Article
Oncology
Deping Yang, Bo Yang, Yanjun Zhu, Qianlin Xia, Yan Zhang, Xin Zhu, Jianming Guo, Tao Ding, Jianghua Zheng
Summary: The study found that circDPP4 was overexpressed in PCa tissues and cell lines, and its expression was associated with Gleason score and clinical stage of PCa patients. In vitro experiments showed that circDPP4 knockdown inhibited PCa cell proliferation, migration, invasion, and cell cycle progression, while circDPP4 overexpression promoted these processes. Knockdown of circDPP4 also suppressed PCa tumor growth in vivo, indicating its potential as a therapeutic target for PCa.
CANCER CELL INTERNATIONAL
(2021)
Article
Neurosciences
Zhongbao Wu
Summary: RUNX1-IT1 is upregulated in glioblastoma and can sponge miR-195 to upregulate cyclin D1 expression, thereby increasing cell proliferation.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai, Donghua Gu
Summary: The study found that hsa_circ_0000520 and CDK2 were highly expressed in cervical cancer tissues, and hsa_circ_0000520 could competitively bind to miR-1296 to affect CDK2 expression, thereby inhibiting cell proliferation and promoting apoptosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Kaijun Liu, Yan Deng, Yongxia Yang, Hui Wang, Ping Zhou
Summary: This study found that SEMA3B-AS1 is downregulated in glioblastoma cells. The expression of SEMA3B-AS1 is inversely correlated with cyclin D1 and positively correlated with miR-195. SEMA3B-AS1 regulates the proliferation of GBM cells through miR-195 and cyclin D1.
Article
Multidisciplinary Sciences
Magdalena Niemira, Anna Erol, Agnieszka Bielska, Anna Zeller, Anna Skwarska, Karolina Chwialkowska, Mariusz Kuzmicki, Jacek Szamatowicz, Joanna Reszec, Pawel Knapp, Marcin Moniuszko, Adam Kretowski
Summary: Epithelial ovarian cancer (EOC) is a common and lethal cancer in women, with high-grade serous ovarian cancer (HGSOC) being the most common subtype. This study identified a miRNA panel that can effectively discriminate HGSOC patients with high diagnostic accuracy. The findings have significant implications for improving the diagnosis of ovarian cancer.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Jia-Xing Sun, Guo-Rui Dou, Zi-Yan Yang, Liang Liang, Juan-Li Duan, Bai Ruan, Man-Hong Li, Tian-Fang Chang, Xin-Yuan Xu, Juan-Juan Chen, Yu-Sheng Wang, Xian-Chun Yan, Hua Han
Summary: The study demonstrates that miR-218 acts as a downstream effector of Notch signaling in quiescent endothelial cells, inhibiting cell proliferation and sprouting, and could be a potential treatment for angiogenesis-related diseases.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Chemistry, Medicinal
Junxia Sun, Ruiying Jin
Summary: PFKFB4 is upregulated in cervical cancer and promotes malignant progression. miR-195-5p is downregulated and inhibits the expression of PFKFB4 in cervical cancer. miR-195-5p and PFKFB4 may serve as new therapeutic targets for cervical cancer patients.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Immunology
Minfei Jin, Lei Wang, Tao Zheng, Jun Yu, Rong Sheng, Hong Zhu
Summary: The study revealed that mir-195-3p was suppressed while BCDIN3D was activated in cervical cancer cells, and they interacted in the regulation. Overexpression of mir-195-3p can inhibit cell viability.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Cell Biology
Xiaohui Hua, Daimin Xiang, Mengxin Guo, Xiaohui Qian, Ruifan Chen, Tengda Li, Zhongxian Tian, Jiheng Xu, Chao Huang, Qipeng Xie, Chuanshu Huang
Summary: In this study, it was discovered that isorhapontigenin (ISO) initiates autophagic responses and inhibits bladder cancer (BC) invasion by activating the RAC1 protein translation and MKK7/JNK phosphorylation. The inhibition of autophagy was found to be crucial for ISO's inhibition of BC invasion. Mechanistic studies revealed that ISO inhibits miR-365a transcription, leading to upregulation of RAC1 translation, through the Dicer/miR145/SOX2/miR365a/RAC1 cascade, which in turn activates MKK7/JNK and induces autophagy.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Xiaomin Liu, Zhen Liu, Yonggang Liu, Ning Wang
Summary: The study revealed that miR-195-5p inhibits proliferation, migration, and EMT of CC cells by suppressing ATG9A expression, while promoting apoptosis and autophagy. miR-195-5p shows promise as a cancer suppressor gene and provides clinical evidence for targeted therapy of CC.
