Article
Biotechnology & Applied Microbiology
Lu Ren, Shaoqin Yang, Qinxue Cao, Jun Tian
Summary: The study revealed that CRNDE promotes cervical cancer progression by regulating the wnt/beta-catenin pathway through interaction with miR-4262 and ZEB1. CRNDE acts as an oncogene in cervical cancer by modulating cell proliferation, migration, invasion, and apoptosis. Targeting the CRNDE/miR-4262/ZEB1 axis may offer a potential therapeutic strategy for cervical cancer.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Emanuela Teveroni, Fiorella Di Nicuolo, Edoardo Vergani, Giada Bianchetti, Carmine Bruno, Giuseppe Maulucci, Marco De Spirito, Tonia Cenci, Francesco Pierconti, Gaetano Gulino, Pierfrancesco Bassi, Alfredo Pontecorvi, Domenico Milardi, Francesca Mancini
Summary: This study investigated the role of PTTG1 in the EMT process in seminoma. The results showed that PTTG1 transcriptionally represses E-Cadherin through its cooperation with the transcriptional repressor ZEB1. It also demonstrated that PTTG1 and ZEB1 strongly localize together in the periphery of the tumors. These findings suggest that PTTG1 is a prognostic factor in seminoma clinical management.
Article
Environmental Sciences
Ping Deng, Miduo Tan, Wei Zhou, Chunhai Chen, Yu Xi, Peng Gao, Qinlong Ma, Yidan Liang, Mengyan Chen, Li Tian, Jia Xie, Mengyu Liu, Yan Luo, Yanqi Li, Lei Zhang, Liting Wang, Youlong Zeng, Huifeng Pi, Zhengping Yu, Zhou Zhou
Summary: The study found that BPA exposure significantly promoted the proliferation and migration of MCF-7 cells by affecting the cell cycle pathway. Screening differentially expressed genes identified PTTG1 and CDC20 as key targets associated with BPA-induced cell proliferation and migration.
Article
Food Science & Technology
Hengju Ge, Jiaxin Li, Yang Xu, Jiahong Xie, Naymul Karim, Fujie Yan, Jianling Mo, Wei Chen
Summary: Curcumin reduces lipid deposition in hepatocytes by activating the AMPK pathway, and miR-3666 directly targets AMPK gene. Overexpression of miR-3666 weakens the hypolipidemic effect of Curcumin.
Article
Biochemistry & Molecular Biology
Zhao-Hui Chen, Yi-Bo Chen, Hao-Ran Yue, Xue-Jie Zhou, Hai-Yan Ma, Xin Wang, Xu-Chen Cao, Yue Yu
Summary: This study identified PAX5 as the upstream regulator of miR-142-5p/3p and demonstrated that PAX5 functions as a tumor suppressor by positively regulating miR-142-5p/3p. The expression of PAX5 is regulated by DNMT1 and ZEB1-mediated methylation of its promoter region. Moreover, miR-142-5p/3p regulates the expression of DNMT1 and ZEB1 by binding to their 3'UTR region, respectively. In conclusion, PAX5-miR-142-DNMT1/ZEB1 forms a negative feedback loop to regulate the progression of breast cancer.
MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Xueyou Ma, Yufan Ying, Jiazhu Sun, Haiyun Xie, Jiangfeng Li, Liujia He, Weiyu Wang, Shiming Chen, Haixiang Shen, Jiahe Yi, Jindan Luo, Xiao Wang, Xiangyi Zheng, Ben Liu, Liping Xie
Summary: circKDM4C acts as a pro-oncogenic factor in BCa invasion and metastasis via the circKDM4C/miR-200bc-3p/ZEB1 axis, suggesting its potential as a biomarker or therapeutic target for bladder cancer.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Florian Posch, Felix Prinz, Amar Balihodzic, Christian Mayr, Tobias Kiesslich, Christiane Klec, Katharina Jonas, Dominik A. Barth, Jakob M. Riedl, Armin Gerger, Martin Pichler
Summary: Biliary tract cancer is a rare malignancy with poor survival rates, and cisplatin-based treatments are commonly used as first-line strategies. MiR-200c-3p may play a significant role in cisplatin resistance in biliary tract cancer, independent of its interaction with ZEB1.
