Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
Volume 367, Issue 1887, Pages 391-409Publisher
ROYAL SOC
DOI: 10.1098/rsta.2008.0229
Keywords
heart rate variability; cardiovascular variability; cardiovascular regulation; multi-channel signal processing; closed-loop identification; Granger's causality
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Funding
- ASI
- DCMC
- EU
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Cardiovascular ( CV) variability as a primary vital sign carrying information about CV regulation systems is reviewed by pointing out the role of the main rhythms and the various control and functional systems involved. The high complexity of the addressed phenomena fosters a multimodal approach that relies on data analysis models and deals with the ongoing interactions of many signals at a time. The importance of closed-loop identification and causal analysis is remarked upon and basic properties, application conditions and methods are recalled. The need of further integration of CV signals relevant to peripheral and systemic haemodynamics, respiratory mechanics, neural afferent and efferent pathways is also stressed.
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