Peripherally Cross-Linking the Shell of Core-Shell Polymer Micelles Decreases Premature Release of Physically Loaded Combretastatin A4 in Whole Blood and Increases its Mean Residence Time and Subsequent Potency Against Primary Murine Breast Tumors After IV Administration

Title
Peripherally Cross-Linking the Shell of Core-Shell Polymer Micelles Decreases Premature Release of Physically Loaded Combretastatin A4 in Whole Blood and Increases its Mean Residence Time and Subsequent Potency Against Primary Murine Breast Tumors After IV Administration
Authors
Keywords
drug delivery, peripheral shell cross-linking, pluronic F127, poloxamer 407, polymer nanocarriers, premature drug release, vascular disrupting agents
Journal
PHARMACEUTICAL RESEARCH
Volume 32, Issue 3, Pages 1028-1044
Publisher
Springer Nature
Online
2014-09-16
DOI
10.1007/s11095-014-1515-z

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