Article
Biochemistry & Molecular Biology
Laeticia Scherler, Sofia N. Verouti, Daniel Ackermann, Bruno Vogt, Genevieve Escher
Summary: In this study, adenine was used to induce nephropathy in mice, showing the loss of protective effects of renal cholesterol and vitamin D-3 metabolism under this condition. It was found that adenine enhanced cholesterol efflux and eliminated lipids in feces, which had a protective effect against atherosclerosis but also affected bone growth.
Article
Multidisciplinary Sciences
Gregory E. Bigford, Angela Szeto, John Kimball, Edward E. Herderick, Armando J. Mendez, Mark S. Nash
Summary: The study conducted in mice with a double mutation of the ApoE gene found that spinal cord injury accelerates the development of atherosclerotic disease (AD), while Salsalate anti-inflammatory treatment can attenuate the impact of SCI on AD. Aortic AD lesion significantly increased after SCI, and Salsalate treatment showed a reduction in this effect.
Article
Rehabilitation
Sugalya Amatachaya, Narongsak Khamnon, Pattra Wattanapan, Arpassanan Wiyanad, Thiwabhorn Thaweewannakij, Wilairat Namwong
Summary: The study aimed to establish the reference values and optimal cutoff scores of the Spinal Cord Independence Measure Version III (SCIM III) for indicating independence in wheelchair users and ambulatory individuals with spinal cord injury (SCI). The results showed a significant correlation between SCIM III scores and levels of independence. SCIM III scores of >= 55 and >= 75 were found to be optimal indicators of modified independence in wheelchair users and ambulatory individuals, respectively, and a score of 90 was identified as an excellent indicator of independence in ambulatory individuals. These findings provide important reference values for assessing and setting functional goals for individuals with SCI in various settings.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Multidisciplinary Sciences
Mathangi Janakiraman, Shin-Young Na, Gurumoorthy Krishnamoorthy
Summary: A novel CD4 mutant allele was identified in this study, causing impaired development of CD4(+) helper T cells. The CRISPR mediated correction restored the normal expression of CD4, validating the significance of this mouse model for the study of CD4(+) T cells.
Article
Food Science & Technology
Marco Busnelli, Stefano Manzini, Alice Colombo, Elsa Franchi, Mitja Laaperi, Reijo Laaksonen, Giulia Chiesa
Summary: This study evaluates the effects of different diets on plasma and aorta lipidome in an athero-prone mouse model. Results show that the cholesterol and fatty acid content of the diets are the main factors affecting lipid accumulation in plasma and aorta. Furthermore, specific lipids such as lactosylceramide, glucosyligalactosylceramide, and individual ceramide species are found to accumulate in diseased aortic segments, serving as markers of atherosclerosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Maria Pechlivanidou, Ioanna Kousiappa, Stella Angeli, Irene Sargiannidou, Andreas M. Koupparis, Savvas S. Papacostas, Kleopas A. Kleopa
Summary: This study examined the changes in glial gap junctions (GJs) in the spinal cord of the 5xFAD mouse model of Alzheimer's disease (AD). The results showed increased astrocyte-to-astrocyte GJ connectivity and oligodendrocyte-to-oligodendrocyte GJ connectivity. Additionally, Cx32 protein levels were reduced while mRNA levels were upregulated. The findings suggest the importance of GJ pathology in neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Curtis A. Benson, Kai-Lan Olson, Siraj Patwa, Marike L. Reimer, Lakshmi Bangalore, Myriam Hill, Stephen G. Waxman, Andrew M. Tan
Summary: Research using viral intervention techniques in mice after spinal cord injury found that knocking out Rac1 protein can restore dendritic spine development and reduce H-reflex excitability, thereby reversing spasticity. This indicates a potential mechanistic relationship between abnormal motor neuron dendritic spines and spasticity induced by SCI.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Weiyi Zhao, Natalie Gasterich, Tim Clarner, Clara Voelz, Victoria Behrens, Cordian Beyer, Athanassios Fragoulis, Adib Zendedel
Summary: This study suggests that activation of Nrf2 in astrocytes protects against spinal cord injury by reducing oxidative damage and neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Medicine, General & Internal
