Article
Chemistry, Analytical
Botao Lu, Penghui Fan, Yiding Wang, Yuchuan Dai, Jingyu Xie, Gucheng Yang, Fan Mo, Zhaojie Xu, Yilin Song, Juntao Liu, Xinxia Cai
Summary: Defense is the basic survival mechanism of animals when facing dangers. This study found that the neuronal activities of dPAG play a crucial role in controlling different types of predator odor-evoked innate fear/defensive behaviors, with stronger activation during the flight stage. The results provide guidance for predicting defense behavior.
Article
Neurosciences
Li-Feng Yeh, Takaaki Ozawa, Joshua P. Johansen
Summary: The dorsolateral subregion of the PAG (dlPAG) plays a key role in memory formation in response to aversive events, while the ventrolateral PAG (vlPAG) does not have the same effect. In addition, specific populations of thalamus-projecting dlPAG neurons projecting to the anterior paraventricular thalamus (aPVT) can affect aversive learning, but do not impact previously learned defensive behaviors.
Article
Biology
Weisheng Wang, Peter J. Schuette, Mimi Q. La-Vu, Anita Torossian, Brooke C. Tobias, Marta Ceko, Philip A. Kragel, Fernando M. C. Reis, Shiyu Ji, Megha Sehgal, Sandra Maesta-Pereira, Meghmik Chakerian, Alcino J. Silva, Newton S. Canteras, Tor Wager, Jonathan C. Kao, Avishek Adhikari
Summary: The study showed that PMd-cck cells in mice are activated during escape, and inhibition of the PMd decreases escape speed. The PMd-dlPAG circuit is identified as a central node controlling escape behavior in response to threats.
Article
Multidisciplinary Sciences
Tianye Jia, Chao Xie, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Christian Buechel, Erin Burke Quinlan, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Trevor W. Robbins, Jianfeng Feng
Summary: Using neural imaging techniques, a study explored the neural network underlying alcoholism onset in adolescents. It identified a network centered on the medial orbitofrontal cortex, with evidence of inhibitory and excitatory coregulation by this region over the dorsal periaqueductal gray. Additionally, the study found significant relationships between baseline excitatory coregulation in this network and impulsivity, supporting the role of negative urgency in alcohol dependence.
Article
Multidisciplinary Sciences
Ricardo P. Bindi, Cibele C. Guimaraes, Amanda R. de Oliveira, Fernando F. Melleu, Miguel A. X. de Lima, Marcus V. C. Baldo, Simone C. Motta, Newton S. Canteras
Summary: The present study systematically analyzed the afferent and efferent projections of the CUN and investigated its role in fear responses. The CUN was found to be a caudal component of the periaqueductal gray and had strong links with the dorsolateral periaqueductal gray. It was also found to mediate innate antipredatory responses but not learned fear responses.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Neurosciences
Fernando M. C. V. Reis, Dean Mobbs, Newton S. Canteras, Avishek Adhikari
Summary: This article discusses the central role of the midbrain periaqueductal gray (PAG) in controlling various defensive responses and explores how PAG-centered circuits influence both innate and learned defensive actions in rodents and humans. It highlights the use of traditional methods like lesions, electrical stimulation, and pharmacology, as well as recent advancements in neural activity imaging and anatomical and genetic control methods to gain a better understanding of PAG function.
Article
Biology
Mimi Q. La-Vu, Ekayana Sethi, Sandra Maesta-Pereira, Peter J. Schuette, Brooke C. Tobias, Fernando M. C. Reis, Weisheng Wang, Anita Torossian, Amy Bishop, Saskia J. Leonard, Lilly Lin, Catherine M. Cahill, Avishek Adhikari
Summary: This study reveals the role of specific cells in the midbrain periaqueductal gray in regulating defensive behaviors. Activation or inhibition of certain cells can induce either flight or freezing responses, respectively. The activity of these cells is associated with the distance and location of the threat.
Article
Biology
B. B. de Paula, E. B. Vieira-Rasteli, F. Calvo, N. C. Coimbra, C. R. A. Leite-Panissi
Summary: This study evaluated the activation pattern of the periaqueductal gray matter (PAG) in guinea pigs during unconditioned and conditioned fear situations using a prey vs predator paradigm. The results showed that the lateral column of the PAG exhibited higher activation of Fos-labeled cells when facing predators, suggesting the recruitment of specific PAG columns may depend on the nature of the threatening stimulus.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Neurosciences
Fernando M. C. V. Reis, Jinhan Liu, Peter J. Schuette, Johannes Y. Lee, Sandra Maesta-Pereira, Meghmik Chakerian, Weisheng Wang, Newton S. Canteras, Jonathan C. Kao, Avishek Adhikari
Summary: The study reveals that the dorsal periaqueductal gray (dPAG) uses shared patterns of activity to encode distance and predict defensive behaviors when encountering threats, indicating its crucial role in defensive responses.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Matthew B. Pomrenze, Leigh C. Walker, William J. Giardino
Summary: This article delves into the importance of midbrain nuclei like EW and DR in the neural circuitry of addiction, emphasizing the contribution of these neurons in affecting addictive behaviors. It also explores the connectivity between EW and DR, as well as their potential roles in addiction-related behaviors.
