Article
Medicine, General & Internal
Shirley Cohen-Mekelburg, Beth I. Wallace, Tony Van, Wyndy L. Wiitala, Shail M. Govani, Jennifer Burns, Rachel Lipson, Huifeng Yun, Jason Hou, James D. Lewis, Jason A. Dominitz, Akbar K. Waljee
Summary: This study in a national cohort of veterans examined the association between the use of anti-TNF or corticosteroids and all-cause mortality in patients with IBD. Results suggest that anti-TNF therapy may be linked to reduced mortality compared with prolonged corticosteroid use, particularly among patients with Crohn disease.
Article
Immunology
Ana Carolina Matias Dinelly Pinto, Rodolfo de Melo Nunes, Igor Albuquerque Nogueira, Bernhard Fischer, Rudolf Lucas, Virginia Claudia Carneiro Girao-Carmona, Vivian Louise Soares de Oliveira, Flavio Almeida Amaral, Georg Schett, Francisco Airton Castro Rocha
Summary: TNF inhibitors are commonly used for the treatment of arthropathies like rheumatoid arthritis (RA), but not all patients achieve remission and there is a risk of infection. This study found that the lectin-like domain of TNF has anti-inflammatory effects and can mitigate the development of immune-mediated arthritis in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Anne Montfort, Florie Bertrand, Julia Rochotte, Julia Gilhodes, Thomas Filleron, Jean Milhes, Carine Dufau, Caroline Imbert, Joelle Riond, Marie Tosolini, Christopher J. Clarke, Florent Dufour, Andrei A. Constantinescu, Nilton De Franca Junior, Virginie Garcia, Michel Record, Pierre Cordelier, Pierre Brousset, Philippe Rochaix, Sandrine Silvente-Poirot, Nicole Therville, Nathalie Andrieu-Abadie, Thierry Levade, Yusuf A. Hannun, Herve Benoist, Nicolas Meyer, Olivier Micheau, Celine Colacios, Bruno Segui
Summary: Dysregulation of lipid metabolism affects cancer cell behavior, and increasing SMPD3 expression can reduce melanoma growth and enhance Th1 polarization and CD8(+) T-cell-dependent immune responses.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Rheumatology
Adrian Ciurea, Seraphina Kissling, Kristina Buerki, Xenofon Baraliakos, Manouk de Hooge, Monika Hebeisen, Eleftherios Papagiannoulis, Pascale Exer, Rene Bram, Michael J. Nissen, Burkhard Moller, Diego Kyburz, Michael Andor, Oliver Distler, Almut Scherer, Raphael Micheroli
Summary: This study compares disease characteristics and outcomes among patients with axial spondyloarthritis with different levels of sacroiliitis. The results show that patients with bilateral grade 2 sacroiliitis have milder disease and better treatment outcomes compared to those with unilateral/bilateral grade 3-4 sacroiliitis.
Article
Gastroenterology & Hepatology
Kunio Asonuma, Keiji Ozeki, Hajime Yamazaki, Shinji Okabayashi, Soh Okano, Ryo Ozaki, Nobuaki Nishimata, Hiroki Kiyohara, Naoki Ichinari, Taku Kobayashi, Masahiro Yamada, Mao Matsubayashi, Yoko Yokoyama, Shoko Arimitsu, Junji Umeno, Yoshinori Munetomo, Akira Andoh, Shinichiro Shinzaki, IBD Terakoya Grp
Summary: The use of immunomodulators after discontinuing anti-TNF-alpha antibody treatment was not significantly associated with relapse in patients with UC. Careful patient follow-up is necessary when discontinuing due to side effects or in younger patients at the time of discontinuation.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Hyun Jin Park, Boyoon Choi, Yun-Kyoung Song, Yoon-Jeong Oh, Eun Bong Lee, In-Wha Kim, Jung Mi Oh
Summary: This study aimed to evaluate the association between the use of TNFi and the risk of NTM infection in patients with rheumatoid arthritis (RA). Using the Korean National Health Insurance Service database, the study found that TNFi use was not associated with an increased risk of NTM infection compared to csDMARDs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Shaokui Chen, Ruixin Li, Yibo Chen, Chon-Kit Chou, Zhexuan Zhang, Yang Yang, Ping Liao, Qingqing Wang, Xin Chen
Summary: This study found that scutellarin, a Chinese herbal extract, can enhance the efficacy of tumor immunotherapy by disrupting the TNF-TNFR2 interaction. Scutellarin inhibits the proliferation of tumor-associated regulatory T cells, leading to increased infiltration of anti-tumor T cells in the tumor.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Manasi Agrawal, Anthony C. Ebert, Gry Poulsen, Ryan C. Ungaro, Adam S. Faye, Tine Jess, Jean-Frederic Colombel, Kristine H. Allin
Summary: This study compared the long-term outcomes of primary ileocecal resection (ICR) and anti-tumor necrosis factor (TNF) therapy in patients with ileocecal Crohn's disease (CD). The results showed that the risk of the composite outcome was 33% lower with ICR compared to anti-TNF therapy. ICR was also associated with a reduced risk of systemic corticosteroid exposure and CD-related surgery.