Article
Biotechnology & Applied Microbiology
Li-Li Quan, Jin-Yang Liu, Li-Xia Qu, Hui La, Hai-Li Wang, Xiao-Xia Chen, Na Wang, Zhen-Zhi Wei
Summary: This study analyzed the expression of Cyclin D1 (CCND1) gene in ovarian cancer using the Oncomine database, finding that its high expression is associated with poor prognosis. Cell experiments showed that silencing CCND1 gene expression can reduce ovarian cancer cell proliferation and promote apoptosis.
Article
Cell Biology
Feng Wu, Xin Guo, Yifan Ren, Yuting Peng, Zhiyong Lai, Jun Xu
Summary: The study reveals that circRNA0007766 plays a crucial role in the progression of adenocarcinoma of the esophagogastric junction (AEG) and may potentially serve as a novel biomarker for AEG.
CELLULAR SIGNALLING
(2023)
Review
Biochemistry & Molecular Biology
Valerio Nardone, Marcella Barbarino, Antonio Angrisani, Pierpaolo Correale, Pierpaolo Pastina, Salvatore Cappabianca, Alfonso Reginelli, Luciano Mutti, Clelia Miracco, Rocco Giannicola, Antonio Giordano, Luigi Pirtoli
Summary: The expanding clinical application of CDK4- and CDK6-inhibiting drugs in breast cancer has sparked interest in testing them in other tumors. Potential combinations with other therapeutic approaches are being explored, with some hypotheses about integrating CDK4 and CDK6 inhibitors with radiotherapy. However, more research is needed to further investigate the potential benefits of these combinations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Xiaolong Qiao, Yinan Chen, Zixuan Wang, Nan Peng, Wanxiang Niu, Shiqiang Hou, Jiaying Wu, Ying Ji, Chaoshi Niu, Chuandong Cheng
Summary: The study shows that GTF2E2 is overexpressed in glioma and is associated with poor prognosis. The biological functions of GTF2E2 were investigated in vitro and in vivo, and it was found to be regulated by miR-340-5p, affecting downstream gene expressions and glioma progression.
CANCER GENE THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Tianci Han, Liang Zhang, Wei Tong, Jian Zhao, Wei Wang
Summary: This study explores the interaction between cyclin D1 and calycosin and provides insights into their binding properties and potential structural changes. The results indicate that hydrogen bonding and van der Waals forces are involved in the binding of calycosin with cyclin D1, leading to structural alterations in cyclin D1. Additionally, calycosin inhibits lung cancer cell proliferation by arresting the cell cycle at the G1 phase.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Engineering, Biomedical
Yuyang Wei, Zhenmin Zou, Zhihui Qian, Lei Ren, Guowu Wei
Summary: Human finger joints are traditionally simplified as rigid joints in robotic hand design and biomechanical hand modelling, but the effect of different joint configurations on hand performance is not well understood. This study investigates the grasping performance of hands with rigid and flexible joints using a computational human hand model. The results show that the rigid joint configuration leads to reductions in hand contact force, pressure, and area compared to the flexible joint configuration. Grasping quality can be significantly reduced by the rigid joint configuration due to its weak rotational stiffness.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Engineering, Biomedical
Zheqi Hu, Lei Ren, Guowu Wei, Zhihui Qian, Wei Liang, Wei Chen, Xuewei Lu, Luquan Ren, Kunyang Wang
Summary: This study aims to determine the contribution of major muscles and the energy flow in the human musculoskeletal system during walking at different speeds. Gait experiments were performed, and muscle forces and mechanical work were calculated. The results showed that different muscles play different roles in energy absorption and generation during different phases of walking. These findings provide insights into human musculoskeletal behaviors during locomotion and can be applied in the bio-design of assistive devices.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Engineering, Manufacturing
Chi Ma, Bing Zhu, Zhihui Qian, Lei Ren, Hengyi Yuan, Yunhao Meng
Summary: In this study, flexible multimodal tactile sensors were fabricated using conductive inks optimized by a direct ink writing process. The rheological properties and printing speed were found to be crucial for printing conductive paths with controllable shape and good conductivity. The sensors showed excellent sensitivities for temperature, strain, and pressure, and exhibited reliability and durability through cyclic loading-unloading tests. The sensors also demonstrated great potential in health monitoring devices, flexible smart robots, and human-machine interfaces in intelligent automobiles.