Article
Behavioral Sciences
Pia R. Stettler, Diogo F. Antunes, Barbara Taborsky
Summary: The study found that the 5-HT1A receptor plays an important role in regulating aggressive, submissive, and affiliative behavior in the cooperatively-breeding cichlid Neolamprologus pulcher. The agonist increased aggression and decreased submission and affiliation, while the antagonist had opposite effects.
HORMONES AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Long Li, Romain Durand-de Cuttoli, Antonio V. Aubry, C. Joseph Burnett, Flurin Cathomas, Lyonna F. Parise, Kenny L. Chan, Carole Morel, Chongzhen Yuan, Yusuke Shimo, Hsiao-yun Lin, Jun Wang, Scott J. Russo
Summary: Research shows that following chronic social defeat stress, a subset of male and female mice tend to avoid social interaction with non-aggressive, same-sex juvenile C57BL/6J mice and do not exhibit context-dependent social reward after encounters. This avoidance behavior seems to be linked to the activation of specific stress-responsive neurons in the lateral septum, which interferes with social reward processing.
Article
Multidisciplinary Sciences
Long Li, Romain Durand-de Cuttoli, Antonio V. Aubry, C. Joseph Burnett, Flurin Cathomas, Lyonna F. Parise, Kenny L. Chan, Carole Morel, Chongzhen Yuan, Yusuke Shimo, Hsiao-yun Lin, Jun Wang, Scott J. Russo
Summary: Traumatic social experiences in humans can lead to psychiatric disorders. In rodents, little is known about the impact of social trauma on social reward. A study on the chronic social defeat stress (CSDS) model in mice suggests that previously rewarding social targets are perceived as threats in susceptible mice.
Article
Behavioral Sciences
Heloisa H. Vilela-Costa, Jhonatan Christian Maraschin, Plinio C. Casarotto, Ana Beatriz Sant'Ana, Valquiria C. de Bortoli, Maria Adrielle Vicente, Alline Cristina Campos, Francisco S. Guimaraes, Helio Zangrossi Jr
Summary: Antidepressant drugs are effective in treating panic disorder, with facilitation of 5-HT1A receptors in the dPAG implicated in panic relief. The panicolytic effect caused by chronic administration of ADs may be related to 5-HT1A receptor-mediated neurotransmission, while the anxiogenic effect of short-term treatment with these drugs may not depend on 5-HT2C receptors.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Neurosciences
Konstanze Simbriger, Ines S. Amorim, Gilliard Lach, Kleanthi Chalkiadaki, Stella Kouloulia, Seyed Mehdi Jafarnejad, Arkady Khoutorsky, Christos G. Gkogkas
Summary: Contextual fear conditioning is a common behavioral paradigm used in neuroscience research to study the mechanisms of learning and memory. Using ribosome profiling, a study demonstrated that an immediate shock in male mice leads to translational and transcriptional changes in Immediate Early Genes in the dorsal hippocampus, an effect often overlooked in research.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Neurosciences
Amanda R. de Oliveira, Adriano E. Reimer, Fernando M. C. V. Reis, Marcus L. Brandao
EXPERIMENTAL BRAIN RESEARCH
(2017)
Article
Behavioral Sciences
M. C. Carvalho, A. C. Veloni, K. Genaro, M. L. Brandao
NEUROBIOLOGY OF LEARNING AND MEMORY
(2018)
Article
Neurosciences
Adriano Edgar Reimer, Amanda Ribeiro de Oliveira, Juliana Belo Diniz, Marcelo Queiroz Hoexter, Euripedes Constantino Miguel, Mohammed Ragib Milad, Marcus Lira Brandao
Article
Neurosciences
Marcus L. Brandao, Norberto C. Coimbra
REVIEWS IN THE NEUROSCIENCES
(2019)
Article
Behavioral Sciences
Nayara C. B. Barroca, Mariana D. Guarda, Naiara T. da Silva, Ana C. Colombo, Adriano E. Reimer, Marcus L. Brandao, Amanda R. de Oliveira
BEHAVIOURAL PHARMACOLOGY
(2019)
Article
Oncology
Juliana Y. Sakita, Michael Bader, Emerson S. Santos, Sergio B. Garcia, Stefania B. Minto, Natalia Alenina, Mariangela O. Brunaldi, Milene C. Carvalho, Thiago Vidotto, Bianca Gasparotto, Ronaldo B. Martins, Wilson A. Silva, Marcus L. Brandao, Caio A. Leite, Fernando Q. Cunha, Gerard Karsenty, Jeremy A. Squire, Sergio A. Uyemura, Vinicius Kannen
JOURNAL OF PATHOLOGY
(2019)
Article
Clinical Neurology
Rebeca Machado Figueiredo, Milene Cristina de Carvalho, Marcus Lira Brandao, Thelma Anderson Lovick
JOURNAL OF PSYCHOPHARMACOLOGY
(2019)
Article
Clinical Neurology
Milene Cristina de Carvalho, Rebeca Machado de Figueiredo, Norberto Cysne Coimbra, Christie Ramos Andrade Leite-Panissi, Maria Angelica de Souza Silva, Joseph P. Huston, Claudia Mattern, Marcus Lira Brandao
JOURNAL OF PSYCHOPHARMACOLOGY
(2019)
Review
Psychiatry