Christina Salchow-Hommen, Thomas Schauer, Philipp Muller, Andrea A. Kuhn, Ursula S. Hofstoetter, Nikolaus Wenger
Summary: The study developed an automated tSCS setup to improve spasticity control and enhance voluntary movement in SCI and multiple sclerosis patients; testing results showed consistent electrode positions and tSCS amplitudes settings in most cases, thus finding clinically suitable tSCS therapy settings; these technological developments may facilitate the dissemination of tSCS into non-academic environments and broaden its use for diagnostic and therapeutic purposes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Isaura Martins, Dalila Neves-Silva, Mariana Ascensao-Ferreira, Ana Filipa Dias, Daniel Ribeiro, Ana Filipa Isidro, Raquel Quiteria, Diogo Paramos-de-Carvalho, Nuno L. Barbosa-Morais, Leonor Saude
Summary: Traumatic spinal cord injury leads to cellular events that result in tissue loss and neuroinflammation. The disruption of the blood-spinal cord barrier allows immune cells to infiltrate and creates a toxic microenvironment that hinders axonal regeneration. Understanding the vascular response to injury is crucial for improving spinal cord repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Lydia E. Strattan, Daimen R. S. Britsch, Chris M. Calulot, Rachel S. J. Maggard, Erin L. Abner, Lance A. Johnson, Warren J. Alilain
Summary: Spinal cord injuries can result in loss of motor and sensory function throughout the body, with limited spontaneous recovery. Gender and genetic background may influence treatment response, with the APOE gene playing a significant role in therapy.
Article
Neurosciences
Naazneen Khan, Yelena Alimova, Sophie J. Clark, Hemendra J. Vekaria, Adeline E. Walsh, Holden C. Williams, Gregory S. Hawk, Patrick G. Sullivan, Lance A. Johnson, Timothy S. McClintock
Summary: The study investigated the effects of APOE genotype on the mouse olfactory epithelium and found that the phenotypic differences caused by APOE alleles were apparent in early adulthood, with an increase in neuronal loss by middle age. The olfactory epithelium is a suitable model for studying age-dependent effects associated with the progression of Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biology
Murtaza S. Nagree, Jitka Rybova, Annie Kleynerman, Carissa J. Ahrenhoerster, Jennifer T. Saville, TianMeng Xu, Maxwell Bachochin, William M. McKillop, Michael W. Lawlor, Alexey V. Pshezhetsky, Olena Isaeva, Matthew D. Budde, Maria Fuller, Jeffrey A. Medin
Summary: Mutations in the ASAH1 gene are associated with two distinct disorders, Farber disease (FD) and spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME). This study describes a mouse model with an SMA-PME-like phenotype (P361R-SMA) caused by a specific mutation in the ASAH1 gene. The P361R-SMA mice show progressive ataxia, bladder dysfunction, demyelination, loss of axons, and altered sphingolipid levels in the spinal cords, providing a valuable tool for studying the effects of ASAH1 deficiency and evaluating potential therapies for SMA-PME.
COMMUNICATIONS BIOLOGY
(2023)
Article
Physiology
Tomoaki Ito, Harumi Saeki, Xin Guo, Polina Sysa-Shah, Kellie L. Tamashiro, Richard S. Lee, Shun Ishiyama, Hajime Orita, Koichi Sato, Malcolm Brock, Kathleen Gabrielson
Summary: Children born to women who experience stress during pregnancy have an increased risk of atherosclerosis in later life. Using a mouse model, it was found that prenatal stress could lead to increased plaque formation and aortic inflammation.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Immunology
Carla Lima, Adolfo Luis Almeida Maleski, Jefferson Thiago Goncalves Bernardo, Vitor Cataldi Zelli, Evilin Naname Komegae, Monica Lopes-Ferreira
Summary: TnP, a patented synthetic peptide, shows potential as a therapeutic drug for multiple sclerosis (MS) by modulating the immune system and promoting neuronal regeneration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Clayton W. Winkler, Tyson A. Woods, Bradley R. Groveman, Aaron B. Carmody, Emily E. Speranza, Craig A. Martens, Sonja M. Best, Cathryn L. Haigh, Karin E. Peterson
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Immunology
Clayton W. Winkler, Alyssa B. Evans, Aaron B. Carmody, Karin E. Peterson
JOURNAL OF IMMUNOLOGY
