Review
Health Care Sciences & Services
Andreea Barbu, Bogdan Neamtu, Marius Zahan, Gabriela Mariana Iancu, Ciprian Bacila, Vioara Miresan
Summary: Chronic wounds pose a major public health issue with high costs globally. An ideal wound dressing should possess various characteristics such as adhesion, non-antigenicity, biocompatibility, semi-permeability, and biodegradability. This paper explores the use of biopolymer materials, specifically alginate forms, in advanced wound healing applications, focusing on hydrogels, nanofibers networks, and 3D-scaffolds.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Engineering, Environmental
Laura Miranda-Calderon, Cristina Yus, Cristina Remirez de Ganuza, Monica Paesa, Guillermo Landa, Elena Tapia, Estela Perez, Marta Perez, Victor Sebastian, Silvia Irusta, Gracia Mendoza, Manuel Arruebo
Summary: Advanced medicated wound dressings fabricated by electrospinning and electrospraying provide dually controlled antibiotic release kinetics, effectively eradicating bacterial infections and preventing biofilm formation. They also exhibit no cytotoxicity to eukaryotic cells and have been proven effective in a chronic wound murine model.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Vojtech Pavlik, Lubos Sobotka, Jaroslav Pejchal, Martin Cepa, Kristina Nesporova, Monika Arenbergerova, Adela Mrozkova, Vladimir Velebny
Summary: The study compared the healing of chronic wounds treated with a standard silver dressing and a dressing containing octenidine antiseptic, finding that the octenidine dressing promoted wound healing, reduced wound slough, and observed direct effects of silver on wound cells during treatment.
Review
Biotechnology & Applied Microbiology
Wentao Shu, Yinan Wang, Xi Zhang, Chaoyang Li, Hanxiang Le, Fei Chang
Summary: Burn treatment is a challenging clinical issue with the future lying in the development of active dressings such as hydrogel dressings that can accelerate wound healing. Various treatment strategies for burns are reviewed, emphasizing the clinical value of hydrogel dressings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Materials Science, Biomaterials
Ana Beatriz Sousa, Artur P. Aguas, Mario A. Barbosa, Judite N. Barbosa
Summary: Successful wound healing involves three phases: inflammatory, proliferative, and remodeling. Chronic wounds are characterized by persistent inflammation that hampers the healing process. Macrophages play a crucial role in wound healing, promoting cleaning and phagocytosis at the early stage and then facilitating the resolution of inflammation, as well as expressing growth factors and cytokines needed for cell proliferation and tissue repair. In chronic wounds, the presence of pro-inflammatory M1 macrophages inhibits tissue repair. Immunomodulatory biomaterials are being explored as potential solutions to overcome the continued inflammatory phase that impairs chronic wound healing.
REGENERATIVE BIOMATERIALS
(2022)
Article
Dermatology
Sebastian P. Nischwitz, Daniel Popp, David Shubitidze, Hanna Luze, Robert Zrim, Klaus Klemm, Matthias Rapp, Herbert L. Haller, Manuel Feisst, Lars-Peter Kamolz
Summary: The study investigated the healing potential of Suprathel in chronic wounds and found a significant reduction in wound size after 8 weeks of treatment, with diabetic and old chronic wounds showing the most pronounced effect. Further research is needed to explore the full potential of advanced wound dressing materials.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Engineering, Biomedical
Le Wang, Wenfu Zheng, Qinghong Hou, Leni Zhong, Qizhen Li, Xingyu Jiang
Summary: In this study, L-thioproline and Boc-capped L-thioproline-decorated gold nanoparticles were used to develop wound dressings with potent antibacterial activity against multidrug-resistant bacteria. The dressings, composed of TBT-GNPs and bacterial cellulose, demonstrated excellent antimicrobial performance both in vitro and in vivo. Additionally, the dressings were breathable and stretchable, facilitating gas exchange and accelerating wound healing.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Marjan Mirhaj, Sheyda Labbaf, Mohamadreza Tavakoli, Amelia Seifalian
Summary: This article reviews widely used types of antibacterial wound dressings and emerging products, with a focus on antibiotics and antibacterial nanoparticles. The perspectives and challenges for future research in this field are also discussed.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Polymer Science
Ilayda Firlar, Mine Altunbek, Colleen McCarthy, Murugan Ramalingam, Gulden Camci-Unal
Summary: Chronic wounds have a severe impact on 1-2% of the population in developed countries. The treatment of chronic wounds is crucial for the well-being and quality of life of patients. Hydrogel dressings, with their functional properties and advantages, have emerged as a promising choice for the treatment of chronic wounds.