Article
Chemistry, Multidisciplinary
Sarah Belperain, Zi Yae Kang, Andrew Dunphy, Brandon Priebe, Norman H. L. Chiu, Zhenquan Jia
Summary: CNDs, as a novel form of nanoparticles, have shown potential anti-inflammatory properties in reducing TNF-alpha induced endothelial cell inflammation. This finding may open up a new direction for the treatment of cardiovascular diseases.
Article
Food Science & Technology
Jong Yeon Park, Bich Hang Do, Ju-Seung Lee, Hyun Cheol Yang, Anh Ngoc Nguyen, Martin Krupa, Chong Jai Kim, Yeon Jin Jang, Han Choe
Summary: The study found that recombinant crotamine has significant antinociceptive and anti-inflammatory effects, which are not related to the opioid receptor. Additionally, the effects of intraperitoneal or intraplantar recombinant crotamine are related to TNF-alpha.
Article
Gastroenterology & Hepatology
Michael D. Kappelman, David A. Wohl, Hans H. Herfarth, Ann M. Firestine, Jeremy Adler, Rana F. Ammoury, Jeanine E. Aronow, Dorsey M. Bass, Julie A. Bass, Keith Benkov, Catalina Berenblum Tobi, Margie E. Boccieri, Brendan M. Boyle, William B. Brinkman, Jose M. Cabera, Kelly Chun, Richard B. Colletti, Cassandra M. Dodds, Jill M. Dorsey, Dawn R. Ebach, Edurne Entrena, Christopher B. Forrest, Joseph A. Galanko, John E. Grunow, Ajay S. Gulati, Anastasia Ivanova, Traci W. Jester, Jess L. Kaplan, Subra Kugathasan, Mark E. Kusek, Ian H. Leibowitz, Tiffany M. Linville, Ellen A. Lipstein, Peter A. Margolis, Phillip Minar, Zarela Molle-Rios, Jonathan Moses, Kelly K. Olano, Lourdes Osaba, Pablo J. Palomo, Helen Pappa, K. T. Park, Dinesh S. Pashankar, Lisa Pitch, Michelle Robinson, Charles M. Samson, Kelly C. Sandberg, Julia R. Schuchard, Michael Seid, Kimberly A. Shelly, Steven J. Steiner, Jennifer A. Strople, Jillian S. Sullivan, Jeanne Tung, Prateek Wali, Michael Zikry, Morris Weinberger, Shehzad A. Saeed, Athos Bousvaros
Summary: This study compared the efficacy and safety of tumor necrosis factor inhibitors combined with oral methotrexate to monotherapy in pediatric Crohn's disease. The results showed that combination therapy with adalimumab can prolong the time to treatment failure and is tolerable. However, there was no significant difference in outcomes between combination and monotherapy for infliximab.
Article
Pharmacology & Pharmacy
Ana R. Fernandes, Tiago dos Santos, Pedro L. Granja, Elena Sanchez-Lopez, Maria L. Garcia, Amelia M. Silva, Eliana B. Souto
Summary: This study found that using cationic nanoemulsions to deliver triamcinolone acetonide (TA) can reduce the production of tumor necrosis factor alpha (TNF-alpha), which in turn decreases VEGF levels, indicating the potential use of these nanoemulsions for the treatment of age-related macular degeneration (AMD).