M. L. Brandao, T. A. Lovick
TRANSLATIONAL PSYCHIATRY
(2019)
Article
Neurosciences
Thiago Oliari Ribeiro, Leticia Morais Bueno-de-Camargo, Ana Paula Farias Waltrick, Amanda Ribeiro de Oliveira, Marcus Lira Brandao, Carolina Demarchi Munhoz, Janaina Menezes Zanoveli
PSYCHOPHARMACOLOGY
(2020)
Article
Multidisciplinary Sciences
Laura A. Leon, Marcus L. Brandao, Fernando P. Cardenas, Diana Parra, Thomas E. Krahe, Antonio Pedro Mello Cruz, J. Landeira-Fernandez
Article
Neurosciences
Geiza Fernanda Antunes, Flavia Venetucci Gouveia, Fabiana Strambio Rezende, Midia Dias de Jesus Seno, Milene Cristina de Carvalho, Caroline Cruz de Oliveira, Lennon Cardoso Tosati dos Santos, Marina Correia de Castro, Mayra Akemi Kuroki, Manoel Jacobsen Teixeira, Jose Pinhata Otoch, Marcus Lira Brandao, Erich Talamoni Fonoff, Raquel Chacon Ruiz Martinez
NEUROBIOLOGY OF STRESS
(2020)
Article
Neurosciences
Vivian M. de Vita, Heloisa R. Zapparoli, Adriano E. Reimer, Marcus L. Brandao, Amanda R. de Oliveira
Summary: Dopamine mediates fear conditioning through its action on D2 receptors in the mesolimbic pathway, primarily influencing the expression rather than acquisition of conditioned fear. Sulpiride reduces the expression of fear without affecting extinction recall, while haloperidol has cataleptic and motor-impairing effects.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Psychiatry
Marcus L. Brandao, Manoel Jorge Nobre, Ruth Estevao
Summary: Fear and anxiety are responses to threatening environments or stimuli, depending on the distance of the threat. This study used virtual reality to examine the effects of threat intensity on behavior and physiological responses in volunteers, revealing a relationship between individual emotional susceptibility and anxiety development.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Debora Fabris, Milene C. Carvalho, Marcus L. Brandao, Wiliam A. Prado, Antonio W. Zuardi, Jose A. Crippa, Amanda R. de Oliveira, Thelma A. Lovick, Karina Genaro
Summary: CBD exhibits anxiolytic effects in both male and female rats, with potential mechanisms involving GABA(A) receptor expression in females and 5-HT1A receptor activation in males. The responsiveness of female rats to CBD is influenced by the stage of the estrous cycle, with higher responsiveness observed in the late diestrus phase. After sub-chronic treatment, female rats in late diestrus maintain their responsiveness to CBD, while those in proestrus remain unresponsive.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Behavioral Sciences
Amine Bahi
Summary: Gestational environmental enrichment (EE) has protective effects on social stress-induced anxiety-like behaviors and excessive ethanol consumption through increasing BDNF levels.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Sarabesh Natarajan, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, Edward D. Levin
Summary: Multiple neural systems, including dopamine D1 receptors and glutamate NMDA receptors, are involved in nicotine reinforcement. Acute blockade of D1 receptors decreases nicotine self-administration, while acute blockade of NMDA receptors increases it. Chronic blockade of NMDA receptors decreases nicotine self-administration. Memantine attenuates the decrease in nicotine self-administration caused by chronic D1 antagonist SCH-23390.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
David R. Maguire
Summary: The study found that Lorcaserin alone reduces ventilation and enhances the ventilatory-depressant effects of opioids. This suggests that combining a 5-HT2C receptor agonist with opioids may increase the risk of ventilatory depression without reducing abuse.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Fen Liu, Qing Tian, Hui-Ling Tang, Xiang Cheng, Wei Zou, Ping Zhang
Summary: This study demonstrates the attenuating effect of H2S on PD-associated depression by improving hippocampal synaptic plasticity.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Mehrsa Rahimi-Danesh, Mohammad-Ali Samizadeh, Amir-Ehsan Sajadi, Tara Rezvankhah, Salar Vaseghi
Summary: This study investigated the effects of lithium on freezing behavior and pain perception in a fear-conditioning model in rats. The results showed that lithium had no effect on freezing behavior and pain subthreshold in all rats. Extinction training decreased freezing behavior, with more efficacy in females. Gender differences were also observed in the effects of extinction training.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)