Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics

Fluoxetine- and Norfluoxetine-Mediated Complex Drug–Drug Interactions: In Vitro to In Vivo Correlation of Effects on CYP2D6, CYP2C19, and CYP3A4

(2014) J E Sager et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Challenges in CYP2D6 Phenotype Assignment from Genotype Data: A Critical Assessment and Call for Standardization

(2014) J. Hicks et al.   CURRENT DRUG METABOLISM

Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity

(2013) Danxin Wang et al.   HUMAN MOLECULAR GENETICS

Potential role of CYP2D6 in the central nervous system

(2013) Jie Cheng et al.   XENOBIOTICA

Paediatric drug use with focus on off-label prescriptions at Swedish hospitals - a nationwide study

(2012) E Kimland et al.   ACTA PAEDIATRICA

Off-Label Drug Use in Pediatric Patients

(2012) E Kimland et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pediatric Information in Drug Product Labeling

(2012) Debbie Avant   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

An accelerated workflow for untargeted metabolomics using the METLIN database

(2012) Ralf Tautenhahn et al.   NATURE BIOTECHNOLOGY

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype

(2011) K R Crews et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Anandamide Oxidation by Wild-Type and Polymorphically Expressed CYP2B6 and CYP2D6

(2011) C. Sridar et al.   DRUG METABOLISM AND DISPOSITION

Pharmacogenomics of CYP2D6: Molecular Genetics, Interethnic Differences and Clinical Importance

(2011) Lay Kek Teh et al.   Drug Metabolism and Pharmacokinetics

CYP2D6,SULT1A1andUGT2B17copy number variation: quantitative detection by multiplex PCR

(2011) Andrea Gaedigk et al.   PHARMACOGENOMICS

Pediatric Dose Selection

(2010) D R Abernethy et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Assessment of Activity Levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 Genes by Population Pharmacokinetics of Dextromethorphan

(2010) K Abduljalil et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Discovery of the nonfunctional CYP2D6*31 allele in Spanish, Puerto Rican, and US Hispanic populations

(2010) Andrea Gaedigk et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Variability in drug metabolizing enzyme activity in HIV-infected patients

(2010) Amanda E. Jones et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Understanding the Relative Roles of Pharmacogenetics and Ontogeny in Pediatric Drug Development and Regulatory Science

(2010) J. Steven Leeder et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Genomewide Association Studies and Assessment of the Risk of Disease

(2010) Teri A. Manolio   NEW ENGLAND JOURNAL OF MEDICINE

Developmental pharmacology of tramadol during infancy: ontogeny, pharmacogenetics and elimination clearance

(2010) Karel Allegaert et al.   PEDIATRIC ANESTHESIA

CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans

(2010) A LLerena et al.   PHARMACOGENOMICS JOURNAL

Identification of Novel CYP2D7-2D6 Hybrids: Non-Functional and Functional Variants

(2010) Andrea Gaedigk et al.   Frontiers in Pharmacology

Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance

(2009) Shu-Feng Zhou   CLINICAL PHARMACOKINETICS

Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance

(2009) Shu-Feng Zhou   CLINICAL PHARMACOKINETICS

The In Silico Child: Using Simulation to Guide Pediatric Drug Development and Manage Pediatric Pharmacotherapy

(2009) Stephanie Läer et al.   JOURNAL OF CLINICAL PHARMACOLOGY

1H NMR metabolomics study of age profiling in children

(2009) Haiwei Gu et al.   NMR IN BIOMEDICINE

CYP2D7–2D6hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction

(2009) Andrea Gaedigk et al.   PHARMACOGENOMICS

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

(2008) Ulrich M. Zanger et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Highly sensitive feature detection for high resolution LC/MS

(2008) Ralf Tautenhahn et al.   BMC BIOINFORMATICS

Pinoline May be Used as a Probe for CYP2D6 Activity

(2008) X.-L. Jiang et al.   DRUG METABOLISM AND DISPOSITION

Developmental Changes in Human Liver CYP2D6 Expression

(2008) J. C. Stevens et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetic predictions in children by using the physiologically based pharmacokinetic modelling

(2008) F. Bouzom et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Metabolite profiling in human urine by LC–MS/MS: Method optimization and application for glucuronides from dextromethorphan metabolism

(2008) Ursula Lutz et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

The Endocannabinoid Anandamide Is a Substrate for the Human Polymorphic Cytochrome P450 2D6

(2008) N. T. Snider et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

HMDB: a knowledgebase for the human metabolome

(2008) D. S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Improving Pediatric Dosing Through Pediatric Initiatives: What We Have Learned

(2008) W. Rodriguez et al.   PEDIATRICS

The problems in scaling adult drug doses to children

(2007) T N Johnson   ARCHIVES OF DISEASE IN CHILDHOOD