(2020)
Article
Microbiology
Michal Caspi Tal, Laughing Bear Torrez Dulgeroff, Lara Myers, Lamin B. Cham, Katrin D. Mayer-Barber, Andrea C. Bohrer, Ehydel Castro, Ying Ying Yiu, Cesar Lopez Angel, Ed Pham, Aaron B. Carmody, Ronald J. Messer, Eric Gars, Jens Kortmann, Maxim Markovic, Michaela Hasenkrug, Karin E. Peterson, Clayton W. Winkler, Tyson A. Woods, Paige Hansen, Sarah Galloway, Dhananjay Wagh, Benjamin J. Fram, Thai Nguyen, Daniel Corey, Raja Sab Kalluru, Niaz Banaei, Jayakumar Rajadas, Denise M. Monack, Aijaz Ahmed, Debashis Sahoo, Mark M. Davis, Jeffrey S. Glenn, Tom Adomati, Karl S. Lang, Irving L. Weissman, Kim J. Hasenkrugc
Article
Multidisciplinary Sciences
Bradley R. Groveman, Natalia C. Ferreira, Simote T. Foliaki, Ryan O. Walters, Clayton W. Winkler, Brent Race, Andrew G. Hughson, Gianluigi Zanusso, Cathryn L. Haigh
Summary: The study demonstrates the potential of using human cerebral organoids as a model for screening therapeutic drug candidates for human prion diseases, showing success in identifying an anti-CJD drug through this model.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Rahul Basu, Vinod Nair, Clayton W. Winkler, Tyson A. Woods, Iain D. C. Fraser, Karin E. Peterson
Summary: The study found that BCECs isolated from adult and weanling mice have differential viral load, infectivity, and susceptibility to LACV. These age-related differences in susceptibility may strongly influence LACV-induced BBB leakage and neurovascular damage allowing virus invasion of the CNS and the development of neurological disease.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Virology
Brent Race, Katie Williams, Chase Baune, James F. Striebel, Clayton W. Winkler, James A. Carroll, Sandra E. Encalada, Bruce Chesebro
Summary: The study did not find any differences in PrPSc spread, distribution, or survival times between KIF5C knock-out mice and control mice.
Article
Microbiology
Durbadal Ojha, Clayton W. Winkler, Jacqueline M. Leung, Tyson A. Woods, Catherine Z. Chen, Vinod Nair, Katherine Taylor, Charles D. Yeh, Gregory J. Tawa, Charles L. Larson, Wei Zheng, Cathryn L. Haigh, Karin E. Peterson
Summary: Rottlerin has been identified as a potent inhibitor of LACV-induced neuronal cell death, with strong antiviral effects in multiple cell lines and even reducing viral replication. In mouse experiments, Rottlerin reduced disease development and replication of other pathogenic orthobunyaviruses, showing promise as a potential treatment for viral encephalitis.
NATURE MICROBIOLOGY
(2021)
Article
Neurosciences
Clayton W. Winkler, Chad S. Clancy, Rebecca Rosenke, Karin E. Peterson
Summary: This study used a mouse model to investigate the impact of vertically transmitted ZIKV infection on neonatal survival and brain development. Modulation of infection dose and treatment frequency extended neonatal survival, leading to chronic ZIKV infection in the brain and structural abnormalities and cell death in multiple brain regions.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Anna Smith, Bradley R. Groveman, Clayton Winkler, Katie Williams, Ryan Walters, Jue Yuan, Wenquan Zou, Karin Peterson, Simote T. Foliaki, Cathryn L. Haigh
Summary: This study developed a cerebral organoid model to investigate the factors that trigger prion protein misfolding. The results showed that neither oxidative stress nor Herpes Simplex Type-1 virus can induce misfolding of E200K prion protein in the organoid system.
Article
Multidisciplinary Sciences
Sydney B. Stein, Sabrina M. Ramelli, Alison A. Grazioli, Joon-Yong S. Chung, Manmeet R. Singh, Claude Kwe R. Yinda, Clayton E. Winkler, Junfeng Sun, James P. Dickey, Kris A. Ylaya, Sung Hee H. Ko, Andrew A. Platt, Peter Burbelo, Martha Quezado, Stefania Pittaluga, Madeleine Purcell, Vincent Munster, Frida Belinky, Marcos Ramos-Benitez, Eli Boritz, Izabella W. Lach, Daniel Herr, Joseph D. Rabin, Kapil Saharia, Ronson Madathil, Ali Tabatabai, Shahabuddin Soherwardi, Michael McCurdy, Karin E. Peterson, Jeffrey I. Cohen, Emmie de Wit, Kevin M. Vannella, Stephen M. Hewitt, David E. Kleiner, Daniel S. Chertow
Summary: This study provides new insights into the extent of COVID-19 infection in patients. It reveals that SARS-CoV-2 can be widely distributed throughout the body, including the brain, and can persist for up to 230 days, particularly in severe cases.
