Pharmacogenetics of drug-induced birth defects: the role of polymorphisms of placental transporter proteins

Organic Cation Transporter 3 (OCT3/SLC22A3) and Multidrug and Toxin Extrusion 1 (MATE1/SLC47A1) Transporter in the Placenta and Fetal Tissues: Expression Profile and Fetus Protective Role at Different Stages of Gestation1

(2013) Davoud Ahmadimoghaddam et al.   BIOLOGY OF REPRODUCTION

Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake

(2012) Min-Koo Choi et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia

(2012) A. Giannoudis et al.   BLOOD

Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure

(2012) Frantisek Staud et al.   JOURNAL OF DRUG TARGETING

Placental drug transporters and their role in fetal protection

(2012) M. Iqbal et al.   PLACENTA

Synchronized Activity of Organic Cation Transporter 3 (Oct3/Slc22a3) and Multidrug and Toxin Extrusion 1 (Mate1/Slc47a1) Transporter in Transplacental Passage of MPP+ in Rat

(2012) Davoud Ahmadimoghaddam et al.   TOXICOLOGICAL SCIENCES

Drug Interactions at the Human Placenta: What is the Evidence?

(2012) Miriam Rubinchik-Stern et al.   Frontiers in Pharmacology

ATP-Binding Cassette Efflux Transporters in Human Placenta

(2011) Zhanglin Ni et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Functional Significance of Genetic Polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2)

(2011) Ichiro Ieiri   Drug Metabolism and Pharmacokinetics

Frequency of the SLCO1B1 388A>G and the 521T>C polymorphism in Tanzania genotyped by a new LightCycler®-based method

(2011) Eleni Aklillu et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Transfer of repaglinide in the dually perfused human placenta and the role of organic anion transporting polypeptides (OATPs)

(2011) Kristiina Tertti et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A Novel MDR1 GT1292-3TG (Cys431Leu) Genetic Variation and Its Effect on P-glycoprotein Biologic Functions

(2010) Matthew H. Crouthamel et al.   AAPS Journal

General maternal medication use, folic acid, the MDR1 C3435T polymorphism, and the risk of a child with a congenital heart defect

(2010) Sylvia A. Obermann-Borst et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Influence of Cremophor EL and Genetic Polymorphisms on the Pharmacokinetics of Paclitaxel and Its Metabolites Using a Mechanism-Based Model

(2010) M. N. Fransson et al.   DRUG METABOLISM AND DISPOSITION

The Role of the Placenta in Fetal Exposure to Xenobiotics: Importance of Membrane Transporters and Human Models for Transfer Studies

(2010) C. Prouillac et al.   DRUG METABOLISM AND DISPOSITION

Organic Anion Transporting Polypeptide 1B1 (OATP1B1) and OATP1B3: Genetic Variability and Haplotype Analysis in White Canadians

(2010) Andrée-Anne Boivin et al.   Drug Metabolism and Pharmacokinetics

Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancy

(2010) Lenka Hahnova-Cygalova et al.   DRUG METABOLISM REVIEWS

Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms

(2010) Takeshi Sakata et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

Placental P-glycoprotein and breast cancer resistance protein: Influence of polymorphisms on fetal drug exposure and physiology

(2010) J.R. Hutson et al.   PLACENTA

Maternal medication use, carriership of theABCB13435C > T polymorphism and the risk of a child with cleft lip with or without cleft palate

(2009) Bart J.B. Bliek et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Modulation of human placental P-glycoprotein expression and activity by MDR1 gene polymorphisms

(2009) Sarah J. Hemauer et al.   BIOCHEMICAL PHARMACOLOGY

Drug transporters in the human blood-placental barrier

(2009) Kirsi Vähäkangas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genetic Variations of the SLC22A4 Gene in Chinese and Indian Populations of Singapore

(2009) Dorothy Su Lin Toh et al.   Drug Metabolism and Pharmacokinetics

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs

(2009) Ichiro Ieiri et al.   Expert Opinion on Drug Metabolism & Toxicology

Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity

(2009) Moto Kajiwara et al.   JOURNAL OF HUMAN GENETICS

The Drug Transporter−Metabolism Alliance: Uncovering and Defining the Interplay

(2009) Leslie Z. Benet   MOLECULAR PHARMACEUTICS

Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function

(2009) Ying Chen et al.   PHARMACOGENOMICS JOURNAL

Pharmacogenetic Studies of Paclitaxel in the Treatment of Ovarian Cancer

(2008) Henrik Gréen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Genetic Variations of the ABCC2 Gene in the Chinese, Malay, and Indian Populations of Singapore

(2008) Woon Fei Ho et al.   Drug Metabolism and Pharmacokinetics

Influence of adenosine triphosphate and ABCB1 (MDR1) genotype on the P-glycoprotein-dependent transfer of saquinavir in the dually perfused human placenta

(2008) M Rahi et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

A Novel Human Multidrug Resistance Gene MDR1 Variant G571A (G191R) Modulates Cancer Drug Resistance and Efflux Transport

(2008) Z. Yang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

BCRP/ABCG2 in the Placenta: Expression, Function and Regulation

(2008) Qingcheng Mao   PHARMACEUTICAL RESEARCH

Influence of genetic polymorphisms on intestinal expression and rifampicin-type induction of ABCC2 and on bioavailability of talinolol

(2008) Sierk Haenisch et al.   Pharmacogenetics and Genomics

Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A)

(2007) Tomohiro Terada et al.   BIOCHEMICAL PHARMACOLOGY