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Cell Biology
Dagmar Schierova, Radka Roubalova, Martin Kolar, Zuzana Stehlikova, Filip Rob, Zuzana Jackova, Stepan Coufal, Tomas Thon, Martin Mihula, Martin Modrak, Miloslav Kverka, Lukas Bajer, Klara Kostovcikova, Pavel Drastich, Jana Hercogova, Michaela Novakova, Martin Vasatko, Milan Lukas, Helena Tlaskalova-Hogenova, Zuzana Jiraskova Zakostelska
Summary: This study investigated the longitudinal effect of anti-TNF therapy on gut microbiota composition and immune response in IBD patients. The results showed differences in microbiota diversity between healthy controls, Crohn's disease, and ulcerative colitis patients, with patients' microbiota becoming more similar to healthy controls after treatment. Additionally, increased IgM levels against specific gut commensals were observed after anti-TNF therapy.
Article
Nutrition & Dietetics
Ji Hyun Lee, Ye An Kim, Young Sik Kim, Young Lee, Je Hyun Seo
Summary: This study examined the association between vitamin D deficiency and clinical parameters such as glycated hemoglobin, body mass index, and inflammatory markers. It found that vitamin D deficiency was associated with higher levels of glycated hemoglobin, body mass index, and inflammatory markers. Especially in older Korean women, vitamin D deficiency was related to higher levels of glycated hemoglobin, body mass index, and inflammatory markers.
Review
Pharmacology & Pharmacy
Henri Chedotal, Dilip Narayanan, Katrine Povlsen, Charlotte H. Gotfredsen, Roberta Brambilla, Michael Gajhede, Anders Bach, Mads H. Clausen
Summary: Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in immune system homeostasis and various diseases. Biologics targeting TNF have limitations, and therefore, small molecules and alternative strategies for modulating TNF signaling are being explored.
DRUG DISCOVERY TODAY
(2023)
Article
Rheumatology
Sinead Maguire, Samar Al-Emadi, Paula Alba, Mathia Cecilia Aguiar, Talal Al Lawati, Gelsomina Alle, Bonnie Bermas, Suleman Bhana, Anic Branimir, Inita Bulina, Megan Clowse, Karina Cogo, Iris Colunga, Claire Cook, Karen J. Cortez, Kathryn Dao, Milena Gianfrancesco, Monique Gore-Massey, Laure Gossec, Rebecca Grainger, Jonathon Hausman, Tiffany Y. T. Hsu, Kimme Hyrich, Carolina Isnardi, Yumeko Kawano, Rachael Kilding, Daria A. Kusevich, Saskia Lawson-Tovey, Jean Liew, Eoghan McCarthy, Anna Montgumery, Sebastian Moyano, Noreen Nasir, Ivan Padjen, Charalampos Papagoras, Naomi J. Patel, Mariana Pera, Cecilia Pisoni, Guillermo Pons-Estel, Antonio L. Quiambao, Rosana Quintana, Eric Ruderman, Sebastian Sattui, Veronica Savio, Savino Sciascia, Marieta Sencarova, Rosa Serrano Morales, Faizah Siddique, Emily Sirotich, Jeffrey Sparks, Anja Strangfeld, Paul Sufka, Helen Tanner, Yohana Tissera, Zachary Wallace, Marina L. Werner, Leanna Wise, Angus B. Worthing, JoAnn Zell, Julija Zepa, Pedro M. Machado, Jinoos Yazdany, Philip Robinson, Richard Conway
Summary: This study describes obstetric outcomes based on COVID-19 vaccination status in pregnant women with rheumatic and musculoskeletal diseases (RMDs). The results show that unvaccinated pregnant women have a higher rate of preterm births, and the need for COVID-19 pharmacological treatment is rare regardless of vaccination status.
Article
Rheumatology
Ryan M. Hum, Pauline Ho, Nisha Nair, Meghna Jani, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Darren Plant, Anne Barton
Summary: This study suggests that higher levels of TNF-a inhibitor serum drug levels (SDLs) are associated with good treatment response in fully adherent patients. Interventions to improve SDLs, such as encouraging adherence, may improve treatment response. The identified SDL cut-offs for adalimumab and certolizumab may be useful in clinical practice.