JOURNAL OF MANUFACTURING PROCESSES
(2023)
Article
Medicine, General & Internal
Mai-Qing Yang, Zhi-Qiang Wang, Li-Qian Chen, Su-Mei Gao, Xing-Ning Fu, Hai-Ning Zhang, Ke-Xin Zhang, Hong-Tao Xu
Summary: This study investigated the clinicopathological characteristics of three cases of thymic lipofibroadenomas. Thymic lipofibroadenomas are extremely rare benign thymic tumors, and surgical removal is usually curative.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Robotics
Jianwei Sun, Zhenyu Wang, Meiling Zhang, Songyu Zhang, Zhihui Qian, Jinkui Chu
Summary: This letter proposes a design method for a metamorphic foot structure based on spring-loaded linkages, which can switch between metatarsal and toe positions. The foot mechanism's degrees of freedom are constrained using the singular position characteristic of a four-bar mechanism, and the structural parameters are calculated based on static analysis. Simulation and physical prototyping experiments verify the effectiveness of the design method, showing that the novel metamorphic foot mechanism provides a uniform solution for walking and running movements.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2023)
Article
Biodiversity Conservation
Dechun Jiang, Xumao Zhao, Jordi Lopez-Pujol, Zhiqiang Wang, Yanhua Qu, Yanming Zhang, Tongzuo Zhang, Dayong Li, Ke Jiang, Bin Wang, Chaochao Yan, Jia-Tang Li
Summary: Climate change and human disturbance have been affecting the distribution of endemic vertebrate species in the Qinghai-Tibet Plateau over the past 40 years. This study used occurrence records of 19 terrestrial vertebrate species to quantify the effects of climate change and human disturbance on their distribution. The results showed that climate change had a larger impact on range variation than human disturbance, and most mammals, amphibians, and reptiles experienced an increase in their suitable geographic range.
CONSERVATION BIOLOGY
(2023)
Article
Environmental Sciences
Tian-Tian Zuo, Jia Zhu, Fei Gao, De-Juan Kong, Ji-Shuang Wang, Qing-Hui Song, Hai-Yan Wang, Lei Sun, Wan-Qiang Zhang, Yuan-Sheng Guo, Jian-Bo Yang, Feng Wei, Qi Wang, Hong-yu Jin, Shuang-Cheng Ma
Summary: This study assessed the health risks of arsenic (As) and lead (Pb) in medical earthworms by analyzing their relative bioavailability (RBA) and bioaccessibility using in vitro physiologically based extraction (PBET) assay. The results showed that As-RBA ranged from 7.2% to 45.1%, and Pb-RBA ranged from 16.1% to 49.8%. In addition, the bioaccessibility of As and Pb varied from 6.7% to 48.3% and 7.8% to 52.5%, respectively. Furthermore, strong in vivo-in vitro correlations (IVIVCs) were observed between metal-RBA and bioaccessibility in medical earthworms.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Engineering, Multidisciplinary
Shengli Wang, Zhihui Qian, Xiangyu Liu, Guangsheng Song, Kunyang Wang, Jianan Wu, Jing Liu, Lei Ren, Luquan Ren
Summary: Accurate knowledge of the kinematics of the in vivo Ankle Joint Complex (AJC) is critical for understanding biomechanics and rehabilitation. However, the detailed analysis of 3D motion of the ankle joints during normal walking is lacking. This study analyzed the natural motions and coupled patterns of the tibiotalar and subtalar joints during walking, revealing significant differences in range of motion and coordinated coupled motion of the two joints.