Article
Multidisciplinary Sciences
Rahul Basu, Sundar Ganesan, Clayton W. Winkler, Sarah L. Anzick, Craig Martens, Karin E. Peterson, Iain D. C. Fraser
Summary: Viral encephalitis is characterized by the ability of virus to enter the central nervous system (CNS). This study found that La Crosse Virus primarily induces encephalitis in children rather than adults, which was also observed in mouse models. Transcriptomics and siRNA screening identified Connexin43 and EphrinA2 as key mediators of LACV-induced neuroinvasion and neurological disease.
NATURE COMMUNICATIONS
(2023)
Article
Infectious Diseases
Alyssa B. Evans, Clayton W. Winkler, Sarah L. Anzick, Stacy M. Ricklefs, Dan E. Sturdevant, Karin E. Peterson
Summary: This study found that there is little restriction on Zika virus (ZIKV) diversity during transmission from the placenta to the fetus at early stages. However, there is a sharp decrease in ZIKV diversity in both fetal bodies and fetal brains at late stages, suggesting possible selection for certain variants during neuroinvasion of ZIKV into fetal brains.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Meeting Abstract
Immunology
Clayton W. Winkler, Alyssa B. Evans, Aaron B. Carmody, Karin E. Peterson
JOURNAL OF IMMUNOLOGY
(2020)
Article
Cell Biology
Kevin M. Vannella, Sydney Stein, Mark Connelly, Joanna Swerczek, Emerito Amaro-Carambot, Elizabeth M. Coyle, Ashley Babyak, Clayton W. Winkler, Greg Saturday, Neville D. Gai, Dima A. Hammoud, Kimberly A. Dowd, Luis Perez Valencia, Marcos J. Ramos-Benitez, Jason Kindrachuk, Theodore C. Pierson, Karin E. Peterson, Jason M. Brenchley, Steve S. Whitehead, Surender Khurana, Richard Herbert, Daniel S. Chertow
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Immunology
Alyssa B. Evans, Clayton W. Winkler, Karin E. Peterson
EMERGING INFECTIOUS DISEASES
(2019)
Article
Behavioral Sciences
Amine Bahi
Summary: Gestational environmental enrichment (EE) has protective effects on social stress-induced anxiety-like behaviors and excessive ethanol consumption through increasing BDNF levels.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Sarabesh Natarajan, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, Edward D. Levin
Summary: Multiple neural systems, including dopamine D1 receptors and glutamate NMDA receptors, are involved in nicotine reinforcement. Acute blockade of D1 receptors decreases nicotine self-administration, while acute blockade of NMDA receptors increases it. Chronic blockade of NMDA receptors decreases nicotine self-administration. Memantine attenuates the decrease in nicotine self-administration caused by chronic D1 antagonist SCH-23390.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
David R. Maguire
Summary: The study found that Lorcaserin alone reduces ventilation and enhances the ventilatory-depressant effects of opioids. This suggests that combining a 5-HT2C receptor agonist with opioids may increase the risk of ventilatory depression without reducing abuse.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Fen Liu, Qing Tian, Hui-Ling Tang, Xiang Cheng, Wei Zou, Ping Zhang
Summary: This study demonstrates the attenuating effect of H2S on PD-associated depression by improving hippocampal synaptic plasticity.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Mehrsa Rahimi-Danesh, Mohammad-Ali Samizadeh, Amir-Ehsan Sajadi, Tara Rezvankhah, Salar Vaseghi
Summary: This study investigated the effects of lithium on freezing behavior and pain perception in a fear-conditioning model in rats. The results showed that lithium had no effect on freezing behavior and pain subthreshold in all rats. Extinction training decreased freezing behavior, with more efficacy in females. Gender differences were also observed in the effects of extinction training.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)