Article
Rheumatology
Manuel F. Ugarte-Gil, Graciela S. Alarcon, Andrea M. Seet, Zara Izadi, Anna D. Montgomery, Ali Duarte-Garcia, Emily L. Gilbert, Maria O. Valenzuela-Almada, Leanna Wise, Jeffrey A. Sparks, Tiffany Y. -T. Hsu, Kristin M. D'Silva, Naomi J. Patel, Emily Sirotich, Jean W. Liew, Jonathan S. Hausmann, Paul Sufka, Rebecca Grainger, Suleman Bhana, Zachary Wallace, Lindsay Jacobsohn, Anja Strangfeld, Elsa F. Mateus, Kimme L. Hyrich, Laure Gossec, Loreto Carmona, Saskia Lawson-Tovey, Lianne Kearsley-Fleet, Martin Schaefer, Pedro M. Machado, Philip C. Robinson, Milena Gianfrancesco, Jinoos Yazdany
Summary: A study on individuals with SLE in the US found that Black and Hispanic patients had higher odds of experiencing more severe COVID-19 outcomes compared to White patients, which may be attributed to socioeconomic and health disparities.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Joeri W. van Straalen, Lianne Kearsley-Fleet, Jens Klotsche, Sytze de Roock, Kirsten Minden, Arnd Heiligenhaus, Kimme L. Hyrich, Joke H. de Boer, Lovro Lamot, Alma N. Olivieri, Romina Gallizzi, Elzbieta Smolewska, Enrique Faugier, Serena Pastore, Philip J. Hashkes, Cristina N. Herrera, Wolfgang Emminger, Rita Consolini, Nico M. Wulffraat, Nicolino Ruperto, Joost F. Swart
Summary: This study aimed to develop and externally validate a prediction model for new-onset chronic uveitis in children with juvenile idiopathic arthritis (JIA). Data from the international Pharmachild registry were used to develop a multivariable Cox proportional hazards model. The model was subsequently validated and recalibrated in two inception cohorts. The results showed that the model had acceptable performance and could be used for risk estimation in clinical practice.
ARTHRITIS & RHEUMATOLOGY
(2023)
Letter
Rheumatology
Sizheng Steven Zhao, Anne Barton, John Bowes
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Kevin L. Winthrop, John D. Isaacs, Philip J. Mease, Dimitrios T. Boumpas, Xenofon Baraliakos, Jacques-Eric Gottenberg, Stefan Siebert, Marta Mosca, Neil Basu, Dana Orange, R. Lories, Daniel Aletaha, Iain B. McInnes, Tom W. J. Huizinga, Reinhard E. Voll, Ellen M. Gravallese, Ferry C. Breedveld, Josef S. Smolen
Summary: This article summarizes the unmet clinical and scientific needs in the field of rheumatology. It highlights the importance of clinical trial design innovation and the need to better understand the natural history of rheumatic diseases. The article also identifies the specific unmet needs in different rheumatological disease-specific groups and emphasizes the importance of developing therapies and therapeutic strategies for treatment-refractory disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Andrej Corovic, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T. Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R. Jayne, Stephen P. Hoole, Patrick A. Calvert, Andrew F. Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D. Fryer, Luigi Aloj, Martin J. Graves, Fiona J. Gilbert, Marc R. Dweck, David E. Newby, Zahi A. Fayad, Gary Reynolds, Ann W. Morgan, Eric O. Aboagye, Anthony P. Davenport, Helle F. Jorgensen, Ziad Mallat, Martin R. Bennett, James E. Peters, James H. F. Rudd, Justin C. Mason, Jason M. Tarkin
Summary: This study investigates the feasibility of using somatostatin receptor 2 (SST2) as a molecular imaging target for inflammation in large vessel vasculitis (LVV), and provides evidence for its potential in the diagnosis and therapeutic monitoring of LVV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Rheumatology
Samantha Louise Smith, Sheree Alexander, Nisha Nair, Sebastien Viatte, Stephen Eyre, Kimme L. Hyrich, Ann W. Morgan, Anthony G. Wilson, John D. Isaacs, Darren Plant, Anne Barton
Summary: The study aimed to explore whether the inflammatory protein MRP8/14 can serve as a biomarker for treatment response in rheumatoid arthritis (RA) patients receiving tumor necrosis factor (TNF) inhibitors. The results showed that in the 3-component and 2-component models, patients with high pre-treatment levels of MRP8/14 were 1.92 and 2.03 times more likely to be classified as EULAR responders compared to those with low levels. However, no significant associations were observed in the 4-component model. Conclusion: Apart from its correlation with CRP, there is no evidence to suggest that MRP8/14 explains additional variability in response to TNFi in RA patients beyond CRP alone.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemical Research Methods
Elena Vigorito, Anne Barton, Costantino Pitzalis, Myles J. Lewis, Chris Wallace
Summary: In this study, a Bayesian beta-binomial mixture model (BBmix) is proposed for calling genotypes using RNA-Seq data, which can model specific biases in RNA-Seq. The benchmarking results show that BBmix generally outperforms competitors in genotype calling, with an increase of up to 1.4% in the accuracy of heterozygous calls. BBmix can be easily incorporated into standard genotype calling pipelines and the model parameters are generally transferable within datasets, making it possible to call genotypes in a large number of samples with less than 1 hour of learning.