JOURNAL OF BIONIC ENGINEERING
(2023)
Article
Oncology
Yang-kun Wang, Xue-xia Lv, Zhi-qiang Wang, Yong-mei Zhou, Bo Jiang, Su-nan Wang, Xiao-dong Chen
Summary: This study aimed to investigate the relationship between microlymphangiogenesis, microangiogenesis, and combined detection of PD-1/ki67 in gastric cancer patients and their disease prognosis. Immunohistochemistry was used to detect microlymphatic density (MLD) and microvessel density (MVD) in different zones of gastric cancer tissue, as well as the expression of PD-1 and ki67. The results showed that the central zone had fewer atretic cord-like lymphatic vessels but the peripheral zone had more lymphatic vessels, and the MLD was significantly decreased in the central zone compared to the peripheral zone. The expression of PD-1 and ki67 also differed between the zones. The differences in microlymphangiogenesis, microangiogenesis, and PD-1/ki67 expression were not statistically significant among different histological types, but were significantly decreased in early-stage gastric cancer compared to advanced-stage cancer. These findings suggest that MLD, MVD, PD-1, and ki67 are important indicators for predicting the prognosis of gastric cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Critical Care Medicine
Man Li, Junqiao Lv, Zhiqiang Wang, Liping Wang, Zhixin Qin, Chen Deng, Jinming Liu, Lin Sun
Summary: HMGB1 promotes the expression of NKCC1 and NHE1 in astrocytes and endothelial cells through activation of the HMGB1-TLR4-TRIF-NF-kappa B signaling pathway, leading to cytotoxic and ionic edema following spinal cord injury. Inhibition of HMGB1 reduces the expression of NKCC1 and NHE1 and decreases spinal cord edema. These findings are important for understanding the regulation of spinal cord edema after injury.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Medicine, General & Internal
Mai-Qing Yang, Zhi-Qiang Wang, Xiu-Feng Li, Li-Qian Chen, Hai-Ning Zhang, Ke-Xin Zhang, Hong-Tao Xu
Summary: This report describes a rare case of primary salivary gland-type acinic cell carcinoma (ACC) in the trachea and lungs. Due to its rarity, it can be misdiagnosed as another type of tracheal or lung tumor. Pathological features and immunohistochemistry are helpful in diagnosing primary ACC of the trachea and lungs.
Article
Nursing
Jiaojiao Sun, Yunxu Zhou, Zhiqiang Wang
Summary: This study established a depression risk warning model for patients with pulmonary nodules based on data analysis of 535 patients. Serum CRP, calcium, social support, and education level were identified as independent risk factors for depression in these patients. The model showed good predictive effect on depression in patients with pulmonary nodules.
PERSPECTIVES IN PSYCHIATRIC CARE
(2023)
Article
Oncology
Tian Wang, Jiaojiao Sun, Danfeng Gu, Siwen Shen, Yunxu Zhou, Zhiqiang Wang
Summary: The study aimed to investigate the dyadic relationships between perceived social support, illness uncertainty, anxiety, and depression among lung cancer patients and their family caregivers. A total of 308 patient-caregiver dyads were included, and questionnaires were used to assess their perceived social support, illness uncertainty, anxiety, and depression. The findings showed that both patient and caregiver perceived social support had actor and partner effects on anxiety and depression, and illness uncertainty mediated the effect of social support on anxiety and depression. Lung cancer stage played a moderating role in patient-caregiver dyads.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Psychology, Developmental
Chunhua Ma, Yongfeng Ma, Youpeng Wang, Xiaoyu Lan
Summary: The present study investigated the underlying mechanism and conditional process of the positive association between bullying victimization and internalizing problems among adolescents. It found that self-esteem partially mediated this association, with bullying victimization negatively impacting self-esteem which, in turn, was negatively associated with internalizing problems. Moreover, the study revealed that peer autonomy support moderated these associations, buffering against the negative effects of bullying victimization and self-esteem on internalizing problems. These findings have important implications for early interventions and prevention efforts aimed at mitigating the adverse consequences of bullying victimization on adolescent emotional well-being.
JOURNAL OF GENETIC PSYCHOLOGY
(2023)
Article
Sport Sciences
Zhiqiang Wang, Yaping Zhong, Sugai Wang
Summary: This review examined the anthropometric, physiological, and physical profiles of elite snowboarding athletes. The findings suggest that elite speed-based and skill-based athletes generally have low body fat percentages, and differences exist in height and body mass between male speed-based and skill-based athletes. The predominant energy system in snowboarding is anaerobic metabolism, while muscle oxidative metabolism can aid in recovery. Lower-body strength, eccentric force production, and explosive concentric power production are crucial for various aspects of snowboarding performance. Further research is needed to explore anthropometry, energy system contributions, and training effects across different snowboarding disciplines.
STRENGTH AND CONDITIONING JOURNAL
(2023)
