyl rings with/without methoxy motifs were synthesized and characterized. The complexes showed high catalytic efficiency in the oxidation of NADH to NAD(+) and exhibited potential applications in biological and medical fields. Furthermore, they demonstrated redox activity and significant cytotoxicity against various cancer cell lines.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Shuang Qi, Zhihui Jin, Yao Jian, Yuanjun Hou, Chao Li, Yao Zhao, Xuesong Wang, Qianxiong Zhou
Summary: Two mitochondria-targeted Ru(II) complexes with photo-labile ligands were found to exhibit both one- and two-photon activatable anticancer activity through a dual mechanism, involving covalent binding to mitochondrial DNA after photo-induced ligand dissociation and photo-catalyzed depletion of NADH. These complexes showed promising activity against cisplatin-resistant cancer cells in both normoxic and hypoxic conditions.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Masoud Moradi, Azra Naderi, Niloufar Bahari, Motahareh Harati, Jorge Rodriguez-Chueca, Roshanak Rezaei Kalantary
Summary: The study found that TiO2NP can effectively photocatalytically inactivate E. coli. Operational parameters such as pH, aeration, inorganic ions, and organic matter content have an impact on bacterial inactivation. TiO2NP has better disinfection effect than other catalysts.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Food Science & Technology
Ourdia-Nouara Kernou, Zahra Azzouz, Amine Belbahi, Kamelia Kerdouche, Ghania Kaanin-Boudraa, Akila Amir, Khodir Madani, Patricia Rijo
Summary: This study focused on the inactivation of Escherichia coli in an orange juice drink using a combined microwave-ultrasound system. The results showed that the combination treatment was more effective than individual treatments in eliminating the bacteria. The optimal treatment conditions were determined as 900 W microwave power, 33 s microwave treatment time, and 20 min time of ultrasound.
Review
Chemistry, Inorganic & Nuclear
Binoy Kar, Utpal Das, Nilmadhab Roy, Priyankar Paira
Summary: Organelle specificity is crucial for the development of efficient and selective drugs with reduced side effects. Photodynamic therapy (PDT) has emerged as a selective treatment for cancer that minimizes damage to normal cells. This article showcases the potential of metal complexes, particularly ruthenium (II), iridium (III), and rhenium (I) complexes, in targeting specific organelles for PDT.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Nicholas Toupin, Sean J. Steinke, Sandeep Nadella, Ao Li, Thomas N. Rohrabaugh, Eric R. Samuels, Claudia Turro, Irina F. Sevrioukova, Jeremy J. Kodanko
Summary: Metal-based inhibitors of CYP3A4 show potent and selective inhibition of the drug metabolizing enzyme, suggesting potential clinical applications in enhancing the therapeutic efficacy of anticancer drugs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Chemistry, Inorganic & Nuclear
Luca Conti, Eleonora Macedi, Claudia Giorgi, Barbara Valtancoli, Vieri Fusi
Summary: The increasing impact of cancer on mortality worldwide calls for the research and development of novel chemotherapeutic agents. Transition metal complexes, particularly Ru(II) polypyridyl complexes, have shown promise in photodynamic therapy and photochemotherapy, providing spatio-temporal control over drug activation. These complexes offer versatile options for both photosensitizer agents and photolabile complexes, addressing issues such as selectivity and oxygen-dependence. This review highlights the opportunities presented by RPCs in these treatment approaches, providing a comprehensive overview of their mechanisms of action.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Min Yang, Hao Zhao, Ziqi Zhang, Qiong Yuan, Qian Feng, Xinrui Duan, Shu Wang, Yanli Tang
Summary: The CO/light dual-activatable Ru(ii)-oligo-(thiophene ethynylene) (Ru-OTE) developed for lysosome-targeted cancer therapy shows significant anticancer effects through physical disruption/PDT/chemotherapy, with efficient drug release and near-infrared PDT using a two-photon laser. It inhibits tumor growth in a breast tumor model with minimal side effects, demonstrating its potential as a new strategy for effective subcellular organelle-targeted multimodal cancer therapeutics.
Article
Chemistry, Inorganic & Nuclear
Rhianne C. C. Curley, Christopher S. S. Burke, Karmel S. S. Gkika, Sara Noorani, Naomi Walsh, Tia E. E. Keyes
Summary: Parent and peptide conjugates of bistridentate Ru(II) complexes with expanded bite angles demonstrate high phototoxicity and exceptional permeability in both 2D and 3D cell models for potential use in photodynamic therapy. The Ru(II) complexes show enhanced emission quantum yields and lifetimes, promoting their photoinduced singlet oxygen production. The complexes exhibit significant phototoxicity toward pancreatic cancer cell monolayers, with phototoxic indices ranging from 580 to 760.
INORGANIC CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes have great potential as photosensitizers for photodynamic therapy. The modular architectures of these complexes allow for tuning of various properties such as cellular uptake, subcellular targeting, solubility, and light absorption. Many studies focus on systematic variation of ligands to investigate their impact on photophysical and photobiological performance. However, comparisons between Ru(II)-based PSs and other generations of PSs are scarce. Nonetheless, quantitative models based on PDT dose metrics are available for qualitative comparisons. This review summarizes the relevant studies on Ru(II)-containing PSs and their potential efficacy.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes are promising photosensitizers for photodynamic therapy with potential in oncology and antimicrobial fields. These complexes can be tuned for different photophysical properties and studies comparing their efficacy to other PSs are limited but possible using PDT dose metrics.
COORDINATION CHEMISTRY REVIEWS
(2022)