Letter
Rheumatology
Philippa D. K. Curry, Hector Chinoy, Meghna Jani, Darren Plant, Kimmie L. Hyrich, Ann W. Morgan, A. G. Wilson, John D. Isaacs, Andrew P. Morris, Anne Barton, James Bluett
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
Joshua. L. L. Bennett, Arthur. G. G. Pratt, Richard Dodds, Avan. A. A. Sayer, John. D. D. Isaacs
Summary: Sarcopenia, characterized by the loss of skeletal muscle strength and mass, is commonly associated with rheumatoid arthritis. This review discusses the epidemiology, pathophysiology, and identification of rheumatoid sarcopenia, as well as the therapeutic roles of physical activity, nutrition, and pharmacotherapy. Rheumatoid sarcopenia is highly prevalent (>= 25%) in individuals with rheumatoid arthritis and is associated with increased risk of falls, fractures, and physical disability.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lisa M. Duff, Andrew F. Scarsbrook, Nishant Ravikumar, Russell Frood, Gijs D. van Praagh, Sarah L. Mackie, Marc A. Bailey, Jason M. Tarkin, Justin C. Mason, Kornelis S. M. van der Geest, Riemer H. J. A. Slart, Ann W. Morgan, Charalampos Tsoumpas
Summary: The aim of this study was to develop and validate an automated pipeline for diagnosing active aortitis using radiomic imaging biomarkers from FDG PET-CT images. The aorta was automatically segmented using a CNN. Radiomic features were extracted, and three different radiomic fingerprints were constructed. The pipeline showed good diagnostic performance across multiple datasets, indicating its potential for generalizability and use in automated clinical decision-making.
Article
Rheumatology
Stephanie F. Ling, Chuan Fu Yap, Nisha Nair, James Bluett, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Anne Barton, Darren Plant
Summary: This study aimed to identify proteomic biomarkers associated with clinical outcome measures in patients with rheumatoid arthritis (RA) starting biologic disease-modifying antirheumatic drugs (bDMARDs). Through SWATH-MS analysis of serum samples from RA patients before and after 3 months of treatment, ten proteins were found to be significantly associated with clinical outcome measures, and one of them was validated in an independent cohort.
Article
Rheumatology
Ciara D. O'Brien, George Kitas, Fiona D. Rayner, John F. Isaacs, Kenneth G. Baker, Arthur D. Pratt, Christopher Buckley, Karim Raza, Andrew Filer, Stefan Siebert, Iain McInnes, Andrew McGucken, Sally A. M. Fenton, BIOFLARE Consortium
Summary: This study aimed to determine the minimum number of monitoring days required to reliably estimate sedentary time, light-intensity physical activity, and moderate-intensity physical activity in people with Rheumatoid Arthritis (RA) across different levels of disease activity. The results showed that at least 4 monitoring days were required to reliably estimate sedentary time and light-intensity physical activity, while at least 5 monitoring days were required to reliably estimate behaviors across the movement continuum. This information is important for accurately assessing physical activity levels and sedentary behavior in RA patients and can help inform interventions for promoting physical activity and reducing sedentary time.
RHEUMATOLOGY INTERNATIONAL
(2023)