Article
Cell & Tissue Engineering
Tayyba Sher Waris, Syed Tahir Abbas Shah, Azra Mehmood, Zohaib Iqbal, Mubashra Zehra, Aqif Anwar Chaudhry, Ihtesham Ur Rehman, Muhammad Yar
Summary: This research investigates the angiogenic and wound healing abilities of thyroxine/heparin-based cotton wound dressing. The results suggest that thyroxine possesses greater potential for angiogenesis and wound healing than heparin.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Marta Torregrossa, Ainur Kakpenova, Jan C. Simon, Sandra Franz
Summary: Nonhealing chronic wounds are common skin disorders with dissatisfying treatment. Macrophages have been highlighted in therapeutic approaches targeting the sustained inflammatory process, particularly in chronic wounds, utilizing ECM-inspired wound dressing materials for modulation strategies.
BIOLOGICAL CHEMISTRY
(2021)
Article
Medicine, General & Internal
Nessr Abu Rached, Susanne Kley, Martin Storck, Thomas Meyer, Markus Stuecker
Summary: The study aimed to investigate the effect of cold plasma therapy on chronic wounds. The results showed that cold plasma therapy significantly accelerates wound closure, reduces antibiotic therapy, relieves pain, and improves quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Environmental
Yuelong Niu, Jun Zhang, Jian Sun, Xinge Zhang, Zhongming Wu
Summary: The pathogenic bacteria-induced diabetic ulcer is a serious problem due to poor healing, but a non-antibiotic strategy utilizing a nanostructure with photothermal therapy shows promise in targeting and killing bacteria, promoting wound healing in diabetic rats.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Ovidio Catanzano, Fabiana Quaglia, Joshua S. Boateng
Summary: Recent research has shifted focus from passive wound dressings to advanced dressings that actively promote wound healing. The use of growth factors (GFs) to accelerate wound healing and reduce scar formation is considered a feasible therapeutic approach, with the integration of micro- and nanotechnologies offering control over GF release rates. Multiple studies have shown promising outcomes in in vitro and in vivo wound models, leading to the expectation that some of these technologies will meet clinical needs and become commercially available.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Biochemistry & Molecular Biology
K. Ngece, B. A. Aderibigbe, D. T. Ndinteh, Y. T. Fonkui, P. Kumar
Summary: Biopolymer alginate-gum acacia sponges loaded with antibiotics demonstrated high absorption capacity and good clotting capability in simulating wound exudates and blood environments, showing potential for treating various types of wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Surgery
Alexandra M. Anker, Lukas Prantl, Magnus Baringer, Marc Ruewe, Silvan M. Klein
Summary: This study found that not using closed-suction drains in abdominoplasty procedures for patients with a BMI <= 30 did not increase the risk of seroma accumulation or complications, but significantly reduced the length of hospital stay.
HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE
(2021)
Article
Surgery
Alexandra M. Anker, Oliver Felthaus, Lukas Prantl, Sebastian Geis, Vanessa Brebant, Andreas Kehrer, Catharina Strauss, Marc Ruewe, Jody Vykoukal, Silvan M. Klein
Summary: The study demonstrated that local administration of triamcinolone significantly reduced postabdominoplasty seroma accumulation and led to a decrease in levels of inflammatory mediators IL-6 and MMP-9. The suppression of inflammatory markers correlated clinically with a decrease in seroma accumulation.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Hematology
Catharina Strauss, Alexandra Anker, Silvan Klein, Robert Kemper, Vanessa Brebant, Lukas Prantl, Sebastian Geis
Summary: This study evaluated the feasibility of using the perfusion index (PI) as a monitoring tool for free flaps and replanted digits. The results showed a significant intra- and interindividual range of PI and pulse oxygen saturation (SpO2). Trends in intraindividual PI changes may be a promising monitoring tool for free flaps and replanted digits.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2022)
Article
Surgery
Andreas Kehrer, Paul Heidekrueger, Daniel Lonic, Silvan Klein, Alexandra Anker, Christian Taeger, Niklas Biermann, Ernst Michael Jung, Lukas Prantl, Natascha Platz Batista da Silva
Summary: This study evaluates the key factors for designing perforator flaps using high-resolution color-coded duplex sonography (CCDS), including device trimming, ultrasound mode selection, and qualitative and quantitative evaluation methods. The research identifies the key steps for safe perforator identification and further assessment, and proposes a standardized protocol for CCDS exams.
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2022)
Article
Surgery
Alexandra M. Anker, Marc Ruewe, Lukas Prantl, Sebastian Geis, Andreas Kehrer, Magnus Baringer, Daniel Schiltz, Florian Zeman, Jody Vykoukal, Silvan M. Klein
Summary: This study aims to identify modifiable risk factors for impaired healing in pressure sore patients and establish a prognostic scoring system (A-PePSI) to assess individual healing risk.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Cell Biology
Antonia Foerch, Susanne Wallner, Florian Zeman, Tobias Ettl, Christoph Brochhausen, Stephan Schreml
Summary: This study investigated the expression profiles of TASK1, TASK3, GPR31, and GPR151 in different types of skin tumors. The results showed that these proteins were expressed in most skin tumors, with different expression patterns observed between basal cell carcinomas and squamous cell carcinomas. The findings highlight the potential importance of these channels in the development of skin tumors.
Letter
Surgery
Alexandra M. Anker, Lukas Prantl, Jody Vykoukal, Silvan M. Klein
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Oncology
Jonas Eichberger, Florian Weber, Gerrit Spanier, Michael Gerken, Stephan Schreml, Daniela Schulz, Mathias Fiedler, Nils Ludwig, Richard Josef Bauer, Torsten Eugen Reichert, Tobias Ettl
Summary: Oral squamous cell carcinoma (OSCC) growth into mandible presents challenges in head and neck surgery, impacting aesthetics, function, and patient's quality of life. Investigating the role of MMP-27, Osteoprotegerin, and RANKL in bone invasion, it was found that reduced MMP-27 expression was strongly associated with invasive tumor growth and mandibular bone invasion. Further studies are needed to elucidate the molecular mechanisms of mandibular bone invasion in OSCC.
Article
Cell Biology
Friedrich Barsch, Andreas Mamilos, Volker H. Schmitt, Maximilian Babel, Lina Winter, Willi Wagner, Hinrich Winther, Christian Ottomann, Tanja Niedermair, Stephan Schreml, Helmut Hierlemann, Christoph Brochhausen
Summary: Synthetic macroporous biomaterials are widely used in skin tissue engineering to mimic native dermis functions. However, they often face limitations due to unfavorable foreign body responses. This study compared the foreign body responses of two different 3D matrix designs and found that the matrix design significantly affected the responses.