Article
Oncology
Yuwei Dong, Fuxia Li, Junjun Wang, Jiangfeng Hu, Zhenghong Li, Yubei Gu, Yun Feng
Summary: miR-369 may act as a tumor suppressor in HCC by targeting ZEB1, inhibiting the proliferation and metastasis of liver cancer cells, and showing a negative association with ZEB1 expression.
Article
Cell Biology
Yazhen Xu, Bingyu Guo, Xiaoyan Liu, Kai Tao
Summary: miR-34a inhibits melanoma growth by targeting ZEB1, suggesting a potential novel target for melanoma treatment.
Article
Biochemistry & Molecular Biology
Fahui Lv, Youwen Zhong, Ling Sang, Xiaoling Wu
Summary: miR-1179 is downregulated in cervical cancer, and it may inhibit cancer cell invasion and EMT transformation by regulating the CHAF1A/ZEB1 axis.
ACTA BIOCHIMICA POLONICA
(2021)
Article
Oncology
Qing Li, Zhi-Wei Zhou, Wei Duan, Cheng-Yuan Qian, Shu-Nan Wang, Meng-Sheng Deng, Dan Zi, Jian-Min Wang, Cheng-Yi Mao, Guanbin Song, Dong Wang, Kenneth D. Westover, Cheng-Xiong Xu
Summary: High APE1 expression is associated with lymph node metastasis in cervical cancer and linked to epithelial to mesenchymal transition (EMT). APE1 promotes invasion and metastasis of cervical cancer cells, while inhibiting APE1 may suppress EMT. Targeting APE1 redox function could be a novel strategy for inhibiting cervical cancer metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Di Zhang, Xiaofeng Liu, Yun Li, Li Sun, Shu-Shu Liu, Yue Ma, Huan Zhang, Xin Wang, Yue Yu
Summary: The study revealed that miR-586 functions as an oncogene promoting breast cancer proliferation and metastasis, while LINC01189 acts as a tumor suppressor inhibiting cancer progression. The interaction and feedback loop between the two are involved in the regulation of Wnt/β-catenin signaling and breast cancer development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Yaoyao Xiong, Xiongbing Zu, Long Wang, Yuan Li, Minfeng Chen, Wei He, Lin Qi
Summary: The study identified lncRNA VIM-AS1 as highly expressed in bladder cancer, especially in metastatic tissues and high-metastatic cell lines. VIM-AS1 acted as a ceRNA for miR-655, competing with ZEB1 for miR-655 binding, promoting EMT in both high- and low-metastatic bladder cancer cells, and enhancing cancer cell metastasis.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Z. Y. Gao, H. Liu, Z. Zhang
Summary: miR-144-3p expression was down-regulated in GC tissue, which can increase the radiosensitivity of those cells by inhibiting ZEB1 expression.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Hanquan Wu, Dengwen Dong, Jiwei Wang, Shiwen Yin, Yuanxiang Gong, Chao Yang, Yihan Bai, Junyi Wang, Yanhong Du
Summary: The study demonstrated that long noncoding RNA nuclear paraspeckle assembly transcript 1 is up-regulated in colorectal cancer tissues and cells, promoting proliferation and invasion of colorectal cancer by targeting miR-448 to promote the expression of ZEB1, which may play a significant role in the tumorigenesis of colorectal cancer.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Biochemistry & Molecular Biology
Qi Zhou, Di Wang, Jiancheng Xu, Baorong Chi
BIOLOGICAL TRACE ELEMENT RESEARCH
(2016)
Article
Pediatrics
Xin Li, Di Wang, Chun Yang, Qi Zhou, Suo-Lang Zhuoga, Li-Qiang Wang, Han-Xin Yao, Qin Zhang, Qing Ai, Chen-Xi Yang, Jian-Cheng Xu
WORLD JOURNAL OF PEDIATRICS
(2018)
Article
Cell Biology
Jiancheng Xu, Qi Zhou, Gilbert Liu, Yi Tan, Lu Cai
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2013)
Article
Multidisciplinary Sciences
Jiancheng Xu, Wei Xu, Hanxin Yao, Weixia Sun, Qi Zhou, Lu Cai
Article
Multidisciplinary Sciences
Jiancheng Xu, Xiumei Duan, Hui Wu, Qi Zhou
Article
Environmental Sciences
Jiancheng Xu, Zhihui Sun, Yanyan Li, Qi Zhou
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2013)