Article
Cell Biology
Silvan Klein, Andreas Siegmund, Andreas Eigenberger, Valerie Hartmann, Felix Langewost, Nicolas Hammer, Alexandra Anker, Konstantin Klein, Christian Morsczeck, Lukas Prantl, Oliver Felthaus
Summary: The study investigated three differentiation protocols for differentiating rat ASCs into specialized SC phenotypes, comparing their expressions of neurotrophins and myelin markers. The results showed diverse expression profiles of differentiated ASCs, with different protocols inducing varying levels of expression of neurotrophins and myelin markers.
Article
Biochemistry & Molecular Biology
Bernadett Kurz, Hannah Philine Michael, Antonia Foerch, Susanne Wallner, Florian Zeman, Sonja-Maria Decking, Ines Ugele, Constantin Hintschich, Frank Haubner, Tobias Ettl, Kathrin Renner, Christoph Brochhausen, Stephan Schreml
Summary: TRPCs are important in tumor biology, particularly in Ca2+ homeostasis in cancer cells. TRPC4, a pH-sensitive protein, may function as a signaling molecule in the altered tumor microenvironment due to the reversed pH-gradient in solid tumors. The study investigated TRPC4 expression profiles in common skin cancers, revealing that SCC, NCN, and MM show positive TRPC4-expression, while BCC only does so in about half of the analyzed samples. This finding suggests TRPC4 as an immunohistochemical marker to distinguish SCC and BCC and warrants further research on its role in tumor progression and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Andreas Mamilos, Lina Winter, Volker H. Schmitt, Friedrich Barsch, David Grevenstein, Willi Wagner, Maximilian Babel, Karsten Keller, Christine Schmitt, Florian Guertler, Stephan Schreml, Tanja Niedermair, Markus Rupp, Volker Alt, Christoph Brochhausen
Summary: Macrophages have a significant impact on the biocompatibility and degradation of implanted biomaterials, making them important in biomaterial-based tissue engineering and regeneration. Understanding their functionality allows for guiding and modulating inflammation towards regeneration. This knowledge improves scaffold material biocompatibility, integration, maturation, preservation, and regeneration.
Article
Biochemistry & Molecular Biology
Vignesh Ramakrishnan, Rebecca Schoenmehl, Annalena Artinger, Lina Winter, Hendrik Boeck, Stephan Schreml, Florian Guertler, Jimmy Daza, Volker H. Schmitt, Andreas Mamilos, Pablo Arbelaez, Andreas Teufel, Tanja Niedermair, Ondrej Topolcan, Marie Karlikova, Samuel Sossalla, Christoph B. Wiedenroth, Markus Rupp, Christoph Brochhausen
Summary: In this paper, a pipeline of vision algorithms is proposed to visualize and analyze 3D blood vessels from tissue samples. The technique involves blood vessel segmentation using a U-net neural network, image registration for alignment, and branching analysis using a skeletonization algorithm. This method is useful for researchers, pathologists, and doctors in understanding vascular morphogenesis and potential diagnostic applications under different pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Philipp von Breitenbuch, Bernadett Kurz, Susanne Wallner, Florian Zeman, Christoph Brochhausen, Hans-Juergen Schlitt, Stephan Schreml
Summary: Solid tumors have a unique metabolism that affects their pH gradient and signaling mechanisms. A study on peritoneal carcinomatosis found lower expression of GPR4 and GPR68, pH-GPCRs, compared to other pH-GPCRs, which could potentially be targeted for future therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Mathias Fiedler, Alisa Off, Jonas Eichberger, Steffen Spoerl, Johannes G. Schuderer, Juergen Taxis, Richard J. Bauer, Stephan Schreml, Torsten E. Reichert, Tobias Ettl, Florian Weber
Summary: A significant number of patients with oral squamous cell carcinoma do not have the typical risk factors of smoking and alcohol consumption. These patients are more likely to be female and older at the time of diagnosis, and have a higher incidence of oral potentially malignant disorders and a better prognosis. Never-smokers/never-drinkers also have distinct characteristics and a more immunogenic microenvironment, which may help in improving the treatment of oral squamous cell carcinoma in this population.